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This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a patient?s response to treatment.
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT03115333 |
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Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
N/A |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
ECOG-ACRIN Cancer Research Group |
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Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Jerrold Boxerman |
| Principal Investigator Affiliation | ECOG-ACRIN Cancer Research Group |
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Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Recruiting |
| Countries | United States |
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Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Gliosarcoma, Recurrent Glioblastoma |
PRIMARY OBJECTIVES:
Experimental: Diagnostic (DSC-MRI)
Patients undergo DSC-MRI within 3 days before bevacizumab initiation and at day 15.
Diagnostic Test: - Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging
Undergo DSC-MRI
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Saint Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013
Status
Recruiting
Address
Mayo Clinic Hospital
Phoenix, Arizona, 85054
Status
Recruiting
Address
Mayo Clinic in Arizona
Scottsdale, Arizona, 85259
Status
Active, not recruiting
Address
Eden Hospital Medical Center
Castro Valley, California, 94546
Status
Recruiting
Address
Loma Linda University Medical Center
Loma Linda, California, 92354
Status
Suspended
Address
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
Status
Recruiting
Address
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
Status
Recruiting
Address
VA Palo Alto Health Care System
Palo Alto, California, 94304
Status
Recruiting
Address
Boca Raton Regional Hospital
Boca Raton, Florida, 33486
Status
Recruiting
Address
Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207
Status
Recruiting
Address
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980
Status
Recruiting
Address
Moffitt Cancer Center-International Plaza
Tampa, Florida, 33607
Status
Recruiting
Address
Moffitt Cancer Center - McKinley Campus
Tampa, Florida, 33612
Status
Recruiting
Address
Moffitt Cancer Center
Tampa, Florida, 33612
Status
Recruiting
Address
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Status
Recruiting
Address
Northside Hospital
Atlanta, Georgia, 30342
Status
Active, not recruiting
Address
Northside Hospital-Forsyth
Cumming, Georgia, 30041
Status
Recruiting
Address
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
Status
Recruiting
Address
IU Health Methodist Hospital
Indianapolis, Indiana, 46202
Status
Recruiting
Address
Baptist Health Lexington
Lexington, Kentucky, 40503
Status
Recruiting
Address
Maryland Proton Treatment Center
Baltimore, Maryland, 21201
Status
Recruiting
Address
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201
Status
Recruiting
Address
Henry Ford Hospital
Detroit, Michigan, 48202
Status
Recruiting
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
Status
Recruiting
Address
Mayo Clinic
Rochester, Minnesota, 55905
Status
Recruiting
Address
Regions Hospital
Saint Paul, Minnesota, 55101
Status
Recruiting
Address
United Hospital
Saint Paul, Minnesota, 55102
Status
Recruiting
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Status
Recruiting
Address
University of Missouri - Ellis Fischel
Columbia, Missouri, 65212
Status
Recruiting
Address
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141
Status
Recruiting
Address
Washington University School of Medicine
Saint Louis, Missouri, 63110
Status
Recruiting
Address
Siteman Cancer Center-South County
Saint Louis, Missouri, 63129
Status
Recruiting
Address
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri, 63376
Status
Recruiting
Address
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748
Status
Active, not recruiting
Address
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87102
Status
Recruiting
Address
Memorial Sloan Kettering Commack
Commack, New York, 11725
Status
Recruiting
Address
Memorial Sloan Kettering Westchester
Harrison, New York, 10604
Status
Recruiting
Address
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
Status
Recruiting
Address
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599
Status
Recruiting
Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
Status
Recruiting
Address
Duke University Medical Center
Durham, North Carolina, 27710
Status
Recruiting
Address
East Carolina University
Greenville, North Carolina, 27834
Status
Suspended
Address
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Status
Active, not recruiting
Address
University of Cincinnati/Barrett Cancer Center
Cincinnati, Ohio, 45219
Status
Recruiting
Address
Oregon Health and Science University
Portland, Oregon, 97239
Status
Recruiting
Address
Rhode Island Hospital
Providence, Rhode Island, 02903
Status
Recruiting
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
Status
Recruiting
Address
Memorial Hermann Texas Medical Center
Houston, Texas, 77030
Status
Active, not recruiting
Address
University Hospital
San Antonio, Texas, 78229
Status
Recruiting
Address
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
Status
Recruiting
Address
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051
Status
Recruiting
Address
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
Status
Recruiting
Address
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Status
Suspended
Address
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
Status
Suspended
Address
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Status
Suspended
Address
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
Status
Recruiting
Address
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
Status
Suspended
Address
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095
