A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

Study Purpose

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	No
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Interventional
Eligible Ages	3 Years - 29 Years
Gender	All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Patients must be >= 3 years and < 30 years at the time of study enrollment.

- Patients must be newly diagnosed with localized primary CNS NGGCT of the suprasellar and/or pineal region by pathology and/or serum or cerebrospinal fluid (CSF) elevation of AFP above institutional normal or > 10 ng/mL or human chorionic gonadotropin (hCG) beta > 100 mIU/mL as confirmed by Rapid Central Marker Screening Review on APEC14B1-CNS.

Suprasellar, pineal and bifocal tumors are included. (CSF tumor markers and cytology must be within 31 days prior to enrollment and start of protocol therapy [repeat if necessary]. Serum tumor markers, AFP and hCGbeta must be within 7 days prior to enrollment and start of protocol therapy [repeat if necessary]). Basal ganglia or other primary sites are excluded.

- Patients with any of the following pathological elements are eligible: endodermal sinus (yolk sac), embryonal carcinoma, choriocarcinoma, malignant/immature teratoma and mixed germ cell tumor (GCT) (i.e., may include some pure germinoma) if malignant elements listed above are present.

Patients with only mature teratoma are excluded. Patients with pure germinoma admixed with mature teratoma are excluded (would be eligible for pure germinoma protocols)

- Patients must have a cranial MRI with and without gadolinium at diagnosis/prior to enrollment.

If surgical resection is performed, patients must have pre-operative and post operative brain MRI with and without gadolinium. The post operative brain MRI should be obtained within 72 hours of surgery. If patient has a biopsy only, post-operative brain MRI is recommended but not required (within 31 days prior to study enrollment and start of protocol therapy )

- Patients must have a spine MRI with gadolinium obtained at diagnosis/prior to enrollment.

Spine MRI with and without gadolinium is recommended (within 31 days prior to study enrollment and start of protocol therapy)

- Lumbar CSF must be obtained prior to study enrollment unless medically contraindicated.

If a patient undergoes surgery and lumbar CSF cytology cannot be obtained at the time of surgery, then it should be performed at least 10 days following surgery and prior to study enrollment. False positive cytology can occur within 10 days of surgery.

- Patients must have RAPID CENTRAL TUMOR MARKER REVIEW CSF tumor markers obtained prior to enrollment unless medically contraindicated.

Ventricular CSF obtained at the time of CSF diversion procedure (if performed) is acceptable for tumor markers but lumbar CSF is preferred. In case CSF diversion and biopsy/surgery are combined, CSF tumor markers should be collected first.

- Peripheral absolute neutrophil count (ANC) >= 1000/uL (within 7 days prior to enrollment) - Platelet count >= 100,000/uL (transfusion independent) (within 7 days prior to enrollment) - Hemoglobin >= 8.0 g/dL (may receive red blood cell [RBC] transfusions) (within 7 days prior to enrollment) - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows (within 7 days prior to enrollment): - Age: Maximum serum creatinine (mg/dL) - 3 to < 6 years: 0.8 (male), 0.8 (female) - 6 to < 10 years: 1 (male), 1 (female) - 10 to < 13 years: 1.2 (male), 1.2 (female) - 13 to < 16 years: 1.5 (male), 1.4 (female) - >= 16 years: male (1.7), 1.4 (female) - Total bilirubin =< 1.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment) - Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 135 U/L (within 7 days prior to enrollment) - Note: For the purpose of this study, the ULN for SGPT (ALT) has been set to the value of 45 U/L.

- Central nervous system function defined as: - Patients with seizure disorder may be enrolled if on anticonvulsants and well controlled.

- Patients must not be in status epilepticus, coma or assisted ventilation prior to study enrollment.

- Protocol therapy must begin within 31 calendar days of definitive surgery or clinical diagnosis, whichever is later.

If a biopsy only was performed, the biopsy date will be considered the date of definitive surgery. For patients who have a biopsy or incomplete resection at diagnosis followed by additional surgery, the date of the last resection will be considered the date of definitive surgery.

- All patients and/or their parents or legal guardians must sign a written informed consent.

- All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

- NEUROCOGNITIVE FUNCTION AND QUALITY OF LIFE ASSESSMENT: - English-, Spanish-, or French- speaking.

- Note: Patients who speak a language other than English, Spanish, or French will be allowed to participate in ACNS2021 but will not complete the neurocognitive and quality of life assessments.

- No known history of neurodevelopmental disorder prior to diagnosis of NGGCT (e.g., Down syndrome, fragile X, William syndrome, intellectual disability).

Patients with NF1 will be allowed to participate.

- Additional eligibility criteria for the COG Standardized Neuropsychological Battery only: must be at a site that has a psychologist to administer the battery.

- Note: If not eligible for the COG Standardized Battery, patients should still complete the Behavior Rating Inventory of Executive Function, Second Edition (BRIEF-2), Pediatric Quality of Life Inventory (PedsQL), Adaptive Behavior Assessment System Third Edition (ABAS-3), and Behavior Assessment System for Children, Third Edition (BASC-3) questionnaires.

Exclusion Criteria:

- Patients with tumors located outside the ventricles (i.e., basal ganglia, thalamus) - Patients with only mature teratoma and non-elevated markers upon tumor sampling at diagnosis.

- Patients who have received any prior tumor-directed therapy for their diagnosis of NGGCT other than surgical intervention and corticosteroids.

- Patients with metastatic disease (i.e., MRI evaluation, lumbar CSF cytology or intraoperative evidence of dissemination) - Female patients who are pregnant, since fetal toxicities and teratogenic effects have been noted for several of the study drugs.

- Note: Serum and urine pregnancy tests may be falsely positive due to HCGbeta-secreting germ cell tumors.

Ensure the patient is not pregnant by institutional standards.

- Lactating females who plan to breastfeed their infants.

- Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT04684368
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.	Phase 2
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	Children's Oncology Group
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	Shannon M MacDonald
Principal Investigator Affiliation	Children's Oncology Group
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other, NIH
Overall Status	Recruiting
Countries	Australia, Canada, New Zealand, United States
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Central Nervous System Nongerminomatous Germ Cell Tumor, Choriocarcinoma, Embryonal Carcinoma, Immature Teratoma, Malignant Teratoma, Mixed Germ Cell Tumor, Pineal Region Germ Cell Tumor, Pineal Region Immature Teratoma, Pineal Region Yolk Sac Tumor, Suprasellar Germ Cell Tumor

Additional Details

PRIMARY OBJECTIVES:

I. To monitor outcome to ensure that children and young adults with localized central nervous system (CNS) non-germinomatous germ cell tumors (NGGCT) treated with induction chemotherapy followed by response evaluation and whole ventricular + spinal canal irradiation (WVSCI) will maintain the excellent 2-year progression free survival (PFS) rate as compared to ACNS0122 (NCT00047320).

II. To improve disease control by decreasing the number of spinal relapses for patients who achieve a complete response (CR) or partial response (PR) and receive WVSCI as compared to whole ventricular radiation on ACNS1123 (NCT01602666).

SECONDARY OBJECTIVES:

I. To estimate the response rates to induction chemotherapy and WVSCI for localized NGGCT patients who achieve a CR/PR.

II. To estimate the PFS and overall survival (OS) for localized NGGCT patients who achieve a CR/PR and receive WVSCI.

III. To estimate the PFS and OS for patients with less than a CR/PR following Induction who subsequently receive high-dose chemotherapy with peripheral stem cell rescue (HDCSCR).

IV. To estimate the response rate for patients with less than a CR/PR following Induction who subsequently receive HDCSCR.

EXPLORATORY OBJECTIVES:

I. To prospectively compare outcomes based on radiation modality, photon versus proton, including cognitive, social and behavioral functioning, auditory, and neuro-endocrine function.

II. To compare spinal column growth and cell counts following radiation as measured by height and weight, and complete blood count (CBC) values during and after radiation therapy, based on treatment modality (photon versus [vs.

] proton therapy) and planned inclusion/exclusion of the vertebral body in patients < 13 years of age.

III. To compare local vs.#46; central review recommendations for second-look surgery and document barriers for performing such surgeries as well as their clinical benefit in pediatric NGGCT.

IV. To prospectively evaluate and longitudinally model the cognitive, social, and behavioral functioning of children and young adults with localized CNS NGGCT with testing as per the Children's Oncology Group (COG) Standardized Neuropsychological and Behavioral Battery.

V. To evaluate patterns of disease recurrence/failure with respect to radiation dose distribution.

OUTLINE: INDUCTION CHEMOTHERAPY: Patients receive carboplatin intravenously (IV) over 15-60 minutes on day 1 and etoposide IV over 90-120 minutes on days 1-3 of cycles 1, 3, and 5. Patients also receive ifosfamide IV over 60 minutes and etoposide IV over 60-120 minutes on days 1-5 of cycles 2, 4, and 6. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients are assigned to 1 of 2 plans (ventricular + spinal canal irradiation [WVSCI] or high-dose chemotherapy with peripheral stem cell rescue [HDCSCR]) based on response to induction chemotherapy:

- Patients who achieve radiographic CR/PR with marker normalization proceed to WVSCI.

Patients who achieve radiographic CR without marker normalization proceed to HDCSCR.

- Patients who achieve less than radiographic CR/PR with marker normalization proceed to second-look surgery (unless contraindicated).

If second-look surgery reveals mature teratoma or non-viable tumor, proceed to WVSCI. If second-look surgery reveals viable tumor, proceed to HDCSCR. Patients who are unable to undergo second-look surgery are removed from protocol therapy but remain on study for follow-up.

- Patients who achieve less than radiographic CR/PR without marker normalization proceed to second-look surgery (unless contraindicated).

Patients then proceed to HDCSCR regardless of whether or not a second-look surgery is performed.

- Patients who achieve radiographic PR without marker normalization proceed to second-look surgery (unless contraindicated).

Patients then proceed to HDCSCR regardless of whether or not a second-look surgery is performed. PLAN A (WVSCI THERAPY): Within 6 weeks of the end of induction chemotherapy or second-look surgery, patients undergo WVSCI once daily (QD) for 5 days weekly (17 fractions followed by a boost dose for 13 fractions) for 6 weeks in the absence of disease progression or unacceptable toxicity. PLAN B (CONSOLIDATION THERAPY [HDCSCR]): Within 6-8 weeks of the end of induction chemotherapy or second-look surgery, patients receive etoposide IV and thiotepa IV over 3 hours on days -5 to -3 and undergo peripheral blood stem cell (PBSC) transplant on day 0. Patients then undergo radiation therapy QD for 5 days weekly (20 fractions followed by a boost dose for 10 fractions) for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients also undergo magnetic resonance imaging (MRI), as well as collection of cerebral spinal fluid (CSF) and blood sample throughout the trial. After completion of study treatment, patients are followed for up to 10 years.

Arms & Interventions

Arms

Experimental: Plan A (chemotherapy, WVSCI, second-look surgery if needed)

See Outline in Detailed Description.

Experimental: Plan B (chemotherapy, HDCSCR, second-look surgery if needed)

See Outline in Detailed Description.

Interventions

Procedure: - Biospecimen Collection

Undergo collection of CSF and blood samples

Drug: - Carboplatin

Given IV

Drug: - Etoposide

Given IV

Biological: - Filgrastim

Given subcutaneously (SC) or IV

Drug: - Ifosfamide

Given IV

Procedure: - Magnetic Resonance Imaging

Undergo MRI

Drug: - Mesna

Given IV or orally

Biological: - Pegfilgrastim

Given SC

Procedure: - Peripheral Blood Stem Cell Transplantation

Undergo PBSC transplant

Other: - Questionnaire Administration

Ancillary studies

Radiation: - Radiation Therapy

Undergo WVSCI radiation therapy

Radiation: - Radiation Therapy

Undergo radiation therapy

Procedure: - Second-Look Surgery

Undergo second-look surgery if needed

Drug: - Thiotepa

Given IV

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Children's Hospital of Alabama, Birmingham 4049979, Alabama 4829764

Status

Suspended

Address

Children's Hospital of Alabama

Birmingham 4049979, Alabama 4829764, 35233

Providence Alaska Medical Center, Anchorage 5879400, Alaska 5879092

Status

Recruiting

Address

Providence Alaska Medical Center

Anchorage 5879400, Alaska 5879092, 99508

Site Contact

Site Public Contact

[email protected]

907-212-6871

Banner Children's at Desert, Mesa 5304391, Arizona 5551752

Status

Active, not recruiting

Address

Banner Children's at Desert

Mesa 5304391, Arizona 5551752, 85202

Phoenix Childrens Hospital, Phoenix 5308655, Arizona 5551752

Status

Recruiting

Address

Phoenix Childrens Hospital

Phoenix 5308655, Arizona 5551752, 85016

Site Contact

Site Public Contact

602-546-0920

Tucson 5318313, Arizona 5551752

Status

Recruiting

Address

Banner University Medical Center - Tucson

Tucson 5318313, Arizona 5551752, 85719

Site Contact

Site Public Contact

[email protected]

Tucson 5318313, Arizona 5551752

Status

Suspended

Address

University of Arizona Cancer Center-North Campus

Tucson 5318313, Arizona 5551752, 85719

Arkansas Children's Hospital, Little Rock 4119403, Arkansas 4099753

Status

Recruiting

Address

Arkansas Children's Hospital

Little Rock 4119403, Arkansas 4099753, 72202-3591

Site Contact

Site Public Contact

501-364-7373

Kaiser Permanente Downey Medical Center, Downey 5343858, California 5332921

Status

Recruiting

Address

Kaiser Permanente Downey Medical Center

Downey 5343858, California 5332921, 90242

Site Contact

Site Public Contact

626-564-3455

Loma Linda University Medical Center, Loma Linda 5367696, California 5332921

Status

Recruiting

Address

Loma Linda University Medical Center

Loma Linda 5367696, California 5332921, 92354

Site Contact

Site Public Contact

909-558-4050

Long Beach 5367929, California 5332921

Status

Recruiting

Address

Miller Children's and Women's Hospital Long Beach

Long Beach 5367929, California 5332921, 90806

Site Contact

Site Public Contact

562-933-5600

Children's Hospital Los Angeles, Los Angeles 5368361, California 5332921

Status

Recruiting

Address

Children's Hospital Los Angeles

Los Angeles 5368361, California 5332921, 90027

Site Contact

Site Public Contact

323-361-4110

Los Angeles 5368361, California 5332921

Status

Suspended

Address

Kaiser Permanente Los Angeles Medical Center

Los Angeles 5368361, California 5332921, 90027

Cedars Sinai Medical Center, Los Angeles 5368361, California 5332921

Status

Recruiting

Address

Cedars Sinai Medical Center

Los Angeles 5368361, California 5332921, 90048

Site Contact

Site Public Contact

310-423-8965

Valley Children's Hospital, Madera 5369568, California 5332921

Status

Recruiting

Address

Valley Children's Hospital

Madera 5369568, California 5332921, 93636

Site Contact

Site Public Contact

[email protected]

559-353-3000

Kaiser Permanente-Oakland, Oakland 5378538, California 5332921

Status

Recruiting

Address

Kaiser Permanente-Oakland

Oakland 5378538, California 5332921, 94611

Site Contact

Site Public Contact

[email protected]

877-642-4691

Children's Hospital of Orange County, Orange 5379513, California 5332921

Status

Recruiting

Address

Children's Hospital of Orange County

Orange 5379513, California 5332921, 92868

Site Contact

Site Public Contact

[email protected]

714-509-8646

Palo Alto 5380748, California 5332921

Status

Recruiting

Address

Lucile Packard Children's Hospital Stanford University

Palo Alto 5380748, California 5332921, 94304

Site Contact

Site Public Contact

[email protected]

800-694-0012

Rady Children's Hospital - San Diego, San Diego 5391811, California 5332921

Status

Recruiting

Address

Rady Children's Hospital - San Diego

San Diego 5391811, California 5332921, 92123

Site Contact

Site Public Contact

858-966-5934

UCSF Medical Center-Mission Bay, San Francisco 5391959, California 5332921

Status

Recruiting

Address

UCSF Medical Center-Mission Bay

San Francisco 5391959, California 5332921, 94158

Site Contact

Site Public Contact

[email protected]

877-827-3222

Children's Hospital Colorado, Aurora 5412347, Colorado 5417618

Status

Recruiting

Address

Children's Hospital Colorado

Aurora 5412347, Colorado 5417618, 80045

Site Contact

Site Public Contact

[email protected]

303-764-5056

Connecticut Children's Medical Center, Hartford 4835797, Connecticut 4831725

Status

Recruiting

Address

Connecticut Children's Medical Center

Hartford 4835797, Connecticut 4831725, 06106

Site Contact

Site Public Contact

860-545-9981

Yale University, New Haven 4839366, Connecticut 4831725

Status

Recruiting

Address

Yale University

New Haven 4839366, Connecticut 4831725, 06520

Site Contact

Site Public Contact

[email protected]

203-785-5702

Alfred I duPont Hospital for Children, Wilmington 4145381, Delaware 4142224

Status

Recruiting

Address

Alfred I duPont Hospital for Children

Wilmington 4145381, Delaware 4142224, 19803

Site Contact

Site Public Contact

[email protected]

302-651-5572

Children's National Medical Center, Washington D.C. 4140963, District of Columbia 4138106

Status

Recruiting

Address

Children's National Medical Center

Washington D.C. 4140963, District of Columbia 4138106, 20010

Site Contact

Site Public Contact

[email protected]

202-476-2800

Fort Myers 4155995, Florida 4155751

Status

Recruiting

Address

Golisano Children's Hospital of Southwest Florida

Fort Myers 4155995, Florida 4155751, 33908

Site Contact

Site Public Contact

[email protected]

239-343-5333

Gainesville 4156404, Florida 4155751

Status

Recruiting

Address

University of Florida Health Science Center - Gainesville

Gainesville 4156404, Florida 4155751, 32610

Site Contact

Site Public Contact

[email protected]

352-273-8010

Nemours Children's Clinic-Jacksonville, Jacksonville 4160021, Florida 4155751

Status

Recruiting

Address

Nemours Children's Clinic-Jacksonville

Jacksonville 4160021, Florida 4155751, 32207

Site Contact

Site Public Contact

[email protected]

302-651-5572

Miami 4164138, Florida 4155751

Status

Recruiting

Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami 4164138, Florida 4155751, 33136

Site Contact

Site Public Contact

305-243-2647

Nicklaus Children's Hospital, Miami 4164138, Florida 4155751

Status

Recruiting

Address

Nicklaus Children's Hospital

Miami 4164138, Florida 4155751, 33155

Site Contact

Site Public Contact

888-624-2778

Arnold Palmer Hospital for Children, Orlando 4167147, Florida 4155751

Status

Recruiting

Address

Arnold Palmer Hospital for Children

Orlando 4167147, Florida 4155751, 32806

Site Contact

Site Public Contact

[email protected]

321-841-5357

Nemours Children's Hospital, Orlando 4167147, Florida 4155751

Status

Recruiting

Address

Nemours Children's Hospital

Orlando 4167147, Florida 4155751, 32827

Site Contact

Site Public Contact

[email protected]

302-651-5572

Nemours Children's Clinic - Pensacola, Pensacola 4168228, Florida 4155751

Status

Recruiting

Address

Nemours Children's Clinic - Pensacola

Pensacola 4168228, Florida 4155751, 32504

Site Contact

Site Public Contact

[email protected]

Sacred Heart Hospital, Pensacola 4168228, Florida 4155751

Status

Suspended

Address

Sacred Heart Hospital

Pensacola 4168228, Florida 4155751, 32504

Johns Hopkins All Children's Hospital, St. Petersburg 4171563, Florida 4155751

Status

Recruiting

Address

Johns Hopkins All Children's Hospital

St. Petersburg 4171563, Florida 4155751, 33701

Site Contact

Site Public Contact

[email protected]

727-767-4784

Tampa 4174757, Florida 4155751

Status

Recruiting

Address

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa 4174757, Florida 4155751, 33607

Site Contact

Site Public Contact

[email protected]

813-357-0849

Atlanta 4180439, Georgia 4197000

Status

Recruiting

Address

Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta 4180439, Georgia 4197000, 30329

Site Contact

Site Public Contact

[email protected]

404-785-0232

Honolulu 5856195, Hawaii 5855797

Status

Recruiting

Address

Kapiolani Medical Center for Women and Children

Honolulu 5856195, Hawaii 5855797, 96826

Site Contact

Site Public Contact

808-983-6090

Saint Luke's Cancer Institute - Boise, Boise 5586437, Idaho 5596512

Status

Recruiting

Address

Saint Luke's Cancer Institute - Boise

Boise 5586437, Idaho 5596512, 83712

Site Contact

Site Public Contact

[email protected]

208-381-2774

Lurie Children's Hospital-Chicago, Chicago 4887398, Illinois 4896861

Status

Recruiting

Address

Lurie Children's Hospital-Chicago

Chicago 4887398, Illinois 4896861, 60611

Site Contact

Site Public Contact

773-880-4562

University of Illinois, Chicago 4887398, Illinois 4896861

Status

Recruiting

Address

University of Illinois

Chicago 4887398, Illinois 4896861, 60612

Site Contact

Site Public Contact

312-355-3046

Chicago 4887398, Illinois 4896861

Status

Recruiting

Address

University of Chicago Comprehensive Cancer Center

Chicago 4887398, Illinois 4896861, 60637

Site Contact

Site Public Contact

[email protected]

773-702-8222

Loyola University Medical Center, Maywood 4901514, Illinois 4896861

Status

Recruiting

Address

Loyola University Medical Center

Maywood 4901514, Illinois 4896861, 60153

Site Contact

Site Public Contact

708-226-4357

Saint Jude Midwest Affiliate, Peoria 4905687, Illinois 4896861

Status

Recruiting

Address

Saint Jude Midwest Affiliate

Peoria 4905687, Illinois 4896861, 61637

Site Contact

Site Public Contact

888-226-4343

Riley Hospital for Children, Indianapolis 4259418, Indiana 4921868

Status

Recruiting

Address

Riley Hospital for Children

Indianapolis 4259418, Indiana 4921868, 46202

Site Contact

Sandeep Batra

[email protected]

317-944-8784

Blank Children's Hospital, Des Moines 4853828, Iowa 4862182

Status

Recruiting

Address

Blank Children's Hospital

Des Moines 4853828, Iowa 4862182, 50309

Site Contact

Site Public Contact

[email protected]

515-241-8912

Iowa City 4862034, Iowa 4862182

Status

Recruiting

Address

University of Iowa/Holden Comprehensive Cancer Center

Iowa City 4862034, Iowa 4862182, 52242

Site Contact

Site Public Contact

800-237-1225

Lexington 4297983, Kentucky 6254925

Status

Recruiting

Address

University of Kentucky/Markey Cancer Center

Lexington 4297983, Kentucky 6254925, 40536

Site Contact

Site Public Contact

859-257-3379

Norton Children's Hospital, Louisville 4299276, Kentucky 6254925

Status

Recruiting

Address

Norton Children's Hospital

Louisville 4299276, Kentucky 6254925, 40202

Site Contact

Site Public Contact

[email protected]

502-629-5500

Ochsner Medical Center Jefferson, New Orleans 4335045, Louisiana 4331987

Status

Recruiting

Address

Ochsner Medical Center Jefferson

New Orleans 4335045, Louisiana 4331987, 70121

Site Contact

Site Public Contact

[email protected]

504-842-8084

Eastern Maine Medical Center, Bangor 4957280, Maine 4971068

Status

Recruiting

Address

Eastern Maine Medical Center

Bangor 4957280, Maine 4971068, 04401

Site Contact

Site Public Contact

207-973-4274

Maine Children's Cancer Program, Scarborough 4977882, Maine 4971068

Status

Recruiting

Address

Maine Children's Cancer Program

Scarborough 4977882, Maine 4971068, 04074

Site Contact

Site Public Contact

[email protected]

207-396-8670

Sinai Hospital of Baltimore, Baltimore 4347778, Maryland 4361885

Status

Recruiting

Address

Sinai Hospital of Baltimore

Baltimore 4347778, Maryland 4361885, 21215

Site Contact

Site Public Contact

410-601-9083

Baltimore 4347778, Maryland 4361885

Status

Recruiting

Address

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore 4347778, Maryland 4361885, 21287

Site Contact

Site Public Contact

[email protected]

410-955-8804

Boston 4930956, Massachusetts 6254926

Status

Recruiting

Address

Massachusetts General Hospital Cancer Center

Boston 4930956, Massachusetts 6254926, 02114

Site Contact

Site Public Contact

877-726-5130

Dana-Farber Cancer Institute, Boston 4930956, Massachusetts 6254926

Status

Recruiting

Address

Dana-Farber Cancer Institute

Boston 4930956, Massachusetts 6254926, 02215

Site Contact

Site Public Contact

877-442-3324

C S Mott Children's Hospital, Ann Arbor 4984247, Michigan 5001836

Status

Recruiting

Address

C S Mott Children's Hospital

Ann Arbor 4984247, Michigan 5001836, 48109

Site Contact

Site Public Contact

800-865-1125

Children's Hospital of Michigan, Detroit 4990729, Michigan 5001836

Status

Recruiting

Address

Children's Hospital of Michigan

Detroit 4990729, Michigan 5001836, 48201

Site Contact

Site Public Contact

[email protected]

Michigan State University, East Lansing 4991640, Michigan 5001836

Status

Active, not recruiting

Address

Michigan State University

East Lansing 4991640, Michigan 5001836, 48823

Grand Rapids 4994358, Michigan 5001836

Status

Suspended

Address

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids 4994358, Michigan 5001836, 49503

Grand Rapids 4994358, Michigan 5001836

Status

Recruiting

Address

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids 4994358, Michigan 5001836, 49503

Site Contact

Site Public Contact

[email protected]

616-391-1230

Corewell Health Children's, Royal Oak 5007804, Michigan 5001836

Status

Recruiting

Address

Corewell Health Children's

Royal Oak 5007804, Michigan 5001836, 48073

Site Contact

Site Public Contact

248-551-7695

Minneapolis 5037649, Minnesota 5037779

Status

Recruiting

Address

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis 5037649, Minnesota 5037779, 55404

Site Contact

Site Public Contact

[email protected]

612-813-5913

Mayo Clinic in Rochester, Rochester 5043473, Minnesota 5037779

Status

Recruiting

Address

Mayo Clinic in Rochester

Rochester 5043473, Minnesota 5037779, 55905

Site Contact

Site Public Contact

855-776-0015

University of Mississippi Medical Center, Jackson 4431410, Mississippi 4436296

Status

Recruiting

Address

University of Mississippi Medical Center

Jackson 4431410, Mississippi 4436296, 39216

Site Contact

Site Public Contact

601-815-6700

Columbia 4381982, Missouri 4398678

Status

Recruiting

Address

University of Missouri Children's Hospital

Columbia 4381982, Missouri 4398678, 65212

Site Contact

Site Public Contact

[email protected]

573-882-1960

Children's Mercy Hospitals and Clinics, Kansas City 4393217, Missouri 4398678

Status

Recruiting

Address

Children's Mercy Hospitals and Clinics

Kansas City 4393217, Missouri 4398678, 64108

Site Contact

Site Public Contact

[email protected]

816-302-6808

St Louis 4407066, Missouri 4398678

Status

Recruiting

Address

Cardinal Glennon Children's Medical Center

St Louis 4407066, Missouri 4398678, 63104

Site Contact

Site Public Contact

314-268-4000

Washington University School of Medicine, St Louis 4407066, Missouri 4398678

Status

Recruiting

Address

Washington University School of Medicine

St Louis 4407066, Missouri 4398678, 63110

Site Contact

Site Public Contact

[email protected]

800-600-3606

Mercy Hospital Saint Louis, St Louis 4407066, Missouri 4398678

Status

Recruiting

Address

Mercy Hospital Saint Louis

St Louis 4407066, Missouri 4398678, 63141

Site Contact

Site Public Contact

314-251-7066

Omaha 5074472, Nebraska 5073708

Status

Recruiting

Address

Children's Hospital and Medical Center of Omaha

Omaha 5074472, Nebraska 5073708, 68114

Site Contact

Site Public Contact

402-955-3949

University of Nebraska Medical Center, Omaha 5074472, Nebraska 5073708

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha 5074472, Nebraska 5073708, 68198

Site Contact

Site Public Contact

[email protected]

402-559-6941

GenesisCare USA - Las Vegas, Las Vegas 5506956, Nevada 5509151

Status

Suspended

Address

GenesisCare USA - Las Vegas

Las Vegas 5506956, Nevada 5509151, 89109

Las Vegas 5506956, Nevada 5509151

Status

Suspended

Address

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas 5506956, Nevada 5509151, 89135

Renown Regional Medical Center, Reno 5511077, Nevada 5509151

Status

Recruiting

Address

Renown Regional Medical Center

Reno 5511077, Nevada 5509151, 89502

Site Contact

Site Public Contact

[email protected]

702-384-0013

Cancer Care Specialists - Reno, Reno 5511077, Nevada 5509151

Status

Suspended

Address

Cancer Care Specialists - Reno

Reno 5511077, Nevada 5509151, 89511

Lebanon 5088597, New Hampshire 5090174

Status

Recruiting

Address

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon 5088597, New Hampshire 5090174, 03756

Site Contact

Site Public Contact

[email protected]

800-639-6918

Hackensack University Medical Center, Hackensack 5098706, New Jersey 5101760

Status

Recruiting

Address

Hackensack University Medical Center

Hackensack 5098706, New Jersey 5101760, 07601

Site Contact

Site Public Contact

551-996-2897

Morristown Medical Center, Morristown 5101427, New Jersey 5101760

Status

Recruiting

Address

Morristown Medical Center

Morristown 5101427, New Jersey 5101760, 07960

Site Contact

Site Public Contact

973-971-5900

Saint Peter's University Hospital, New Brunswick 5101717, New Jersey 5101760

Status

Recruiting

Address

Saint Peter's University Hospital

New Brunswick 5101717, New Jersey 5101760, 08901

Site Contact

Site Public Contact

[email protected]

732-745-8600 #6163

New Brunswick 5101717, New Jersey 5101760

Status

Recruiting

Address

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick 5101717, New Jersey 5101760, 08903

Site Contact

Site Public Contact

732-235-8675

Newark Beth Israel Medical Center, Newark 5101798, New Jersey 5101760

Status

Suspended

Address

Newark Beth Israel Medical Center

Newark 5101798, New Jersey 5101760, 07112

Saint Joseph's Regional Medical Center, Paterson 5102466, New Jersey 5101760

Status

Recruiting

Address

Saint Joseph's Regional Medical Center

Paterson 5102466, New Jersey 5101760, 07503

Site Contact

Site Public Contact

[email protected]

973-754-2207

Albany Medical Center, Albany 5106834, New York 5128638

Status

Recruiting

Address

Albany Medical Center

Albany 5106834, New York 5128638, 12208

Site Contact

Site Public Contact

518-262-5513

Maimonides Medical Center, Brooklyn 5110302, New York 5128638

Status

Recruiting

Address

Maimonides Medical Center

Brooklyn 5110302, New York 5128638, 11219

Site Contact

Site Public Contact

718-765-2500

New Hyde Park 5128514, New York 5128638

Status

Recruiting

Address

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park 5128514, New York 5128638, 11040

Site Contact

Site Public Contact

718-470-3460

New York 5128581, New York 5128638

Status

Recruiting

Address

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York 5128581, New York 5128638, 10016

Site Contact

Site Public Contact

[email protected]

Memorial Sloan Kettering Cancer Center, New York 5128581, New York 5128638

Status

Recruiting

Address

Memorial Sloan Kettering Cancer Center

New York 5128581, New York 5128638, 10065

Site Contact

Site Public Contact

212-639-7592

Stony Brook University Medical Center, Stony Brook 5139865, New York 5128638

Status

Recruiting

Address

Stony Brook University Medical Center

Stony Brook 5139865, New York 5128638, 11794

Site Contact

Site Public Contact

800-862-2215

Syracuse 5140405, New York 5128638

Status

Recruiting

Address

State University of New York Upstate Medical University

Syracuse 5140405, New York 5128638, 13210

Site Contact

Site Public Contact

315-464-5476

The Bronx 5110266, New York 5128638

Status

Suspended

Address

Montefiore Medical Center-Einstein Campus

The Bronx 5110266, New York 5128638, 10461

Montefiore Medical Center - Moses Campus, The Bronx 5110266, New York 5128638

Status

Recruiting

Address

Montefiore Medical Center - Moses Campus

The Bronx 5110266, New York 5128638, 10467

Site Contact

Site Public Contact

[email protected]

718-379-6866

New York Medical College, Valhalla 5142090, New York 5128638

Status

Recruiting

Address

New York Medical College

Valhalla 5142090, New York 5128638, 10595

Site Contact

Site Public Contact

914-594-3794

Charlotte 4460243, North Carolina 4482348

Status

Recruiting

Address

Carolinas Medical Center/Levine Cancer Institute

Charlotte 4460243, North Carolina 4482348, 28203

Site Contact

Site Public Contact

800-804-9376

Duke University Medical Center, Durham 4464368, North Carolina 4482348

Status

Recruiting

Address

Duke University Medical Center

Durham 4464368, North Carolina 4482348, 27710

Site Contact

Site Public Contact

888-275-3853

East Carolina University, Greenville 4469160, North Carolina 4482348

Status

Recruiting

Address

East Carolina University

Greenville 4469160, North Carolina 4482348, 27834

Site Contact

Site Public Contact

[email protected]

252-744-1015

Wake Forest University Health Sciences, Winston-Salem 4499612, North Carolina 4482348

Status

Recruiting

Address

Wake Forest University Health Sciences

Winston-Salem 4499612, North Carolina 4482348, 27157

Site Contact

Site Public Contact

336-713-6771

Sanford Broadway Medical Center, Fargo 5059163, North Dakota 5690763

Status

Recruiting

Address

Sanford Broadway Medical Center

Fargo 5059163, North Dakota 5690763, 58122

Site Contact

Site Public Contact

[email protected]

701-323-5760

Akron 5145476, Ohio 5165418

Status

Recruiting

Address

Children's Hospital Medical Center of Akron

Akron 5145476, Ohio 5165418, 44308

Site Contact

Site Public Contact

330-543-3193

Cincinnati 4508722, Ohio 5165418

Status

Recruiting

Address

Cincinnati Children's Hospital Medical Center

Cincinnati 4508722, Ohio 5165418, 45229

Site Contact

Site Public Contact

[email protected]

513-636-2799

Rainbow Babies and Childrens Hospital, Cleveland 5150529, Ohio 5165418

Status

Recruiting

Address

Rainbow Babies and Childrens Hospital

Cleveland 5150529, Ohio 5165418, 44106

Site Contact

Site Public Contact

216-844-5437

Cleveland Clinic Foundation, Cleveland 5150529, Ohio 5165418

Status

Active, not recruiting

Address

Cleveland Clinic Foundation

Cleveland 5150529, Ohio 5165418, 44195

Nationwide Children's Hospital, Columbus 4509177, Ohio 5165418

Status

Recruiting

Address

Nationwide Children's Hospital

Columbus 4509177, Ohio 5165418, 43205

Site Contact

Site Public Contact

[email protected]

614-722-6039

Dayton Children's Hospital, Dayton 4509884, Ohio 5165418

Status

Recruiting

Address

Dayton Children's Hospital

Dayton 4509884, Ohio 5165418, 45404

Site Contact

Site Public Contact

800-228-4055

ProMedica Flower Hospital, Sylvania 5173572, Ohio 5165418

Status

Suspended

Address

ProMedica Flower Hospital

Sylvania 5173572, Ohio 5165418, 43560

Toledo 5174035, Ohio 5165418

Status

Recruiting

Address

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo 5174035, Ohio 5165418, 43606

Site Contact

Site Public Contact

[email protected]

419-824-1842

Oklahoma City 4544349, Oklahoma 4544379

Status

Recruiting

Address

University of Oklahoma Health Sciences Center

Oklahoma City 4544349, Oklahoma 4544379, 73104

Site Contact

Site Public Contact

[email protected]

405-271-8777

Legacy Emanuel Children's Hospital, Portland 5746545, Oregon 5744337

Status

Recruiting

Address

Legacy Emanuel Children's Hospital

Portland 5746545, Oregon 5744337, 97227

Site Contact

Site Public Contact

503-413-2560

Oregon Health and Science University, Portland 5746545, Oregon 5744337

Status

Recruiting

Address

Oregon Health and Science University

Portland 5746545, Oregon 5744337, 97239

Site Contact

Site Public Contact

[email protected]

503-494-1080

Lehigh Valley Hospital-Cedar Crest, Allentown 5178127, Pennsylvania 6254927

Status

Recruiting

Address

Lehigh Valley Hospital-Cedar Crest

Allentown 5178127, Pennsylvania 6254927, 18103

Site Contact

Site Public Contact

[email protected]

610-402-9543

Geisinger Medical Center, Danville 5186327, Pennsylvania 6254927

Status

Recruiting

Address

Geisinger Medical Center

Danville 5186327, Pennsylvania 6254927, 17822

Site Contact

Site Public Contact

[email protected]

570-271-5251

Penn State Children's Hospital, Hershey 5193342, Pennsylvania 6254927

Status

Recruiting

Address

Penn State Children's Hospital

Hershey 5193342, Pennsylvania 6254927, 17033

Site Contact

Site Public Contact

717-531-6012

Philadelphia 4560349, Pennsylvania 6254927

Status

Recruiting

Address

Saint Christopher's Hospital for Children

Philadelphia 4560349, Pennsylvania 6254927, 19134

Site Contact

Site Public Contact

215-427-8991

Pittsburgh 5206379, Pennsylvania 6254927

Status

Recruiting

Address

Children's Hospital of Pittsburgh of UPMC

Pittsburgh 5206379, Pennsylvania 6254927, 15224

Site Contact

Site Public Contact

[email protected]

412-692-8570

Rhode Island Hospital, Providence 5224151, Rhode Island 5224323

Status

Recruiting

Address

Rhode Island Hospital

Providence 5224151, Rhode Island 5224323, 02903

Site Contact

Site Public Contact

401-444-1488

Medical University of South Carolina, Charleston 4574324, South Carolina 4597040

Status

Recruiting

Address

Medical University of South Carolina

Charleston 4574324, South Carolina 4597040, 29425

Site Contact

Site Public Contact

[email protected]

843-792-9321

Prisma Health Richland Hospital, Columbia 4575352, South Carolina 4597040

Status

Recruiting

Address

Prisma Health Richland Hospital

Columbia 4575352, South Carolina 4597040, 29203

Site Contact

Site Public Contact

[email protected]

864-522-4317

BI-LO Charities Children's Cancer Center, Greenville 4580543, South Carolina 4597040

Status

Recruiting

Address

BI-LO Charities Children's Cancer Center

Greenville 4580543, South Carolina 4597040, 29605

Site Contact

Site Public Contact

[email protected]

864-522-4317

Prisma Health Cancer Institute - Faris, Greenville 4580543, South Carolina 4597040

Status

Suspended

Address

Prisma Health Cancer Institute - Faris

Greenville 4580543, South Carolina 4597040, 29605

Sanford USD Medical Center - Sioux Falls, Sioux Falls 5231851, South Dakota 5769223

Status

Recruiting

Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls 5231851, South Dakota 5769223, 57117-5134

Site Contact

Site Public Contact

[email protected]

605-312-3320

Saint Jude Children's Research Hospital, Memphis 4641239, Tennessee 4662168

Status

Recruiting

Address

Saint Jude Children's Research Hospital

Memphis 4641239, Tennessee 4662168, 38105

Site Contact

Site Public Contact

[email protected]

888-226-4343

Nashville 4644585, Tennessee 4662168

Status

Recruiting

Address

The Children's Hospital at TriStar Centennial

Nashville 4644585, Tennessee 4662168, 37203

Site Contact

Site Public Contact

615-342-1919

Nashville 4644585, Tennessee 4662168

Status

Recruiting

Address

Vanderbilt University/Ingram Cancer Center

Nashville 4644585, Tennessee 4662168, 37232

Site Contact

Site Public Contact

800-811-8480

Austin 4671654, Texas 4736286

Status

Recruiting

Address

Dell Children's Medical Center of Central Texas

Austin 4671654, Texas 4736286, 78723

Site Contact

Site Public Contact

[email protected]

512-628-1902

Driscoll Children's Hospital, Corpus Christi 4683416, Texas 4736286

Status

Recruiting

Address

Driscoll Children's Hospital

Corpus Christi 4683416, Texas 4736286, 78411

Site Contact

Site Public Contact

[email protected]

361-694-5311

Medical City Dallas Hospital, Dallas 4684888, Texas 4736286

Status

Recruiting

Address

Medical City Dallas Hospital

Dallas 4684888, Texas 4736286, 75230

Site Contact

Site Public Contact

972-566-5588

Dallas 4684888, Texas 4736286

Status

Recruiting

Address

UT Southwestern/Simmons Cancer Center-Dallas

Dallas 4684888, Texas 4736286, 75390

Site Contact

Daniel C. Bowers

[email protected]

214-648-3896

El Paso Children's Hospital, El Paso 5520993, Texas 4736286

Status

Recruiting

Address

El Paso Children's Hospital

El Paso 5520993, Texas 4736286, 79905

Site Contact

Site Public Contact

[email protected]

915-298-5444

Cook Children's Medical Center, Fort Worth 4691930, Texas 4736286

Status

Recruiting

Address

Cook Children's Medical Center

Fort Worth 4691930, Texas 4736286, 76104

Site Contact

Site Public Contact

[email protected]

682-885-2103

Houston 4699066, Texas 4736286

Status

Recruiting

Address

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston 4699066, Texas 4736286, 77030

Site Contact

Site Public Contact

[email protected]

713-798-1354

M D Anderson Cancer Center, Houston 4699066, Texas 4736286

Status

Recruiting

Address

M D Anderson Cancer Center

Houston 4699066, Texas 4736286, 77030

Site Contact

Najat C. Daw

[email protected]

713-792-6315

Children's Hospital of San Antonio, San Antonio 4726206, Texas 4736286

Status

Recruiting

Address

Children's Hospital of San Antonio

San Antonio 4726206, Texas 4736286, 78207

Site Contact

Site Public Contact

[email protected]

210-704-2894

San Antonio 4726206, Texas 4736286

Status

Recruiting

Address

Methodist Children's Hospital of South Texas

San Antonio 4726206, Texas 4736286, 78229

Site Contact

Site Public Contact

[email protected]

210-575-6240

San Antonio 4726206, Texas 4736286

Status

Recruiting

Address

University of Texas Health Science Center at San Antonio

San Antonio 4726206, Texas 4736286, 78229

Site Contact

Site Public Contact

[email protected]

210-450-3800

Primary Children's Hospital, Salt Lake City 5780993, Utah 5549030

Status

Recruiting

Address

Primary Children's Hospital

Salt Lake City 5780993, Utah 5549030, 84113

Site Contact

Site Public Contact

801-585-5270

Burlington 5234372, Vermont 5242283

Status

Recruiting

Address

University of Vermont and State Agricultural College

Burlington 5234372, Vermont 5242283, 05405

Site Contact

Site Public Contact

[email protected]

802-656-8990

University of Virginia Cancer Center, Charlottesville 4752031, Virginia 6254928

Status

Recruiting

Address

University of Virginia Cancer Center

Charlottesville 4752031, Virginia 6254928, 22908

Site Contact

Site Public Contact

[email protected]

434-243-6303

Norfolk 4776222, Virginia 6254928

Status

Recruiting

Address

Children's Hospital of The King's Daughters

Norfolk 4776222, Virginia 6254928, 23507

Site Contact

Site Public Contact

[email protected]

757-668-7243

VCU Massey Comprehensive Cancer Center, Richmond 4781708, Virginia 6254928

Status

Recruiting

Address

VCU Massey Comprehensive Cancer Center

Richmond 4781708, Virginia 6254928, 23298

Site Contact

Site Public Contact

[email protected]

804-628-6430

Carilion Children's, Roanoke 4782167, Virginia 6254928

Status

Recruiting

Address

Carilion Children's

Roanoke 4782167, Virginia 6254928, 24014

Site Contact

Site Public Contact

[email protected]

540-266-6238

Seattle Children's Hospital, Seattle 5809844, Washington 5815135

Status

Recruiting

Address

Seattle Children's Hospital

Seattle 5809844, Washington 5815135, 98105

Site Contact

Site Public Contact

866-987-2000

Spokane 5811696, Washington 5815135

Status

Recruiting

Address

Providence Sacred Heart Medical Center and Children's Hospital

Spokane 5811696, Washington 5815135, 99204

Site Contact

Site Public Contact

[email protected]

800-228-6618

Tacoma 5812944, Washington 5815135

Status

Recruiting

Address

Mary Bridge Children's Hospital and Health Center

Tacoma 5812944, Washington 5815135, 98405

Site Contact

Site Public Contact

[email protected]

253-403-1461

Madigan Army Medical Center, Tacoma 5812944, Washington 5815135

Status

Recruiting

Address

Madigan Army Medical Center

Tacoma 5812944, Washington 5815135, 98431

Site Contact

Site Public Contact

[email protected]

253-968-6144

West Virginia University Healthcare, Morgantown 4815352, West Virginia 4826850

Status

Recruiting

Address

West Virginia University Healthcare

Morgantown 4815352, West Virginia 4826850, 26506

Site Contact

Site Public Contact

[email protected]

304-293-7374

Madison 5261457, Wisconsin 5279468

Status

Recruiting

Address

University of Wisconsin Carbone Cancer Center - University Hospital

Madison 5261457, Wisconsin 5279468, 53792

Site Contact

Site Public Contact

[email protected]

800-622-8922

Marshfield Medical Center-Marshfield, Marshfield 5261969, Wisconsin 5279468

Status

Suspended

Address

Marshfield Medical Center-Marshfield

Marshfield 5261969, Wisconsin 5279468, 54449

International Sites

Sydney Children's Hospital, Randwick 2208285, New South Wales 2155400, Australia

Status

Recruiting

Address

Sydney Children's Hospital

Randwick 2208285, New South Wales 2155400, 2031

Site Contact

Site Public Contact

(02) 9382-1721

The Children's Hospital at Westmead, Westmead 2143973, New South Wales 2155400, Australia

Status

Recruiting

Address

The Children's Hospital at Westmead

Westmead 2143973, New South Wales 2155400, 2145

Site Contact

Site Public Contact

61-2-9845 1400

Queensland Children's Hospital, South Brisbane 2207259, Queensland 2152274, Australia

Status

Recruiting

Address

Queensland Children's Hospital

South Brisbane 2207259, Queensland 2152274, 4101

Site Contact

Site Public Contact

61 7 3068 1111

Royal Children's Hospital, Parkville 2153770, Victoria 2145234, Australia

Status

Recruiting

Address

Royal Children's Hospital

Parkville 2153770, Victoria 2145234, 3052

Site Contact

Site Public Contact

[email protected]

61 3 9345 5656

Perth Children's Hospital, Perth 2063523, Western Australia 2058645, Australia

Status

Recruiting

Address

Perth Children's Hospital

Perth 2063523, Western Australia 2058645, 6009

Site Contact

Site Public Contact

[email protected]

Alberta Children's Hospital, Calgary 5913490, Alberta 5883102, Canada

Status

Recruiting

Address

Alberta Children's Hospital

Calgary 5913490, Alberta 5883102, T3B 6A8

Site Contact

Site Public Contact

[email protected]

403-220-6898

University of Alberta Hospital, Edmonton 5946768, Alberta 5883102, Canada

Status

Recruiting

Address

University of Alberta Hospital

Edmonton 5946768, Alberta 5883102, T6G 2B7

Site Contact

Site Public Contact

[email protected]

780-407-8798

British Columbia Children's Hospital, Vancouver 6173331, British Columbia 5909050, Canada

Status

Recruiting

Address

British Columbia Children's Hospital

Vancouver 6173331, British Columbia 5909050, V6H 3V4

Site Contact

Site Public Contact

604-875-2345 #6477

CancerCare Manitoba, Winnipeg 6183235, Manitoba 6065171, Canada

Status

Recruiting

Address

CancerCare Manitoba

Winnipeg 6183235, Manitoba 6065171, R3E 0V9

Site Contact

Site Public Contact

[email protected]

866-561-1026

IWK Health Centre, Halifax 6324729, Nova Scotia 6091530, Canada

Status

Recruiting

Address

IWK Health Centre

Halifax 6324729, Nova Scotia 6091530, B3K 6R8

Site Contact

Site Public Contact

[email protected]

902-470-8520

Hamilton 5969782, Ontario 6093943, Canada

Status

Recruiting

Address

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton 5969782, Ontario 6093943, L8N 3Z5

Site Contact

Site Public Contact

905-521-2100

Hospital for Sick Children, Toronto 6167865, Ontario 6093943, Canada

Status

Recruiting

Address

Hospital for Sick Children

Toronto 6167865, Ontario 6093943, M5G 1X8

Site Contact

Site Public Contact

[email protected]

416-813-7654

Montreal 6077243, Quebec 6115047, Canada

Status

Recruiting

Address

The Montreal Children's Hospital of the MUHC

Montreal 6077243, Quebec 6115047, H3H 1P3

Site Contact

Site Public Contact

[email protected]

514-412-4445

Montreal 6077243, Quebec 6115047, Canada

Status

Recruiting

Address

Centre Hospitalier Universitaire Sainte-Justine

Montreal 6077243, Quebec 6115047, H3T 1C5

Site Contact

Site Public Contact

[email protected]

514-345-4931

Sherbrooke 6146143, Quebec 6115047, Canada

Status

Recruiting

Address

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke 6146143, Quebec 6115047, J1H 5N4

Site Contact

Site Public Contact

[email protected]

819-820-6480

Québec 6325494, Canada

Status

Recruiting

Address

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

Québec 6325494, , G1V 4G2

Site Contact

Site Public Contact

[email protected]

418-525-4444

Christchurch Hospital, Christchurch 2192362, New Zealand

Status

Recruiting

Address

Christchurch Hospital

Christchurch 2192362, , 8011

Site Contact

Site Public Contact

03 364 0640

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