Inclusion Criteria:
- - Eligible patients for this study must meet all of the following criteria:
1.
Pathologically or cytologically diagnosed as locally advanced or metastases
extrapulmonary neuroendocrine carcinoma that cannot be surgically removed.
2. Aged 18-75，male and female. 3. Patients who have not received systemic treatment for advanced or metastatic EP-NEC .
Subjects who have previously received adjuvant or neoadjuvant therapy (including
chemotherapy, radiotherapy or radiochemotherapy) for EP-NEC must have completed the
last dose at least 6 months before enrollment . Palliative radiotherapy is permitted,
but it must be completed at least 2 weeks prior to the study treatment. The lesions in
the irradiation field cannot be used as target lesions for efficacy evaluation, and
radiotherapy-related adverse reactions must be restored to at least Grade 0-1.
4. ECOG PS 0-1.
5. At least 1 measurable lesion according to RECIST criteria.
6. Adequate organ and bone marrow function, defined as follows:
- - White blood cell count (WBC) ≥ 3,000/mm3 (3.0 × 109/L);
- Absolute neutrophil count (ANC) ≥ 1,500/mm3 (1.5 × 109/L);
- Platelet count (PLT) ≥ 100,000/mm3 (100 × 109/L);
- Hemoglobin (Hb) ≥ 9 g/dL (90 g/L);
- Serum albumin ≥ 3.0 g/dL (30 g/L);
- Serum creatinine ≤ 1.5 x ULN or creatinine clearance ≥ 50 ml/min;
- Total bilirubin (BIL) ≤ 1.5 x ULN;
- AST or ALT ≤ 2.5 x ULN, patients with liver metastases should ≤ 5×ULN;
international normalized ratio (INR) ≤ 1.5, prothrombin time (PT) and activated
partial thromboplastin time (APTT) ≤ 1.5 x ULN;
- Urine protein<2+; if the urine protein is ≥2+, the 24-hour urine protein must be
≤1g.
7. Subjects must agree and have signed the informed consent form, be willing and able to
follow the scheduled visits, study treatment, laboratory tests, and other study
procedures.
8. Life expectancy > 12 weeks.
9. Female subjects of childbearing age are not pregnant or breastfeeding and are strictly
contraceptive.
Exclusion Criteria:
1. Presence of known uncontrolled or symptomatic active central nervous system (CNS)
metastasis, manifested as clinical symptoms, cerebral edema, spinal cord compression,
cancerous meningitis, leptomeningeal disease, and/or progressive growth. For CNS
metastases that have been adequately treated, and neurological symptoms can return to
baseline levels at least 2 weeks before enrollment (except for residual signs or
symptoms related to CNS treatment), they can be included . In addition, subjects must
stop corticosteroids or receive a stable dose of ≤ 10 mg/d or a gradually decreasing
dose of prednisone (or an equivalent dose of other corticosteroids) at least 2 weeks
before enrollment.
2. Have received the following treatments or drugs before enrollment:
① A major operation was performed within 28 days before enrollment (tissue biopsy and
peripheral venipuncture for central venous catheterization [PICC]/infusion port
implantation are allowed).
② Using immunosuppressive drugs within 7 days before enrollment, excluding nasal spray
and inhaled corticosteroids or physiological doses of systemic steroid hormones (no
more than 10 mg/d prednisone or other corticosteroids with equivalent physiological
doses)
③ within 28 days before enrollment or planned to receive live attenuated vaccine
during the study period and 60 days after the end of study drug treatment.
④ Receive chemotherapy within 28 days before enrollment;
3. Prior malignancy within 3 years, except adequately treated basal cell carcinoma or
squamous cell skin cancer ,superficial bladder cancer, cervical carcinoma in situ,
breast ductal carcinoma in situ and papillary thyroid cancer.
4. Prescence of any active, known or suspected autoimmune diseases. Subjects who are in a
stable state and do not require systemic immunosuppressive therapy are allowed, such
as type I diabetes, hypothyroidism that only requires hormone replacement therapy, and
skin diseases that do not require systemic therapy (eg, vitiligo, psoriasis disease
and hair loss).
5. Prior treatment with anti-PD-1/PD-L1 antibodies, anti-PD-L2 antibodies, anti-CD137
antibodies, CTLA-4 antibodies, or other drugs/antibodies that act on T cell
costimulation or checkpoint pathways.
6. Prescence of clinically significant bleeding symptoms or a clear bleeding tendency
within 3 months before enrollment; gastrointestinal perforation and/or
gastrointestinal fistula occurred within 6 months before enrollment; 6 before
enrollment Arterial/venous thrombosis events that occurred within a month, such as
cerebrovascular accidents (including temporary ischemic attacks, cerebral hemorrhage,
cerebral infarction), deep vein thrombosis, and pulmonary embolism.
7. Have major vascular disease (for example, an aortic aneurysm that requires surgical
repair or recent peripheral arterial thrombosis) occurred within 6 months before the
start of study treatment.
8. Severe, unhealed or dehisced wounds and active ulcers or untreated fractures.
9. Have intestinal obstruction and/or have clinical signs or symptoms of gastrointestinal
obstruction within 6 months before the start of the study treatment.
10. Prescence of interstitial lung disease, non-infectious pneumonia or uncontrollable
systemic disease.
11. Known to be allergic to the study drug or any of its excipients; or have a severe
allergic reaction to other monoclonal antibodies.
12. Human immunodeficiency virus (HIV) infection or known acquired immunodeficiency
syndrome (AIDS), untreated active hepatitis (hepatitis B, defined as HBV-DNA ≥ 500
IU/ml; hepatitis C,defined as HCV-RNA higher than the detection limit of the
analytical method) or combined hepatitis B and C co-infection.
13. Any of the following conditions observed within 6 months prior to the enrollment:
myocardial infarction, severe/unstable angina, NYHA grade 2 or higher cardiac
insufficiency, clinically significant supraventricular or ventricular arrhythmia, and
symptomatic congestive heart failure exhaustion.
14. Hypertension, which cannot be well controlled by antihypertensive drugs (systolic
blood pressure> 140 mmHg or diastolic blood pressure> 90 mmHg).
15. Systemic use of antibiotics for ≥ 7 days within 4 weeks before enrollment, or
unexplained fever > 38.5 ° C during screening / before the first administration
(according to the judgment of the investigator, fever caused by tumor can be enrolled)
.
16. Known history of allogeneic organ transplantation or allogeneic hematopoietic stem
cell transplantation.
17. Participated in any other drug clinical research within 4 weeks before enrollment, or
no more than 5 half-lives from the last drug use in the study. Known history of
psychotropic drug abuse or drug abuse.
18. Subjects with other severe physical or psychiatric disorders or laboratory
abnormalities, which may increase the risk of participating in this study or interfere
with the study results, as well as those deemed unsuitable by the investigator.
