Measurable locally advanced, recurrent, or metastatic cancer associated with one of the
following cancer types: 1.) gastric/esophagogastric, 2.) colorectal, 3.) pancreatic, 4.)
sarcoma, 5.) mesothelioma, 6.) neuroendocrine, 7.) squamous cell cancer, 8.) Merkle cell,
9.) mismatch repair deficient and/or microsatellite unstable cancers, and 10.) patients who
have exhausted conventional systemic therapy options. Patients with locally advanced disease should be unresectable by conventional surgical
Patients with distant metastatic spread must have previously received approved first-line
systemic therapies if they are eligible to receive these treatments.
Patients must be co-enrolled on the companion protocol HCC 17-220 (Cell Harvest and
Preparation to Support Adoptive Cell Therapy Clinical Protocols and Pre-Clinical Studies)
and have available TIL cultures for therapy.
Patients with 3 or fewer brain metastases that are less than 1 cm in diameter and
asymptomatic are eligible. Lesions that have been treated with stereotactic radiosurgery
must be clinically stable for 1 month after treatment for the patient to be eligible.
Patients with surgically resected brain metastases are eligible.
Greater than or equal to 18 years of age and less than or equal to age 75. Able to understand and sign the Informed Consent Document. Clinical performance status of ECOG 0 or 1. Life expectancy of greater than three months. Patients of both genders who are of child-bearing potential must be willing to practice
birth control from the time of enrollment on this study and for up to four months after
receiving the treatment.
- - Seronegative for HIV antibody.
(The experimental treatment being evaluated in this
protocol depends on an intact immune system. Patients who are HIV seropositive can
have decreased immune-competence and thus be less responsive to the experimental
treatment and more susceptible to its toxicities.)
- - Seronegative for hepatitis B antigen.
- - Seronegative for hepatitis C antibody.
If hepatitis C antibody test is positive, then
patient must be tested for the presence of antigen by RT-PCR and be HCV RNA negative.
Women of child-bearing potential must have a negative pregnancy test because of the
potentially dangerous effects of the treatment on the fetus.
- - Absolute neutrophil count greater than 1000/mm3 without the support of filgrastim.
- - Platelet count ≥ 100,000/mm3.
- - Serum ALT/AST ≤ to 3.5 times the upper limit of normal Serum creatinine ≤ to 1.6 mg/dl.
- - Total bilirubin ≤ to 2.0 mg/dl, except in patients with Gilbert's Syndrome who must
have a total bilirubin less than 3.0 mg/dl.
More than four weeks must have elapsed since any prior systemic therapy at the time the
patient receives the preparative regimen, and patients' toxicities must have recovered to a
clinically manageable level (except for toxicities such as alopecia or vitiligo). (Note:
Patients may have undergone minor surgical procedures within the past 3 weeks, as long as
all toxicities have recovered to grade 1 or less)
Women of child-bearing potential who are pregnant or breastfeeding because of the
potentially dangerous effects of the treatment on the fetus or infant.
Any form of primary immunodeficiency (such as Severe Combined Immunodeficiency Disease).
Concurrent opportunistic infections (The experimental treatment being evaluated in this
protocol depends on an intact immune system. Patients who have decreased immune competence
may be less responsive to the experimental treatment and more susceptible to its
Active systemic infections (e.g.: requiring anti-infective treatment),
Clinically significant coagulation disorder. Active major medical illnesses deemed clinically significant by the treating physician. History of clinically significant major organ autoimmune disease. Patients with a history of hypothyroidism are eligible. Concurrent systemic steroid therapy.
History of severe immediate hypersensitivity reaction to any of the agents used in this
History of active coronary or ischemic symptoms.
Documented LVEF of less than or equal to 45%; note: testing is required in patients with:
- - Clinically significant atrial and or ventricular arrhythmias including but not limited
to: atrial fibrillation, ventricular tachycardia, second- or third-degree heart block
or have a history of ischemic heart disease, chest pain.
Documented FEV1 less than or equal to 60% predicted tested in patients with:
- - A prolonged history of cigarette smoking (20 pk/year of smoking within the past 2
- - Symptoms of respiratory dysfunction.
Patients who are receiving any other investigational agents.