Clinical Trial Finder

Inclusion Criteria:

• - Age ≥ 18 years of age.

• - Patients with non-squamous locally advanced lung cancer defined by American Joint Committee on Cancer (AJCC) version 8 stage IIIA, IIIB, or IIIC disease.

• - Histology described as adeno-squamous or not otherwise specified favoring squamous are eligible.

• - Patients may be enrolled before or after the start of radiation therapy but must be enrolled and have their first surveillance MRI brain at 120 +/- 10 days of their first treatment of radiation therapy for their locally advanced lung cancer.

The first radiation treatment is defined as day 1.

• - Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 3.

• - Epidermal growth factor receptor (EGFR) > 30 mL/min/1.73m2.

• - Patients must be eligible for a brain MRI per the Wake Forest MRI safety screening checklist questionnaire.

This will be completed by a MRI imaging technician, enrolling physician, CPDM staff member, a magnetic resonance safety officer, and/or a radiologist as indicated in the form.

Exclusion Criteria:

• - Known brain metastases on staging MRI.

• - Questionable findings that may represent a differential of vasculature abnormalities/stroke/ and or metastatic disease with recommended short interval follow-up are not an exclusion factor for study participation.

The recommended follow-up imaging for such findings should have no bearing on the imaging schedule in this protocol, and this research protocol imaging should NOT serve as an official follow-up scan for such findings.

• - Patients who are pregnant or breastfeeding.

• - Premenopausal persons of childbearing potential must have a negative pregnancy test within 14 days of enrollment.

If women are not of childbearing potential as defined by women who are menopausal female or has had a hysterectomy, bilateral oophorectomy, or medically-documented ovarian failure, they will not require a pregnancy test. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.

Primary Objective: To evaluate whether additional follow up brain MRI in patients with non-squamous stage III nonsmall cell lung cancer who were previously treated with curative intent radiation therapy reduces the rate of symptomatic brain metastasis presentation as compared to historical controls. Secondary Objectives:

• - To estimate time to brain failure in patients with non-squamous stage III nonsmall cell lung cancer previously treated with curative intent radiation therapy who undergo additional surveillance brain magnetic resonance imaging.

• - To describe documented brain metastasis(es) characteristics in patients with non-squamous stage III nonsmall cell lung cancer previously treated with curative intent radiation therapy who undergo additional surveillance brain magnetic resonance imaging.

OUTLINE: Patients undergo MRI with or without gadolinium contrast intravenously (IV) as well as blood sample collection on study. Patients are followed for approximately 780 days from the first treatment of radiation or until death, whichever occurs first

Arms

Experimental: Surveillance MRI of the Brain

Brain MRI will be performed as scheduled for up to 14 months or until detection of a brain metastasis, whichever occurs first.

Interventions

Diagnostic Test: - MRI of the Brain

An MRI brain scan with and without gadolinium contrast. Three scans are planned for each participant.

Other: - Blood draws

Before each MRI, participants will give about a teaspoon of blood to test for clinical purposes.

Other: - Quality of Life Questionnaires

Participants will fill out two questionnaires about their health. These questionnaires will tell investigators about any symptoms participants may be having that might be related to cancer spreading to their brain. This will take about 10-15 minutes to complete.

Drug: - Gadolinium

Given intravenously