Integrated Cancer Repository for Cancer Research

Study Purpose

The iCaRe2 is a multi-institutional resource created and maintained by the Fred & Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Yes
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Observational [Patient Registry]
Eligible Ages 19 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria.

  • - Adult individuals (male and female) who have a personal diagnosis/history of cancer.
  • - Adult individuals who have a risk for developing cancer or suspicious clinical findings.
  • - Adult individuals with no history of cancer for normal control registry.
  • - Able to provide consent.
  • - 19 years of age or older.
  • - Adult individuals who are able to speak English.
Exclusion Criteria.
  • - Individuals under age 19.
  • - Individuals unable to provide informed consent by virtue of cognitive impairment.
  • - Anyone who does not meet the above inclusion criteria for this project.
  • - Non-English speaking individuals.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT02012699
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

University of Nebraska
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Ken Cowan, MD
Principal Investigator Affiliation University of Nebraska
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Recruiting
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, Gastrointestinal Stromal Tumors, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, Central Nervous System Tumor, Central Nervous System Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control
Study Website: View Trial Website
Additional Details

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: (i) the Pancreatic Cancer Collaborative Registry (PCCR) established in 2001, (ii) the Breast Cancer Collaborative Registry (BCCR) established in 2006, (iii) the Thyroid Cancer Collaborative Registry (TCCR) established in 2006, and (iv) the Great Plains Health Informatics Database (GPHID) established in 2011, to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment. At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Penrose Cancer Center, Colorado Springs, Colorado

Status

Completed

Address

Penrose Cancer Center

Colorado Springs, Colorado, 80907

Porter Adventist Hospital, Denver, Colorado

Status

Completed

Address

Porter Adventist Hospital

Denver, Colorado, 80210

Mercy Regional Medical Center, Durango, Colorado

Status

Completed

Address

Mercy Regional Medical Center

Durango, Colorado, 81301

St. Anthony Hospital, Lakewood, Colorado

Status

Completed

Address

St. Anthony Hospital

Lakewood, Colorado, 80228

Littleton Cancer Center, Littleton, Colorado

Status

Completed

Address

Littleton Cancer Center

Littleton, Colorado, 80122

Longmont Cancer Center, Longmont, Colorado

Status

Completed

Address

Longmont Cancer Center

Longmont, Colorado, 80501

Avista Cancer Center, Louisville, Colorado

Status

Completed

Address

Avista Cancer Center

Louisville, Colorado, 80027

Parker Adventist Hospital, Parker, Colorado

Status

Completed

Address

Parker Adventist Hospital

Parker, Colorado, 80138

St. Mary Corwin Medical Center, Pueblo, Colorado

Status

Completed

Address

St. Mary Corwin Medical Center

Pueblo, Colorado, 81004

St. Anthony North Cancer Center, Westminster, Colorado

Status

Completed

Address

St. Anthony North Cancer Center

Westminster, Colorado, 80228

Bristol Health Beekley, Bristol, Connecticut

Status

Recruiting

Address

Bristol Health Beekley

Bristol, Connecticut, 06010

Site Contact

Jeannie Robbins

[email protected]

860-585-3999

Florida Hospital Memorial Medical Center, Daytona Beach, Florida

Status

Recruiting

Address

Florida Hospital Memorial Medical Center

Daytona Beach, Florida, 32117

Site Contact

Sandy Allten, RN

[email protected]

386-231-4023

Florida Hospital DeLand, DeLand, Florida

Status

Recruiting

Address

Florida Hospital DeLand

DeLand, Florida, 32720

Site Contact

Sandra Allten, RN,OCN,CCRP

[email protected]

386-231-3267

Florida Hospital FISH, Orange City, Florida

Status

Recruiting

Address

Florida Hospital FISH

Orange City, Florida, 32763

Site Contact

Sandy Allten, RN

[email protected]

386-231-4023

Florida Hospital Flagler, Palm Coast, Florida

Status

Recruiting

Address

Florida Hospital Flagler

Palm Coast, Florida, 32164

Site Contact

Sandy Allten, RN

[email protected]

386-231-4023

Tallahassee Memorial Hospital, Tallahassee, Florida

Status

Recruiting

Address

Tallahassee Memorial Hospital

Tallahassee, Florida, 32308

Site Contact

Kellie Hyde

[email protected]

701-857-3174

Rush-Copley Cancer Care Center, Aurora, Illinois

Status

Recruiting

Address

Rush-Copley Cancer Care Center

Aurora, Illinois, 60504

Site Contact

Joseph Meschi, MD

[email protected]

402-559-4238

Trinity Medical Center, Moline, Illinois

Status

Completed

Address

Trinity Medical Center

Moline, Illinois, 61265

Rush-Copley Healthcare Center, Yorkville, Illinois

Status

Recruiting

Address

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560

Site Contact

Amanda Baker, CCRP

[email protected]

630-978-6212

Parkview Research Center, Fort Wayne, Indiana

Status

Recruiting

Address

Parkview Research Center

Fort Wayne, Indiana, 46845

Site Contact

Neil Sharma, MD

[email protected]

402-559-4238

Community Health Network, Indianapolis, Indiana

Status

Recruiting

Address

Community Health Network

Indianapolis, Indiana, 46219

Site Contact

Betsy Glowinski

[email protected]

317-497-2836

Community Cancer Center South, Indianapolis, Indiana

Status

Recruiting

Address

Community Cancer Center South

Indianapolis, Indiana, 46227

Site Contact

Betsy Glowinski

[email protected]

317-497-2836

Community Cancer Center North, Indianapolis, Indiana

Status

Recruiting

Address

Community Cancer Center North

Indianapolis, Indiana, 46256

Site Contact

Betsy Glowinski

[email protected]

317-497-2836

Community Howard Regional Hospital, Kokomo, Indiana

Status

Recruiting

Address

Community Howard Regional Hospital

Kokomo, Indiana, 46902

Site Contact

Anuj Agarwala, MD

[email protected]

402-559-4238

Methodist Jennie Edmundson Hospital, Council Bluffs, Iowa

Status

Recruiting

Address

Methodist Jennie Edmundson Hospital

Council Bluffs, Iowa, 51503

Site Contact

Michael Zlomke, MD

[email protected]

712-396-4117

Genesis Medical Center, Davenport, Iowa

Status

Completed

Address

Genesis Medical Center

Davenport, Iowa, 52804

Abben Cancer Center, Spencer, Iowa

Status

Completed

Address

Abben Cancer Center

Spencer, Iowa, 51301

Covenant Medical Center, Inc, Waterloo, Iowa

Status

Recruiting

Address

Covenant Medical Center, Inc

Waterloo, Iowa, 50702

Site Contact

Karrie Cheeseman, BSN, RN

[email protected]

319-272-2388

Saint Luke's Cancer Instititue - South, Overland Park, Kansas

Status

Recruiting

Address

Saint Luke's Cancer Instititue - South

Overland Park, Kansas, 66213

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Tulane University, New Orleans, Louisiana

Status

Completed

Address

Tulane University

New Orleans, Louisiana, 70112

Breast Care Specialists of Maine, Portland, Maine

Status

Completed

Address

Breast Care Specialists of Maine

Portland, Maine, 04102

Northwest Hospital, Randallstown, Maryland

Status

Recruiting

Address

Northwest Hospital

Randallstown, Maryland, 21133

Site Contact

Judy Bosley

[email protected]

410-871-7450

William E Kahlert Regional Cancer Center, Westminster, Maryland

Status

Recruiting

Address

William E Kahlert Regional Cancer Center

Westminster, Maryland, 21157

Site Contact

Judy Bosley

[email protected]

410-871-7450

Holyoke Medical Center, Holyoke, Massachusetts

Status

Recruiting

Address

Holyoke Medical Center

Holyoke, Massachusetts, 01040

Site Contact

Lynn Downey, RHIT, CTR

[email protected]

413-534-2500

University of Michigan Health System, Ann Arbor, Michigan

Status

Completed

Address

University of Michigan Health System

Ann Arbor, Michigan, 48109

Riverwood Healthcare Center, Aitkin, Minnesota

Status

Recruiting

Address

Riverwood Healthcare Center

Aitkin, Minnesota, 56431

Site Contact

Lauren Keppeler

[email protected]

402-559-4238

Brainerd, Minnesota

Status

Recruiting

Address

Essentia Health-St. Joseph's Medical Center

Brainerd, Minnesota, 56401

Site Contact

Lauren Keppeler

[email protected]

402-559-4238

Essentia Health - Duluth Clinic, Duluth, Minnesota

Status

Recruiting

Address

Essentia Health - Duluth Clinic

Duluth, Minnesota, 55805

Site Contact

Lauren Keppeler

[email protected]

402-559-4238

St. Luke's Hospital of Duluth, Duluth, Minnesota

Status

Recruiting

Address

St. Luke's Hospital of Duluth

Duluth, Minnesota, 55805

Site Contact

Andrea Berget

[email protected]

218-249-5002

Lake Region Healthcare, Fergus Falls, Minnesota

Status

Recruiting

Address

Lake Region Healthcare

Fergus Falls, Minnesota, 56537

Site Contact

Lauren Keppeler

[email protected]

218-786-1018

Avera Cancer Institute- Marshall, Marshall, Minnesota

Status

Completed

Address

Avera Cancer Institute- Marshall

Marshall, Minnesota, 56258

Mercy Hospital - Joplin, Joplin, Missouri

Status

Completed

Address

Mercy Hospital - Joplin

Joplin, Missouri, 64804

Saint Luke's Cancer Institute, East, Kansas City, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute, East

Kansas City, Missouri, 64086

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Saint Luke's Cancer Institute, Kansas City, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute

Kansas City, Missouri, 64111

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Kansas City, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute, Kansas City North

Kansas City, Missouri, 64118

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Saint Luke's Cancer Institute, Liberty, Liberty, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute, Liberty

Liberty, Missouri, 64068

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Saint Joseph, Missouri

Status

Recruiting

Address

Heartland Regional Medical Center dba Mosaic Life Care

Saint Joseph, Missouri, 64507

Site Contact

Molly Kidwell

[email protected]

816-271-7654

Bozeman Health Deaconess Hospital, Bozeman, Montana

Status

Recruiting

Address

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715

Site Contact

Adam Gott

[email protected]

406-414-3745

Logan Health, Kalispell, Montana

Status

Recruiting

Address

Logan Health

Kalispell, Montana, 59901

Site Contact

Melissa Lundbeck Kaptanian, MD

[email protected]

406-752-8669

Missoula, Montana

Status

Completed

Address

Providence St. Patrick Hospital Montana Cancer Center

Missoula, Montana, 59802

Hastings, Nebraska

Status

Recruiting

Address

Mary Lanning Healthcare, Morrison Cancer Center

Hastings, Nebraska, 68901

Site Contact

Joan Meese

[email protected]

402-460-5899

Norfolk, Nebraska

Status

Recruiting

Address

Faith Regional Health Services, Carson Cancer Center

Norfolk, Nebraska, 68701

Site Contact

Cynthia Montgomery, RN

[email protected]

402-644-7534

Great Plains Regional Medical Center, North Platte, Nebraska

Status

Recruiting

Address

Great Plains Regional Medical Center

North Platte, Nebraska, 69101

Site Contact

Lisa Kosmacek

[email protected]

308-696-7386

Avera St. Anthony's Hospital, O'Neill, Nebraska

Status

Completed

Address

Avera St. Anthony's Hospital

O'Neill, Nebraska, 68763

Methodist Estabrook Cancer Center, Omaha, Nebraska

Status

Recruiting

Address

Methodist Estabrook Cancer Center

Omaha, Nebraska, 68114

Site Contact

Russell Smith, MD

[email protected]

402-559-4238

Nebraska Methodist Health System, Omaha, Nebraska

Status

Recruiting

Address

Nebraska Methodist Health System

Omaha, Nebraska, 68114

Site Contact

Kathryn Bartz

[email protected]

402-354-7939

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Site Contact

Whitney Goldner, MD

[email protected]

402-559-3579

Regional West Health Services, Scottsbluff, Nebraska

Status

Completed

Address

Regional West Health Services

Scottsbluff, Nebraska, 69361

Glens Falls, New York

Status

Recruiting

Address

C.R. Wood Cancer Center, Glens Falls Hospital

Glens Falls, New York, 12801

Site Contact

Beth Brundage, RN, ORC

[email protected]

518-926-6701

Utica, New York

Status

Suspended

Address

Faxton St. Luke's Healthcare, Mohawk Valley

Utica, New York, 13501

Cape Fear Valley Health System, Fayetteville, North Carolina

Status

Recruiting

Address

Cape Fear Valley Health System

Fayetteville, North Carolina, 28304

Site Contact

Kenneth Manning, MD

[email protected]

402-559-4238

Essentia Health, Fargo, North Dakota

Status

Recruiting

Address

Essentia Health

Fargo, North Dakota, 58103

Site Contact

Joni Buechler-Price, MD

[email protected]

218-786-1018

Trinity Hospital Cancer Care Center, Minot, North Dakota

Status

Recruiting

Address

Trinity Hospital Cancer Care Center

Minot, North Dakota, 58701

Site Contact

Pamela Brewer

[email protected]

701-857-3163

Aultman Alliance Community Hospital, Alliance, Ohio

Status

Recruiting

Address

Aultman Alliance Community Hospital

Alliance, Ohio, 44601

Site Contact

Carla Larch

[email protected]

330-363-7412

Aultman Hospital, Canton, Ohio

Status

Recruiting

Address

Aultman Hospital

Canton, Ohio, 44710

Site Contact

Carla Larch

[email protected]

330-363-7412

University of Pittsburgh, Pittsburgh, Pennsylvania

Status

Completed

Address

University of Pittsburgh

Pittsburgh, Pennsylvania, 15323

Aberdeen, South Dakota

Status

Completed

Address

Avera Medical Group Oncology and Hematology Aberdeen

Aberdeen, South Dakota, 57401

Avera Cancer Institute, Mitchell, South Dakota

Status

Completed

Address

Avera Cancer Institute

Mitchell, South Dakota, 57301

Avera Cancer Institute, Sioux Falls, South Dakota

Status

Completed

Address

Avera Cancer Institute

Sioux Falls, South Dakota, 57105

Sanford Health, Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford Health

Sioux Falls, South Dakota, 57105

Site Contact

William Spanos, MD

[email protected]

605-328-8200

Avera Cancer Center Yankton, Yankton, South Dakota

Status

Completed

Address

Avera Cancer Center Yankton

Yankton, South Dakota, 57078

Avera Sacred Heart Hospital, Yankton, South Dakota

Status

Completed

Address

Avera Sacred Heart Hospital

Yankton, South Dakota, 57078

Yankton Medical Clinic, Yankton, South Dakota

Status

Completed

Address

Yankton Medical Clinic

Yankton, South Dakota, 57078

Rutland Regional Medical Center, Rutland, Vermont

Status

Recruiting

Address

Rutland Regional Medical Center

Rutland, Vermont, 05701

Site Contact

Tonya Welch

[email protected]

802-747-1692

Mary Washington Hospital, Fredericksburg, Virginia

Status

Recruiting

Address

Mary Washington Hospital

Fredericksburg, Virginia, 22401

Site Contact

Anna Mason, CCRP

[email protected]

540-741-4868

Ascension St. Elizabeth Hospital, Appleton, Wisconsin

Status

Completed

Address

Ascension St. Elizabeth Hospital

Appleton, Wisconsin, 54915

Brookfield, Wisconsin

Status

Completed

Address

Wheaton Franciscan Healthcare - Elmbrook Memorial Hospital

Brookfield, Wisconsin, 53045

Franklin, Wisconsin

Status

Completed

Address

Wheaton Franciscan Healthcare, Reiman Cancer Care

Franklin, Wisconsin, 53132

Bellin Memorial Hospital, Green Bay, Wisconsin

Status

Recruiting

Address

Bellin Memorial Hospital

Green Bay, Wisconsin, 54305

Site Contact

Abigail Hecker

[email protected]

920-430-4660

Columbia St. Mary's, Mequon, Wisconsin

Status

Completed

Address

Columbia St. Mary's

Mequon, Wisconsin, 53097

Columbia St. Mary's, Milwaukee, Wisconsin

Status

Completed

Address

Columbia St. Mary's

Milwaukee, Wisconsin, 53211

Ascension Mercy Hospital, Oshkosh, Wisconsin

Status

Completed

Address

Ascension Mercy Hospital

Oshkosh, Wisconsin, 54904

Racine, Wisconsin

Status

Completed

Address

Wheaton Franciscan Healthcare, All Saints

Racine, Wisconsin, 53405

Wauwatosa, Wisconsin

Status

Completed

Address

Wheaton Franciscan Healthcare, Wauwatosa Cancer Care

Wauwatosa, Wisconsin, 53226

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