Integrated Cancer Repository for Cancer Research

Study Purpose

The iCaRe2 is a multi-institutional resource created and maintained by the Fred & Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Yes
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Observational [Patient Registry]
Eligible Ages 19 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria.

  • - Diagnosis/history of cancer.
  • - Risk for developing cancer or suspicious clinical findings.
  • - No history of cancer (normal control registry) - Able to provide informed consent.
  • - 19 years of age or older.
  • - English or Spanish speaking individuals.
Exclusion Criteria.
  • - Unable to provide informed consent because of cognitive impairment.
- Non-English or non-Spanish speaking individuals

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT02012699
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

University of Nebraska
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Quan Ly, MD
Principal Investigator Affiliation University of Nebraska
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Recruiting
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, Gastrointestinal Stromal Tumors, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, Central Nervous System Tumor, Central Nervous System Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control
Study Website: View Trial Website
Additional Details

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2.unmc.edu) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically interoperable and easily customizable cancer data resource, which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: Pancreatic Cancer Collaborative Registry (PCCR), Breast Cancer Collaborative Registry (BCCR), Thyroid Cancer Collaborative Registry (TCCR), and Great Plains Health Informatics Database (GPHID; to enroll subjects with no history of cancer diagnosis at time of enrollment). The repository now includes: Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), Non-Melanoma Skin Cancer Registry (NMSC) and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data. The iCaRe2 provides a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; utilization of standard vocabulary and data elements; and ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Advent Health, Greenwood Village, Colorado

Status

Recruiting

Address

Advent Health

Greenwood Village, Colorado, 80111

Site Contact

Roseann Johnson

[email protected]

303-765-6840

Florida Hospital Memorial Medical Center, Daytona Beach, Florida

Status

Recruiting

Address

Florida Hospital Memorial Medical Center

Daytona Beach, Florida, 32117

Site Contact

Sandy Allten, RN

[email protected]

386-231-4023

Florida Hospital DeLand, DeLand, Florida

Status

Recruiting

Address

Florida Hospital DeLand

DeLand, Florida, 32720

Site Contact

Sandra Allten, RN,OCN,CCRP

[email protected]

386-231-3267

Florida Hospital FISH, Orange City, Florida

Status

Recruiting

Address

Florida Hospital FISH

Orange City, Florida, 32763

Site Contact

Sandy Allten, RN

[email protected]

386-231-4023

Florida Hospital Flagler, Palm Coast, Florida

Status

Recruiting

Address

Florida Hospital Flagler

Palm Coast, Florida, 32164

Site Contact

Sandy Allten, RN

[email protected]

386-231-4023

Tallahassee Memorial Hospital, Tallahassee, Florida

Status

Recruiting

Address

Tallahassee Memorial Hospital

Tallahassee, Florida, 32308

Site Contact

Justin Lee

[email protected]

701-857-3174

Rush-Copley Cancer Care Center, Aurora, Illinois

Status

Recruiting

Address

Rush-Copley Cancer Care Center

Aurora, Illinois, 60504

Site Contact

Joseph Meschi, MD

[email protected]

402-559-8885

Rush-Copley Healthcare Center, Yorkville, Illinois

Status

Recruiting

Address

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560

Site Contact

Amanda Baker, CCRP

[email protected]

630-978-6212

Parkview Research Center, Fort Wayne, Indiana

Status

Recruiting

Address

Parkview Research Center

Fort Wayne, Indiana, 46845

Site Contact

Christina Zelt

[email protected]

260-266-4153

Community Health Network, Indianapolis, Indiana

Status

Recruiting

Address

Community Health Network

Indianapolis, Indiana, 46219

Site Contact

Betsy Glowinski

[email protected]

317-497-2836

Community Cancer Center South, Indianapolis, Indiana

Status

Recruiting

Address

Community Cancer Center South

Indianapolis, Indiana, 46227

Site Contact

Betsy Glowinski

[email protected]

317-497-2836

Methodist Jennie Edmundson Hospital, Council Bluffs, Iowa

Status

Recruiting

Address

Methodist Jennie Edmundson Hospital

Council Bluffs, Iowa, 51503

Site Contact

Michael Zlomke, MD

[email protected]

712-396-4117

Covenant Medical Center, Inc, Waterloo, Iowa

Status

Recruiting

Address

Covenant Medical Center, Inc

Waterloo, Iowa, 50702

Site Contact

Karrie Cheeseman, BSN, RN

[email protected]

319-272-2388

Saint Luke's Cancer Instititue - South, Overland Park, Kansas

Status

Recruiting

Address

Saint Luke's Cancer Instititue - South

Overland Park, Kansas, 66213

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Northwest Hospital, Randallstown, Maryland

Status

Recruiting

Address

Northwest Hospital

Randallstown, Maryland, 21133

Site Contact

Judy Bosley

[email protected]

410-871-7450

William E Kahlert Regional Cancer Center, Westminster, Maryland

Status

Recruiting

Address

William E Kahlert Regional Cancer Center

Westminster, Maryland, 21157

Site Contact

Judy Bosley

[email protected]

410-871-7450

Holyoke Medical Center, Holyoke, Massachusetts

Status

Recruiting

Address

Holyoke Medical Center

Holyoke, Massachusetts, 01040

Site Contact

Lynn Downey, RHIT, CTR

[email protected]

413-534-2500

University of Michigan Health System, Ann Arbor, Michigan

Status

Completed

Address

University of Michigan Health System

Ann Arbor, Michigan, 48109

Riverwood Healthcare Center, Aitkin, Minnesota

Status

Recruiting

Address

Riverwood Healthcare Center

Aitkin, Minnesota, 56431

Site Contact

Lauren Keppeler

[email protected]

402-559-8885

Brainerd, Minnesota

Status

Recruiting

Address

Essentia Health-St. Joseph's Medical Center

Brainerd, Minnesota, 56401

Site Contact

Lauren Keppeler

[email protected]

402-559-8885

Essentia Health - Duluth Clinic, Duluth, Minnesota

Status

Recruiting

Address

Essentia Health - Duluth Clinic

Duluth, Minnesota, 55805

Site Contact

Lauren Keppeler

[email protected]

402-559-8885

St. Luke's Hospital of Duluth, Duluth, Minnesota

Status

Recruiting

Address

St. Luke's Hospital of Duluth

Duluth, Minnesota, 55805

Site Contact

Andrea Berget

[email protected]

218-249-5002

Lake Region Healthcare, Fergus Falls, Minnesota

Status

Recruiting

Address

Lake Region Healthcare

Fergus Falls, Minnesota, 56537

Site Contact

Lauren Keppeler

[email protected]

218-786-1018

Saint Luke's Cancer Institute, East, Kansas City, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute, East

Kansas City, Missouri, 64086

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Saint Luke's Cancer Institute, Kansas City, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute

Kansas City, Missouri, 64111

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Kansas City, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute, Kansas City North

Kansas City, Missouri, 64118

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Saint Luke's Cancer Institute, Liberty, Liberty, Missouri

Status

Recruiting

Address

Saint Luke's Cancer Institute, Liberty

Liberty, Missouri, 64068

Site Contact

Kelley Aldrich

[email protected]

816-287-6057

Saint Joseph, Missouri

Status

Recruiting

Address

Heartland Regional Medical Center dba Mosaic Life Care

Saint Joseph, Missouri, 64507

Site Contact

Molly Kidwell

[email protected]

816-271-7654

Bozeman Health Deaconess Hospital, Bozeman, Montana

Status

Recruiting

Address

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715

Site Contact

Adam Gott

[email protected]

406-414-3745

Logan Health, Kalispell, Montana

Status

Recruiting

Address

Logan Health

Kalispell, Montana, 59901

Site Contact

Melissa Lundbeck Kaptanian, MD

[email protected]

406-752-8669

Hastings, Nebraska

Status

Recruiting

Address

Mary Lanning Healthcare, Morrison Cancer Center

Hastings, Nebraska, 68901

Site Contact

Joan Meese

[email protected]

402-460-5899

Norfolk, Nebraska

Status

Recruiting

Address

Faith Regional Health Services, Carson Cancer Center

Norfolk, Nebraska, 68701

Site Contact

Cynthia Montgomery, RN

[email protected]

402-644-7534

Great Plains Regional Medical Center, North Platte, Nebraska

Status

Recruiting

Address

Great Plains Regional Medical Center

North Platte, Nebraska, 69101

Site Contact

Lisa Kosmacek

[email protected]

308-696-7386

Methodist Estabrook Cancer Center, Omaha, Nebraska

Status

Recruiting

Address

Methodist Estabrook Cancer Center

Omaha, Nebraska, 68114

Site Contact

Russell Smith, MD

[email protected]

402-559-8885

Nebraska Methodist Health System, Omaha, Nebraska

Status

Recruiting

Address

Nebraska Methodist Health System

Omaha, Nebraska, 68114

Site Contact

Kathryn Bartz

[email protected]

402-354-7939

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Site Contact

Michelle Desler, MS

[email protected]

402-559-8885

Regional West Health Services, Scottsbluff, Nebraska

Status

Completed

Address

Regional West Health Services

Scottsbluff, Nebraska, 69361

Glens Falls, New York

Status

Recruiting

Address

C.R. Wood Cancer Center, Glens Falls Hospital

Glens Falls, New York, 12801

Site Contact

Beth Brundage, RN, ORC

[email protected]

518-926-6701

Utica, New York

Status

Suspended

Address

Faxton St. Luke's Healthcare, Mohawk Valley

Utica, New York, 13501

Cape Fear Valley Health System, Fayetteville, North Carolina

Status

Recruiting

Address

Cape Fear Valley Health System

Fayetteville, North Carolina, 28304

Site Contact

Kenneth Manning, MD

[email protected]

402-559-8885

Essentia Health, Fargo, North Dakota

Status

Recruiting

Address

Essentia Health

Fargo, North Dakota, 58103

Site Contact

Joni Buechler-Price, MD

[email protected]

218-786-1018

Trinity Hospital Cancer Care Center, Minot, North Dakota

Status

Recruiting

Address

Trinity Hospital Cancer Care Center

Minot, North Dakota, 58701

Site Contact

Pamela Brewer

[email protected]

701-857-3163

Aultman Alliance Community Hospital, Alliance, Ohio

Status

Recruiting

Address

Aultman Alliance Community Hospital

Alliance, Ohio, 44601

Site Contact

Carla Larch

[email protected]

330-363-7412

Aultman Hospital, Canton, Ohio

Status

Recruiting

Address

Aultman Hospital

Canton, Ohio, 44710

Site Contact

Carla Larch

[email protected]

330-363-7412

University of Pittsburgh, Pittsburgh, Pennsylvania

Status

Completed

Address

University of Pittsburgh

Pittsburgh, Pennsylvania, 15323

Rutland Regional Medical Center, Rutland, Vermont

Status

Recruiting

Address

Rutland Regional Medical Center

Rutland, Vermont, 05701

Site Contact

Tonya Welch

[email protected]

802-747-1692

Bellin Memorial Hospital, Green Bay, Wisconsin

Status

Recruiting

Address

Bellin Memorial Hospital

Green Bay, Wisconsin, 54305

Site Contact

Abigail Hecker

[email protected]

920-430-4660

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