Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Study Purpose

Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	No
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Observational
Eligible Ages	18 Years and Over
Gender	All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

- patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories; - diagnosis of Parkinson's disease or cerebellar tremor.

Exclusion Criteria:

- Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings; - Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings; - Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings; - Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT05998486
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	Henri Mondor University Hospital
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	Emilie Hutin
Principal Investigator Affiliation	Henri Mondor University Hospital
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other
Overall Status	Recruiting
Countries	France
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Parkinson, Cerebellar Tumor, Rest Tremor, Diagnoses Disease, Movement; Abnormal, Involuntary

Additional Details

This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Arms & Interventions

Arms

: Tremor of rest

Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

: Cerebellar tremor

Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Interventions

Diagnostic Test: - EMG in wrist flexor-pronators and extensor-supinators

The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Contact a Trial Team

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International Sites

Créteil, France

Status

Recruiting

Address

Laboratoire Analyse et Restauration du Mouvement

Créteil, ,

Site Contact

Emilie Hutin, PhD

[email protected]

+33149812549

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