Clinical Trial Finder

Inclusion Criteria:

• - Histologically-proven glioblastoma (World Health Organization [WHO] 2021 criteria) - Progressive or recurrent disease per Response Assessment in Neuro-Oncology (RANO) criteria.

• - No IDH mutation (IDH1 R132H negative by immunohistochemistry [IHC] or sequencing) - Patients must be in first recurrence of glioblastoma following radiation therapy and temozolomide.

• - No prior therapies except radiation, temozolomide, Tumor Treating Fields (TTFields), and/or Gliadel wafers (placed during the first surgery at diagnosis of glioblastoma multiforme [GBM]).

Prior radiation therapy, TTFields, or placement of Gliadel wafers must be completed at least 12 weeks prior to registration. Prior temozolomide must be completed at least 3 weeks prior to registration.

• - No prior use of nivolumab or other anti-PD1 agents.

• - Patients must be neurologically stable off corticosteroids for at least 5 days prior to registration.

• - Age: ≥ 18 years.

• - Karnofsky Performance Status: ≥ 60% (i.e. patient must be able to care for themselves with occasional help from others) - Absolute lymphocyte count (ALC): ≥ 1000/mm^3.

• - Absolute neutrophil count (ANC): ≥ 1500/mm^3.

• - Platelet count: ≥ 100,000/mm^3.

• - Hemoglobin: ≥ 9.0 g/dL.

• - Activated partial thromboplastin time (APTT) or partial thromboplastin time (PTT): ≤ 1.5 x upper limit of normal (ULN) - Total bilirubin: < 2.0 x ULN (Except for patients with Gilbert's syndrome, who must have direct bilirubin < 2.0 x ULN) - Aspartate aminotransferase (AST) / alanine aminotransferase (ALT): < 3.0 x ULN.

• - Creatinine: ≤ 1.0 x ULN (For patients with creatinine > 1.0 x ULN, calculated creatinine clearance must be ≥ 50 mL/min/1.73m^2) - Thyroid-stimulating hormone (TSH): within normal limits (WNL) (Supplementation is acceptable to achieve a TSH WNL.

In patients with abnormal TSH, if Free T4 is normal and patient is clinically euthyroid, patient is eligible)

• - Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown and an agent that has known genotoxic, mutagenic and teratogenic effects.

Therefore, for women of childbearing potential only, a negative pregnancy test done within 14 days prior to registration is required.

• - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.

• - No active brain metastases or leptomeningeal disease.

• - HIV: HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial.

• - Hepatitis B: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.

• - Hepatitis C: Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured.

For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.

• - No known medical condition causing an inability to swallow oral formulations of agents.

• - No current symptomatic pulmonary disease.

- No autoimmune disorders that require systemic treatment (except hyperthyroidism or diabetes mellitus)

PRIMARY OBJECTIVE:

• I. To compare the restricted mean survival time (RMST) for overall survival (OS) between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care chloroethylcyclohexylnitrosourea (CCNU) (lomustine).

SECONDARY OBJECTIVES:

• I. To compare the 12-month OS rates between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine).

• II. To compare the restricted mean survival times for progression-free survival (PFS) between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine).

• III. To compare the radiographic response rate between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine).

• IV. To compare the safety/adverse event rate between patients receiving the combination of relatlimab (BMS-986016) and nivolumab versus patients receiving standard of care CCNU (lomustine).

OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes followed by relatlimab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo magnetic resonance imaging (MRI) at baseline and every 8 weeks until progression and then at least 8 weeks after objective response. Additionally patients undergo surgery or biopsy and blood sample collection throughout study. ARM II: Patients receive lomustine orally (PO) on day 1 of each cycle. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Patients also undergo MRI every 9 weeks until progression and then at least 6 weeks after objective response. Additionally patients undergo surgery or biopsy and blood sample collection throughout study. After completion of study treatment, patients are followed up every 6 months for up to 5 years from time of randomization.

Arms

Experimental: Arm I (nivolumab, relatlimab)

Patients receive nivolumab IV over 30 minutes followed by relatlimab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo MRI at baseline and every 8 weeks until progression and then at least 8 weeks after objective response. Additionally patients undergo surgery or biopsy and blood sample collection throughout study.

Active Comparator: Arm II (lomustine)

Patients receive lomustine PO on day 1 of each cycle. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Patients also undergo MRI every 9 weeks until progression and then at least 6 weeks after objective response. Additionally patients undergo surgery or biopsy and blood sample collection throughout study.

Interventions

Procedure: - Biopsy

Undergo biopsy

Procedure: - Biospecimen Collection

Undergo blood sample collection

Drug: - Lomustine

Given PO

Procedure: - Magnetic Resonance Imaging

Undergo MRI

Biological: - Nivolumab

Given IV

Biological: - Relatlimab

Given IV

Procedure: - Surgical Procedure

Undergo surgery