A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

Study Purpose

The purpose of this study is to learn about the effects of three study medicines (encorafenib, binimetinib, and pembrolizumab) given together for the treatment of melanoma that:

  • - is advanced or metastatic (spread to other parts of the body); - has a certain type of abnormal gene called "BRAF"; and.
  • - has not received prior treatment.
All participants in this study will receive pembrolizumab at the study clinic once every 3 weeks as an intravenous (IV) infusion (given directly into a vein). In addition, half of the participants will take encorafenib and binimetinib orally (by mouth) at home every day. Participants may receive pembrolizumab for up to two years. Those participants taking encorafenib and binimetinib can continue until their melanoma is no longer responding. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Male or female participants ≥ 18 years at the time of informed consent.
  • - Participants who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures.
  • - Histologically confirmed unresectable (Stage IIIB, IIIC, or IIID) or metastatic (Stage IV) cutaneous melanoma, according to the AJCC 8th edition.
  • - Presence of at least 1 measurable lesion as detected by radiological and/or photographic methods according to RECIST v1.1.
  • - ECOG performance status 0 or 1.
  • - Documented evidence of a BRAF V600E or V600K mutation in melanoma tumor tissue as previously determined by either PCR or NGS-based local laboratory assay (eg, US FDA-approved test, CE-marked [European conformity] in vitro diagnostic in EU countries, or equivalent), obtained during the course of normal clinical care, in a CLIA- or similarly certified laboratory.
  • - Submission of adequate tumor tissue (archival or newly obtained; block or slides to the sponsor central laboratory(ies) during the screening period and prior to enrollment (SLI)/randomization (Phase 3).
  • - Have not received prior first-line systemic therapy for metastatic or unresectable locally advanced melanoma.
  • - Adequate bone marrow function, hepatic and renal function.
  • - Capable of giving signed informed consent.
Exclusion Criteria.
  • - Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.
  • - Mucosal or ocular melanoma.
  • - Diagnosis of immunodeficiency or an active autoimmune disease that required systemic treatment in the past 2 years (ie, with use of disease modifying agents, corticosteroids, or immunosuppressive drugs).
  • - Clinically significant multiple or severe drug allergies, intolerance to topical corticosteroids, or severe post-treatment hypersensitivity reactions (including, but not limited to, erythema multiforme major, linear IgA dermatosis, toxic epidermal necrolysis, and exfoliative dermatitis).
  • - Unable to swallow, retain, and absorb oral medications.
  • - Impairment of GI function or disease which may significantly alter the absorption of oral study intervention (eg, uncontrolled nausea, vomiting or diarrhea, malabsorption syndrome, including malabsorption syndrome secondary to prior GI surgery).
  • - Clinically significant cardiovascular diseases, - History of thromboembolic or cerebrovascular events ≤ 12 weeks prior to enrollment (SLI)/randomization (Phase 3).
Examples include transient ischemic attacks, cerebrovascular accidents, hemodynamically significant (ie, massive or sub-massive) deep vein thrombosis or pulmonary emboli.
  • - History or current evidence of RVO or current risk factors for RVO (eg, uncontrolled glaucoma or ocular hypertension, history of hyperviscosity or hypercoagulability syndromes) - Concurrent neuromuscular disorder that is associated with the potential of elevated CK (eg, inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis, spinal muscular atrophy).
  • - Current noninfectious pneumonitis or history of noninfectious pneumonitis requiring steroids, or history of radiation pnuemonitis.
  • - Evidence of HBV or HCV infection.
  • - Known history of a positive test for HIV or known AIDS.
  • - Any active infection requiring systemic therapeutic treatment within 2 weeks prior to enrollment (SLI)/ randomization (Phase 3).
  • - Participants with prior or current symptomatic brain metastasis, leptomeningeal disease or other active CNS metastases.
  • - Concurrent or previous other malignancy within 2 years of study entry, except curatively treated basal or squamous cell skin cancer, prostate intraepithelial neoplasm, carcinoma in-situ of the cervix, Bowen's disease and Gleason ≤ 6 prostate cancer.
Participants with a history of other curatively treated cancers must be reviewed with the sponsor or designee prior to entering the study.
  • - Participants who previously received and subsequently discontinued encorafenib and/or binimetinib and/or anti-PD-1/-L1 due to severe toxicity.
  • - For participants in the SLI only: Current use or anticipated need for food or drugs that are known moderate or strong CYP3A4 inhibitors during screening and through the DLT-evaluation period.
  • - Participant has not recovered to Grade ≤ 1 from toxic effects of prior therapy and/or complications from prior surgical intervention before enrollment (SLI)/ randomization (Phase 3).
  • - Receipt of protocol defined medications or treatments outside of required intervals before enrollment (SLI)/randomization (Phase 3): - Previous administration with an investigational drug ≤ 6 months prior to enrollment (SLI)/randomization (Phase 3).
  • - Known sensitivity or contraindication to any component of study intervention (encorafenib, binimetinib and pembrolizumab), or their excipients.
  • - Pregnant, confirmed by a positive β-hCG laboratory test result, or is breastfeeding (lactating).
  • - Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04657991
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Pfizer
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Pfizer CT.gov Call Center
Principal Investigator Affiliation Pfizer
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Belgium, Brazil, Bulgaria, Canada, Czechia, Finland, Germany, Greece, Hungary, Italy, Mexico, New Zealand, Norway, Poland, Russian Federation, Slovakia, South Africa, Spain, Switzerland, Turkey, Ukraine, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Melanoma
Study Website: View Trial Website
Additional Details

This study will compare the efficacy, safety, and tolerability of encorafenib and binimetinib plus pembrolizumab (Triplet Arm) versus placebo plus pembrolizumab (Control Arm) in participants with metastatic or unresectable locally advanced BRAF V600E/K mutation-positive melanoma. The study will have an open-label safety lead-in (SLI) phase to determine the safety recommend Phase 3 dose (RP3D) and pharmacokinetics (PK) of encorafenib and binimetinib plus pembrolizumab combination therapy prior to initiation of the randomized Phase 3 part of the study. Two dose levels of encorafenib in combination with binimetinib plus pembrolizumab will be explored in parallel. A minimum of 12 evaluable participants will be enrolled per dose level. During the double-blind randomized Phase 3 part of the study, approximately 600 eligible participants will be randomized in a 1:1 ratio to the Triplet Arm (at RP3D determined in the SLI) or Control Arm (approximately 300 participants per arm). Randomization will be stratified by prior systemic adjuvant therapy and stage of disease by AJCC (ED8).

Arms & Interventions

Arms

Experimental: Triplet Arm

Encorafenib and Binimetinib in combination with Pembrolizumab

Active Comparator: Control Arm

Pembrolizumab

Interventions

Drug: - Encorafenib

Encorafenib

Drug: - Binimetinib

Binimetinib

Drug: - Pembrolizumab

Pembrolizumab

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Los Angeles, California

Status

Not yet recruiting

Address

UCLA - Hematology/Oncology - Administrative Office

Los Angeles, California, 90024

Los Angeles, California

Status

Not yet recruiting

Address

Ronald Reagan UCLA Medical Center Drug Information Center , Dept. of Pharmaceutical Services (Drug

Los Angeles, California, 90095

Los Angeles, California

Status

Not yet recruiting

Address

Ronald Reagan UCLA Medical Center, Drug Information Center, Dept. of Pharmaceutical Services (Main O

Los Angeles, California, 90095

Los Angeles, California

Status

Not yet recruiting

Address

UCLA Hematology/Oncology - Westwood (Building 100)

Los Angeles, California, 90095

UCHealth Sue Anschutz-Rodgers Eye Center, Aurora, Colorado

Status

Not yet recruiting

Address

UCHealth Sue Anschutz-Rodgers Eye Center

Aurora, Colorado, 80045

University of Colorado Denver CTO/CTRC, Aurora, Colorado

Status

Not yet recruiting

Address

University of Colorado Denver CTO/CTRC

Aurora, Colorado, 80045

Aurora, Colorado

Status

Not yet recruiting

Address

University of Colorado Hospital - Anschutz Cancer Pavilion (ACP)

Aurora, Colorado, 80045

Aurora, Colorado

Status

Not yet recruiting

Address

University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)

Aurora, Colorado, 80045

Aurora, Colorado

Status

Not yet recruiting

Address

University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)

Aurora, Colorado, 80045

Florida Cancer Specialists, Cape Coral, Florida

Status

Recruiting

Address

Florida Cancer Specialists

Cape Coral, Florida, 33909

Florida Cancer Specialists, Fort Myers, Florida

Status

Recruiting

Address

Florida Cancer Specialists

Fort Myers, Florida, 33901

AdventHealth Hematology and Oncology, Orlando, Florida

Status

Recruiting

Address

AdventHealth Hematology and Oncology

Orlando, Florida, 32804

AdventHealth Orlando Infusion Center, Orlando, Florida

Status

Recruiting

Address

AdventHealth Orlando Infusion Center

Orlando, Florida, 32804

Orlando, Florida

Status

Recruiting

Address

AdventHealth Orlando, Investigational Drug Services

Orlando, Florida, 32804

Park Ridge, Illinois

Status

Not yet recruiting

Address

Advocate Medical Group-Park Ridge, Luther Lane-Oncology

Park Ridge, Illinois, 60068

The University of Kansas Cancer Center, Westwood, Kansas

Status

Recruiting

Address

The University of Kansas Cancer Center

Westwood, Kansas, 66205

Massachusetts General Hospital, Boston, Massachusetts

Status

Not yet recruiting

Address

Massachusetts General Hospital

Boston, Massachusetts, 02114

Boston, Massachusetts

Status

Not yet recruiting

Address

Ophthalmic Consultants of Boston Inc (OCB)

Boston, Massachusetts, 02114

Revive Research Institute, Inc., Farmington Hills, Michigan

Status

Not yet recruiting

Address

Revive Research Institute, Inc.

Farmington Hills, Michigan, 48334

Michigan Health Professionals, Farmington Hills, Michigan

Status

Not yet recruiting

Address

Michigan Health Professionals

Farmington Hills, Michigan, 48344

St. Vincent Healthcare, Billings, Montana

Status

Recruiting

Address

St. Vincent Healthcare

Billings, Montana, 59101

St. Vincent Frontier Cancer Center, Billings, Montana

Status

Recruiting

Address

St. Vincent Frontier Cancer Center

Billings, Montana, 59102

University of Cincinnati Medical Center, Cincinnati, Ohio

Status

Recruiting

Address

University of Cincinnati Medical Center

Cincinnati, Ohio, 45219

University of Cincinnati Medical Center, West Chester, Ohio

Status

Recruiting

Address

University of Cincinnati Medical Center

West Chester, Ohio, 45069

University of Tennessee Medical Center, Knoxville, Tennessee

Status

Recruiting

Address

University of Tennessee Medical Center

Knoxville, Tennessee, 37920

Sarah Cannon Research Institute, Nashville, Tennessee

Status

Recruiting

Address

Sarah Cannon Research Institute

Nashville, Tennessee, 37203

Tennessee Oncology, PLLC, Nashville, Tennessee

Status

Recruiting

Address

Tennessee Oncology, PLLC

Nashville, Tennessee, 37203

Texas Oncology - Carrollton, Carrollton, Texas

Status

Not yet recruiting

Address

Texas Oncology - Carrollton

Carrollton, Texas, 75010

North Dallas Eye Associates, Flower Mound, Texas

Status

Not yet recruiting

Address

North Dallas Eye Associates

Flower Mound, Texas, 75028

Texas Oncology - Flower Mound, Flower Mound, Texas

Status

Not yet recruiting

Address

Texas Oncology - Flower Mound

Flower Mound, Texas, 75028

Baylor Clinic, Houston, Texas

Status

Not yet recruiting

Address

Baylor Clinic

Houston, Texas, 77030

Houston, Texas

Status

Not yet recruiting

Address

Baylor College of Medicine Medical Center

Houston, Texas, 77030

Baylor College of Medicine, Houston, Texas

Status

Not yet recruiting

Address

Baylor College of Medicine

Houston, Texas, 77030

Houston, Texas

Status

Not yet recruiting

Address

CHI St. Luke's Health Baylor College of Medicine Medical Center

Houston, Texas, 77030

Harris Health System - Ben Taub Hospital, Houston, Texas

Status

Not yet recruiting

Address

Harris Health System - Ben Taub Hospital

Houston, Texas, 77030

Harris Health System - Smith Clinic, Houston, Texas

Status

Not yet recruiting

Address

Harris Health System - Smith Clinic

Houston, Texas, 77054

Dan Brown O.D., Paris, Texas

Status

Not yet recruiting

Address

Dan Brown O.D.

Paris, Texas, 75460

Texas Oncology-Paris, Paris, Texas

Status

Not yet recruiting

Address

Texas Oncology-Paris

Paris, Texas, 75460

Temple, Texas

Status

Not yet recruiting

Address

Baylor Scott & White Medical Center - Temple

Temple, Texas, 76508

Utah Cancer Specialists, American Fork, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

American Fork, Utah, 84003

Utah Cancer Specialists, Bountiful, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

Bountiful, Utah, 84010

Utah Cancer Specialists, Layton, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

Layton, Utah, 84041

Utah Cancer Specialists, Murray, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

Murray, Utah, 84157

Utah Cancer Specialists, Ogden, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

Ogden, Utah, 84405

Utah Cancer Specialists, Provo, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

Provo, Utah, 84604

Utah Cancer Specialists, Salt Lake City, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

Salt Lake City, Utah, 84102

Utah Cancer Specialists, Salt Lake City, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

Salt Lake City, Utah, 84106

Utah Cancer Specialists, West Jordan, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

West Jordan, Utah, 84088

Utah Cancer Specialists, West Valley City, Utah

Status

Not yet recruiting

Address

Utah Cancer Specialists

West Valley City, Utah, 84119

International Sites

Instituto Alexander Fleming, Caba, Buenos Aires, Argentina

Status

Not yet recruiting

Address

Instituto Alexander Fleming

Caba, Buenos Aires, C1426ANZ

Clinica Viedma S. A, Viedma, RÍO Negro, Argentina

Status

Recruiting

Address

Clinica Viedma S. A

Viedma, RÍO Negro, 8500

Instituto de Oncologia de Rosario, Rosario, Santa FE, Argentina

Status

Not yet recruiting

Address

Instituto de Oncologia de Rosario

Rosario, Santa FE, S2000KZE

UZ Brussel, Brussels, Bruxelles-capitale, Région DE, Belgium

Status

Not yet recruiting

Address

UZ Brussel

Brussels, Bruxelles-capitale, Région DE, 1090

AZ Sint-Jan Brugge-Oostende AV, Brugge, West-vlaanderen, Belgium

Status

Not yet recruiting

Address

AZ Sint-Jan Brugge-Oostende AV

Brugge, West-vlaanderen, 8000

Cliniques universitaires Saint-Luc, Brussels, Belgium

Status

Not yet recruiting

Address

Cliniques universitaires Saint-Luc

Brussels, , 1200

Centre Hospitalier de Jolimont, Haine Saint Paul, Belgium

Status

Not yet recruiting

Address

Centre Hospitalier de Jolimont

Haine Saint Paul, , 7100

VITAZ, Sint-Niklaas, Belgium

Status

Not yet recruiting

Address

VITAZ

Sint-Niklaas, , 9100

Hospital de Clinicas de Porto Alegre, Porto Alegre, RIO Grande DO SUL, Brazil

Status

Not yet recruiting

Address

Hospital de Clinicas de Porto Alegre

Porto Alegre, RIO Grande DO SUL, 90035-903

Complex Oncology Center - Plovdiv EOOD, Plovdiv, Bulgaria

Status

Not yet recruiting

Address

Complex Oncology Center - Plovdiv EOOD

Plovdiv, , 4004

Complex Oncology Center-Ruse EOOD, Ruse, Bulgaria

Status

Not yet recruiting

Address

Complex Oncology Center-Ruse EOOD

Ruse, , 7002

Medical Center Nadezhda Clinical EOOD, Sofia, Bulgaria

Status

Not yet recruiting

Address

Medical Center Nadezhda Clinical EOOD

Sofia, , 1373

Sofia, Bulgaria

Status

Not yet recruiting

Address

Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD

Sofia, , 1407

Umhato Ead, Sofia, Bulgaria

Status

Not yet recruiting

Address

Umhato Ead

Sofia, , 1756

Kingston, Ontario, Canada

Status

Not yet recruiting

Address

Kingston Health Sciences Centre-Kingston General Hospital Site

Kingston, Ontario, K7L 2V7

CIUSSS du Saguenay-Lac-Saint-Jean, Chicoutimi, Quebec, Canada

Status

Recruiting

Address

CIUSSS du Saguenay-Lac-Saint-Jean

Chicoutimi, Quebec, G7H 5H6

Montreal, Quebec, Canada

Status

Recruiting

Address

McGill University Health Centre - Glen Site

Montreal, Quebec, H4A 3J1

Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada

Status

Not yet recruiting

Address

Saskatoon Cancer Center

Saskatoon, Saskatchewan, S7N4H4

Fakultni nemocnice Olomouc, Olomouc, Olomoucký KRAJ, Czechia

Status

Not yet recruiting

Address

Fakultni nemocnice Olomouc

Olomouc, Olomoucký KRAJ, 779 00

Fakultni nemocnice Bulovka, Praha 8-Liben, Czechia

Status

Not yet recruiting

Address

Fakultni nemocnice Bulovka

Praha 8-Liben, , 180 81

Tampereen yliopistollinen sairaala, Tampere, Pirkanmaa, Finland

Status

Not yet recruiting

Address

Tampereen yliopistollinen sairaala

Tampere, Pirkanmaa, 33520

Helsinki, Finland

Status

Not yet recruiting

Address

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)

Helsinki, , 00029

Universitaetsklinikum Erlangen, Erlangen, Bayern, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Erlangen

Erlangen, Bayern, 91054

München, Bayern, Germany

Status

Not yet recruiting

Address

Klinik und Poliklinik für Dermatologie und Allergologie

München, Bayern, 80337

Buxtehude, Niedersachsen, Germany

Status

Not yet recruiting

Address

Elbe Kliniken Stade-Buxtehude, Klinikum Buxtehude

Buxtehude, Niedersachsen, 21614

Johannes Wesling Klinikum Minden, Minden, Nordrhein-westfalen, Germany

Status

Not yet recruiting

Address

Johannes Wesling Klinikum Minden

Minden, Nordrhein-westfalen, 32429

Mainz, Rheinland-pfalz, Germany

Status

Not yet recruiting

Address

Universitätsmedizin Johannes Gutenberg Universität Mainz

Mainz, Rheinland-pfalz, 55131

Dresden, Sachsen, Germany

Status

Recruiting

Address

Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, Sachsen, 01307

Kiel, Schleswig-holstein, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Schleswig-Holstein Campus Kiel

Kiel, Schleswig-holstein, 24105

SRH Wald-Klinikum Gera, Gera, Thüringen, Germany

Status

Not yet recruiting

Address

SRH Wald-Klinikum Gera

Gera, Thüringen, 07548

Helios Klinikum Erfurt, Erfurt, Germany

Status

Not yet recruiting

Address

Helios Klinikum Erfurt

Erfurt, , 99089

Universitätsklinikum Essen (AöR), Essen, Germany

Status

Recruiting

Address

Universitätsklinikum Essen (AöR)

Essen, , 45147

Halle, Germany

Status

Not yet recruiting

Address

Universitaetsklinikum Halle - Universitaetsklinik und Poliklinik fuer Dermatologie und Venerologie

Halle, , 06120

Medizinische Hochschule Hannover, Hannover, Germany

Status

Not yet recruiting

Address

Medizinische Hochschule Hannover

Hannover, , 30625

Universitätsklinikum Heidelberg, Heidelberg, Germany

Status

Not yet recruiting

Address

Universitätsklinikum Heidelberg

Heidelberg, , 69120

University Hospital Muenster, Muenster, Germany

Status

Not yet recruiting

Address

University Hospital Muenster

Muenster, , 48149

Fachklinik Hornheide, Münster, Germany

Status

Not yet recruiting

Address

Fachklinik Hornheide

Münster, , 48157

Klinikum Nürnberg Nord, Nürnberg, Germany

Status

Not yet recruiting

Address

Klinikum Nürnberg Nord

Nürnberg, , 90419

General Hospital of Athens "Laiko", Athens, Attikí, Greece

Status

Recruiting

Address

General Hospital of Athens "Laiko"

Athens, Attikí, 11527

Metropolitan Hospital, Piraeus, Attikí, Greece

Status

Not yet recruiting

Address

Metropolitan Hospital

Piraeus, Attikí, 185 47

University General Hospital of Heraklion, Heraklion, Irakleío, Greece

Status

Not yet recruiting

Address

University General Hospital of Heraklion

Heraklion, Irakleío, 71500

Thessaloniki, Kentrikí Makedonía, Greece

Status

Not yet recruiting

Address

Bioclinic Thessalonikis Private Clinic Single Member S.A.

Thessaloniki, Kentrikí Makedonía, 546 22

Pécsi Tudományegyetem Klinikai Központ, Pécs, Baranya, Hungary

Status

Recruiting

Address

Pécsi Tudományegyetem Klinikai Központ

Pécs, Baranya, 7632

Semmelweis Egyetem, Budapest, Hungary

Status

Recruiting

Address

Semmelweis Egyetem

Budapest, , 1085

Orszagos Onkologiai Intezet, Budapest, Hungary

Status

Recruiting

Address

Orszagos Onkologiai Intezet

Budapest, , 1122

Debreceni Egyetem Klinikai Kozpont, Debrecen, Hungary

Status

Recruiting

Address

Debreceni Egyetem Klinikai Kozpont

Debrecen, , 4032

Szent-Gyorgyi Albert Klinikai Kozpont, Szeged, Hungary

Status

Recruiting

Address

Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, , 6720

Szolnok, Hungary

Status

Recruiting

Address

Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház

Szolnok, , 5004

Udine, Friuli Venezia Giulia, Italy

Status

Not yet recruiting

Address

Azienda Sanitaria Universitaria Friuli Centrale

Udine, Friuli Venezia Giulia, 33100

Milano, MI, Italy

Status

Recruiting

Address

Fondazione IRCCS Istituto Nazionale dei Tumori

Milano, MI, 20133

Roma, RM, Italy

Status

Not yet recruiting

Address

Istituto Dermopatico dell'Immacolata (IDI-IRCCS)

Roma, RM, 00167

A.O.U.S. Policlinico "Le Scotte", Siena, SI, Italy

Status

Not yet recruiting

Address

A.O.U.S. Policlinico "Le Scotte"

Siena, SI, 53100

Candiolo, Torino, Italy

Status

Recruiting

Address

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia

Candiolo, Torino, 10060

Istituto Tumori Giovanni Paolo II, Bari, Italy

Status

Not yet recruiting

Address

Istituto Tumori Giovanni Paolo II

Bari, , 70124

IRCCS Ospedale Policlinico San Martino, Genova, Italy

Status

Not yet recruiting

Address

IRCCS Ospedale Policlinico San Martino

Genova, , 16132

Istituto Europeo di Oncologia IRCCS, Milano, Italy

Status

Recruiting

Address

Istituto Europeo di Oncologia IRCCS

Milano, , 20141

Napoli, Italy

Status

Recruiting

Address

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Napoli, , 80131

Istituto Oncologico Veneto IOV - IRCCS, Padova, Italy

Status

Not yet recruiting

Address

Istituto Oncologico Veneto IOV - IRCCS

Padova, , 35128

Perugia, Italy

Status

Recruiting

Address

AO di Perugia - Ospedale S. Maria della Misericordia, S.C Oncologia Medica

Perugia, , 06132

Istituto Nazionale Tumori Regina Elena, Roma, Italy

Status

Recruiting

Address

Istituto Nazionale Tumori Regina Elena

Roma, , 00144

Preparaciones Oncológicas S.C., León, Guanajuato, Mexico

Status

Recruiting

Address

Preparaciones Oncológicas S.C.

León, Guanajuato, 37178

I Can Oncology Center S.A. de C.V., Monterrey, Nuevo LEÓN, Mexico

Status

Recruiting

Address

I Can Oncology Center S.A. de C.V.

Monterrey, Nuevo LEÓN, 64710

BRCR Global Mexico - CDMX, Ciudad de México, Mexico

Status

Not yet recruiting

Address

BRCR Global Mexico - CDMX

Ciudad de México, , 01120

El Cielo Medical Center RSB, S.C, Puebla, Mexico

Status

Recruiting

Address

El Cielo Medical Center RSB, S.C

Puebla, , 72160

El Cielo Medical Center, Puebla, Mexico

Status

Recruiting

Address

El Cielo Medical Center

Puebla, , 72160

Christchurch, Canterbury, New Zealand

Status

Recruiting

Address

New Zealand Clinical Research (Christchurch)

Christchurch, Canterbury, 8011

Palmerston North Hospital, Palmerston North, Manawatu, New Zealand

Status

Recruiting

Address

Palmerston North Hospital

Palmerston North, Manawatu, 4414

Auckland City Hospital, Auckland, New Zealand

Status

Not yet recruiting

Address

Auckland City Hospital

Auckland, , 1023

Oslo, Norway

Status

Not yet recruiting

Address

Oslo universitetssykehus, Radiumhospitalet

Oslo, , 0379

Poznan, Poland

Status

Recruiting

Address

Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu

Poznan, , 60-780

Warszawa, Poland

Status

Recruiting

Address

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Warszawa, , 02-781

Pushkin, Saint-petersburg, Russian Federation

Status

Active, not recruiting

Address

Private Medical Institution "Euromedservice"

Pushkin, Saint-petersburg, 196603

Ars Medika Center, LLC, Kaliningrad, Russian Federation

Status

Active, not recruiting

Address

Ars Medika Center, LLC

Kaliningrad, ,

Omsk, Russian Federation

Status

Active, not recruiting

Address

BIH of Omsk Region "Clinical Oncological Dispensary"

Omsk, , 644046

Eurocityclinic LLC, St.Petersburg, Russian Federation

Status

Active, not recruiting

Address

Eurocityclinic LLC

St.Petersburg, , 197022

Onkologicky ustav sv. Alzbety, s.r.o., Bratislava, Slovakia

Status

Not yet recruiting

Address

Onkologicky ustav sv. Alzbety, s.r.o.

Bratislava, , 812 50

POKO Poprad, s.r.o., Poprad, Slovakia

Status

Not yet recruiting

Address

POKO Poprad, s.r.o.

Poprad, , 058 01

Sandton Oncology Medical Group (Pty) Ltd, Johannesburg, Gauteng, South Africa

Status

Not yet recruiting

Address

Sandton Oncology Medical Group (Pty) Ltd

Johannesburg, Gauteng, 2196

Drs Alberts, Bouwer and Jordaan Inc., Pretoria, Gauteng, South Africa

Status

Recruiting

Address

Drs Alberts, Bouwer and Jordaan Inc.

Pretoria, Gauteng, 0081

Badalona, Barcelona, Spain

Status

Recruiting

Address

ICO-Badalona Hospital Germans Trias i Pujol

Badalona, Barcelona, 08916

Santander, Cantabria, Spain

Status

Not yet recruiting

Address

Hospital Universitario Marqués de Valdecilla

Santander, Cantabria, 39008

Majadahonda, Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, 28222

El Palmar, Murcia, Spain

Status

Not yet recruiting

Address

Hospital Clinico Universitario Virgen de la Arrixaca

El Palmar, Murcia, 30120

Complejo Hospitalario De Navarra, Pamplona, Navarra, Spain

Status

Not yet recruiting

Address

Complejo Hospitalario De Navarra

Pamplona, Navarra, 31008

CHUAC-Hospital Teresa Herrera, A Coruña, Spain

Status

Recruiting

Address

CHUAC-Hospital Teresa Herrera

A Coruña, , 15006

Barcelona, Spain

Status

Recruiting

Address

Hospital Universitari Vall D'Hebron, Servicio de Oncología Médica

Barcelona, , 08035

Hospital Clinic Barcelona, Barcelona, Spain

Status

Recruiting

Address

Hospital Clinic Barcelona

Barcelona, , 08036

Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Status

Not yet recruiting

Address

Hospital de la Santa Creu i Sant Pau

Barcelona, , 08041

Hospital Universitario Reina Sofía, Cordoba, Spain

Status

Recruiting

Address

Hospital Universitario Reina Sofía

Cordoba, , 14004

Complejo Hospitalario de Jaen, Jaen, Spain

Status

Not yet recruiting

Address

Complejo Hospitalario de Jaen

Jaen, , 23007

Hospital Universitario Arnau de Vilanova, Lleida, Spain

Status

Not yet recruiting

Address

Hospital Universitario Arnau de Vilanova

Lleida, , 25198

Madrid, Spain

Status

Not yet recruiting

Address

Hospital General Universitario Gregorio Marañón

Madrid, , 28007

Hospital Universitario Ramón y Cajal, Madrid, Spain

Status

Recruiting

Address

Hospital Universitario Ramón y Cajal

Madrid, , 28034

Málaga, Spain

Status

Recruiting

Address

Hospital Regional Universitario de Malaga - Hospital Civil

Málaga, , 29011

Hospital Universitario Virgen Macarena, Sevilla, Spain

Status

Recruiting

Address

Hospital Universitario Virgen Macarena

Sevilla, , 41009

Hospital Universitario Virgen del Rocio, Sevilla, Spain

Status

Recruiting

Address

Hospital Universitario Virgen del Rocio

Sevilla, , 41013

Valencia, Spain

Status

Recruiting

Address

Fundacion Instituto Valenciano de Oncologia

Valencia, , 46009

Kantonsspital Winterthur, Winterthur, Switzerland

Status

Not yet recruiting

Address

Kantonsspital Winterthur

Winterthur, , 8401

UniversitätsSpital Zürich, Zürich Flughafen, Switzerland

Status

Not yet recruiting

Address

UniversitätsSpital Zürich

Zürich Flughafen, , 8058

Medipol Mega Universite Hastanesi, İstanbul, İ̇stanbul, Turkey

Status

Not yet recruiting

Address

Medipol Mega Universite Hastanesi

İstanbul, İ̇stanbul, 34214

Ankara City Hospital, Ankara, Turkey

Status

Not yet recruiting

Address

Ankara City Hospital

Ankara, , 06800

Pliuty Village, KYIV Region, Obukhiv District, Ukraine

Status

Not yet recruiting

Address

Medical and diagnostic center of MedX-Ray International Group Limited Liability Company Israeli

Pliuty Village, KYIV Region, Obukhiv District, 08720

Dnipro, Ukraine

Status

Not yet recruiting

Address

Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council

Dnipro, , 49102

Khmelnytskyi, Ukraine

Status

Not yet recruiting

Address

Municipal non-profit enterprise Khmelnytsky regional antitumor center of Khmelnytsky regional

Khmelnytskyi, , 29009

Kyiv, Ukraine

Status

Not yet recruiting

Address

Municipal non-profit enterprise "Kyiv City Clinical Hospital No. 2" of the executive body of the

Kyiv, , 02094

National Cancer Institute, Kyiv, Ukraine

Status

Active, not recruiting

Address

National Cancer Institute

Kyiv, , 03022

Lviv, Ukraine

Status

Active, not recruiting

Address

Communal Noncommercial Enterprise of Lviv Regional Council "Lviv Oncological Regional Therapeutica

Lviv, , 79031

M. Kharkiv, Ukraine

Status

Recruiting

Address

Derzhavna ustanova Instytut zahalnoi ta nevidkladnoi khirurhii im.V.T.Zaitseva Natsionalnoi akademii

M. Kharkiv, , 61103

M. Kharkiv, Ukraine

Status

Active, not recruiting

Address

Komunalne nekomertsiine pidpryiemstvo Kharkivskoi oblasnoi rady "Oblasnyi klinichnyi spetsializovan

M. Kharkiv, , 61166

Zaporizhzhia, Ukraine

Status

Not yet recruiting

Address

Municipal non-profit enterprise "Zaporizhzhia Regional Antitumor Center" Zaporizhzhya Regional Counc

Zaporizhzhia, , 69040

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