Clinical Trial Finder

Inclusion Criteria:

• - Appearance of high-grade glioma on magnetic resonance imaging.

• - History of histologically-confirmed diagnosis of glioma undergoing repeat resection of a recurrent/progressive tumor that is likely high-grade glioma.

• - Age ≥ 18 years old.

• - Volumetric MRI within 1 month before surgery.

• - Karnofsky performance status of 60 or higher.

• - The participant (or legally acceptable representative if applicable) provides written informed consent for the trial.

• - Considered an appropriate neurosurgical candidate based on screening/baseline laboratory values within 1 month before surgery.

Exclusion Criteria:

• - Severe co-morbidity that would confer excess risk of surgery as determined by the treating physician.

• - Any other major medical illnesses or psychiatric impairments that in the investigator's opinion will prevent administration or completion of protocol therapy.

• - Pregnancy.

• - Coagulopathy or platelet dysfunction that increases the risk of intra and postoperative hemorrhage.

- Tumor location requiring Depth Electrode placement/biopsy in eloquent or critical region of the brain (e.g. primary motor and sensory cortices, speech and vision centers, thalamus, basal ganglia, cerebellum, brain stem)as deemed by the neurosurgeon designing the surgical plan

High-grade gliomas are incurable primary brain tumors. Recent data support that glioma cells can integrate within neuronal circuits. Glioma cells and neurons communicate via electrical impulses and chemically, through neurotransmitters. This crosstalk has been shown to promote glioma cell migration and invasion in preclinical models. However, the nature of the electrical activity and underlying molecular mechanisms are poorly understood. The long-term goal of this study is to determine the impact of high electrical activity and pattern of activity on tumor invasion, and mechanistic basis of its regulation and functional consequences. This phase I safety and feasibility study is being proposed as a first step toward dissecting the connection between electrical activity and glioma behavior. The goal is to determine the safety and feasibility of recording electrical activity in the tumor-neuron interface using technologies that are already being used clinically for participants undergoing brain surgery.

Arms

Experimental: Standard Surgical Treatment + Intraoperative Electrocorticography

Each participant will undergo intraoperative electrocorticography (ECOG) through subdural grid (SDG) and depth electrode (DE) via FDA-cleared, standardized, brain recording technology. During this surgery, participants will also undergo a tissue biopsy at recording sites for correlation to neural recording data.

Interventions

Procedure: - Standard Surgical Treatment

During this surgery, participants will also undergo a tissue biopsy at recording sites for correlation to neural recording data.

Procedure: - Intraoperative Electrocorticography

Each participant will undergo intraoperative electrocorticography (ECOG) through subdural grid (SDG) and depth electrode (DE) via FDA-cleared, standardized, brain recording technology.