A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

Study Purpose

This phase III trial compares memantine to placebo in treating patients with primary central nervous system tumors. Memantine may block receptors (parts of nerve cells) in the brain known to contribute to a decline in cognitive function. Giving memantine may make a difference in cognitive function (attention, memory, or other thought processes) in children and adolescents receiving brain radiation therapy to treat a primary central nervous system tumors.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 4 Years - 17 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - >= 4 and < 18 years at time of study entry.
  • - Patients must weigh 15 kg or greater at time of study entry.
  • - Primary central nervous system tumors that have not received prior cranial radiotherapy.
  • - Planned focal, cranial or craniospinal radiation treatment for a primary central nervous system tumor.
  • - The patient must have receptive and expressive language skills in English, French or Spanish since the neurocognitive function and quality of life (QOL) assessment instruments are available in these languages only.
  • - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/sex as follows: - Age: 4 to < 6 years; Maximum serum creatinine (mg/dL): 0.8 male; 0.8 female.
  • - Age: 6 to < 10 years; Maximum serum creatinine (mg/dL): 1 male; 1 female.
  • - Age: 10 to < 13 years; Maximum serum creatinine (mg/dL): 1.2 male; 1.2 female.
  • - Age: 13 to < 16 years; Maximum serum creatinine (mg/dL): 1.5 male; 1.4 female.
  • - Age: >= 16 years; Maximum serum creatinine (mg/dL): 1.7 male; 1.4 female.
  • - Total bilirubin =< 1.5 x upper limit of normal (ULN) for age.
  • - Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 135 U/L.
  • - Note: For the purpose of this study, the ULN for SGPT (ALT) has been set to the value of 45 U/L.
  • - The patient must be able to undergo magnetic resonance imaging.
  • - All patients and/or their parents or legal guardians must sign a written informed consent.
  • - All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

Exclusion Criteria:

  • - Life expectancy of less than 18 months.
  • - Pre-existing conditions: - Any contraindication or allergy to study drug (memantine or placebo) - Intractable seizures while on adequate anticonvulsant therapy, defined as more than one seizure per month for the past 2 months or since initiating anticonvulsant therapy.
  • - History of neurodevelopmental disorder such as Down syndrome, Fragile X, William's Syndrome, intellectual disability (presumed intelligence quotient [IQ] < 70), etc.
  • - Co-morbid systemic illnesses, psychiatric conditions, social situations, or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens or would limit compliance with the study requirements.
  • - Patients with a motor, visual, or auditory condition that precludes participation in computerized neurocognitive assessments.
  • - Patients with any medical condition or taking medications that lead to alterations of urine pH towards the alkaline condition (e.g., renal tubular acidosis, carbonic anhydrase inhibitors, sodium bicarbonate) - Personal history of prior cranial or craniospinal radiotherapy is not allowed.
  • - Note: Prior anti-cancer therapy including surgery, chemotherapy, targeted agents are allowed as per standard of care clinical treatment guidelines.
  • - Female patients who are pregnant are excluded since fetal toxicities and teratogenic effects have been noted for the study drug.
A pregnancy test is required for female patients of childbearing potential.
  • - Lactating females who plan to breastfeed their infants.
- Sexually active patients of reproductive potential who do not agree to use an effective contraceptive method for the duration of their study participation

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04939597
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Children's Oncology Group
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Nadia N Laack
Principal Investigator Affiliation Children's Oncology Group
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Active, not recruiting
Countries Puerto Rico, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Central Nervous System Carcinoma
Additional Details

PRIMARY OBJECTIVE:

  • I. To determine the efficacy, as measured by the slope of change of the Cogstate composite Z score from baseline to 12 months, of oral memantine hydrochloride (memantine) administered for a period of 6 months, when compared to placebo, in children ages 4-18 receiving cranial or craniospinal radiotherapy for primary central nervous system tumors.
EXPLORATORY OBJECTIVES:
  • I. To determine if memantine is associated with improved cognitive function as measured for participants in the optional Children's Oncology Group (COG) Standardized Battery at 12 months.
  • II. To determine if memantine is associated with change in cognitive function versus (vs.#46;) placebo as measured by Cogstate composite score at end of radiation therapy (RT), 3 and 6 months.
  • III. To determine if memantine is associated with differences in cognitive function vs.#46; placebo as measured by Cogstate composite score at 24 and 48 months for participants in the optional COG Standardized Battery.
  • IV. To correlate early cognitive changes (end of RT, 3, 6, 12 months Cogstate composite score) with late cognitive function (24 and 48 months Cogstate composite score).
  • V. To correlate COG Standardized Battery scores to Cogstate composite scores at 12, 24, and 48 months.
  • VI. To estimate the 36-month disease-free and overall survival (of primary brain tumor) after memantine treatment compared to placebo.
  • VII. To correlate changes in quantitative volumetric magnetic resonance imaging (MRI) measurements of critical brain regions with cognitive function over time.
  • VIII. To evaluate impact of memantine versus placebo on molecular biomarkers associated with cognitive decline after radiotherapy.
  • IX. To determine whether oral memantine, when compared to placebo, is associated with reduction in the incidence of decline of composite Cogstate score at 12 months in children ages 4-18 receiving cranial radiotherapy for primary central nervous system tumors.
OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive memantine hydrochloride orally (PO) once daily (QD) for week 1 and then twice daily (BID) for weeks 2-24 in the absence of disease progression or unacceptable toxicity. Patients also complete cognitive testing over 20-30 minutes at baseline, end of radiation therapy, and at 3, 6, 12, 24, and 48 months. Patients undergo MRI and may optionally undergo blood sample collection throughout the trial. ARM II: Patients receive placebo PO QD for week 1 and then BID for weeks 2-24 in the absence of disease progression or unacceptable toxicity. Patients also complete cognitive testing over 20-30 minutes at baseline, end of radiation therapy, and at 3, 6, 12, 24, and 48 months. Patients undergo MRI and may optionally undergo blood sample collection throughout the trial.

Arms & Interventions

Arms

Experimental: Arm I (memantine hydrochloride)

Patients receive memantine hydrochloride orally PO QD for week 1 and then BID for weeks 2-24 in the absence of disease progression or unacceptable toxicity. Patients also complete cognitive testing over 20-30 minutes at baseline, end of radiation therapy, and at 3, 6, 12, 24, and 48 months. Patients undergo MRI and may optionally undergo blood sample collection throughout the trial.

Placebo Comparator: Arm II (placebo)

Patients receive placebo PO QD for week 1 and then BID for weeks 2-24 in the absence of disease progression or unacceptable toxicity. Patients also complete cognitive testing over 20-30 minutes at baseline, end of radiation therapy, and at 3, 6, 12, 24, and 48 months. Patients undergo MRI and may optionally undergo blood sample collection throughout the trial.

Interventions

Procedure: - Biospecimen Collection

Undergo blood sample collection

Procedure: - Cognitive Assessment

Complete cognitive testing

Procedure: - Magnetic Resonance Imaging

Undergo MRI

Drug: - Memantine Hydrochloride

Given PO

Drug: - Placebo Administration

Given PO

Other: - Questionnaire Administration

Ancillary studies

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Children's Hospital of Alabama, Birmingham, Alabama

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Children's Hospital of Alabama

Birmingham, Alabama, 35233

Providence Alaska Medical Center, Anchorage, Alaska

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Providence Alaska Medical Center

Anchorage, Alaska, 99508

Banner Children's at Desert, Mesa, Arizona

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Banner Children's at Desert

Mesa, Arizona, 85202

Phoenix Childrens Hospital, Phoenix, Arizona

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Phoenix Childrens Hospital

Phoenix, Arizona, 85016

Tucson, Arizona

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Banner University Medical Center - Tucson

Tucson, Arizona, 85719

Arkansas Children's Hospital, Little Rock, Arkansas

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Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3591

Kaiser Permanente Downey Medical Center, Downey, California

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Address

Kaiser Permanente Downey Medical Center

Downey, California, 90242

Loma Linda University Medical Center, Loma Linda, California

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Loma Linda University Medical Center

Loma Linda, California, 92354

Long Beach, California

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Miller Children's and Women's Hospital Long Beach

Long Beach, California, 90806

Children's Hospital Los Angeles, Los Angeles, California

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Children's Hospital Los Angeles

Los Angeles, California, 90027

Valley Children's Hospital, Madera, California

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Valley Children's Hospital

Madera, California, 93636

UCSF Benioff Children's Hospital Oakland, Oakland, California

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UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609

Kaiser Permanente-Oakland, Oakland, California

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Kaiser Permanente-Oakland

Oakland, California, 94611

Children's Hospital of Orange County, Orange, California

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Children's Hospital of Orange County

Orange, California, 92868

Palo Alto, California

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Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304

Rady Children's Hospital - San Diego, San Diego, California

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Address

Rady Children's Hospital - San Diego

San Diego, California, 92123

UCSF Medical Center-Mission Bay, San Francisco, California

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UCSF Medical Center-Mission Bay

San Francisco, California, 94158

Children's Hospital Colorado, Aurora, Colorado

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Children's Hospital Colorado

Aurora, Colorado, 80045

Denver, Colorado

Status

Address

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, Colorado, 80218

Connecticut Children's Medical Center, Hartford, Connecticut

Status

Address

Connecticut Children's Medical Center

Hartford, Connecticut, 06106

Alfred I duPont Hospital for Children, Wilmington, Delaware

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Address

Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803

Children's National Medical Center, Washington, District of Columbia

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Children's National Medical Center

Washington, District of Columbia, 20010

Fort Myers, Florida

Status

Address

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908

Gainesville, Florida

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University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

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Address

Nemours Children's Clinic-Jacksonville

Jacksonville, Florida, 32207

Miami, Florida

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Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Nicklaus Children's Hospital, Miami, Florida

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Nicklaus Children's Hospital

Miami, Florida, 33155

Miami Cancer Institute, Miami, Florida

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Miami Cancer Institute

Miami, Florida, 33176

AdventHealth Orlando, Orlando, Florida

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AdventHealth Orlando

Orlando, Florida, 32803

Nemours Children's Hospital, Orlando, Florida

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Address

Nemours Children's Hospital

Orlando, Florida, 32827

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

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Johns Hopkins All Children's Hospital

Saint Petersburg, Florida, 33701

Tampa General Hospital, Tampa, Florida

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Tampa General Hospital

Tampa, Florida, 33606

Tampa, Florida

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Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607

Atlanta, Georgia

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Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, 30329

Honolulu, Hawaii

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Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826

Saint Luke's Cancer Institute - Boise, Boise, Idaho

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Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712

University of Illinois, Chicago, Illinois

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University of Illinois

Chicago, Illinois, 60612

Chicago, Illinois

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University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

Loyola University Medical Center, Maywood, Illinois

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Loyola University Medical Center

Maywood, Illinois, 60153

Saint Jude Midwest Affiliate, Peoria, Illinois

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Address

Saint Jude Midwest Affiliate

Peoria, Illinois, 61637

Riley Hospital for Children, Indianapolis, Indiana

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Address

Riley Hospital for Children

Indianapolis, Indiana, 46202

Blank Children's Hospital, Des Moines, Iowa

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Blank Children's Hospital

Des Moines, Iowa, 50309

Iowa City, Iowa

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Address

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242

Norton Children's Hospital, Louisville, Kentucky

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Address

Norton Children's Hospital

Louisville, Kentucky, 40202

Children's Hospital New Orleans, New Orleans, Louisiana

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Address

Children's Hospital New Orleans

New Orleans, Louisiana, 70118

Ochsner Medical Center Jefferson, New Orleans, Louisiana

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Address

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121

Maine Children's Cancer Program, Scarborough, Maine

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Address

Maine Children's Cancer Program

Scarborough, Maine, 04074

Sinai Hospital of Baltimore, Baltimore, Maryland

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Sinai Hospital of Baltimore

Baltimore, Maryland, 21215

Baltimore, Maryland

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Address

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Bethesda, Maryland

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Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600

Boston, Massachusetts

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Address

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114

Dana-Farber Cancer Institute, Boston, Massachusetts

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Address

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

C S Mott Children's Hospital, Ann Arbor, Michigan

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Address

C S Mott Children's Hospital

Ann Arbor, Michigan, 48109

Children's Hospital of Michigan, Detroit, Michigan

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Children's Hospital of Michigan

Detroit, Michigan, 48201

East Lansing, Michigan

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Address

Michigan State University Clinical Center

East Lansing, Michigan, 48824

Grand Rapids, Michigan

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Address

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503

Corewell Health Children's, Royal Oak, Michigan

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Address

Corewell Health Children's

Royal Oak, Michigan, 48073

Minneapolis, Minnesota

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Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404

Mayo Clinic in Rochester, Rochester, Minnesota

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Mayo Clinic in Rochester

Rochester, Minnesota, 55905

University of Mississippi Medical Center, Jackson, Mississippi

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University of Mississippi Medical Center

Jackson, Mississippi, 39216

Columbia, Missouri

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University of Missouri Children's Hospital

Columbia, Missouri, 65212

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

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Address

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108

Saint Louis, Missouri

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Address

Cardinal Glennon Children's Medical Center

Saint Louis, Missouri, 63104

Washington University School of Medicine, Saint Louis, Missouri

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Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Mercy Hospital Saint Louis, Saint Louis, Missouri

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Address

Mercy Hospital Saint Louis

Saint Louis, Missouri, 63141

Omaha, Nebraska

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Address

Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, 68114

University of Nebraska Medical Center, Omaha, Nebraska

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Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Las Vegas, Nevada

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Address

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135

Summerlin Hospital Medical Center, Las Vegas, Nevada

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Address

Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144

Lebanon, New Hampshire

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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756

Hackensack University Medical Center, Hackensack, New Jersey

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Hackensack University Medical Center

Hackensack, New Jersey, 07601

Morristown Medical Center, Morristown, New Jersey

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Morristown Medical Center

Morristown, New Jersey, 07960

Saint Peter's University Hospital, New Brunswick, New Jersey

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Saint Peter's University Hospital

New Brunswick, New Jersey, 08901

New Brunswick, New Jersey

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Address

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903

Saint Joseph's Regional Medical Center, Paterson, New Jersey

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Address

Saint Joseph's Regional Medical Center

Paterson, New Jersey, 07503

Albany Medical Center, Albany, New York

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Albany Medical Center

Albany, New York, 12208

Montefiore Medical Center - Moses Campus, Bronx, New York

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Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

Maimonides Medical Center, Brooklyn, New York

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Maimonides Medical Center

Brooklyn, New York, 11219

Roswell Park Cancer Institute, Buffalo, New York

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Roswell Park Cancer Institute

Buffalo, New York, 14263

New Hyde Park, New York

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The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, New York, 11040

New York, New York

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Address

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016

Mount Sinai Hospital, New York, New York

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Mount Sinai Hospital

New York, New York, 10029

Memorial Sloan Kettering Cancer Center, New York, New York

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Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Stony Brook University Medical Center, Stony Brook, New York

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Stony Brook University Medical Center

Stony Brook, New York, 11794

Syracuse, New York

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State University of New York Upstate Medical University

Syracuse, New York, 13210

Mission Hospital, Asheville, North Carolina

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Mission Hospital

Asheville, North Carolina, 28801

Chapel Hill, North Carolina

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Address

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599

Charlotte, North Carolina

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Address

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

Duke University Medical Center, Durham, North Carolina

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Duke University Medical Center

Durham, North Carolina, 27710

East Carolina University, Greenville, North Carolina

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East Carolina University

Greenville, North Carolina, 27834

Wake Forest University Health Sciences, Winston-Salem, North Carolina

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Address

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

Sanford Broadway Medical Center, Fargo, North Dakota

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Sanford Broadway Medical Center

Fargo, North Dakota, 58122

Akron, Ohio

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Children's Hospital Medical Center of Akron

Akron, Ohio, 44308

Cincinnati, Ohio

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Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

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Address

Rainbow Babies and Childrens Hospital

Cleveland, Ohio, 44106

Cleveland Clinic Foundation, Cleveland, Ohio

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Address

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

Nationwide Children's Hospital, Columbus, Ohio

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Nationwide Children's Hospital

Columbus, Ohio, 43205

Dayton Children's Hospital, Dayton, Ohio

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Dayton Children's Hospital

Dayton, Ohio, 45404

Toledo, Ohio

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Address

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606

Oklahoma City, Oklahoma

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Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Legacy Emanuel Children's Hospital, Portland, Oregon

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Legacy Emanuel Children's Hospital

Portland, Oregon, 97227

Oregon Health and Science University, Portland, Oregon

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Oregon Health and Science University

Portland, Oregon, 97239

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania

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Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103

Geisinger Medical Center, Danville, Pennsylvania

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Geisinger Medical Center

Danville, Pennsylvania, 17822

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

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Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104

Philadelphia, Pennsylvania

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Saint Christopher's Hospital for Children

Philadelphia, Pennsylvania, 19134

Pittsburgh, Pennsylvania

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Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224

Rhode Island Hospital, Providence, Rhode Island

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Rhode Island Hospital

Providence, Rhode Island, 02903

Prisma Health Richland Hospital, Columbia, South Carolina

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Address

Prisma Health Richland Hospital

Columbia, South Carolina, 29203

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

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Address

BI-LO Charities Children's Cancer Center

Greenville, South Carolina, 29605

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

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Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

East Tennessee Childrens Hospital, Knoxville, Tennessee

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Address

East Tennessee Childrens Hospital

Knoxville, Tennessee, 37916

Saint Jude Children's Research Hospital, Memphis, Tennessee

Status

Address

Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105

Nashville, Tennessee

Status

Address

The Children's Hospital at TriStar Centennial

Nashville, Tennessee, 37203

Nashville, Tennessee

Status

Address

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

Austin, Texas

Status

Address

Dell Children's Medical Center of Central Texas

Austin, Texas, 78723

Medical City Dallas Hospital, Dallas, Texas

Status

Address

Medical City Dallas Hospital

Dallas, Texas, 75230

Dallas, Texas

Status

Address

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

El Paso Children's Hospital, El Paso, Texas

Status

Address

El Paso Children's Hospital

El Paso, Texas, 79905

Cook Children's Medical Center, Fort Worth, Texas

Status

Address

Cook Children's Medical Center

Fort Worth, Texas, 76104

M D Anderson Cancer Center, Houston, Texas

Status

Address

M D Anderson Cancer Center

Houston, Texas, 77030

Children's Hospital of San Antonio, San Antonio, Texas

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Children's Hospital of San Antonio

San Antonio, Texas, 78207

San Antonio, Texas

Status

Address

Methodist Children's Hospital of South Texas

San Antonio, Texas, 78229

San Antonio, Texas

Status

Address

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

Primary Children's Hospital, Salt Lake City, Utah

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Address

Primary Children's Hospital

Salt Lake City, Utah, 84113

University of Virginia Cancer Center, Charlottesville, Virginia

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University of Virginia Cancer Center

Charlottesville, Virginia, 22908

Norfolk, Virginia

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Address

Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507

Richmond, Virginia

Status

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Carilion Children's, Roanoke, Virginia

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Address

Carilion Children's

Roanoke, Virginia, 24014

Seattle Children's Hospital, Seattle, Washington

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Address

Seattle Children's Hospital

Seattle, Washington, 98105

Spokane, Washington

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Address

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, Washington, 99204

Tacoma, Washington

Status

Address

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, 98405

Madigan Army Medical Center, Tacoma, Washington

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Address

Madigan Army Medical Center

Tacoma, Washington, 98431

West Virginia University Healthcare, Morgantown, West Virginia

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Address

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Madison, Wisconsin

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Address

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Status

Address

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

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Address

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226

International Sites

HIMA San Pablo Oncologic Hospital, Caguas, Puerto Rico

Status

Address

HIMA San Pablo Oncologic Hospital

Caguas, , 00726

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