Recording High Frequency Oscillations in Patients With Tumors and Epilepsy

Study Purpose

The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation. The investigators want to show that recording of high-frequency oscillations (HFOs) is feasible in our project population both intraoperatively and during presurgical physiological conditions.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.

An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.

Searching Both is inclusive of interventional and observational studies.

Eligible Ages 18 Years - 99 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Patients intend to be treated at the Klinik für Neurochirurgie.
  • - Patients fall into one of the patient groups: (1) Patients with symptomatic epilepsy with focal and/or secondary generalized seizures resistant to medication where a neurosurgical resection is considered as an intervention of epilepsy surgery.
(2)Patients where a tumor is planned to be resected that has caused preoperative seizures.
  • (3) Patients where a tumor is planned to be resected that has not caused preoperative seizures.
  • - Male and Female subjects 18 years to 99 years of age.
  • - Written informed consent after participants' information.

Exclusion Criteria:

  • - contraindications on ethical grounds.
- known or suspected non-compliance, drug or alcohol abuse, - enrolment into a clinical trial within last 4 weeks

Trial Details

Trial ID:

This trial id was obtained from, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.


Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

University of Zurich
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Johannes Sarnthein, Prof Dr
Principal Investigator Affiliation Universitätsspital Zürich
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Overall Status Enrolling by invitation

The disease, disorder, syndrome, illness, or injury that is being studied.

Epilepsy, Tumor
Arms & Interventions


: epilepsy

epilepsy patients

: tumor with epilepsy

tumor patients with epileptic seizures

: tumor without epilepsy

tumor patients without epileptic seizures


Behavioral: - cognitive testing

patients perform simple tasks like watching a video or memorizing items

Contact Information

This trial has no sites locations listed at this time. If you are interested in learning more, you can contact the trial's primary contact:

For additional contact information, you can also visit the trial on

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