1. written informed consent. 2. histologically confirmed glioblastoma patients who will take TMZ treatment. 3. KPS >70. 4. adequte end-organ function. 5. prior major surgery > 4 weeks (prior minor surgery > 1weeks)
6. prior standard concurrent chemo-radiation therapy > 4 weeks. 7. prior radiation therapy (including stereotactic radiosurgery) > 12 weeks.
1. contraindication to TMZ. 2. prior anti-cancer therapy except standard of care (*standard of care includes surgery,
Stupp regimen, and radiotherapy)
3. uncontrolled systemic medical illness. 4. pregnancy