A Neurocognitive Study in Patients With Brain Oligometastases Receiving Hypofractionated SRT
For newly-diagnosed patients with brain metastasis, conventional whole-brain radiation
therapy (WBRT) might still remain a common palliative management even for those with brain
oligometastases. However, WBRT-related late consequences, particularly a decline in
neurocognitive functions (NCFs), are a major concern. Actually, WBRT-related neurocognitive
dysfunction is usually characterized as deterioration involving learning and memory, in which
the extremely radiosensitive hippocampus indeed plays a critical role. In order to postpone
or mitigate the effect of conventional WBRT-induced neurocognitive impairments, there...