A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

Study Purpose

This is a Phase 1/2a, open-label, study to evaluate the safety and preliminary efficacy of intratumoral T3011 given alone and in combination with intravenous pembrolizumab in partients with advanced or metastatic solid tumors.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Key

Inclusion Criteria:

1. Age 18 years or older. 2. Disease progression after standard of care (SOC) therapy or in the opinion of. 3. The Investigator unlikely to benefit from SOC therapy. Inclusion Diagnosis Phase 1
  • - Histologically or pathologically confirmed locally recurrent or metastatic advanced malignancy.
Phase 2a Part 1 i. Arm A
  • - locally recurrent or metastatic melanoma.
Participants must have received no more than 3 prior regimens for advanced or metastatic disease. ii. Arm B
  • - locally recurrent or metastatic HNSCC.
It must also meet the following criteria: 1) Disease progression to platinum-containing chemotherapy; 2) Failure to anti-PD-1/PDL1 blockade after receiving at least 2 doses alone or in combination. iii. Arm C
  • - Sarcoma.
Participants must have received no more than three lines of prior anti-cancer therapies. iv. Arm D
  • - locally recurrent or metastatic cSCC.
Participants must have received no more than 3 prior regimens for advanced or metastatic disease. Phase 2a Part 2 i.v. Arm E
  • - Histologically or pathologically confirmed NSCLC that is advanced or recurrent, without EGFR mutation or ALK rearrangement.
Participants must have received at least one line but no more than three lines of prior anti-cancer therapies. 4. Measurable disease per RECIST version 1.1. 5. Must have at least 1 tumor lesion that is accessible for IT injection of T3011 in the opinion of the investigator. 6. Eastern Cooperative Oncology Group (ECOG) performance status 0-1. 7. Life expectancy > 12 weeks. 8. Demonstrate adequate organ function as defined by acceptable laboratory testing results. 9. Women of child-bearing potential (WCBP) and men must agree to use adequate contraception prior to study entry, while on study treatment, and for six months after receiving last dose of T3011. WCBP must have a negative serum pregnancy test prior to W1D1. 10. Last dose of previous anticancer therapy ≥ 21 days, radiotherapy > 21 days, or surgical intervention > 21 days prior to the first dose of T3011. 11. Recovered from all prior anticancer therapy toxicities. 12. Willingness to provide fresh tumor biopsy specimens as specified in the Schedule of Assessments. 13. Capable of understanding and complying with protocol requirements. 14. Signed and dated institutional review board/independent ethics committee-approved informed consent form before any protocol-directed screening procedures are performed. Key

Exclusion Criteria:

1. Have only uninjectable tumors.. 2. Patients with injectable tumors impinging upon major airways or blood vessels. 3. HNSCC only: Prior re-irradiation field containing carotid artery. 4. Greater than 3 distant metastatic lymph node regions and/or metastatic lesions or the largest distant metastases with a diameter of more than 3 cm (non-sarcoma)/5 cm (sarcoma) unless the lesion is to be injected. 5. Prior treatment with another OV (including T-VEC), tumor vaccines, cellular therapy or gene therapy. 6. Prior intolerance to anti-PD-(L)1 monoclonal antibody or history of immunotherapy related non-infectious pneumonitis/interstitial lung disease. 7. Prior treatment with anti-PD-(L)1 monoclonal antibody in combination with IL-12. 8. Requires continued concurrent therapy with any drug active against HSV. 9. Live vaccines, attenuated vaccines within 4 weeks prior to initiation of study treatment (participants vaccinated with inactivated vaccines can be enrolled. 10. Primary or acquired immunodeficient states. 11. Pregnant or lactating. 12. Prior organ transplantation. 13. Active hepatitis B virus, hepatitis C virus, and HIV infection or a positive serological test at Screening within 14 days of dosing with T3011. 14. Active autoimmune disease or medical conditions requiring chronic steroid or immunosuppressive therapy within 4 weeks prior to first administration of study treatment. 15. History of or current central nervous system metastases. 16. History of seizure disorders within 6 months of Screening. 17. Active oral or skin herpes lesion at Screening. 18. Active interstitial lung disease (ILD)/pneumonitis or a history of ILD/pneumonitis requiring treatment with systemic steroids. 19. Congestive heart failure, active coronary artery disease, unevaluated new onset angina within 3 months or unstable angina, or clinically significant cardiac arrhythmias. 20. History of allergic reactions attributed to compounds of similar biological composition to HSV-1, IL-12, or anti-PD-1 monoclonal antibody. 18. Active infection with SARS-CoV-2 virus. 21. Participants with moderate to large amount of pleural effusion, ascites or pericardial effusion who need drug or medical intervention. 22. Other systemic conditions or organ abnormalities that, in the opinion of the investigator, may interfere with the conduct and/or interpretation of the current study.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04370587
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 1/Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

ImmVira Pharma Co. Ltd
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

N/A
Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Australia, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Solid Tumor, Melanoma, HNSCC, Sarcoma, Squamous Cell Carcinoma, NSCLC
Additional Details

This is a Phase 1/2a, open-label, first-in-human study of T3011 given via intratumoral (IT) injection as a single agent and in combination with IV pembrolizumab in participants with advanced or metastatic solid tumors. The Phase 1 portion of the study is a single agent dose escalation which will use a 3+3 design to evaluate escalating doses of T3011. Total enrollment will depend on the toxicities and/or activity observed, with approximately 15 to 30 evaluable participants enrolled. Once the RP2D is established Phase 2a Part 1 will enroll approximately 10 participants with locally recurrent or metastatic melanoma (in Arm A) 23 to 53 participants with HNSCC in Arm B, 40 to 80 participants with sarcoma in Arm C and 10 participants with cSCC in Arm D. During Phase 2a Part 1 the safety, tolerability, and preliminary efficacy of T3011 as a single agent will be evaluated. Phase 2a Part 2 will enroll in parallel to Phase 2a Part 1 once the RP2D is established. The safety, tolerability, and preliminary efficacy of IT T3011 given in combination with IV pembrolizumab will be evaluated in 15 participants with histologically or pathologically confirmed metastatic NSCLC (Arm E). A rollover arm is also included in this study to allow participants who have documented progression on T3011 alone to receive T3011 in combination with pembrolizumab if considered eligible.

Arms & Interventions

Arms

Experimental: Phase 1

T3011 single agent dose escalation in participants with solid tumors

Experimental: Phase 2a Part 1 Arm A

RP2D T3011 single agent in participants with melanoma

Experimental: Phase 2a Part 1 Arm B

RP2D T3011 single agent in participants with other solid tumors

Experimental: Phase 2a Part 2 Arm C

RP2D T3011 + pembrolizumab in participants with NSCLC

Experimental: Rollover Arm

RP2D T3011 + pembrolizumab in participants who have progressed on T3011 single agent

Interventions

Biological: - T3011

T3011 will be administered up to 4mL as an intratumoral injection given Q2W.

Combination Product: - T3011 + pembrolizumab

T3011 will be administered up to 4mL as an intratumoral injection in combination with intravenous pembrolizumab given Q3W.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Banner MD Anderson Cancer Center, Gilbert, Arizona

Status

Recruiting

Address

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234

Site Contact

Jiaxin Niu, MD, PhD

clinicaltrials@immviragroup.com

781-718-5121

Massachusetts General Hospital, Boston, Massachusetts

Status

Recruiting

Address

Massachusetts General Hospital

Boston, Massachusetts, 02114

Site Contact

Howard Kaufman, MD

clinicaltrials@immviragroup.com

781-718-5121

Dana Farber Cancer Institute, Boston, Massachusetts

Status

Recruiting

Address

Dana Farber Cancer Institute

Boston, Massachusetts, 02215

Site Contact

Elizabeth Buchbinder, MD

clinicaltrials@immviragroup.com

781-718-5121

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Status

Recruiting

Address

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232

Site Contact

John Kirkwood, MD

clinicaltrials@immviragroup.com

781-718-5121

Mary Crowley Cancer Research, Dallas, Texas

Status

Recruiting

Address

Mary Crowley Cancer Research

Dallas, Texas, 75230

Site Contact

Minal Barve, MD

clinicaltrials@immviragroup.com

781-718-5121

Virginia Cancer Specialists, Fairfax, Virginia

Status

Recruiting

Address

Virginia Cancer Specialists

Fairfax, Virginia, 22031

Site Contact

Alexander Spira, MD

clinicaltrials@immviragroup.com

781-718-5121

International Sites

Southern Oncology, Bedford Park, Australia

Status

Recruiting

Address

Southern Oncology

Bedford Park, ,

Site Contact

Ganessan Kichenadasse

clinicaltrials@immviragroup.com

781-718-5121

Frankston, Australia

Status

Recruiting

Address

Peninsula & South Eastern Haematology and Oncology Group

Frankston, ,

The Alfred, Melbourne, Australia

Status

Recruiting

Address

The Alfred

Melbourne, ,

Site Contact

Andrew Haydon

clinicaltrials@immviragroup.com

781-718-5121

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