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Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Study Purpose

This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

 No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

 Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Pathologically (histologically or cytologically) proven diagnosis of small cell lung cancer within 5 years of registration.
If the original histologic proof of malignancy is greater than 5 years, then pathological (i.e., more recent) confirmation is required (e.g., from a systemic or brain metastasis);
  • - Patients with de novo or recurrent small cell lung cancer are permitted.
  • - Brain metastases =< 4 cm in largest diameter and outside a 5-mm margin around either hippocampus must be visible on contrast-enhanced magnetic resonance imaging (MRI) performed =< 21 days prior to study entry.
  • - The total tumor volume must be 30 cm^3 or less.
Lesion volume will be approximated by measuring the lesion's three perpendicular diameters on contrast enhanced, T1-weighted MRI and the product of those diameters will be divided by 2 to estimate the lesion volume (e.g. xyz/2). Alternatively, direct volumetric measurements via slice by slice contouring on a treatment planning software package can be used to calculate the total tumor volume.
  • - Brain metastases can be diagnosed synchronous to the initial diagnosis of small cell lung cancer or metachronous to the initial diagnosis and management of small cell lung cancer.
  • - Brain metastases must be diagnosed on MRI, which will include the following elements: - REQUIRED MRI ELEMENTS.
  • - Post gadolinium contrast-enhanced T1-weighted three-dimensional (3D) spoiled gradient (SPGR).
Acceptable 3D SPGR sequences include magnetization prepared 3D gradient recalled echo (GRE) rapid gradient echo (MP-RAGE), turbo field echo (TFE) MRI, BRAVO (Brain Volume Imaging) or 3D Fast FE (field echo). The T1-weighted 3D scan should use the smallest possible axial slice thickness, not to exceed 1.5 mm.
  • - Pre-contrast T1 weighted imaging (3D imaging sequence strongly encouraged).
  • - A minimum of one axial T2 FLAIR (preferred) or T2 sequence is required.
This can be acquired as a two dimensional (2D) or 3D image. If 2D, the images should be obtained in the axial plane.
  • - ADDITIONAL RECOMMENDATIONS.
  • - Recommendation is that an axial T2 FLAIR (preferred) sequence be performed instead of a T2 sequence.
  • - Recommendation is that that pre-contrast 3D T1 be performed with the same parameters as the post-contrast 3D T1.
  • - Recommendation is that imaging be performed on a 3 Tesla (3T) MRI.
  • - Recommendation is that the study participants be scanned on the same MRI instrument at each time point.
  • - Recommendation is that if additional sequences are obtained, these should meet the criteria outlined in Kaufmann et al.
, 2020.
  • - If additional sequences are obtained, total imaging time should not exceed 60 minutes.
  • - If additional metastases not known at the time of registration/randomization or seen in the MRI used for eligibility are subsequently found on the radiation therapy (RT) planning MRI such that the total intacranial volume exceeds 30 cm^3, the patient is still considered eligible.
  • - History/physical examination.
  • - Age >= 18.
  • - Karnofsky performance status of >= 70.
  • - Creatinine clearance >= 30 ml/min.
  • - Following the diagnosis of brain metastases, patients can initiate and treat with systemic (chemotherapy and/or immunotherapy) before enrollment only if their brain metastases are asymptomatic and not located in eloquent locations (e.g., brainstem, pre-/post-central gyrus, visual cortex).
However, within 21 days prior to enrollment, brain MRI must be repeated to confirm eligibility.
  • - Patients with symptomatic brain metastases and/or brain metastases in eloquent locations (e.g., brainstem, pre-/post central gyrus, visual cortex) are eligible for enrollment on the trial; however, the specific treatment approach of starting with systemic therapy alone and delaying brain radiation is not recommended for these patients.
  • - Concurrent immunotherapy with brain radiation (SRS or HA-WBRT) is permitted.
  • - Negative urine or serum pregnancy test (in women of childbearing potential) within 14 days prior to registration.
Women of childbearing potential and men who are sexually active must use contraception while on study.
  • - Patients may have had prior intracranial surgical resection.
  • - Because neurocognitive testing is the primary goal of this study, patients must be proficient in English or French Canadian.
  • - The patient must provide study-specific informed consent prior to study entry.
  • - Patients with impaired decision-making capacity are not permitted on study.
  • - ELIGIBILITY CRITERIA PRIOR TO STEP 2 REGISTRATION.
  • - The following baseline neurocognitive tests must be completed within 21 days prior to Step 2 registration: HVLT-R, TMT, and COWA.
The neurocognitive test will be uploaded into RAVE for evaluation by Dr. Wefel. Once the upload is complete, within 3 business days a notification will be sent via email to the RA to proceed to Step 2.
  • - NOTE: Completed baseline neurocognitive tests can be uploaded at the time of Step 1 registration.
  • - PRIOR TO STEP 2 REGISTRATION: The following baseline neurocognitive tests must be completed within 21 days prior to Step 2 registration: HVLT-R, TMT, and COWA.
The neurocognitive tests will be uploaded into RAVE for evaluation by Dr. Wefel. Once the upload is complete, within 3 business days a notification will be sent via email to the RA to proceed to Step 2. NOTE: Completed baseline neurocognitive tests can be uploaded at the time of Step 1 registration.

Exclusion Criteria:

  • - Planned infusion of cytotoxic chemotherapy on the same day as SRS or HA-WBRT treatment.
Patients may have had prior chemotherapy. Concurrent immunotherapy is permitted.
  • - For patients receiving fractionated SRS on an every-other-day basis, planned infusion of cytotoxic chemotherapy is not permitted between SRS treatments.
  • - Brainstem metastasis > 10 cm^3.
  • - Prior allergic reaction to memantine.
  • - Patients with definitive leptomeningeal metastases.
  • - Known history of demyelinating disease such as multiple sclerosis.
  • - Contraindication to MR imaging such as implanted metal devices that are MRI-incompatible, allergy to MRI contrast that cannot be adequately addressed with pre-contrast medications, or foreign bodies that preclude MRI imaging.
(Questions regarding MRI compatibility of implanted objects should be reviewed with the Radiology Department performing the MRI).
  • - Current use of (other N-methyl-D-aspartate [NMDA] antagonists) amantadine, ketamine, or dextromethorphan.
  • - Radiographic evidence of hydrocephalus or other architectural change of the ventricular system resulting in significant anatomic distortion of the hippocampus, including placement of external ventricular drain or ventriculoperitoneal shunt.
  • - Mild cases of hydrocephalus not resulting in significant anatomic distortion of the hippocampus are permitted.
  • - Prior radiotherapy to the brain, including SRS, WBRT, or prophylactic cranial irradiation (PCI).

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

 NCT04804644
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

 Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

 NRG Oncology
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

 Vinai Gondi
Principal Investigator Affiliation NRG Oncology
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

 Other, NIH
Overall Status Recruiting
Countries Canada, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

 Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Recurrent Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Additional Details

PRIMARY OBJECTIVE:

  • I. Determine whether stereotactic radiosurgery (SRS) relative to whole brain radiotherapy with hippocampal avoidance (HA-WBRT) plus memantine hydrochloride (memantine) for brain metastases from small cell lung cancer (SCLC) prevents cognitive function failure as measured by cognitive decline on a battery of tests: the Hopkins Verbal Learning Test - Revised (HVLT-R), Controlled Oral Word Association (COWA) test, and the Trail Making Test (TMT).
SECONDARY OBJECTIVES:
  • I. Determine whether SRS relative to HA-WBRT plus memantine for brain metastases from SCLC preserves cognitive function as separately measured by the HVLT-R, COWA, TMT Parts A and B, and Clinical Trial Battery Composite (CTB COMP).
  • II. Assess perceived difficulties in cognitive abilities using Patient Reported Outcomes Measurement Information System (PROMIS) after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • III. Assess symptom burden using the MD Anderson Symptom Inventory for brain tumor (MDASI-BT) after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • IV. Compare cumulative incidence of intracranial disease progression after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • V. Compare overall survival after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • VI. Compare cumulative incidence of neurologic death after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • VII. Compare the number of salvage procedures used to manage recurrent intracranial disease following SRS relative to HA-WBRT plus memantine for SCLC brain metastases.
  • VIII. Compare adverse events between the treatment arms according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0 criteria.
  • IX. Compare the risk of developing cerebral necrosis between SRS and HA-WBRT plus memantine in patients receiving concurrent immunotherapy.
EXPLORATORY OBJECTIVES:
  • I. Compare cumulative incidence of local brain recurrence, distant brain relapse, and leptomeningeal dissemination after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • II. Compare the cost of brain-related therapies and quality-adjusted life years in patients who receive SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • III. Evaluate the time delay to salvage WBRT or HA-WBRT in patients enrolled on the SRS arm.
  • IV. Evaluate whether a time delay for chemotherapy has an effect on overall survival in patients receiving HA WBRT plus memantine relative to SRS for brain metastases from SCLC.
  • V. Evaluate baseline magnetic resonance (MR) imaging biomarkers of white matter injury and hippocampal volumetry as potential predictors of cognitive decline and differential benefit from SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • VI. Evaluate the correlation between neurocognitive functioning and patient-reported outcomes.
  • VII. Collect serum, plasma and imaging studies for future translational research analyses.
OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients undergo SRS over 1 day (in some cases several days). ARM II: Patients undergo HA-WBRT once daily (QD) for 2 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive memantine orally (PO) QD or twice daily (BID) for up to 24 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo blood sample collection and magnetic resonance imaging (MRI) throughout the study. After completion of study treatment, patients are followed up every 2-3 months for 1 year, and then every 6 months thereafter.

Arms & Interventions

Arms

Experimental: Arm I (SRS)

Patients undergo SRS over 1 day (in some cases several days). Patients undergo blood sample collection and MRI throughout the study.

Active Comparator: Arm II (HA-WBRT, memantine)

Patients also undergo HA-WBRT QD for 2 weeks in the absence of disease progression or unacceptable toxicity. Patients will also receive memantine PO QD or BID for up to 24 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo blood sample collection and MRI throughout the study.

Interventions

Procedure: - Biospecimen Collection

Undergo blood sample collection

Procedure: - Magnetic Resonance Imaging

Undergo MRI

Drug: - Memantine Hydrochloride

Given PO

Other: - Neurocognitive Assessment

Ancillary studies

Radiation: - Stereotactic Radiosurgery

Undergo SRS

Radiation: - Whole-Brain Radiotherapy

Undergo HA-WBRT

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Mayo Clinic Hospital in Arizona, Phoenix 5308655, Arizona 5551752

Status

Active, not recruiting

Address

Mayo Clinic Hospital in Arizona

Phoenix 5308655, Arizona 5551752, 85054

Kaiser Permanente-Anaheim, Anaheim 5323810, California 5332921

Status

Recruiting

Address

Kaiser Permanente-Anaheim

Anaheim 5323810, California 5332921, 92806

Site Contact

Site Public Contact

[email protected]

800-398-3996

Kaiser Permanente-Bellflower, Bellflower 5327422, California 5332921

Status

Recruiting

Address

Kaiser Permanente-Bellflower

Bellflower 5327422, California 5332921, 90706

Site Contact

Site Public Contact

[email protected]

800-398-3996

Los Angeles 5368361, California 5332921

Status

Recruiting

Address

Kaiser Permanente Los Angeles Medical Center

Los Angeles 5368361, California 5332921, 90027

Site Contact

Site Public Contact

[email protected]

800-398-3996

Los Angeles General Medical Center, Los Angeles 5368361, California 5332921

Status

Recruiting

Address

Los Angeles General Medical Center

Los Angeles 5368361, California 5332921, 90033

Site Contact

Site Public Contact

[email protected]

323-865-0451

USC / Norris Comprehensive Cancer Center, Los Angeles 5368361, California 5332921

Status

Recruiting

Address

USC / Norris Comprehensive Cancer Center

Los Angeles 5368361, California 5332921, 90033

Site Contact

Site Public Contact

323-865-0451

Kaiser Permanente-Ontario, Ontario 5379439, California 5332921

Status

Recruiting

Address

Kaiser Permanente-Ontario

Ontario 5379439, California 5332921, 91761

Site Contact

Site Public Contact

[email protected]

800-398-3996

UCHealth University of Colorado Hospital, Aurora 5412347, Colorado 5417618

Status

Active, not recruiting

Address

UCHealth University of Colorado Hospital

Aurora 5412347, Colorado 5417618, 80045

UCHealth Memorial Hospital Central, Colorado Springs 5417598, Colorado 5417618

Status

Active, not recruiting

Address

UCHealth Memorial Hospital Central

Colorado Springs 5417598, Colorado 5417618, 80909

Memorial Hospital North, Colorado Springs 5417598, Colorado 5417618

Status

Active, not recruiting

Address

Memorial Hospital North

Colorado Springs 5417598, Colorado 5417618, 80920

Greenwich 4835395, Connecticut 4831725

Status

Terminated

Address

Smilow Cancer Hospital Care Center at Greenwich

Greenwich 4835395, Connecticut 4831725, 06830

Guilford 4835512, Connecticut 4831725

Status

Terminated

Address

Smilow Cancer Hospital Care Center - Guilford

Guilford 4835512, Connecticut 4831725, 06437

New Haven 4839366, Connecticut 4831725

Status

Terminated

Address

Smilow Cancer Center/Yale-New Haven Hospital

New Haven 4839366, Connecticut 4831725, 06510

Yale University, New Haven 4839366, Connecticut 4831725

Status

Terminated

Address

Yale University

New Haven 4839366, Connecticut 4831725, 06520

Trumbull 4844459, Connecticut 4831725

Status

Terminated

Address

Smilow Cancer Hospital Care Center-Trumbull

Trumbull 4844459, Connecticut 4831725, 06611

Waterford 8480031, Connecticut 4831725

Status

Terminated

Address

Smilow Cancer Hospital Care Center - Waterford

Waterford 8480031, Connecticut 4831725, 06385

Beebe Medical Center, Lewes 4143354, Delaware 4142224

Status

Recruiting

Address

Beebe Medical Center

Lewes 4143354, Delaware 4142224, 19958

Site Contact

Site Public Contact

[email protected]

302-291-6730

Newark 4143861, Delaware 4142224

Status

Suspended

Address

Delaware Clinical and Laboratory Physicians PA

Newark 4143861, Delaware 4142224, 19713

Helen F Graham Cancer Center, Newark 4143861, Delaware 4142224

Status

Recruiting

Address

Helen F Graham Cancer Center

Newark 4143861, Delaware 4142224, 19713

Site Contact

Site Public Contact

[email protected]

302-623-4450

Newark 4143861, Delaware 4142224

Status

Recruiting

Address

Medical Oncology Hematology Consultants PA

Newark 4143861, Delaware 4142224, 19713

Site Contact

Site Public Contact

[email protected]

302-623-4450

Newark 4143861, Delaware 4142224

Status

Recruiting

Address

Christiana Care Health System-Christiana Hospital

Newark 4143861, Delaware 4142224, 19718

Site Contact

Site Public Contact

[email protected]

302-623-4450

Beebe Health Campus, Rehoboth Beach 4144284, Delaware 4142224

Status

Recruiting

Address

Beebe Health Campus

Rehoboth Beach 4144284, Delaware 4142224, 19971

Site Contact

Site Public Contact

[email protected]

302-291-6730

Wilmington 4145381, Delaware 4142224

Status

Recruiting

Address

Christiana Care Health System-Wilmington Hospital

Wilmington 4145381, Delaware 4142224, 19801

Site Contact

Site Public Contact

[email protected]

302-623-4450

Coral Gables 4151871, Florida 4155751

Status

Active, not recruiting

Address

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables 4151871, Florida 4155751, 33146

Deerfield Beach 4153071, Florida 4155751

Status

Active, not recruiting

Address

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach 4153071, Florida 4155751, 33442

Gainesville 4156404, Florida 4155751

Status

Active, not recruiting

Address

University of Florida Health Science Center - Gainesville

Gainesville 4156404, Florida 4155751, 32610

Miami 4164138, Florida 4155751

Status

Active, not recruiting

Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami 4164138, Florida 4155751, 33136

Tampa 4174757, Florida 4155751

Status

Recruiting

Address

Moffitt Cancer Center-International Plaza

Tampa 4174757, Florida 4155751, 33607

Site Contact

Site Public Contact

[email protected]

800-679-0775

Moffitt Cancer Center - McKinley Campus, Tampa 4174757, Florida 4155751

Status

Recruiting

Address

Moffitt Cancer Center - McKinley Campus

Tampa 4174757, Florida 4155751, 33612

Site Contact

Site Public Contact

[email protected]

800-679-0775

Moffitt Cancer Center, Tampa 4174757, Florida 4155751

Status

Recruiting

Address

Moffitt Cancer Center

Tampa 4174757, Florida 4155751, 33612

Site Contact

Site Public Contact

[email protected]

800-679-0775

Moffitt Cancer Center at Wesley Chapel, Wesley Chapel 4177727, Florida 4155751

Status

Recruiting

Address

Moffitt Cancer Center at Wesley Chapel

Wesley Chapel 4177727, Florida 4155751, 33544

Site Contact

Site Public Contact

[email protected]

800-679-0775

Emory University Hospital Midtown, Atlanta 4180439, Georgia 4197000

Status

Active, not recruiting

Address

Emory University Hospital Midtown

Atlanta 4180439, Georgia 4197000, 30308

Atlanta 4180439, Georgia 4197000

Status

Active, not recruiting

Address

Emory University Hospital/Winship Cancer Institute

Atlanta 4180439, Georgia 4197000, 30322

Emory Saint Joseph's Hospital, Atlanta 4180439, Georgia 4197000

Status

Active, not recruiting

Address

Emory Saint Joseph's Hospital

Atlanta 4180439, Georgia 4197000, 30342

Northside Hospital, Atlanta 4180439, Georgia 4197000

Status

Recruiting

Address

Northside Hospital

Atlanta 4180439, Georgia 4197000, 30342

Site Contact

Site Public Contact

[email protected]

404-303-3355

Northside Hospital-Cherokee, Canton 4186213, Georgia 4197000

Status

Recruiting

Address

Northside Hospital-Cherokee

Canton 4186213, Georgia 4197000, 30115

Site Contact

Site Public Contact

[email protected]

404-303-3355

Northside Hospital-Forsyth, Cumming 4190396, Georgia 4197000

Status

Recruiting

Address

Northside Hospital-Forsyth

Cumming 4190396, Georgia 4197000, 30041

Site Contact

Site Public Contact

[email protected]

404-303-3355

Savannah 4221552, Georgia 4197000

Status

Recruiting

Address

Memorial Health University Medical Center

Savannah 4221552, Georgia 4197000, 31404

Site Contact

Site Public Contact

[email protected]

912-350-7887

Rush - Copley Medical Center, Aurora 4883817, Illinois 4896861

Status

Recruiting

Address

Rush - Copley Medical Center

Aurora 4883817, Illinois 4896861, 60504

Site Contact

Site Public Contact

[email protected]

630-978-6212

Centralia Oncology Clinic, Centralia 4235587, Illinois 4896861

Status

Recruiting

Address

Centralia Oncology Clinic

Centralia 4235587, Illinois 4896861, 62801

Site Contact

Site Public Contact

[email protected]

217-876-4762

Rush University Medical Center, Chicago 4887398, Illinois 4896861

Status

Active, not recruiting

Address

Rush University Medical Center

Chicago 4887398, Illinois 4896861, 60612

Chicago 4887398, Illinois 4896861

Status

Active, not recruiting

Address

University of Chicago Comprehensive Cancer Center

Chicago 4887398, Illinois 4896861, 60637

Carle at The Riverfront, Danville 4889426, Illinois 4896861

Status

Recruiting

Address

Carle at The Riverfront

Danville 4889426, Illinois 4896861, 61832

Site Contact

Site Public Contact

[email protected]

800-446-5532

Decatur 4236895, Illinois 4896861

Status

Recruiting

Address

Cancer Care Specialists of Illinois - Decatur

Decatur 4236895, Illinois 4896861, 62526

Site Contact

Site Public Contact

[email protected]

217-876-4762

Decatur Memorial Hospital, Decatur 4236895, Illinois 4896861

Status

Recruiting

Address

Decatur Memorial Hospital

Decatur 4236895, Illinois 4896861, 62526

Site Contact

Site Public Contact

[email protected]

217-876-4762

DeKalb 4889553, Illinois 4896861

Status

Recruiting

Address

Northwestern Medicine Cancer Center Kishwaukee

DeKalb 4889553, Illinois 4896861, 60115

Site Contact

Site Public Contact

[email protected]

630-352-5360

Carle Physician Group-Effingham, Effingham 4237727, Illinois 4896861

Status

Recruiting

Address

Carle Physician Group-Effingham

Effingham 4237727, Illinois 4896861, 62401

Site Contact

Site Public Contact

[email protected]

800-446-5532

Crossroads Cancer Center, Effingham 4237727, Illinois 4896861

Status

Recruiting

Address

Crossroads Cancer Center

Effingham 4237727, Illinois 4896861, 62401

Site Contact

Site Public Contact

[email protected]

217-876-4762

Geneva 4893591, Illinois 4896861

Status

Recruiting

Address

Northwestern Medicine Cancer Center Delnor

Geneva 4893591, Illinois 4896861, 60134

Site Contact

Site Public Contact

[email protected]

630-352-5360

Carle Physician Group-Mattoon/Charleston, Mattoon 4244099, Illinois 4896861

Status

Recruiting

Address

Carle Physician Group-Mattoon/Charleston

Mattoon 4244099, Illinois 4896861, 61938

Site Contact

Site Public Contact

[email protected]

800-446-5532

New Lenox 4903535, Illinois 4896861

Status

Recruiting

Address

UC Comprehensive Cancer Center at Silver Cross

New Lenox 4903535, Illinois 4896861, 60451

Site Contact

Site Public Contact

[email protected]

773-702-8222

Cancer Care Center of O'Fallon, O'Fallon 4245926, Illinois 4896861

Status

Recruiting

Address

Cancer Care Center of O'Fallon

O'Fallon 4245926, Illinois 4896861, 62269

Site Contact

Site Public Contact

[email protected]

217-876-4762

HSHS Saint Elizabeth's Hospital, O'Fallon 4245926, Illinois 4896861

Status

Recruiting

Address

HSHS Saint Elizabeth's Hospital

O'Fallon 4245926, Illinois 4896861, 62269

Site Contact

Site Public Contact

[email protected]

217-876-4762

OSF Saint Francis Medical Center, Peoria 4905687, Illinois 4896861

Status

Recruiting

Address

OSF Saint Francis Medical Center

Peoria 4905687, Illinois 4896861, 61637

Site Contact

Site Public Contact

[email protected]

309-243-3605

Carle Cancer Center, Urbana 4914570, Illinois 4896861

Status

Recruiting

Address

Carle Cancer Center

Urbana 4914570, Illinois 4896861, 61801

Site Contact

Site Public Contact

[email protected]

800-446-5532

The Carle Foundation Hospital, Urbana 4914570, Illinois 4896861

Status

Recruiting

Address

The Carle Foundation Hospital

Urbana 4914570, Illinois 4896861, 61801

Site Contact

Site Public Contact

[email protected]

800-446-5532

Warrenville 4915525, Illinois 4896861

Status

Recruiting

Address

Northwestern Medicine Cancer Center Warrenville

Warrenville 4915525, Illinois 4896861, 60555

Site Contact

Site Public Contact

[email protected]

630-352-5360

IU Health West Hospital, Avon 4254021, Indiana 4921868

Status

Recruiting

Address

IU Health West Hospital

Avon 4254021, Indiana 4921868, 46123

Site Contact

Site Public Contact

[email protected]

317-278-5632

IU Health North Hospital, Carmel 4255466, Indiana 4921868

Status

Recruiting

Address

IU Health North Hospital

Carmel 4255466, Indiana 4921868, 46032

Site Contact

Site Public Contact

[email protected]

317-278-5632

Goshen Center for Cancer Care, Goshen 4920808, Indiana 4921868

Status

Recruiting

Address

Goshen Center for Cancer Care

Goshen 4920808, Indiana 4921868, 46526

Site Contact

Site Public Contact

[email protected]

574-364-2973

Indianapolis 4259418, Indiana 4921868

Status

Recruiting

Address

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis 4259418, Indiana 4921868, 46202

Site Contact

Site Public Contact

[email protected]

317-278-5632

IU Health Methodist Hospital, Indianapolis 4259418, Indiana 4921868

Status

Recruiting

Address

IU Health Methodist Hospital

Indianapolis 4259418, Indiana 4921868, 46202

Site Contact

Site Public Contact

[email protected]

317-278-5632

Mary Greeley Medical Center, Ames 4846834, Iowa 4862182

Status

Recruiting

Address

Mary Greeley Medical Center

Ames 4846834, Iowa 4862182, 50010

Site Contact

Site Public Contact

515-956-4132

McFarland Clinic - Ames, Ames 4846834, Iowa 4862182

Status

Recruiting

Address

McFarland Clinic - Ames

Ames 4846834, Iowa 4862182, 50010

Site Contact

Site Public Contact

[email protected]

515-239-4734

Baptist Health Lexington, Lexington 4297983, Kentucky 6254925

Status

Active, not recruiting

Address

Baptist Health Lexington

Lexington 4297983, Kentucky 6254925, 40503

Louisville 4299276, Kentucky 6254925

Status

Recruiting

Address

The James Graham Brown Cancer Center at University of Louisville

Louisville 4299276, Kentucky 6254925, 40202

Site Contact

Site Public Contact

502-562-3429

UofL Health Medical Center Northeast, Louisville 4299276, Kentucky 6254925

Status

Recruiting

Address

UofL Health Medical Center Northeast

Louisville 4299276, Kentucky 6254925, 40245

Site Contact

Site Public Contact

[email protected]

502-852-2755

Mary Bird Perkins Cancer Center, Baton Rouge 4315588, Louisiana 4331987

Status

Recruiting

Address

Mary Bird Perkins Cancer Center

Baton Rouge 4315588, Louisiana 4331987, 70809

Site Contact

Site Public Contact

[email protected]

225-215-1353

Annapolis 4347242, Maryland 4361885

Status

Active, not recruiting

Address

Luminis Health Anne Arundel Medical Center

Annapolis 4347242, Maryland 4361885, 21401

Baltimore 4347778, Maryland 4361885

Status

Recruiting

Address

University of Maryland/Greenebaum Cancer Center

Baltimore 4347778, Maryland 4361885, 21201

Site Contact

Site Public Contact

800-888-8823

Baltimore 4347778, Maryland 4361885

Status

Suspended

Address

MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore 4347778, Maryland 4361885, 21237

UM Upper Chesapeake Medical Center, Bel Air 4348240, Maryland 4361885

Status

Recruiting

Address

UM Upper Chesapeake Medical Center

Bel Air 4348240, Maryland 4361885, 21014

Site Contact

Site Public Contact

443-643-3010

Columbia 4352053, Maryland 4361885

Status

Recruiting

Address

Central Maryland Radiation Oncology in Howard County

Columbia 4352053, Maryland 4361885, 21044

Site Contact

Site Public Contact

443-546-1300

Easton 4353962, Maryland 4361885

Status

Recruiting

Address

University of Maryland Shore Medical Center at Easton

Easton 4353962, Maryland 4361885, 21601

Site Contact

Site Public Contact

[email protected]

410-822-1000

Glen Burnie 4356188, Maryland 4361885

Status

Recruiting

Address

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie 4356188, Maryland 4361885, 21061

Site Contact

Site Public Contact

410-553-8100

Ocean Pines 4364326, Maryland 4361885

Status

Active, not recruiting

Address

TidalHealth Richard A Henson Cancer Institute

Ocean Pines 4364326, Maryland 4361885, 21811

TidalHealth Peninsula Regional, Salisbury 4368711, Maryland 4361885

Status

Active, not recruiting

Address

TidalHealth Peninsula Regional

Salisbury 4368711, Maryland 4361885, 21801

Boston Medical Center, Boston 4930956, Massachusetts 6254926

Status

Recruiting

Address

Boston Medical Center

Boston 4930956, Massachusetts 6254926, 02118

Site Contact

Site Public Contact

617-638-8265

Ann Arbor 4984247, Michigan 5001836

Status

Recruiting

Address

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor 4984247, Michigan 5001836, 48106

Site Contact

Site Public Contact

[email protected]

734-712-7251

Brighton 4986994, Michigan 5001836

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton 4986994, Michigan 5001836, 48114

Site Contact

Site Public Contact

[email protected]

734-712-7251

Trinity Health Medical Center - Brighton, Brighton 4986994, Michigan 5001836

Status

Recruiting

Address

Trinity Health Medical Center - Brighton

Brighton 4986994, Michigan 5001836, 48114

Site Contact

Site Public Contact

[email protected]

734-712-7251

Canton 4987990, Michigan 5001836

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton 4987990, Michigan 5001836, 48188

Site Contact

Site Public Contact

[email protected]

734-712-7251

Trinity Health Medical Center - Canton, Canton 4987990, Michigan 5001836

Status

Recruiting

Address

Trinity Health Medical Center - Canton

Canton 4987990, Michigan 5001836, 48188

Site Contact

Site Public Contact

[email protected]

734-712-7251

Caro Cancer Center, Caro 4988059, Michigan 5001836

Status

Suspended

Address

Caro Cancer Center

Caro 4988059, Michigan 5001836, 48723

Chelsea Hospital, Chelsea 4988628, Michigan 5001836

Status

Recruiting

Address

Chelsea Hospital

Chelsea 4988628, Michigan 5001836, 48118

Site Contact

Site Public Contact

[email protected]

734-712-7251

Chelsea 4988628, Michigan 5001836

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea 4988628, Michigan 5001836, 48118

Site Contact

Site Public Contact

[email protected]

734-712-7251

Detroit 4990729, Michigan 5001836

Status

Recruiting

Address

Wayne State University/Karmanos Cancer Institute

Detroit 4990729, Michigan 5001836, 48201

Site Contact

Site Public Contact

[email protected]

313-576-9790

Weisberg Cancer Treatment Center, Farmington Hills 4992523, Michigan 5001836

Status

Recruiting

Address

Weisberg Cancer Treatment Center

Farmington Hills 4992523, Michigan 5001836, 48334

Site Contact

Site Public Contact

[email protected]

313-576-9790

Livonia 4999837, Michigan 5001836

Status

Recruiting

Address

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia 4999837, Michigan 5001836, 48154

Site Contact

Site Public Contact

[email protected]

734-712-7251

Marlette 5000938, Michigan 5001836

Status

Suspended

Address

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette 5000938, Michigan 5001836, 48453

MyMichigan Medical Center Saginaw, Saginaw 5007989, Michigan 5001836

Status

Recruiting

Address

MyMichigan Medical Center Saginaw

Saginaw 5007989, Michigan 5001836, 48601

Site Contact

Site Public Contact

[email protected]

734-712-7251

Saginaw 5007989, Michigan 5001836

Status

Suspended

Address

Oncology Hematology Associates of Saginaw Valley PC

Saginaw 5007989, Michigan 5001836, 48604

MyMichigan Medical Center Tawas, Tawas City 5011900, Michigan 5001836

Status

Recruiting

Address

MyMichigan Medical Center Tawas

Tawas City 5011900, Michigan 5001836, 48764

Site Contact

Site Public Contact

[email protected]

734-712-7251

West Branch 5014413, Michigan 5001836

Status

Suspended

Address

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch 5014413, Michigan 5001836, 48661

Ypsilanti 5015688, Michigan 5001836

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti 5015688, Michigan 5001836, 48197

Site Contact

Site Public Contact

[email protected]

734-712-7251

Sanford Joe Lueken Cancer Center, Bemidji 5017822, Minnesota 5037779

Status

Recruiting

Address

Sanford Joe Lueken Cancer Center

Bemidji 5017822, Minnesota 5037779, 56601

Site Contact

Site Public Contact

[email protected]

218-333-5000

Minnesota Oncology - Burnsville, Burnsville 5019767, Minnesota 5037779

Status

Recruiting

Address

Minnesota Oncology - Burnsville

Burnsville 5019767, Minnesota 5037779, 55337

Site Contact

Site Public Contact

[email protected]

952-993-1517

Mercy Hospital, Coon Rapids 5022025, Minnesota 5037779

Status

Recruiting

Address

Mercy Hospital

Coon Rapids 5022025, Minnesota 5037779, 55433

Site Contact

Site Public Contact

[email protected]

952-993-1517

Fairview Southdale Hospital, Edina 5025264, Minnesota 5037779

Status

Recruiting

Address

Fairview Southdale Hospital

Edina 5025264, Minnesota 5037779, 55435

Site Contact

Site Public Contact

[email protected]

952-993-1517

Unity Hospital, Fridley 5027482, Minnesota 5037779

Status

Active, not recruiting

Address

Unity Hospital

Fridley 5027482, Minnesota 5037779, 55432

Maple Grove 5036493, Minnesota 5037779

Status

Recruiting

Address

Fairview Clinics and Surgery Center Maple Grove

Maple Grove 5036493, Minnesota 5037779, 55369

Site Contact

Site Public Contact

[email protected]

952-993-1517

Maplewood 5036588, Minnesota 5037779

Status

Recruiting

Address

Minnesota Oncology Hematology PA-Maplewood

Maplewood 5036588, Minnesota 5037779, 55109

Site Contact

Site Public Contact

[email protected]

952-993-1517

Abbott-Northwestern Hospital, Minneapolis 5037649, Minnesota 5037779

Status

Recruiting

Address

Abbott-Northwestern Hospital

Minneapolis 5037649, Minnesota 5037779, 55407

Site Contact

Site Public Contact

[email protected]

952-993-1517

Monticello Cancer Center, Monticello 5038045, Minnesota 5037779

Status

Recruiting

Address

Monticello Cancer Center

Monticello 5038045, Minnesota 5037779, 55362

Site Contact

Site Public Contact

[email protected]

952-993-1517

Saint Cloud 5044407, Minnesota 5037779

Status

Recruiting

Address

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud 5044407, Minnesota 5037779, 56303

Site Contact

Site Public Contact

[email protected]

877-229-4907

Regions Hospital, Saint Paul 5045360, Minnesota 5037779

Status

Recruiting

Address

Regions Hospital

Saint Paul 5045360, Minnesota 5037779, 55101

Site Contact

Site Public Contact

[email protected]

952-993-1517

United Hospital, Saint Paul 5045360, Minnesota 5037779

Status

Recruiting

Address

United Hospital

Saint Paul 5045360, Minnesota 5037779, 55102

Site Contact

Site Public Contact

[email protected]

952-993-1517

Lakeview Hospital, Stillwater 5048814, Minnesota 5037779

Status

Recruiting

Address

Lakeview Hospital

Stillwater 5048814, Minnesota 5037779, 55082

Site Contact

Site Public Contact

[email protected]

952-993-1517

Woodbury 5053358, Minnesota 5037779

Status

Recruiting

Address

Minnesota Oncology Hematology PA-Woodbury

Woodbury 5053358, Minnesota 5037779, 55125

Site Contact

Site Public Contact

[email protected]

952-993-1517

Saint Francis Medical Center, Cape Girardeau 4379966, Missouri 4398678

Status

Recruiting

Address

Saint Francis Medical Center

Cape Girardeau 4379966, Missouri 4398678, 63703

Site Contact

Site Public Contact

[email protected]

573-334-2230

Parkland Health Center - Farmington, Farmington 4386289, Missouri 4398678

Status

Recruiting

Address

Parkland Health Center - Farmington

Farmington 4386289, Missouri 4398678, 63640

Site Contact

Site Public Contact

314-996-5569

Freeman Health System, Joplin 4392768, Missouri 4398678

Status

Recruiting

Address

Freeman Health System

Joplin 4392768, Missouri 4398678, 64804

Site Contact

Site Public Contact

[email protected]

417-347-4030

Sainte Genevieve 4407294, Missouri 4398678

Status

Recruiting

Address

Sainte Genevieve County Memorial Hospital

Sainte Genevieve 4407294, Missouri 4398678, 63670

Site Contact

Site Public Contact

314-996-5569

Mercy Hospital Springfield, Springfield 4409896, Missouri 4398678

Status

Recruiting

Address

Mercy Hospital Springfield

Springfield 4409896, Missouri 4398678, 65804

Site Contact

Site Public Contact

417-269-4520

Missouri Baptist Medical Center, St Louis 4407066, Missouri 4398678

Status

Recruiting

Address

Missouri Baptist Medical Center

St Louis 4407066, Missouri 4398678, 63131

Site Contact

Site Public Contact

314-996-5569

Missouri Baptist Sullivan Hospital, Sullivan 4410669, Missouri 4398678

Status

Recruiting

Address

Missouri Baptist Sullivan Hospital

Sullivan 4410669, Missouri 4398678, 63080

Site Contact

Site Public Contact

314-996-5569

BJC Outpatient Center at Sunset Hills, Sunset Hills 4410836, Missouri 4398678

Status

Recruiting

Address

BJC Outpatient Center at Sunset Hills

Sunset Hills 4410836, Missouri 4398678, 63127

Site Contact

Site Public Contact

314-996-5569

Billings Clinic Cancer Center, Billings 5640350, Montana 5667009

Status

Recruiting

Address

Billings Clinic Cancer Center

Billings 5640350, Montana 5667009, 59101

Site Contact

Site Public Contact

[email protected]

800-996-2663

Benefis Sletten Cancer Institute, Great Falls 5655240, Montana 5667009

Status

Suspended

Address

Benefis Sletten Cancer Institute

Great Falls 5655240, Montana 5667009, 59405

Logan Health Medical Center, Kalispell 5660340, Montana 5667009

Status

Suspended

Address

Logan Health Medical Center

Kalispell 5660340, Montana 5667009, 59901

Camden 4501018, New Jersey 5101760

Status

Recruiting

Address

Cooper Hospital University Medical Center

Camden 4501018, New Jersey 5101760, 08103

Site Contact

Site Public Contact

856-325-6757

Sands Cancer Center, Canandaigua 5111405, New York 5128638

Status

Active, not recruiting

Address

Sands Cancer Center

Canandaigua 5111405, New York 5128638, 14424

Lake Success 5123853, New York 5128638

Status

Active, not recruiting

Address

Northwell Health/Center for Advanced Medicine

Lake Success 5123853, New York 5128638, 11042

Northern Westchester Hospital, Mount Kisco 5127744, New York 5128638

Status

Active, not recruiting

Address

Northern Westchester Hospital

Mount Kisco 5127744, New York 5128638, 10549

New York 5128581, New York 5128638

Status

Active, not recruiting

Address

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York 5128581, New York 5128638, 10032

Rochester 5134086, New York 5128638

Status

Active, not recruiting

Address

Wilmot Cancer Institute Radiation Oncology at Greece

Rochester 5134086, New York 5128638, 14606

University of Rochester, Rochester 5134086, New York 5128638

Status

Active, not recruiting

Address

University of Rochester

Rochester 5134086, New York 5128638, 14642

Syracuse 5140405, New York 5128638

Status

Recruiting

Address

State University of New York Upstate Medical University

Syracuse 5140405, New York 5128638, 13210

Site Contact

Site Public Contact

315-464-5476

The Bronx 5110266, New York 5128638

Status

Active, not recruiting

Address

Montefiore Medical Center-Einstein Campus

The Bronx 5110266, New York 5128638, 10461

The Bronx 5110266, New York 5128638

Status

Active, not recruiting

Address

Montefiore Medical Center-Weiler Hospital

The Bronx 5110266, New York 5128638, 10461

Montefiore Medical Center - Moses Campus, The Bronx 5110266, New York 5128638

Status

Active, not recruiting

Address

Montefiore Medical Center - Moses Campus

The Bronx 5110266, New York 5128638, 10467

Upstate Cancer Center at Verona, Verona 5142333, New York 5128638

Status

Suspended

Address

Upstate Cancer Center at Verona

Verona 5142333, New York 5128638, 13478

Wilmot Cancer Institute at Webster, Webster 5143495, New York 5128638

Status

Active, not recruiting

Address

Wilmot Cancer Institute at Webster

Webster 5143495, New York 5128638, 14580

Wake Forest University Health Sciences, Winston-Salem 4499612, North Carolina 4482348

Status

Recruiting

Address

Wake Forest University Health Sciences

Winston-Salem 4499612, North Carolina 4482348, 27157

Site Contact

Site Public Contact

336-713-6771

Sanford Bismarck Medical Center, Bismarck 5688025, North Dakota 5690763

Status

Recruiting

Address

Sanford Bismarck Medical Center

Bismarck 5688025, North Dakota 5690763, 58501

Site Contact

Site Public Contact

[email protected]

701-323-5760

Sanford Broadway Medical Center, Fargo 5059163, North Dakota 5690763

Status

Recruiting

Address

Sanford Broadway Medical Center

Fargo 5059163, North Dakota 5690763, 58122

Site Contact

Site Public Contact

[email protected]

701-323-5760

Sanford Roger Maris Cancer Center, Fargo 5059163, North Dakota 5690763

Status

Recruiting

Address

Sanford Roger Maris Cancer Center

Fargo 5059163, North Dakota 5690763, 58122

Site Contact

Site Public Contact

[email protected]

701-234-6161

Cincinnati 4508722, Ohio 5165418

Status

Recruiting

Address

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati 4508722, Ohio 5165418, 45219

Site Contact

Site Public Contact

[email protected]

513-584-7698

Case Western Reserve University, Cleveland 5150529, Ohio 5165418

Status

Recruiting

Address

Case Western Reserve University

Cleveland 5150529, Ohio 5165418, 44106

Site Contact

Site Public Contact

[email protected]

800-641-2422

Columbus 4509177, Ohio 5165418

Status

Recruiting

Address

Ohio State University Comprehensive Cancer Center

Columbus 4509177, Ohio 5165418, 43210

Site Contact

Site Public Contact

[email protected]

800-293-5066

Riverside Methodist Hospital, Columbus 4509177, Ohio 5165418

Status

Recruiting

Address

Riverside Methodist Hospital

Columbus 4509177, Ohio 5165418, 43214

Site Contact

Site Public Contact

[email protected]

614-788-3860

Grant Medical Center, Columbus 4509177, Ohio 5165418

Status

Recruiting

Address

Grant Medical Center

Columbus 4509177, Ohio 5165418, 43215

Site Contact

Site Public Contact

[email protected]

614-788-3860

Delaware 5151891, Ohio 5165418

Status

Recruiting

Address

Delaware Health Center-Grady Cancer Center

Delaware 5151891, Ohio 5165418, 43015

Site Contact

Site Public Contact

[email protected]

614-788-3860

Grady Memorial Hospital, Delaware 5151891, Ohio 5165418

Status

Recruiting

Address

Grady Memorial Hospital

Delaware 5151891, Ohio 5165418, 43015

Site Contact

Site Public Contact

[email protected]

614-788-3860

Mentor 5162645, Ohio 5165418

Status

Recruiting

Address

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor 5162645, Ohio 5165418, 44060

Site Contact

Site Public Contact

[email protected]

800-641-2422

Mercy Health - Perrysburg Hospital, Perrysburg 5166516, Ohio 5165418

Status

Recruiting

Address

Mercy Health - Perrysburg Hospital

Perrysburg 5166516, Ohio 5165418, 43551

Site Contact

Site Public Contact

[email protected]

614-488-2745

Mercy Health - Saint Anne Hospital, Toledo 5174035, Ohio 5165418

Status

Suspended

Address

Mercy Health - Saint Anne Hospital

Toledo 5174035, Ohio 5165418, 43623

West Chester 4520522, Ohio 5165418

Status

Recruiting

Address

University of Cincinnati Cancer Center-West Chester

West Chester 4520522, Ohio 5165418, 45069

Site Contact

Site Public Contact

[email protected]

513-584-7698

Oklahoma City 4544349, Oklahoma 4544379

Status

Recruiting

Address

University of Oklahoma Health Sciences Center

Oklahoma City 4544349, Oklahoma 4544379, 73104

Site Contact

Site Public Contact

[email protected]

405-271-8777

Saint Luke's Cancer Center - Allentown, Allentown 5178127, Pennsylvania 6254927

Status

Active, not recruiting

Address

Saint Luke's Cancer Center - Allentown

Allentown 5178127, Pennsylvania 6254927, 18104

UPMC Altoona, Altoona 5178195, Pennsylvania 6254927

Status

Recruiting

Address

UPMC Altoona

Altoona 5178195, Pennsylvania 6254927, 16601

Site Contact

Site Public Contact

[email protected]

412-339-5294

Bethlehem 5180225, Pennsylvania 6254927

Status

Active, not recruiting

Address

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem 5180225, Pennsylvania 6254927, 18015

Carlisle Regional Cancer Center, Carlisle 5183234, Pennsylvania 6254927

Status

Recruiting

Address

Carlisle Regional Cancer Center

Carlisle 5183234, Pennsylvania 6254927, 17015

Site Contact

Site Public Contact

[email protected]

412-339-5294

Chadds Ford 4557084, Pennsylvania 6254927

Status

Recruiting

Address

Christiana Care Health System-Concord Health Center

Chadds Ford 4557084, Pennsylvania 6254927, 19317

Site Contact

Site Public Contact

[email protected]

302-623-4450

Chambersburg Hospital, Chambersburg 4557109, Pennsylvania 6254927

Status

Recruiting

Address

Chambersburg Hospital

Chambersburg 4557109, Pennsylvania 6254927, 17201

Site Contact

Site Public Contact

[email protected]

412-339-5294

Geisinger Medical Center, Danville 5186327, Pennsylvania 6254927

Status

Recruiting

Address

Geisinger Medical Center

Danville 5186327, Pennsylvania 6254927, 17822

Site Contact

Site Public Contact

[email protected]

570-271-5251

Saint Luke's Hospital-Anderson Campus, Easton 5188140, Pennsylvania 6254927

Status

Active, not recruiting

Address

Saint Luke's Hospital-Anderson Campus

Easton 5188140, Pennsylvania 6254927, 18045

Ephrata Cancer Center, Ephrata 5188815, Pennsylvania 6254927

Status

Recruiting

Address

Ephrata Cancer Center

Ephrata 5188815, Pennsylvania 6254927, 17522

Site Contact

Site Public Contact

717-721-4840

Saint Vincent Hospital, Erie 5188843, Pennsylvania 6254927

Status

Active, not recruiting

Address

Saint Vincent Hospital

Erie 5188843, Pennsylvania 6254927, 16544

Adams Cancer Center, Gettysburg 4558183, Pennsylvania 6254927

Status

Recruiting

Address

Adams Cancer Center

Gettysburg 4558183, Pennsylvania 6254927, 17325

Site Contact

Site Public Contact

877-441-7957

Greensburg 5192029, Pennsylvania 6254927

Status

Recruiting

Address

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg 5192029, Pennsylvania 6254927, 15601

Site Contact

Site Public Contact

724-838-1900

Harrisburg 5192726, Pennsylvania 6254927

Status

Recruiting

Address

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg 5192726, Pennsylvania 6254927, 17109

Site Contact

Site Public Contact

[email protected]

717-724-6765

Sechler Family Cancer Center, Lebanon 5197517, Pennsylvania 6254927

Status

Recruiting

Address

Sechler Family Cancer Center

Lebanon 5197517, Pennsylvania 6254927, 17042

Site Contact

Site Public Contact

[email protected]

717-741-8303

Geisinger Medical Oncology-Lewisburg, Lewisburg 5197842, Pennsylvania 6254927

Status

Recruiting

Address

Geisinger Medical Oncology-Lewisburg

Lewisburg 5197842, Pennsylvania 6254927, 17837

Site Contact

Site Public Contact

[email protected]

570-374-8555

UPMC Cancer Center - Monroeville, Monroeville 5201734, Pennsylvania 6254927

Status

Recruiting

Address

UPMC Cancer Center - Monroeville

Monroeville 5201734, Pennsylvania 6254927, 15146

Site Contact

Site Public Contact

[email protected]

412-339-5294

Thomas Jefferson University Hospital, Philadelphia 4560349, Pennsylvania 6254927

Status

Suspended

Address

Thomas Jefferson University Hospital

Philadelphia 4560349, Pennsylvania 6254927, 19107

Jefferson Torresdale Hospital, Philadelphia 4560349, Pennsylvania 6254927

Status

Suspended

Address

Jefferson Torresdale Hospital

Philadelphia 4560349, Pennsylvania 6254927, 19114

Allegheny General Hospital, Pittsburgh 5206379, Pennsylvania 6254927

Status

Active, not recruiting

Address

Allegheny General Hospital

Pittsburgh 5206379, Pennsylvania 6254927, 15212

UPMC-Magee Womens Hospital, Pittsburgh 5206379, Pennsylvania 6254927

Status

Recruiting

Address

UPMC-Magee Womens Hospital

Pittsburgh 5206379, Pennsylvania 6254927, 15213

Site Contact

Site Public Contact

412-647-2811

UPMC-Presbyterian Hospital, Pittsburgh 5206379, Pennsylvania 6254927

Status

Recruiting

Address

UPMC-Presbyterian Hospital

Pittsburgh 5206379, Pennsylvania 6254927, 15213

Site Contact

Site Public Contact

412-647-2811

UPMC-Saint Margaret, Pittsburgh 5206379, Pennsylvania 6254927

Status

Recruiting

Address

UPMC-Saint Margaret

Pittsburgh 5206379, Pennsylvania 6254927, 15215

Site Contact

Site Public Contact

412-784-4900

UPMC-Shadyside Hospital, Pittsburgh 5206379, Pennsylvania 6254927

Status

Recruiting

Address

UPMC-Shadyside Hospital

Pittsburgh 5206379, Pennsylvania 6254927, 15232

Site Contact

Site Public Contact

412-621-2334

UPMC-Passavant Hospital, Pittsburgh 5206379, Pennsylvania 6254927

Status

Recruiting

Address

UPMC-Passavant Hospital

Pittsburgh 5206379, Pennsylvania 6254927, 15237

Site Contact

Site Public Contact

412-367-6454

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh 5206379, Pennsylvania 6254927

Status

Recruiting

Address

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh 5206379, Pennsylvania 6254927, 15243

Site Contact

Site Public Contact

412-502-3920

Quakertown 5207381, Pennsylvania 6254927

Status

Active, not recruiting

Address

Saint Luke's Hospital - Upper Bucks Campus

Quakertown 5207381, Pennsylvania 6254927, 18951

Saint Luke's Hospital-Quakertown Campus, Quakertown 5207381, Pennsylvania 6254927

Status

Suspended

Address

Saint Luke's Hospital-Quakertown Campus

Quakertown 5207381, Pennsylvania 6254927, 18951

Saint Luke's Hospital - Monroe Campus, Stroudsburg 5214543, Pennsylvania 6254927

Status

Active, not recruiting

Address

Saint Luke's Hospital - Monroe Campus

Stroudsburg 5214543, Pennsylvania 6254927, 18360

Wilkes-Barre 5219488, Pennsylvania 6254927

Status

Recruiting

Address

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre 5219488, Pennsylvania 6254927, 18711

Site Contact

Site Public Contact

[email protected]

570-271-5251

Divine Providence Hospital, Williamsport 5219585, Pennsylvania 6254927

Status

Recruiting

Address

Divine Providence Hospital

Williamsport 5219585, Pennsylvania 6254927, 17754

Site Contact

Site Public Contact

[email protected]

412-339-5294

WellSpan Health-York Cancer Center, York 4562407, Pennsylvania 6254927

Status

Recruiting

Address

WellSpan Health-York Cancer Center

York 4562407, Pennsylvania 6254927, 17403

Site Contact

Site Public Contact

877-441-7957

WellSpan Health-York Hospital, York 4562407, Pennsylvania 6254927

Status

Recruiting

Address

WellSpan Health-York Hospital

York 4562407, Pennsylvania 6254927, 17403

Site Contact

Site Public Contact

877-441-7957

UPMC Memorial, York 4562407, Pennsylvania 6254927

Status

Recruiting

Address

UPMC Memorial

York 4562407, Pennsylvania 6254927, 17408

Site Contact

Site Public Contact

717-724-6760

McLeod Regional Medical Center, Florence 4578737, South Carolina 4597040

Status

Recruiting

Address

McLeod Regional Medical Center

Florence 4578737, South Carolina 4597040, 29506

Site Contact

Site Public Contact

[email protected]

843-777-0770

Gibbs Cancer Center-Gaffney, Gaffney 4579418, South Carolina 4597040

Status

Active, not recruiting

Address

Gibbs Cancer Center-Gaffney

Gaffney 4579418, South Carolina 4597040, 29341

Self Regional Healthcare, Greenwood 4580569, South Carolina 4597040

Status

Recruiting

Address

Self Regional Healthcare

Greenwood 4580569, South Carolina 4597040, 29646

Site Contact

Site Public Contact

[email protected]

864-725-4771

Gibbs Cancer Center-Pelham, Greer 4580599, South Carolina 4597040

Status

Active, not recruiting

Address

Gibbs Cancer Center-Pelham

Greer 4580599, South Carolina 4597040, 29651

Spartanburg Medical Center, Spartanburg 4597200, South Carolina 4597040

Status

Active, not recruiting

Address

Spartanburg Medical Center

Spartanburg 4597200, South Carolina 4597040, 29303

SMC Center for Hematology Oncology Union, Union 4599214, South Carolina 4597040

Status

Active, not recruiting

Address

SMC Center for Hematology Oncology Union

Union 4599214, South Carolina 4597040, 29379

Sanford Cancer Center Oncology Clinic, Sioux Falls 5231851, South Dakota 5769223

Status

Recruiting

Address

Sanford Cancer Center Oncology Clinic

Sioux Falls 5231851, South Dakota 5769223, 57104

Site Contact

Site Public Contact

[email protected]

605-312-3320

Avera Cancer Institute, Sioux Falls 5231851, South Dakota 5769223

Status

Active, not recruiting

Address

Avera Cancer Institute

Sioux Falls 5231851, South Dakota 5769223, 57105

Sanford USD Medical Center - Sioux Falls, Sioux Falls 5231851, South Dakota 5769223

Status

Recruiting

Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls 5231851, South Dakota 5769223, 57117-5134

Site Contact

Site Public Contact

[email protected]

605-312-3320

MD Anderson in The Woodlands, Conroe 4682991, Texas 4736286

Status

Recruiting

Address

MD Anderson in The Woodlands

Conroe 4682991, Texas 4736286, 77384

Site Contact

Site Public Contact

[email protected]

866-632-6789

M D Anderson Cancer Center, Houston 4699066, Texas 4736286

Status

Recruiting

Address

M D Anderson Cancer Center

Houston 4699066, Texas 4736286, 77030

Site Contact

Site Public Contact

[email protected]

877-632-6789

MD Anderson West Houston, Houston 4699066, Texas 4736286

Status

Recruiting

Address

MD Anderson West Houston

Houston 4699066, Texas 4736286, 77079

Site Contact

Site Public Contact

[email protected]

877-632-6789

MD Anderson League City, League City 4705692, Texas 4736286

Status

Recruiting

Address

MD Anderson League City

League City 4705692, Texas 4736286, 77573

Site Contact

Site Public Contact

[email protected]

877-632-6789

MD Anderson in Sugar Land, Sugar Land 4734825, Texas 4736286

Status

Recruiting

Address

MD Anderson in Sugar Land

Sugar Land 4734825, Texas 4736286, 77478

Site Contact

Site Public Contact

[email protected]

877-632-6789

Richmond 4781708, Virginia 6254928

Status

Active, not recruiting

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond 4781708, Virginia 6254928, 23298

Langlade Hospital and Cancer Center, Antigo 5244010, Wisconsin 5279468

Status

Recruiting

Address

Langlade Hospital and Cancer Center

Antigo 5244010, Wisconsin 5279468, 54409

Site Contact

Site Public Contact

[email protected]

715-623-9869

ThedaCare Regional Cancer Center, Appleton 5244080, Wisconsin 5279468

Status

Recruiting

Address

ThedaCare Regional Cancer Center

Appleton 5244080, Wisconsin 5279468, 54911

Site Contact

Site Public Contact

[email protected]

920-364-3604

Gundersen Lutheran Medical Center, La Crosse 5258957, Wisconsin 5279468

Status

Active, not recruiting

Address

Gundersen Lutheran Medical Center

La Crosse 5258957, Wisconsin 5279468, 54601

Madison 5261457, Wisconsin 5279468

Status

Recruiting

Address

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison 5261457, Wisconsin 5279468, 53718

Site Contact

Site Public Contact

[email protected]

800-622-8922

Madison 5261457, Wisconsin 5279468

Status

Recruiting

Address

University of Wisconsin Carbone Cancer Center - University Hospital

Madison 5261457, Wisconsin 5279468, 53792

Site Contact

Site Public Contact

[email protected]

800-622-8922

Froedtert Menomonee Falls Hospital, Menomonee Falls 5262630, Wisconsin 5279468

Status

Recruiting

Address

Froedtert Menomonee Falls Hospital

Menomonee Falls 5262630, Wisconsin 5279468, 53051

Site Contact

Site Public Contact

262-257-5100

Medical College of Wisconsin, Milwaukee 5263045, Wisconsin 5279468

Status

Recruiting

Address

Medical College of Wisconsin

Milwaukee 5263045, Wisconsin 5279468, 53226

Site Contact

Site Public Contact

414-805-3666

Cancer Center of Western Wisconsin, New Richmond 5264475, Wisconsin 5279468

Status

Recruiting

Address

Cancer Center of Western Wisconsin

New Richmond 5264475, Wisconsin 5279468, 54017

Site Contact

Site Public Contact

[email protected]

952-993-1517

Drexel Town Square Health Center, Oak Creek 5265228, Wisconsin 5279468

Status

Recruiting

Address

Drexel Town Square Health Center

Oak Creek 5265228, Wisconsin 5279468, 53154

Site Contact

Site Public Contact

414-805-0505

Rhinelander 5268720, Wisconsin 5279468

Status

Recruiting

Address

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander 5268720, Wisconsin 5279468, 54501

Site Contact

Site Public Contact

[email protected]

715-847-2353

Aspirus Cancer Care - Stevens Point, Stevens Point 5274644, Wisconsin 5279468

Status

Recruiting

Address

Aspirus Cancer Care - Stevens Point

Stevens Point 5274644, Wisconsin 5279468, 54481

Site Contact

Site Public Contact

[email protected]

715-847-2353

Aspirus Regional Cancer Center, Wausau 5278120, Wisconsin 5279468

Status

Recruiting

Address

Aspirus Regional Cancer Center

Wausau 5278120, Wisconsin 5279468, 54401

Site Contact

Site Public Contact

877-405-6866

West Bend 5278422, Wisconsin 5279468

Status

Recruiting

Address

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend 5278422, Wisconsin 5279468, 53095

Site Contact

Site Public Contact

414-805-0505

International Sites

Toronto 6167865, Ontario 6093943, Canada

Status

Recruiting

Address

University Health Network-Princess Margaret Hospital

Toronto 6167865, Ontario 6093943, M5G 2M9

Site Contact

Site Public Contact

[email protected]

416-946-4501

Québec 6325494, Quebec 6115047, Canada

Status

Recruiting

Address

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec 6325494, Quebec 6115047, G1R 2J6

Site Contact

Site Public Contact

[email protected]

Allan Blair Cancer Centre, Regina 6119109, Saskatchewan 6141242, Canada

Status

Recruiting

Address

Allan Blair Cancer Centre

Regina 6119109, Saskatchewan 6141242, S4T 7T1

Site Contact

Site Public Contact

306-766-2213

Saskatoon Cancer Centre, Saskatoon 6141256, Saskatchewan 6141242, Canada

Status

Recruiting

Address

Saskatoon Cancer Centre

Saskatoon 6141256, Saskatchewan 6141242, S7N 4H4

Site Contact

Site Public Contact

306-655-2914

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