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The iCaRe2 is a multi-institutional resource created and maintained by the Fred & Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies.
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
Yes |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Observational [Patient Registry] |
Eligible Ages | 19 Years and Over |
Gender | All |
Inclusion Criteria.
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT02012699 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
University of Nebraska |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Ken Cowan, MD |
Principal Investigator Affiliation | University of Nebraska |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other |
Overall Status | Recruiting |
Countries | United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, Gastrointestinal Stromal Tumors, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, Central Nervous System Tumor, Central Nervous System Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control |
Study Website: | View Trial Website |
The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: (i) the Pancreatic Cancer Collaborative Registry (PCCR) established in 2001, (ii) the Breast Cancer Collaborative Registry (BCCR) established in 2006, (iii) the Thyroid Cancer Collaborative Registry (TCCR) established in 2006, and (iv) the Great Plains Health Informatics Database (GPHID) established in 2011, to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment. At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Completed
Address
Penrose Cancer Center
Colorado Springs, Colorado, 80907
Status
Completed
Address
Porter Adventist Hospital
Denver, Colorado, 80210
Status
Completed
Address
Mercy Regional Medical Center
Durango, Colorado, 81301
Status
Completed
Address
St. Anthony Hospital
Lakewood, Colorado, 80228
Status
Completed
Address
Littleton Cancer Center
Littleton, Colorado, 80122
Status
Completed
Address
Longmont Cancer Center
Longmont, Colorado, 80501
Status
Completed
Address
Avista Cancer Center
Louisville, Colorado, 80027
Status
Completed
Address
Parker Adventist Hospital
Parker, Colorado, 80138
Status
Completed
Address
St. Mary Corwin Medical Center
Pueblo, Colorado, 81004
Status
Completed
Address
St. Anthony North Cancer Center
Westminster, Colorado, 80228
Status
Recruiting
Address
Bristol Health Beekley
Bristol, Connecticut, 06010
Status
Recruiting
Address
Florida Hospital Memorial Medical Center
Daytona Beach, Florida, 32117
Status
Recruiting
Address
Florida Hospital DeLand
DeLand, Florida, 32720
Status
Recruiting
Address
Florida Hospital FISH
Orange City, Florida, 32763
Status
Recruiting
Address
Florida Hospital Flagler
Palm Coast, Florida, 32164
Status
Recruiting
Address
Tallahassee Memorial Hospital
Tallahassee, Florida, 32308
Status
Recruiting
Address
Rush-Copley Cancer Care Center
Aurora, Illinois, 60504
Status
Completed
Address
Trinity Medical Center
Moline, Illinois, 61265
Status
Recruiting
Address
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
Status
Recruiting
Address
Parkview Research Center
Fort Wayne, Indiana, 46845
Status
Recruiting
Address
Community Health Network
Indianapolis, Indiana, 46219
Status
Recruiting
Address
Community Cancer Center South
Indianapolis, Indiana, 46227
Status
Recruiting
Address
Community Cancer Center North
Indianapolis, Indiana, 46256
Status
Recruiting
Address
Community Howard Regional Hospital
Kokomo, Indiana, 46902
Status
Recruiting
Address
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa, 51503
Status
Completed
Address
Genesis Medical Center
Davenport, Iowa, 52804
Status
Completed
Address
Abben Cancer Center
Spencer, Iowa, 51301
Status
Recruiting
Address
Covenant Medical Center, Inc
Waterloo, Iowa, 50702
Status
Recruiting
Address
Saint Luke's Cancer Instititue - South
Overland Park, Kansas, 66213
Status
Completed
Address
Tulane University
New Orleans, Louisiana, 70112
Status
Completed
Address
Breast Care Specialists of Maine
Portland, Maine, 04102
Status
Recruiting
Address
Northwest Hospital
Randallstown, Maryland, 21133
Status
Recruiting
Address
William E Kahlert Regional Cancer Center
Westminster, Maryland, 21157
Status
Recruiting
Address
Holyoke Medical Center
Holyoke, Massachusetts, 01040
Status
Completed
Address
University of Michigan Health System
Ann Arbor, Michigan, 48109
Status
Recruiting
Address
Riverwood Healthcare Center
Aitkin, Minnesota, 56431
Status
Recruiting
Address
Essentia Health-St. Joseph's Medical Center
Brainerd, Minnesota, 56401
Status
Recruiting
Address
Essentia Health - Duluth Clinic
Duluth, Minnesota, 55805
Status
Recruiting
Address
St. Luke's Hospital of Duluth
Duluth, Minnesota, 55805
Status
Recruiting
Address
Lake Region Healthcare
Fergus Falls, Minnesota, 56537
Status
Completed
Address
Avera Cancer Institute- Marshall
Marshall, Minnesota, 56258
Status
Completed
Address
Mercy Hospital - Joplin
Joplin, Missouri, 64804
Status
Recruiting
Address
Saint Luke's Cancer Institute, East
Kansas City, Missouri, 64086
Status
Recruiting
Address
Saint Luke's Cancer Institute
Kansas City, Missouri, 64111
Status
Recruiting
Address
Saint Luke's Cancer Institute, Kansas City North
Kansas City, Missouri, 64118
Status
Recruiting
Address
Saint Luke's Cancer Institute, Liberty
Liberty, Missouri, 64068
Status
Recruiting
Address
Heartland Regional Medical Center dba Mosaic Life Care
Saint Joseph, Missouri, 64507
Status
Recruiting
Address
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
Status
Recruiting
Address
Logan Health
Kalispell, Montana, 59901
Status
Completed
Address
Providence St. Patrick Hospital Montana Cancer Center
Missoula, Montana, 59802
Status
Recruiting
Address
Mary Lanning Healthcare, Morrison Cancer Center
Hastings, Nebraska, 68901
Status
Recruiting
Address
Faith Regional Health Services, Carson Cancer Center
Norfolk, Nebraska, 68701
Status
Recruiting
Address
Great Plains Regional Medical Center
North Platte, Nebraska, 69101
Status
Completed
Address
Avera St. Anthony's Hospital
O'Neill, Nebraska, 68763
Status
Recruiting
Address
Methodist Estabrook Cancer Center
Omaha, Nebraska, 68114
Status
Recruiting
Address
Nebraska Methodist Health System
Omaha, Nebraska, 68114
Status
Recruiting
Address
University of Nebraska Medical Center
Omaha, Nebraska, 68198
Status
Completed
Address
Regional West Health Services
Scottsbluff, Nebraska, 69361
Status
Recruiting
Address
C.R. Wood Cancer Center, Glens Falls Hospital
Glens Falls, New York, 12801
Status
Suspended
Address
Faxton St. Luke's Healthcare, Mohawk Valley
Utica, New York, 13501
Status
Recruiting
Address
Cape Fear Valley Health System
Fayetteville, North Carolina, 28304
Status
Recruiting
Address
Essentia Health
Fargo, North Dakota, 58103
Status
Recruiting
Address
Trinity Hospital Cancer Care Center
Minot, North Dakota, 58701
Status
Recruiting
Address
Aultman Alliance Community Hospital
Alliance, Ohio, 44601
Status
Recruiting
Address
Aultman Hospital
Canton, Ohio, 44710
Status
Completed
Address
University of Pittsburgh
Pittsburgh, Pennsylvania, 15323
Status
Completed
Address
Avera Medical Group Oncology and Hematology Aberdeen
Aberdeen, South Dakota, 57401
Status
Completed
Address
Avera Cancer Institute
Mitchell, South Dakota, 57301
Status
Completed
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
Status
Recruiting
Address
Sanford Health
Sioux Falls, South Dakota, 57105
Status
Completed
Address
Avera Cancer Center Yankton
Yankton, South Dakota, 57078
Status
Completed
Address
Avera Sacred Heart Hospital
Yankton, South Dakota, 57078
Status
Completed
Address
Yankton Medical Clinic
Yankton, South Dakota, 57078
Status
Recruiting
Address
Rutland Regional Medical Center
Rutland, Vermont, 05701
Status
Recruiting
Address
Mary Washington Hospital
Fredericksburg, Virginia, 22401
Status
Completed
Address
Ascension St. Elizabeth Hospital
Appleton, Wisconsin, 54915
Status
Completed
Address
Wheaton Franciscan Healthcare - Elmbrook Memorial Hospital
Brookfield, Wisconsin, 53045
Status
Completed
Address
Wheaton Franciscan Healthcare, Reiman Cancer Care
Franklin, Wisconsin, 53132
Status
Recruiting
Address
Bellin Memorial Hospital
Green Bay, Wisconsin, 54305
Status
Completed
Address
Columbia St. Mary's
Mequon, Wisconsin, 53097
Status
Completed
Address
Columbia St. Mary's
Milwaukee, Wisconsin, 53211
Status
Completed
Address
Ascension Mercy Hospital
Oshkosh, Wisconsin, 54904
Status
Completed
Address
Wheaton Franciscan Healthcare, All Saints
Racine, Wisconsin, 53405
Status
Completed
Address
Wheaton Franciscan Healthcare, Wauwatosa Cancer Care
Wauwatosa, Wisconsin, 53226