Clinical Trial Finder

Inclusion Criteria:

• - Previous treatment for meningioma including surgery, when possible, and radiation therapy (conventional fractionated or radiosurgery).

Pathologic confirmation of meningioma is not required for patients who are not surgical candidates and received radiation therapy based on magnetic resonance imaging (MRI) consistent with meningioma. Patients with prior surgery will have pathologic confirmation of meningioma with either formalin-fixed paraffin-embedded (FFPE) tumor block OR meningioma tissue slides available for submission to central pathology review.

• - Radiographic evidence of meningioma progression with measurable disease, defined as an increase in size of the measurable primary lesion on imaging by 15% or more (sum of the bidirectional measurements) in an approximate 6 month time period (i.e., calculated rate of growth 15% / 6 months based on available scans) or by the appearance of a new measurable lesion.

• - Previous treatment with either fractionated radiation therapy or stereotactic radiosurgery at the site of progressive meningioma, without safe option for further radiotherapy.

• - Willing to undergo 68Ga-DOTATATE PET imaging.

68Ga-DOTATATE PET imaging must be Krenning score must be a score of 2 or higher, suggesting somatostatin receptor expression, to be enrolled on the study. A PET/MRI is preferred, but PET/CT is permitted if a patient is not technically able to receive a PET/MRI or at the discretion of the primary investigator (PI).

• - Measurable disease.

• - Eastern Cooperative Oncology Group (ECOG) performance status (PS) =< 2.

• - Absolute neutrophil count (ANC) >= 1500/mm (obtained =< 14 days prior to registration) - Platelet count >= 100,000/mm (obtained =< 14 days prior to registration) - Hemoglobin >= 9.0 g/dL (obtained =< 14 days prior to registration) - Direct bilirubin < 1.5 x upper limit of normal (ULN) (or total bilirubin =< 3.0 x ULN with direct bilirubin =< 1.5 x ULN in patients with well-documented Gilbert's syndrome) (obtained =< 14 days prior to registration) - Aspartate transaminase (AST) =< 3 x ULN (obtained =< 14 days prior to registration) - Prothrombin time (PT)/international normalized ratio (INR)/partial thromboplastin time (PTT) =< 1.5 x ULN OR if patient is receiving anticoagulant therapy and PT or PTT is within therapeutic range of intended use of coagulants (obtained =< 14 days prior to registration) - Calculated creatinine clearance must be >= 40 ml/min using the Cockcroft-Gault formula (obtained =< 14 days prior to registration) using the Chronic Kidney Disease Epidemiology Collaboration (CDK-EPI) equation.

• - Negative pregnancy test done =< 7 days prior to registration, for women of childbearing potential only.

• - NOTE: A negative pregnancy test needs to be done within 48 hours of receiving LUTATHERA treatment.

• - NOTE: Patients with surgical sterilization or who have been post-menopausal for at least 2 years are excluded from pregnancy testing, but this must be documented.

• - Ability to complete questionnaire(s) by themselves or with assistance.

• - Provide written informed consent.

• - Willing to return to enrolling institution for follow-up (during the Active Monitoring Phase and the Event Monitoring Phase of the study) and it is highly recommend seeing study staff in Radiation Oncology, Medical Oncology and/or Neuro-Oncology.

• - Willing to sign consent onto the Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking study, IRB number 15-000136.

• - NOTE: The blood draw is optional.

Exclusion Criteria:

• - Eligibility for surgical or radiation treatment with curative intent.

• - Any of the following because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects: - Pregnant women.

• - Nursing women.

• - Men or women of childbearing potential who are unwilling to employ adequate contraception.

• - Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.

• - Contraindications to or intolerance of MRI.

• - Immunocompromised patients and patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapy.

• - NOTE: Patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for this trial.

• - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association [NYHA] II, III, IV), unstable angina pectoris, uncontrolled diabetes mellitus (fasting blood glucose > 2 ULN), cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

• - Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm.

• - Note: This includes treatment with somatostatin LAR within 4 weeks prior to enrollment, or any patient receiving treatment with short-acting octreotide that cannot be interrupted for greater than 24 hours before treatment.

• - Other active malignancy =< 2 years prior to registration.

• - EXCEPTIONS: Non-melanotic skin cancer or carcinoma-in-situ of the cervix.

• - NOTE: If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer.

• - History of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias.

• - Current spontaneous urinary incontinence making impossible the safe administration of LUTATHERA.

• - Untreated, refractory and/or symptomatic toxicity related to previous radiation therapy including radiation necrosis, radiation optic neuropathy, or radiation retinopathy.

- Optic nerve sheath meningioma, extracranial meningioma

PRIMARY OBJECTIVES:

• I. To estimate the efficacy of lutetium Lu 177 dotatate (LUTATHERA) treatment in patients with recurrent grade 1 meningioma as measured by 6-month progression-free survival (PFS) rate.

• II. To estimate the efficacy of LUTATHERA treatment in patients with recurrent grade 2 or 3 meningioma as measured by 6-month PFS rate.

SECONDARY OBJECTIVES:

• I. To determine the overall survival (by grade cohort) of patients with recurrent meningioma during or after treatment of LUTATHERA.

• II. To determine the progression-free survival (by grade cohort) of patients with recurrent meningioma during or after treatment of LUTATHERA.

• III. To determine the toxicity of LUTATHERA treatment in patients with recurrent meningioma.

CORRELATIVE RESEARCH OBJECTIVES:

• I. To assess the impact of treatment on the patient's quality of life (QOL) using the Promise-10, Brief Fatigue Inventory (BFI), and Mayo Patient Survey National Comprehensive Cancer Network (NCCN)-Functional Assessment of Cancer Therapy (FACT) Brain Symptom Index Questionnaire-24 (FBrSI-24) (version 2) instruments.

• II. To compare the response assessment between standard of care brain magnetic resonance imaging (MRI) and gallium Ga 68-DOTATATE (68Ga-DOTATATE) positron emission tomography (PET) imaging.

• III. To determine the best objective response (Macdonald criteria) of patients with recurrent meningioma during or after treatment of LUTATHERA.

• IV. To determine the duration of local control with death as a competing risk (by grade cohort) of patients with recurrent meningioma during or after treatment of LUTATHERA.

• V. To perform a quantitative dosimetric analysis of radiation dose delivered with lutathera: Va.

To determine intratherapeutic dosimetry for the target meningioma; Vb. To correlate treatment response of lutathera with target dose received; Vc. To determine intratherapeutic dosimetry for kidneys and other abdominal organs. OUTLINE: Patients receive gallium Ga 68-DOTATATE intravenously (IV) and undergo a PET/MRI or PET/computed tomography (CT) before cycles 1 and 4. Patients then receive lutetium Lu 177 dotatate IV over 30-40 minutes. Treatment repeats every 8 weeks for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo MRI on study and during follow-up, as well as blood sample collection and possible single photon emission computed tomography (SPECT)/CT dosimetry on study. After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for up to 5 years.

Arms

Experimental: Treatment (gallium Ga 68-DOTATATE PET/MRI, Lutathera)

Patients receive gallium Ga 68-DOTATATE IV and undergo a PET/MRI or PET/CT before cycles 1 and 4. Patients then receive lutetium Lu 177 dotatate IV over 30-40 minutes. Treatment repeats every 8 weeks for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo MRI on study and during follow-up, as well as blood sample collection and possible SEPCT/CT dosimetry on study.

Interventions

Radiation: - Gallium Ga 68-DOTATATE

Given IV

Drug: - Lutetium Lu 177 Dotatate

Given IV

Procedure: - Magnetic Resonance Imaging

Undergo PET/MRI

Procedure: - Positron Emission Tomography

Undergo PET/MRI

Other: - Questionnaire Administration

Ancillary studies

Procedure: - Computed Tomography

Undergo PET/CT and/or SPECT/CT

Procedure: - Biospecimen Collection

Undergo blood sample collection

Procedure: - Single Photon Emission Computed Tomography

Undergo SPECT/CT