Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics

Study Purpose

Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	No
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Observational
Eligible Ages	18 Years and Over
Gender	All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Age≥18 years.

- Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂<150 mmHg,and requiring prone ventilation.

- Expected duration of mechanical ventilation>48 hours.

- Written informed consent obtained.

Exclusion Criteria:

- Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension) - Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics.

- Life-threatening ARDS.

- Patients who are unable to undergo neurological assessment.

- Poor image quality or absence of images

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT06967285
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	Sichuan Provincial People's Hospital
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	lingai Pan, PhD
Principal Investigator Affiliation	Sichuan Provincial People's Hospital
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other
Overall Status	Recruiting
Countries	China
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	ARDS (Moderate or Severe)

Additional Details

Collecting Medical Records, Demographic Characteristics, and Clinical Data of Moderate to Severe ARDS Patients Requiring Prone Positioning Treatment at Chengdu Pixdu District People's Hospital, Sichuan Provincial People's Hospital, The Fourth People's Hospital of Chengdu, and Chengdu Shuangliu District First People's Hospital from March 2025 to March 2026.

Contact a Trial Team

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International Sites

Sichuan Provincial People's Hospital,, Chengdu 1815286, Sichuan 1794299, China

Status

Recruiting

Address

Sichuan Provincial People's Hospital,

Chengdu 1815286, Sichuan 1794299, 610072

Site Contact

lingai Pan, PhD

[email protected]

17708130236

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