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This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Observational |
| Eligible Ages | N/A - 21 Years |
| Gender | All |
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00898755 |
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Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Children's Oncology Group |
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Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Charles P Reynolds |
| Principal Investigator Affiliation | Children's Oncology Group |
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Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Recruiting |
| Countries | Canada, United States |
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Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Central Nervous System Neoplasm, Ewing Sarcoma, Germ Cell Tumor, Leukemia, Lymphoma, Malignant Neoplasm, Neuroblastoma, Osteosarcoma, Retinoblastoma, Rhabdoid Tumor, Rhabdomyosarcoma, Soft Tissue Sarcoma |
PRIMARY OBJECTIVES:
: Ancillary-Correlative (tissue sample collection)
Leftover tissue from diagnostic procedures and/or surgery is cryopreserved and banked. Blood and/or bone marrow are also collected and banked. Cell lines are established and characterized via reverse-transcriptase polymerase chain reaction and/or flow cytometry for biomarkers and by DNA fingerprinting. Markers to be identified may include the following: NEUROBLASTOMA: tyrosine hydroxylase, protein gene product (PGP) 9.5, GD2, HLA class I, and HSAN 1.2 antigens EWING FAMILY OF TUMORS: EWS-FLI1, EWS-ERG, and PGP 9.5 RETINOBLASTOMA: interphotoreceptor retinoid-binding protein ACUTE LYMPHOBLASTIC LEUKEMIA: immunophenotype ALVEOLOR RHADOMYOSARCOMA: PAX3-FKHR, PAX7-FKHR, and MyoD1 ALL CELL TYPES: telomerase expression including hTR and hTERTMutations of TP53 gene are detected by flow cytometry and/or immunocytochemistry
Other: - Cytology Specimen Collection Procedure
Correlative studies
Other: - Laboratory Biomarker Analysis
Correlative studies
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Children's Hospital of Alabama
Birmingham, Alabama, 35233
Status
Active, not recruiting
Address
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
Status
Recruiting
Address
Arkansas Children's Hospital
Little Rock, Arkansas, 72202-3591
Status
Active, not recruiting
Address
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Status
Recruiting
Address
Kaiser Permanente Downey Medical Center
Downey, California, 90242
Status
Active, not recruiting
Address
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
Status
Recruiting
Address
Miller Children's and Women's Hospital Long Beach
Long Beach, California, 90806
Status
Recruiting
Address
Children's Hospital Los Angeles
Los Angeles, California, 90027
Status
Recruiting
Address
Children's Hospital and Research Center at Oakland
Oakland, California, 94609-1809
Status
Recruiting
Address
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver, Colorado, 80218
Status
Recruiting
Address
Connecticut Children's Medical Center
Hartford, Connecticut, 06106
Status
Recruiting
Address
MedStar Georgetown University Hospital
Washington, District of Columbia, 20007
Status
Active, not recruiting
Address
Lee Memorial Health System
Fort Myers, Florida, 33901
Status
Recruiting
Address
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908
Status
Active, not recruiting
Address
Johns Hopkins All Children's Hospital
Saint Petersburg, Florida, 33701
Status
Active, not recruiting
Address
Tampa General Hospital
Tampa, Florida, 33606
Status
Active, not recruiting
Address
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, 33607
Status
Recruiting
Address
Saint Mary's Hospital
West Palm Beach, Florida, 33407
Status
Active, not recruiting
Address
Saint Luke's Mountain States Tumor Institute
Boise, Idaho, 83712
Status
Recruiting
Address
University of Illinois
Chicago, Illinois, 60612
Status
Recruiting
Address
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637
Status
Recruiting
Address
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Status
Active, not recruiting
Address
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
Status
Recruiting
Address
Norton Children's Hospital
Louisville, Kentucky, 40202
Status
Suspended
Address
Tulane University Health Sciences Center
New Orleans, Louisiana, 70112
Status
Recruiting
Address
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
Status
Recruiting
Address
Sinai Hospital of Baltimore
Baltimore, Maryland, 21215
Status
Active, not recruiting
Address
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
Status
Active, not recruiting
Address
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Status
Recruiting
Address
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201
Status
Recruiting
Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
Status
Active, not recruiting
Address
Kalamazoo Center for Medical Studies
Kalamazoo, Michigan, 49008
Status
Recruiting
Address
Columbia Regional
Columbia, Missouri, 65201
Status
Withdrawn
Address
University of Missouri - Ellis Fischel
Columbia, Missouri, 65212
Status
Active, not recruiting
Address
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108
Status
Recruiting
Address
Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, 68114
Status
Recruiting
Address
University of Nebraska Medical Center
Omaha, Nebraska, 68198
Status
Recruiting
Address
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102
Status
Recruiting
Address
Nevada Cancer Research Foundation CCOP
Las Vegas, Nevada, 89106
Status
Recruiting
Address
Sunrise Hospital and Medical Center
Las Vegas, Nevada, 89109
Status
Recruiting
Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135
Status
Recruiting
Address
Summerlin Hospital Medical Center
Las Vegas, Nevada, 89144
Status
Recruiting
Address
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Status
Recruiting
Address
Morristown Medical Center
Morristown, New Jersey, 07960
Status
Active, not recruiting
Address
Overlook Hospital
Summit, New Jersey, 07902
Status
Recruiting
Address
Albany Medical Center
Albany, New York, 12208
Status
Recruiting
Address
Montefiore Medical Center - Moses Campus
Bronx, New York, 10467
Status
Recruiting
Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
Status
Active, not recruiting
Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
Status
Recruiting
Address
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Status
Recruiting
Address
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308
Status
Recruiting
Address
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, 44106
Status
Active, not recruiting
Address
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Status
Recruiting
Address
Dayton Children's Hospital
Dayton, Ohio, 45404
Status
Recruiting
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Status
Recruiting
Address
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224
Status
Recruiting
Address
BI-LO Charities Children's Cancer Center
Greenville, South Carolina, 29605
Status
Active, not recruiting
Address
Greenville Cancer Treatment Center
Greenville, South Carolina, 29605
Status
Recruiting
Address
East Tennessee Childrens Hospital
Knoxville, Tennessee, 37916
Status
Recruiting
Address
Texas Tech University Health Sciences Center-Amarillo
Amarillo, Texas, 79106
Status
Recruiting
Address
Driscoll Children's Hospital
Corpus Christi, Texas, 78411
Status
Recruiting
Address
Covenant Children's Hospital
Lubbock, Texas, 79410
Status
Recruiting
Address
UMC Cancer Center / UMC Health System
Lubbock, Texas, 79415
Status
Recruiting
Address
Methodist Children's Hospital of South Texas
San Antonio, Texas, 78229
Status
Active, not recruiting
Address
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
Status
Recruiting
Address
Madigan Army Medical Center
Tacoma, Washington, 98431
Status
Recruiting
Address
British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4
Status
Active, not recruiting
Address
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, H3T 1C5
Status
Active, not recruiting
Address
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
