TTFields and Pulsed Bevacizumab for Recurrent Glioblastoma
Glioblastoma multiforme (GBM) is the most common and deadliest primary malignant neoplasm of
the central nervous system in adults. Despite an aggressive multimodality treatment approach
including surgery, radiation therapy and chemotherapy, overall survival remains poor.
Novocure has shown that when properly tuned, very low intensity, intermediate frequency
electric fields (TTFields) stunt the growth of tumor cells. The Optune system (NovoTTFTM
Therapy) is a portable battery operated device, which produces TTFields within the human body
by means of surface transducer arrays. The TTFields are applied to the patient by means of