Inclusion Criteria:
1. Adults ≥ 18 years of age.
2. Patient has histologically or cytologically confirmed metastatic or locally advanced
unresectable solid tumors with TP53 mutation/loss and with/without brain metastasis.
Patients must have relapsed/be refractory to at least 1 line of systemic therapy in
the metastatic setting (excluding melanoma).
3. Prostate cancer:
1. mCRPC with histologic confirmation of adenocarcinoma. mCRPC with neuroendocrine
features or mixed histology are excluded. 2. Patients will be enrolled irrespective of the TP53 status. 3. Participant must have prostate specific antigen (PSA) of ≥ 2 ng/mL. 4. Is surgically or medically castrated, with testosterone levels of less than 50
ng/dL. 5. Patients who progressed on at least 1 prior novel androgen receptor AR-targeted
therapy (that is, abiraterone acetate, apalutamide, enzalutamide,
darolutamide), and or at least 1 prior systemic chemotherapy (e.g., docetaxel)
4. Solid tumors with brain metastasis:
1. Histologically or cytologically confirmed metastatic or locally advanced
unresectable solid tumors excluding melanoma with TP53 mutation/loss and tumor
must have relapsed/be refractory to at least 1 line of systemic therapy.
Untreated brain metastases not requiring immediate local CNS therapy. 2. Previously treated brain metastases with progression of previous lesions or new
lesions, but not requiring immediate local CNS therapy. 3. At least one measurable untreated brain lesion ≥0.5 cm and <3.0 cm in the
longest axis. 4. Prior SRS radiosurgery (must be completed within 7 days of study treatment
initiation) is allowed as long as the previous treatment volume does not
overlap with the current targets.
5. Measurable disease per RECIST v1.1 criteria. For mCRPC patients, tumor response will
be evaluated using RECIST version 1.1 (soft tissue) and PCWG-3 criteria (bone) and
efficacy endpoints will also include radiographic progression-free survival (rPFS),
PSA50 response and PSA progression. 6. Adequate bone marrow reserve, cardiac, liver, and renal function:
1. Absolute neutrophil count (ANC) ≥ 1,500/mm3. 2. Platelet count ≥ 100,000/mm3. 3. Hemoglobin ≥ 9 g/dL. 4. Bilirubin ≤ 1.5 × upper limit of normal (ULN) or direct bilirubin ≤ ULN for
patients with total bilirubin levels >1.5 × ULN. 5. Alanine aminotransferase (ALT, SGPT) and aspartate aminotransferase (AST, SGOT)
≤ 2.5 × ULN (≤ 5 × ULN if liver metastases are present)
6. INR ≤ 1.5 × ULN unless patient is receiving anticoagulant therapy and PT or
aPTT is within therapeutic range of intended use of anticoagulants. 7. Creatinine clearance ≥ 60 mL/min (by Cockroft Gault formula).
7. Female patients of child-bearing potential must have a negative serum pregnancy test
and use at least 1 form of acceptable birth control method listed below as approved
by the Investigator before initiating study treatment and for 3 months after the
last dose of study drug.
1. Sterilization. 2. Any hormonal contraceptives (non-CYP 3A4 inhibitors) associated with inhibition
of ovulation. 3. IUD (intrauterine device) or intrauterine hormone releasing system. 8. Male patients must be sterilized or use a form of barrier contraception, such as
condoms with spermicide, during the study and for 3 months after the last dose of
study drug.
9. Life expectancy of ≥ 3 months.
10. Ability to provide written informed consent.
11. An Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1.
Exclusion Criteria:
1. Patients with symptomatic brain metastases requiring treatment and/or leptomeningeal
disease. 2. Patients with a previous history of another malignancy (other than cured basal cell
or squamous cell carcinoma of the skin or cured in-situ carcinoma) within 3 years of
study entry.
3. Patients with uncontrolled pleural effusions, pericardial effusion, or ascites that
do not resolve.
4. Patients with gastrointestinal tract disease causing the inability to take oral
medication (e.g., swallowing difficulties, malabsorption syndromes, extensive small
bowel resection [> 100cm], gastric bypass surgery).
5. Pregnant or breast-feeding patients or any patient with child-bearing potential not
using adequate contraception.
6. Known human immunodeficiency virus, hepatitis B virus (HBV), or hepatitis C virus
(HCV) infection (excluding cured HBV and/or cured HCV infection).
7. Presence of any serious concomitant systemic disorders incompatible with the study
in the opinion of the Investigator (e.g., uncontrolled congestive heart failure,
active infection).
8. Radiation therapy to > 30% of bone marrow within 3 months before study entry.
9. Patients with clinically significant autoimmune disease, either currently present of
present within 2 years, including a current requirement for systemic
immunosuppressive therapy equivalent to > 10 mg/prednisone daily (local
immunosuppressive therapy such as inhaled or topical corticosteroids is allowed).
11. Patients with abnormal or clinically significant electrocardiogram (ECG) abnormality,
including but not limited to a confirmed corrected QT interval using Fridericia's formula
(QTcF) > 470 msec.
12. Patient has received systemic anticancer therapy within 3 weeks or 5 half-lives,
whichever is shorter.
13. Patients must have recovered from all AEs due to previous therapies to ≤ Grade 1 or
baseline.
14. Any of the following conditions (on-study testing is not required):
a. Known HIV-infected patients unless on effective anti-retroviral therapy with an
undetectable viral load within 6 months and no opportunistic infection within the past 12
months, or b. Known or suspected hepatitis B if active infection (patients with chronic
hepatitis B infection must have an undetectable HBV viral load on suppressive therapy, if
indicated; positive surface antibody alone is not an exclusion), or c. Known or suspected
hepatitis C infection that has not been treated and cured unless currently on treatment
with an undetectable viral load.
15. Administration of strong or moderate cytochrome (CYP) 3A4 inhibitors and inducers
within 14 days or 5 half-lives (whichever is shorter) prior to the administration of
study drug.
