Inclusion Criteria:
1. Provide signed and dated informed consent prior to initiation of any study-related
procedures.
2. Male or female patients aged ≥ 18 years.
3. Phase I dose escalation stage: Patients who have been diagnosed with histologically or
cytological documented, unresectable/metastatic tumors that are refractory or
intolerant to standard therapy or for whom no curative standard therapy exists.
- - For LCH/ECD: Eligible patients must have multifocal disease and the diagnosis must
be confirmed by pathological evaluation of the affected tissue.
4. Phase I expansion stage and Phase II stage: Histologically or cytologically documented
unresectable/metastatic tumors with evidence of genetic mutations affecting MAPK
pathway is required. Patients with a BRAF V600 mutation must have progressed on or
after standard therapy, including BRAF and/or MEK inhibitors (≤3 lines). Patients
entering the Phase 2 portion of the trial will be enrolled in Cohorts 1-4 depending
upon their tumor type.
- - Cohort 1: Patients with BRAF/NRAS (mutation sites as follows: NRAS G13V, NRAS
Q61, BRAF V600, BRAF G469A, L485W, L597Q, T599dup) mutated melanoma;
- Cohort 2: Patients with BRAF/NRAS (mutation sites as follows: NRAS G13V, NRAS
Q61, BRAF V600, BRAF G469A, L485W, L597Q, T599dup) mutated non-small cell lung
cancer;
- Cohort 3: Patients with BRAF V600 mutated Langerhans Cell Histiocytosis Syndrome
(LCH)/ Erdheim-Chester disease (ECD);
- For LCH/ECD: Eligible patients must have multifocal disease and the diagnosis
must be confirmed by pathological evaluation of the affected tissue.
- - Cohort 4: Patients with RAS/RAF/MEK/ERK mutated tumor types that are not included
in other cohorts.
5. Patients in the Phase I dose escalation portion of the trial may have measurable (per
RECIST v1.1) or evaluable disease. Patients in the Phase I expansion and Phase II
portions of the trial must have measurable disease per RECIST v1.1.
6. Eastern Cooperative Oncology Group (ECOG) performance status≤1.
7. Predicted life expectancy ≥ 3 months;
8. Adequate renal function defined as a creatinine clearance ≥ 60 mL/min;
9. Adequate hepatic function [total bilirubin ≤ 1.5 x UNL; AST (aspartate
aminotransferase) and ALT (alanine aminotransferase) ≤ 3 x UNL or ≤ 5 x UNL if due to
liver involvement by tumor];
10. Adequate cardiac function, > institutional lower limit of normal e.g., left
ventricular ejection fraction (LVEF) of ≥ 50% as assessed by
ultrasound/echocardiography (ECHO) or multi-gated acquisition (MUGA) ; corrected QT
interval (QTcF) < 460 ms (male patients), < 470 ms (female patients) (using QTc
Fridericia's formula.
11. Adequate bone marrow function, patients must not have required blood transfusion or
growth factor support ≤ 7 days before sample collection for the following ：
• Absolute neutrophil count ≥ 1.5 × 109/L; • Hemoglobin ≥ 9 g/dL; • Platelet count
≥100 × 109/L; • International normalized ratio (INR) ≤ 1.5; • Activated partial
prothrombin time (APTT) ≤ 1.5 × ULN;
12. Willing and able to participate in the trial and comply with all study requirements;
Exclusion Criteria:
1. Gastrointestinal condition which could impair absorption of study medication;
2. Congenital long QT syndrome, or any known history of torsade de pointes (TdP), or
family history of unexplained sudden death;
3. Clinically uncontrolled hypertension (after standard antihypertensive treatment,
systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg);
4. Undergone a bone marrow or solid organ transplant;
5. Any toxicities from prior treatment that have not recovered to ≤ CTCAE Grade 1 before
the start of study drug, with the exception of hair loss or fatigue;
6. Patients who have previously participated in clinical trials of ERK inhibitors drug;
7. Allergic to similar drugs or their excipients;
8. HIV (human immunodeficiency virus) infection, active hepatitis B or hepatitis C
patients (HBsAg positive patients also detected HBV (hepatitis B virus) DNA ≥ 103
copies or ≥ 200 IU/ml; HCV antibody test results are positive, and HCV (hepatitis C
virus) RNA PCR test results are positive);
9. Uncontrolled or severe intercurrent medical condition:
- - Unstable angina pectoris ≤3 months prior to starting study drug;
- Acute myocardial infarction ≤3 months prior to starting study drug;
10.
Symptomatic CNS metastases that are neurologically unstable or requiring increasing
doses of steroids to control CNS disease. Note: Controlled CNS metastases are allowed.
Radiotherapy or surgery for CNS metastases must have been completed >2 weeks prior to
study entry. No new neurologic deficits on clinical examination and no new findings on
CNS imaging are permitted. Steroid use for management of CNS metastases must be at a
stable dose for two weeks preceding study entry;
11. Any cancer-directed therapy (chemotherapy, radiotherapy, hormonal therapy, biologic or
immunotherapy, Chinese medicine/Chinese patent medicine with anti-tumor effect, etc.)
within 28 days or 5 half-lives, whichever is shorter;
12. Major surgery within 4 weeks prior to first dose;
13. Any use of an investigational drug within 28 days or 5 half-lives (whichever is
shorter) prior to the first dose of HH2710;
14. Pregnant or breast-feeding women;
15. Severe chronic or active infections requiring systemic antibacterial, antifungal or
antiviral therapy, including tuberculosis infection, etc.
- - Severe infections within 4 weeks prior to the first dose, including but not
limited to hospitalization for complications of infection, bacteremia, or severe
pneumonia.
- - Received therapeutic oral or IV antibiotics within 2 weeks prior to the first
dose of study drug.
16. Any important or severe medical illness or abnormal laboratory finding that would
increase the risk of participating in this study;
17. A history or current evidence/risk of retinal vein occlusion, central serous
retinopathy or choroidneovascularization (CNV) ;
18. Concurrent therapy with any other investigational agent;
19. Concomitant malignancies or previous malignancies with less than 2 years disease-free
interval at the time of enrollment; (But basal cell carcinoma skin cancer, cervical
CIS(carcinoma in situ), CIS of the breast, localized or low Gleason grade prostate
cancer, and < T2 bladder cancer can be included);
20. Current treatment with agents including vitamins, supplements, and herbal supplements
that are metabolized solely through CYP3A4;
21. Severe chronic obstructive pulmonary disease, severe asthma, pneumoconiosis,
asbestosis and other occupational lung diseases.
22. A history of acute or chronic pancreatitis, surgery of the pancreas, or any risk
factors that may increase the risk of pancreatitis;
23. Contraception: Patients who do not meet the following conditions will be excluded,
- -
For women: Negative pregnancy test for females of child-bearing potential; must be
surgically sterile, postmenopausal (defined as no menstrual cycle for at least 12
consecutive months), or compliant with an acceptable contraceptive regimen (2 highly
effective forms, such as oral contraceptives, condom with spermicide, etc.) during and
for 6 months after the treatment period.
Abstinence is not considered an adequate
contraceptive regimen;
- - For men: Must be surgically sterile, or compliant with a
contraceptive regimen (as above) during and for a minimum of 6 months after the
treatment period.
