Cohort 1: Newly Diagnosed MGMT Unmethylated Glioblastoma.Inclusion Criteria Cohort 1
- - Newly Diagnosed MGMT Unmethylated Glioblastoma:
- Histologically-confirmed glioblastoma (WHO Grade IV glioma); tumors situated
primarily in the infratentorial compartment will be excluded.
- - Optimal surgical resection performed, with satisfactory clinical recovery in the
judgment of the investigator (patients for who whom "optimal" surgical resection is
considered only a subtotal resection or a biopsy, will be considered eligible).
- - No clear evidence of tumor progression through radiation.
- - Patient must have had previous radiation.
NOTE: For patients with post-radiation
scans suggestive of radiation-induced "pseudoprogression", patients can be consented
and enrolled on this trial but investigational treatment will not start until a
repeat MRI scan is obtained 4 weeks later (8-9 weeks following completion of
radiation). If that scan shows no further tumor progression, despite no interval
treatment in those preceding 4-weeks, then it will be assumed that the
post-radiation MRI scans represent radiation-induced pseudoprogression rather than
true tumor progression. In such a case, patients will start on treatment with
paxalisib, the ketogenic diet and metformin. Assessment of PFS will start for such
patients from this 8-9 week time point. By contrast, for patients whose 8-9 week
"pseudoprogression assessment" MRI scan shows continued tumor progression, then
these patients will be assumed to have true tumor progression and will not be
eligible to remain treated on this study. Such patients will be deemed for the sake
of the study as consented and screened. They will be evaluable for toxicity but not
evaluable for response. Such patients may be replaced by an evaluable patient.
- - Chemoradiotherapy administered according to the Stupp regimen, with at least 90% of
the radiation prescribed dosing administered, and with initiation occurring less
than six weeks after surgery and completion occurring 5 weeks prior to accrual into
this study.
- - Demonstrated unmethylated MGMT promotor status confirmed by validated PCR or
alternate genomic analysis; subjects with methylated or indeterminate MGMT status
that are unwilling, or otherwise unable, to undergo treatment with temozolomide may
be enrolled.
- - Patients of any gender, with age ≥ 18 years at the time of randomization.
- - Written, signed, and dated informed consent to participate in this study, in a
format approved by each site's Institutional Review Board (IRB).
- - Life expectancy > 12 weeks in the judgment of the investigator.
- - Karnofsky Performance Status (KPS) ≥ 70.
- - If receiving dexamethasone, dose is < 4mg daily.
- - No history of allergy or other intolerance to metformin.
- - Adequate organ and bone marrow function at the time of screening, including.
1. White blood cell count (WBC) > 3,000/µL;
2. Absolute neutrophil count > 1,500/mm3. 3. Platelet count of > 100,000/mm3;
4. Hemoglobin > 10 mg/dL (post-transfusion allowed)
5. Total bilirubin ≤ 1.5 x ULN. 6. AST and ALT ≤ 2.5 x ULN. 7. Serum glucose < 140 mg/dL. 8. Urine dipstick for proteinuria < 2+. Patients discovered to have ≥ 2+
proteinuria on dipstick urinalysis should undergo a 24-hour urine collection
and must demonstrate ≤ 1.0 g of protein in 24 hours, OR Urine
protein/creatinine ratio ≤ 1.
- - The effects of paxalisib on the developing human fetus are unknown.
For this reason,
women of child-bearing potential and men must agree to use adequate contraception
(e.g. hormonal or barrier method of birth control) prior to study entry, for the
duration of study participation and for a three month period (90 days) afterwards in
an abundance of caution. Female subjects will be required to demonstrate a negative
urine pregnancy test prior to study entry and subjects who are lactating should be
excluded.
- - Able and willing, in the judgment of the investigator, to meet all protocol-required
treatments, investigations and visits.
This must include the ability for the subject
to comply with daily self-administration of an oral therapy, or reliable means for
treatment to be administered by a dependable third party such as a relative or
caregiver. In addition, subjects must be willing and able to comply with the
requirements of a ketogenic diet. Subjects must also be able and willing to undergo
cranial magnetic resonance imaging and positron-emission tomography, and to receive
gadolinium-containing contrast agent.
Exclusion Criteria Cohort 1
- - Newly Diagnosed MGMT Unmethylated Glioblastoma:
- Patients with tumors exhibiting mutated isocitrate dehydrogenase-1 or 2 (IDH-1, 2).
- - Patients receiving treatment with any other standard or investigational anti-glioma
agents (e.g. Optune, bevacizumab).
- - Patients with type 1 diabetes or poorly controlled type 2 diabetes with A1C > 7.5%.
- - QT interval of ≥ 450 msec.
- - Any ongoing malignancy requiring treatment currently or expected to require
treatment in the next 12 months.
- - Any pre-existing or inter-current illness or pathology which, in the judgment of the
investigator, has the potential to increase the safety risk associated with
paxalisib administration, or to confound the results of the study.
- - Patients receiving any medications or substances that are moderate and/or potent
enzyme inducers or inhibitors which may have an effect on the metabolism of
paxalisib.
- - Known hypersensitivity or intolerance to paxalisib or metformin.
- - Patients unable to undergo an MRI scan.
- - Tumor Progression through chemoradiation (see section 4.2.
1.4 above regarding
question of radiation-induced "pseudoprogression").
- - History of bariatric surgery.
- - History of severe nephrolithiasis requiring urologic intervention.
- - History of severe pancreatitis or pancreatic exocrine insufficiency.
- - History of primary hypertriglyceridemia (Familial chylomicronemia, familial
hypertriglyceridemia, or familial dysbetalipoproteinemia).
Cohort 2: Recurrent Glioblastoma.Inclusion Criteria Cohort 2
- - Recurrent Glioblastoma:
- Histologically-confirmed, on initial diagnosis and/or at the time of recurrence,
glioblastoma (WHO Grade IV glioma); tumors situated primarily in the infratentorial
compartment will be excluded.
- - Radiologically-confirmed disease progression at a minimum of three months after
completion of chemoradiotherapy.
- - Having previously been treated with definitive fractionated radiation consistent
with NCCN guidelines for radiotherapy of GBM.
- - Any MGMT promoter methylation status is acceptable.
- - Patients of any gender, with age ≥ 18 years at the time of randomization.
- - Written, signed, and dated informed consent to participate in this study, in a
format approved by each site's Institutional Review Board (IRB).
- - Life expectancy > 12 weeks in the judgment of the investigator.
- - Karnofsky Performance Status (KPS) ≥ 70.
- - If receiving dexamethasone, dose is < 4mg daily.
- - No history of allergy or other intolerance to metformin.
- - Adequate organ and bone marrow function at the time of screening, including.
1. White blood cell count (WBC) > 3,000/µL;
2. absolute neutrophil count > 1,500/mm3. 3. Platelet count of > 100,000/mm3;
4. Hemoglobin > 10 mg/dL (post-transfusion allowed)
5. Total bilirubin ≤ 1.5 x ULN. 6. AST and ALT ≤ 2.5 x ULN. 7. Serum glucose < 140 mg/dL. 8. Urine dipstick for proteinuria < 2+. Patients discovered to have ≥ 2+
proteinuria on dipstick urinalysis should undergo a 24-hour urine collection
and must demonstrate ≤ 1.0 g of protein in 24 hours, OR Urine
protein/creatinine ratio ≤ 1.
- - Patients having undergone recent resection of recurrent or progressive tumor will be
eligible as long as all of the following conditions apply:
1.
They have recovered from the effects of surgery. 2. Residual disease following resection of recurrent tumor is not mandated for
eligibility into the study. To best assess the extent of residual disease
post-operatively, a MRI should be done:
i. No later than 96 hours in the immediate post-operative period OR ii. At least 4
weeks post-operatively In both cases, they also need to have it within 21 days of
registration and be on a steroid dosage (<4mg of dex) that has been stable for at
least 5 days before registration on a steroid dosage that has been stable for at
least 5 days. If the steroid dose is increased (but not if its decreased) between
the date of imaging and registration, a new baseline MRI is required on a stable
steroid dosage for at least 5 days.
- - The effects of paxalisib on the developing human fetus are unknown.
For this reason,
women of child-bearing potential and men must agree to use adequate contraception
(e.g., hormonal or barrier method of birth control) prior to study entry, for the
duration of study participation and for a three-month period (90 days) afterwards in
an abundance of caution. Female subjects will be required to demonstrate a negative
urine pregnancy test prior to study entry and subjects who are lactating should be
excluded.
- - Able and willing, in the judgment of the investigator, to meet all protocol-required
treatments, investigations and visits.
This must include the ability for the subject
to comply with daily self-administration of an oral therapy, or reliable means for
treatment to be administered by a dependable third party such as a relative or
caregiver. In addition, subjects must be willing and able to comply with the
requirements of a ketogenic diet. Subjects must also be able and willing to undergo
cranial magnetic resonance imaging and positron-emission tomography, and to receive
gadolinium-containing contrast agent.
Exclusion Criteria Cohort 2
- - Recurrent Glioblastoma:
- Patients with tumors exhibiting mutated isocitrate dehydrogenase-1 or 2 (IDH-1, 2).
- - Patients receiving prior treatment with bevacizumab, other PI3K inhibitors or
inhibitors of the PI3K pathway (e.g. mTOR inhibitors).
- - Patients currently are during the course of their illness on a ketogenic diet for
more than 2 weeks.
- - Patients with type 1 diabetes or poorly controlled type 2 diabetes with A1C > 7.5%.
- - QT interval of ≥ 450 msec.
- - Any ongoing malignancy requiring treatment currently or expected to require
treatment in the next 12 months.
- - Any pre-existing or inter-current illness or pathology which, in the judgment of the
investigator, has the potential to increase the safety risk associated with
paxalisib administration, or to confound the results of the study.
- - Patients receiving any medications or substances that are moderate and/or potent
enzyme inducers or inhibitors which may have an effect on the metabolism of
paxalisib (e.g. Nystatin swish and swallow, rather than Fluconazole, will be used
for oral candidiasis).
- - Known hypersensitivity or intolerance to paxalisib or metformin.
- - Patients unable to undergo an MRI scan.
- - History of bariatric surgery.
- - History of severe nephrolithiasis requiring urologic intervention.
- - History of severe pancreatitis or pancreatic exocrine insufficiency.
- - History of primary hypertriglyceridemia (Familial chylomicronemia, familial
hypertriglyceridemia, or familial dysbetalipoproteinemia).
