Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

Study Purpose

Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Pre-Registration

Inclusion Criteria:

  • - United States (US) and Canadian sites: * This review is mandatory prior to registration to confirm eligibility; patients must be willing to submit tissue samples for mandatory central pathology review submission; it should be initiated as soon after surgery as possible.
  • - Tissue must have been determined to have local 1p/9q co-deletion and IDH mutation prior to submission for central path review.
  • - Tumor tissue must show co-deletion of chromosomes 1p and 19q; for eligibility, the 1p/19q analysis results will be accepted from the local site, as determined by either a locally available or reference laboratory (for US, must be Clinical Laboratory Improvement Act [CLIA] certified); acceptable methods for determination of 1p/19q loss include fluorescent in-situ hybridization (FISH), by genomic sequencing or methylomic analyses; US and Canadian sites must send a copy of the official report to the pathology coordinator and quality assurance specialist (QAS) - Tumor must also show evidence of IDH mutation by immunohistochemistry or genomic analyses; this should be performed at the local site (US: performed in a CLIA certified laboratory); the site must send a copy of the official report to the pathology coordinator and QAS.
Registration

Inclusion Criteria:

  • - Newly diagnosed and =< 3 months from surgical diagnosis; patients are also eligible if they have had a prior surgical procedure > 3 months earlier for low grade glioma, as long as the patient has not received prior radiation or prior chemotherapy.
  • - Histological evidence of World Health Organization (WHO) grade III anaplastic glioma or WHO grade II low grade glioma with locally diagnosed combined 1p/19q loss and the presence of an either IDH1 or IDH2, both as established by a local or referenced laboratory qualified for the study.
* Note: mixed gliomas are eligible, regardless of the degree of astrocytic or oligodendrocytic predominance, as long as the tumor is also co-deleted for 1p and 19q.
  • - Patients with codeleted low grade gliomas must also be considered "high risk" by exhibiting one or more of the following characteristics: - Age >= 40 and any surgical therapy.
  • - Age < 40 with prior and subtotal resection or biopsy (i.e., anything less than gross total resection) - Documented growth following prior surgery (NOTE: patients with prior surgery cannot have received prior radiation, chemotherapy or targeted therapy) - Intractable seizures.
  • - Surgery (partial or gross total resection or biopsy) must be performed >= 2 weeks prior to registration; patient must have recovered adequately from the effects of surgery.
  • - Absolute neutrophil count (ANC) >= 1,500/mm^3 obtained =< 21 days prior to registration.
  • - Platelet (PLTs) count >= 100,000/mm^3 obtained =< 21 days prior to registration.
  • - Hemoglobin (Hgb) > 9.0 g/dL obtained =< 21 days prior to registration.
  • - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) obtained =< 21 days prior to registration.
  • - Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 3 x ULN obtained =< 21 days prior to registration.
  • - Creatinine =< 1.5 x ULN obtained =< 21 days prior to registration.
  • - Negative serum or urine pregnancy test done =< 7 days prior to registration, for women of childbearing potential only.
  • - Willingness and ability to personally complete neurocognitive testing (without assistance) and willingness to complete the QOL testing, (either personally or with assistance) - Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1 or 2.
  • - Written informed consent.
  • - Willingness to return to enrolling institution for follow-up during the active monitoring phase (that is, the active treatment and observation portion) of the study); patients who have been formally transferred to another active and approved site participating in this study would not need to return to the enrolling institution for this purpose.
  • - Willingness to allow the provision of tissue samples for correlative research, as long as adequate tissues are available; patients will not be excluded from participation in the study, if they are willing to allow provision of tissues for the correlative research, but there are insufficient quantities of tissue for the correlative analyses (e.g., a patient otherwise eligible and willing who had biopsy only) Willingness to allow the provision of blood samples for correlative research; patients are not excluded from participation in the study, if they are willing to provide the mandatory biospecimens for translational/correlative research, but for logistical reasons the specimens(s) were not obtainable or if the volume collected was insufficient.
Registration

Exclusion Criteria:

  • - The following categories are ineligible: - Pregnant women.
  • - Nursing women.
  • - Men or women of childbearing potential who are unwilling to employ adequate contraception or contraceptive method during this study and 6 months following the completion of chemotherapy treatments.
  • - History of prior radiation therapy or chemotherapy for glioma; note: patients who have a history of prior low grade glioma (with or without a distant history of prior surgery for that glioma), but who have never received prior chemotherapy or radiation therapy for the glioma are eligible for the study.
  • - Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
  • - Concomitant serious immunocompromised status (other than that related to concomitant steroids) that would compromise the safety of the patient on the study.
  • - Patients known to be human immunodeficiency virus (HIV) positive and currently receiving retroviral therapy are not eligible; note: patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for the study.
  • - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  • - Receiving any other investigational agent that would be considered as a treatment for the primary neoplasm.
  • - Other active malignancy within 5 years of registration; exceptions: non-melanotic skin cancer or carcinoma-in-situ of the cervix; note: if there is a history of prior malignancy, the patient is not eligible if they are receiving other specific treatment (with the exclusion of hormonal therapy or Her-2 inhibitors) for their cancer or if they have received prior total body irradiation which included the brain.
  • - History of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias.
- Recent history of hepatitis infection or if the treating physician determined that the patient would be at significant risk of reactivation of hepatitis

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT00887146
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Alliance for Clinical Trials in Oncology
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Kurt Jaeckle, MD
Principal Investigator Affiliation Mayo Clinic
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other, NIH
Overall Status Recruiting
Countries Austria, Belgium, Canada, France, Netherlands, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Brain and Central Nervous System Tumors
Study Website: View Trial Website
Additional Details

This study will be a randomized phase III for patients with newly diagnosed co-deleted 1p/19q anaplastic glioma or high risk low grade glioma. The trial will only enroll patients with 1p/19q co-deletion. This study includes two arms as described in the "Arms" section. A dynamic allocation procedure will be used to allocate an equal number of patients to different arms (Arms A:B = 1:1). This procedure will balance the marginal distributions of the stratification factors among arms. The stratification factors that will be used are cooperative groups (EORTC vs.#46; all North American groups), age (≤ 50 vs.#46; > 50), performance score (ECOG 0-1 vs.#46; 2), and tumor grade (anaplastic glioma vs.#46; low grade glioma). The primary goal is to determine whether patients who receive radiotherapy with concomitant temozolomide (TMZ) followed by adjuvant temozolomide (RT + TMZ --> TMZ) (Arm B) have a marginally better progression free survival (PFS) as compared with patients who receive radiotherapy followed by PCV chemotherapy (RT --> PCV)(Arm A). Secondary Goals: 1. Time to Progression

  • - To determine whether patients who receive (RT + TMZ --> TMZ) have a significantly longer time to progression (clinical or radiographic progression) as compared with patients who receive radiotherapy followed by adjuvant PCV chemotherapy (RT --> PCV).
2. Correlation between exploratory biomarkers and survival
  • - To determine whether there is a difference in survival based on t(1;19)(q10, p10) translocation status and MGMT promoter hypermethylation status.
3. Descriptive Comparisons of Additional Secondary Endpoints
  • - To perform descriptive comparisons of additional secondary outcome endpoints, including overall survival, objective tumor response, prognostic factor analysis and quality of life.
4. Toxicity
  • - To determine the toxicity of the treatment in each arm and perform descriptive comparisons.
5. Neurocognitive and Quality of Life (QOL) Effects
  • - To determine the neurocognitive and QOL effects in patients treated on this protocol and correlate these results with outcome endpoints.
6. Banking of Biospecimens and Neuroimaging Studies
  • - To store blood products (i.e., plasma, DNA and buffy coat), tumor tissue and MRI/CT images for future scientific investigations.
After completion of study treatment, patients are followed every 12 weeks for 1 year, then every 4 months for 2 years and then every 6 months until progressive disease or until the end of study participation.

Arms & Interventions

Arms

Experimental: Arm A (RT, procarbazine, lomustine, vincristine)

Patients undergo 3D-CRT or IMRT on days 1-5 for 5-7 weeks. Patients also receive procarbazine hydrochloride PO on days 8-21, lomustine PO on day 1 and vincristine sulfate IV on days 8 and 29 of courses 3-8. Treatment repeats every 6-7 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity.

Experimental: Arm B (RT, temozolomide)

Patients undergo RT as in arm I and receive temozolomide PO QD on days 1-5 for 5-7 weeks. Beginning 4 weeks after completion of concurrent chemoradiotherapy, patients receive adjuvant temozolomide PO QD days 1-5. Treatment with adjuvant temozolomide repeats every 4 weeks for 6-12 courses in the absence of disease progression and unacceptable toxicity.

Interventions

Drug: - concomitant temozolomide (TMZ)

75 mg/m^2, orally daily

Radiation: - radiotherapy

Drug: - procarbazine

Days 8-21: 60 mg/m^2 orally

Drug: - adjuvant temozolomide (TMZ)

150 or 200 mg/m^2 orally

Drug: - CCNU

Day 1: 110 mg/m^2 orally

Drug: - vincristine

Days 8 and 29: 1.4 mg/m^2 IV

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Birmingham, Alabama

Status

Recruiting

Address

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

Site Contact

Site Public Contact

[email protected]

205-934-0220

Providence Hospital, Mobile, Alabama

Status

Suspended

Address

Providence Hospital

Mobile, Alabama, 36608

Site Contact

904-953-7102

Anchorage, Alaska

Status

Suspended

Address

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508

Site Contact

904-953-7102

Alaska Oncology and Hematology LLC, Anchorage, Alaska

Status

Suspended

Address

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508

Site Contact

904-953-7102

Alaska Women's Cancer Care, Anchorage, Alaska

Status

Suspended

Address

Alaska Women's Cancer Care

Anchorage, Alaska, 99508

Site Contact

904-953-7102

Anchorage Oncology Centre, Anchorage, Alaska

Status

Suspended

Address

Anchorage Oncology Centre

Anchorage, Alaska, 99508

Site Contact

904-953-7102

Katmai Oncology Group, Anchorage, Alaska

Status

Suspended

Address

Katmai Oncology Group

Anchorage, Alaska, 99508

Site Contact

904-953-7102

Providence Alaska Medical Center, Anchorage, Alaska

Status

Recruiting

Address

Providence Alaska Medical Center

Anchorage, Alaska, 99508

Site Contact

Site Public Contact

[email protected]

907-212-6871

Phoenix, Arizona

Status

Recruiting

Address

Saint Joseph's Hospital and Medical Center

Phoenix, Arizona, 85013

Site Contact

Site Public Contact

877-602-4111

Arizona Oncology-Deer Valley Center, Phoenix, Arizona

Status

Suspended

Address

Arizona Oncology-Deer Valley Center

Phoenix, Arizona, 85027

Site Contact

904-953-7102

Arizona Oncology Services Foundation, Scottsdale, Arizona

Status

Suspended

Address

Arizona Oncology Services Foundation

Scottsdale, Arizona, 85260

Site Contact

904-953-7102

Kaiser Permanente-Anaheim, Anaheim, California

Status

Recruiting

Address

Kaiser Permanente-Anaheim

Anaheim, California, 92806

Site Contact

Site Public Contact

[email protected]

800-398-3996

Auburn, California

Status

Suspended

Address

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603

Site Contact

904-953-7102

Mills-Peninsula Medical Center, Burlingame, California

Status

Suspended

Address

Mills-Peninsula Medical Center

Burlingame, California, 94010

Site Contact

904-953-7102

Cameron Park, California

Status

Suspended

Address

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682

Site Contact

904-953-7102

Community Cancer Institute, Clovis, California

Status

Active, not recruiting

Address

Community Cancer Institute

Clovis, California, 93611

Site Contact

904-953-7102

University Oncology Associates, Clovis, California

Status

Active, not recruiting

Address

University Oncology Associates

Clovis, California, 93611

Site Contact

904-953-7102

UC San Diego Moores Cancer Center, La Jolla, California

Status

Recruiting

Address

UC San Diego Moores Cancer Center

La Jolla, California, 92093

Site Contact

Site Public Contact

[email protected]

858-822-5354

Los Angeles, California

Status

Recruiting

Address

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027

Site Contact

Site Public Contact

[email protected]

800-398-3996

Cedars Sinai Medical Center, Los Angeles, California

Status

Active, not recruiting

Address

Cedars Sinai Medical Center

Los Angeles, California, 90048

Site Contact

904-953-7102

Memorial Medical Center, Modesto, California

Status

Suspended

Address

Memorial Medical Center

Modesto, California, 95355

Site Contact

904-953-7102

Kaiser Permanente Oakland-Broadway, Oakland, California

Status

Suspended

Address

Kaiser Permanente Oakland-Broadway

Oakland, California, 94611

Site Contact

904-953-7102

Kaiser Permanente-Ontario, Ontario, California

Status

Recruiting

Address

Kaiser Permanente-Ontario

Ontario, California, 91761

Site Contact

Site Public Contact

[email protected]

800-398-3996

Orange, California

Status

Recruiting

Address

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868

Site Contact

Site Public Contact

[email protected]

877-827-8839

Roseville, California

Status

Recruiting

Address

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661

Site Contact

Site Public Contact

[email protected]

904-953-7102

Sutter Roseville Medical Center, Roseville, California

Status

Suspended

Address

Sutter Roseville Medical Center

Roseville, California, 95661

Site Contact

904-953-7102

Sutter Medical Center Sacramento, Sacramento, California

Status

Recruiting

Address

Sutter Medical Center Sacramento

Sacramento, California, 95816

Site Contact

Site Public Contact

[email protected]

904-953-7102

Sacramento, California

Status

Recruiting

Address

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

Site Contact

Site Public Contact

916-734-3089

Santa Clara, California

Status

Suspended

Address

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051

Site Contact

904-953-7102

Kaiser Permanente-South San Francisco, South San Francisco, California

Status

Suspended

Address

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080

Site Contact

904-953-7102

Vacaville, California

Status

Suspended

Address

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, 95687

Site Contact

904-953-7102

Vallejo, California

Status

Suspended

Address

Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589

Site Contact

904-953-7102

The Medical Center of Aurora, Aurora, Colorado

Status

Active, not recruiting

Address

The Medical Center of Aurora

Aurora, Colorado, 80012

Site Contact

904-953-7102

UCHealth University of Colorado Hospital, Aurora, Colorado

Status

Active, not recruiting

Address

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045

Site Contact

904-953-7102

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado

Status

Recruiting

Address

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907

Site Contact

Site Public Contact

[email protected]

720-874-1881

Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado

Status

Recruiting

Address

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907

Site Contact

Site Public Contact

[email protected]

720-874-1881

UCHealth Memorial Hospital Central, Colorado Springs, Colorado

Status

Active, not recruiting

Address

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909

Site Contact

904-953-7102

Saint Francis Cancer Center, Colorado Springs, Colorado

Status

Recruiting

Address

Saint Francis Cancer Center

Colorado Springs, Colorado, 80923

Site Contact

Site Public Contact

[email protected]

720-874-1881

Porter Adventist Hospital, Denver, Colorado

Status

Recruiting

Address

Porter Adventist Hospital

Denver, Colorado, 80210

Site Contact

Site Public Contact

[email protected]

719-776-6550

Saint Anthony Hospital, Lakewood, Colorado

Status

Suspended

Address

Saint Anthony Hospital

Lakewood, Colorado, 80228

Site Contact

904-953-7102

Littleton Adventist Hospital, Littleton, Colorado

Status

Recruiting

Address

Littleton Adventist Hospital

Littleton, Colorado, 80122

Site Contact

Site Public Contact

[email protected]

719-776-6550

Longmont United Hospital, Longmont, Colorado

Status

Recruiting

Address

Longmont United Hospital

Longmont, Colorado, 80501

Site Contact

Site Public Contact

[email protected]

720-874-1881

Banner McKee Medical Center, Loveland, Colorado

Status

Suspended

Address

Banner McKee Medical Center

Loveland, Colorado, 80539

Site Contact

904-953-7102

Parker Adventist Hospital, Parker, Colorado

Status

Recruiting

Address

Parker Adventist Hospital

Parker, Colorado, 80138

Site Contact

Site Public Contact

[email protected]

719-776-6550

Saint Mary Corwin Medical Center, Pueblo, Colorado

Status

Recruiting

Address

Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004

Site Contact

Site Public Contact

[email protected]

720-874-1881

Yale University, New Haven, Connecticut

Status

Recruiting

Address

Yale University

New Haven, Connecticut, 06520

Site Contact

Site Public Contact

[email protected]

203-785-5702

Trumbull, Connecticut

Status

Recruiting

Address

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

Site Contact

Site Public Contact

[email protected]

203-785-5702

Sibley Memorial Hospital, Washington, District of Columbia

Status

Recruiting

Address

Sibley Memorial Hospital

Washington, District of Columbia, 20016

Site Contact

Site Public Contact

[email protected]

202-243-2373

Boca Raton Regional Hospital, Boca Raton, Florida

Status

Recruiting

Address

Boca Raton Regional Hospital

Boca Raton, Florida, 33486

Site Contact

Site Public Contact

561-955-4800

Gainesville, Florida

Status

Recruiting

Address

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

Site Contact

Site Public Contact

[email protected]

352-273-8010

Baptist MD Anderson Cancer Center, Jacksonville, Florida

Status

Suspended

Address

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207

Site Contact

904-953-7102

Mayo Clinic in Florida, Jacksonville, Florida

Status

Recruiting

Address

Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980

Site Contact

Site Public Contact

855-776-0015

AdventHealth Orlando, Orlando, Florida

Status

Recruiting

Address

AdventHealth Orlando

Orlando, Florida, 32803

Site Contact

Site Public Contact

[email protected]

407-303-2090

Orlando Health Cancer Institute, Orlando, Florida

Status

Recruiting

Address

Orlando Health Cancer Institute

Orlando, Florida, 32806

Site Contact

Site Public Contact

[email protected]

321-841-7246

Emory Proton Therapy Center, Atlanta, Georgia

Status

Suspended

Address

Emory Proton Therapy Center

Atlanta, Georgia, 30308

Site Contact

904-953-7102

Emory University Hospital Midtown, Atlanta, Georgia

Status

Suspended

Address

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Site Contact

904-953-7102

Piedmont Hospital, Atlanta, Georgia

Status

Active, not recruiting

Address

Piedmont Hospital

Atlanta, Georgia, 30309

Site Contact

904-953-7102

Atlanta, Georgia

Status

Recruiting

Address

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

Site Contact

Site Public Contact

404-778-1868

Caldwell, Idaho

Status

Recruiting

Address

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605

Site Contact

Site Public Contact

[email protected]

734-712-3671

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho

Status

Recruiting

Address

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687

Site Contact

Site Public Contact

[email protected]

406-969-6060

Post Falls, Idaho

Status

Suspended

Address

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854

Site Contact

904-953-7102

Illinois CancerCare-Bloomington, Bloomington, Illinois

Status

Recruiting

Address

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704

Site Contact

Site Public Contact

[email protected]

309-243-3605

Illinois CancerCare-Canton, Canton, Illinois

Status

Recruiting

Address

Illinois CancerCare-Canton

Canton, Illinois, 61520

Site Contact

Site Public Contact

[email protected]

309-243-3605

Illinois CancerCare-Carthage, Carthage, Illinois

Status

Recruiting

Address

Illinois CancerCare-Carthage

Carthage, Illinois, 62321

Site Contact

Site Public Contact

[email protected]

309-243-3605

Centralia Oncology Clinic, Centralia, Illinois

Status

Suspended

Address

Centralia Oncology Clinic

Centralia, Illinois, 62801

Site Contact

904-953-7102

Northwestern University, Chicago, Illinois

Status

Active, not recruiting

Address

Northwestern University

Chicago, Illinois, 60611

Site Contact

904-953-7102

University of Illinois, Chicago, Illinois

Status

Recruiting

Address

University of Illinois

Chicago, Illinois, 60612

Site Contact

Site Public Contact

312-355-3046

Chicago, Illinois

Status

Suspended

Address

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

Site Contact

904-953-7102

Decatur, Illinois

Status

Suspended

Address

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526

Site Contact

904-953-7102

Decatur Memorial Hospital, Decatur, Illinois

Status

Recruiting

Address

Decatur Memorial Hospital

Decatur, Illinois, 62526

Site Contact

Site Public Contact

[email protected]

217-876-4762

Crossroads Cancer Center, Effingham, Illinois

Status

Recruiting

Address

Crossroads Cancer Center

Effingham, Illinois, 62401

Site Contact

Site Public Contact

[email protected]

217-876-4762

Illinois CancerCare-Eureka, Eureka, Illinois

Status

Recruiting

Address

Illinois CancerCare-Eureka

Eureka, Illinois, 61530

Site Contact

Site Public Contact

[email protected]

309-243-3605

Illinois CancerCare-Galesburg, Galesburg, Illinois

Status

Recruiting

Address

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401

Site Contact

Site Public Contact

[email protected]

309-243-3605

Western Illinois Cancer Treatment Center, Galesburg, Illinois

Status

Suspended

Address

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401

Site Contact

904-953-7102

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois

Status

Recruiting

Address

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443

Site Contact

Site Public Contact

[email protected]

309-243-3605

AMITA Health Adventist Medical Center, La Grange, Illinois

Status

Active, not recruiting

Address

AMITA Health Adventist Medical Center

La Grange, Illinois, 60525

Site Contact

904-953-7102

Illinois CancerCare-Macomb, Macomb, Illinois

Status

Recruiting

Address

Illinois CancerCare-Macomb

Macomb, Illinois, 61455

Site Contact

Site Public Contact

[email protected]

309-243-3605

Loyola University Medical Center, Maywood, Illinois

Status

Recruiting

Address

Loyola University Medical Center

Maywood, Illinois, 60153

Site Contact

Site Public Contact

708-226-4357

Cancer Care Center of O'Fallon, O'Fallon, Illinois

Status

Suspended

Address

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269

Site Contact

904-953-7102

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois

Status

Recruiting

Address

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350

Site Contact

Site Public Contact

[email protected]

309-243-3605

Advocate Lutheran General Hospital, Park Ridge, Illinois

Status

Active, not recruiting

Address

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068

Site Contact

904-953-7102

Illinois CancerCare-Pekin, Pekin, Illinois

Status

Recruiting

Address

Illinois CancerCare-Pekin

Pekin, Illinois, 61554

Site Contact

Site Public Contact

[email protected]

309-243-3605

Pekin, Illinois

Status

Recruiting

Address

OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554

Site Contact

Site Public Contact

[email protected]

309-243-3605

Illinois CancerCare-Peoria, Peoria, Illinois

Status

Recruiting

Address

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

Site Contact

Site Public Contact

[email protected]

309-243-3605

Peoria, Illinois

Status

Recruiting

Address

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615

Site Contact

Site Public Contact

[email protected]

309-243-3605

Methodist Medical Center of Illinois, Peoria, Illinois

Status

Suspended

Address

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

Site Contact

904-953-7102

OSF Saint Francis Medical Center, Peoria, Illinois

Status

Recruiting

Address

OSF Saint Francis Medical Center

Peoria, Illinois, 61637

Site Contact

Site Public Contact

[email protected]

309-243-3605

Illinois CancerCare-Peru, Peru, Illinois

Status

Recruiting

Address

Illinois CancerCare-Peru

Peru, Illinois, 61354

Site Contact

Site Public Contact

[email protected]

309-243-3605

Valley Radiation Oncology, Peru, Illinois

Status

Suspended

Address

Valley Radiation Oncology

Peru, Illinois, 61354

Site Contact

904-953-7102

Illinois CancerCare-Princeton, Princeton, Illinois

Status

Recruiting

Address

Illinois CancerCare-Princeton

Princeton, Illinois, 61356

Site Contact

Site Public Contact

[email protected]

309-243-3605

Memorial Medical Center, Springfield, Illinois

Status

Recruiting

Address

Memorial Medical Center

Springfield, Illinois, 62781

Site Contact

Site Public Contact

[email protected]

217-528-7541

Parkview Hospital Randallia, Fort Wayne, Indiana

Status

Active, not recruiting

Address

Parkview Hospital Randallia

Fort Wayne, Indiana, 46805

Site Contact

904-953-7102

Parkview Regional Medical Center, Fort Wayne, Indiana

Status

Active, not recruiting

Address

Parkview Regional Medical Center

Fort Wayne, Indiana, 46845

Site Contact

904-953-7102

Memorial Regional Cancer Center Day Road, Mishawaka, Indiana

Status

Suspended

Address

Memorial Regional Cancer Center Day Road

Mishawaka, Indiana, 46545

Site Contact

904-953-7102

Memorial Hospital of South Bend, South Bend, Indiana

Status

Suspended

Address

Memorial Hospital of South Bend

South Bend, Indiana, 46601

Site Contact

904-953-7102

McFarland Clinic - Ames, Ames, Iowa

Status

Active, not recruiting

Address

McFarland Clinic - Ames

Ames, Iowa, 50010

Site Contact

904-953-7102

Mercy Cancer Center-West Lakes, Clive, Iowa

Status

Recruiting

Address

Mercy Cancer Center-West Lakes

Clive, Iowa, 50325

Site Contact

Site Public Contact

[email protected]

515-358-6613

Clive, Iowa

Status

Suspended

Address

Mission Cancer and Blood - West Des Moines

Clive, Iowa, 50325

Site Contact

904-953-7102

Greater Regional Medical Center, Creston, Iowa

Status

Recruiting

Address

Greater Regional Medical Center

Creston, Iowa, 50801

Site Contact

Site Public Contact

[email protected]

515-358-6613

Iowa Methodist Medical Center, Des Moines, Iowa

Status

Recruiting

Address

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

Site Contact

Site Public Contact

515-241-6727

Mission Cancer and Blood - Des Moines, Des Moines, Iowa

Status

Suspended

Address

Mission Cancer and Blood - Des Moines

Des Moines, Iowa, 50309

Site Contact

904-953-7102

Broadlawns Medical Center, Des Moines, Iowa

Status

Suspended

Address

Broadlawns Medical Center

Des Moines, Iowa, 50314

Site Contact

904-953-7102

Mercy Medical Center - Des Moines, Des Moines, Iowa

Status

Recruiting

Address

Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314

Site Contact

Site Public Contact

[email protected]

515-358-6613

Mission Cancer and Blood - Laurel, Des Moines, Iowa

Status

Suspended

Address

Mission Cancer and Blood - Laurel

Des Moines, Iowa, 50314

Site Contact

904-953-7102

Iowa Lutheran Hospital, Des Moines, Iowa

Status

Suspended

Address

Iowa Lutheran Hospital

Des Moines, Iowa, 50316

Site Contact

904-953-7102

Methodist West Hospital, West Des Moines, Iowa

Status

Suspended

Address

Methodist West Hospital

West Des Moines, Iowa, 50266-7700

Site Contact

904-953-7102

Mercy Medical Center-West Lakes, West Des Moines, Iowa

Status

Suspended

Address

Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266

Site Contact

904-953-7102

University of Kansas Cancer Center, Kansas City, Kansas

Status

Recruiting

Address

University of Kansas Cancer Center

Kansas City, Kansas, 66160

Site Contact

Site Public Contact

[email protected]

913-588-3671

Overland Park, Kansas

Status

Recruiting

Address

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210

Site Contact

Site Public Contact

[email protected]

913-588-3671

Overland Park, Kansas

Status

Recruiting

Address

University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211

Site Contact

Site Public Contact

[email protected]

913-588-3671

Westwood, Kansas

Status

Recruiting

Address

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205

Site Contact

Site Public Contact

[email protected]

913-588-3671

Lexington, Kentucky

Status

Recruiting

Address

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Site Contact

Site Public Contact

859-257-3379

Louisville, Kentucky

Status

Recruiting

Address

Norton Hospital Pavilion and Medical Campus

Louisville, Kentucky, 40202

Site Contact

Site Public Contact

[email protected]

502-629-2500

Louisville, Kentucky

Status

Recruiting

Address

Norton Brownsboro Hospital and Medical Campus

Louisville, Kentucky, 40241

Site Contact

Site Public Contact

[email protected]

888-823-5923

West Jefferson Medical Center, Marrero, Louisiana

Status

Recruiting

Address

West Jefferson Medical Center

Marrero, Louisiana, 70072

Site Contact

Site Public Contact

[email protected]

504-210-3539

Maine Medical Center-Bramhall Campus, Portland, Maine

Status

Active, not recruiting

Address

Maine Medical Center-Bramhall Campus

Portland, Maine, 04102

Site Contact

904-953-7102

Maine Medical Center- Scarborough Campus, Scarborough, Maine

Status

Recruiting

Address

Maine Medical Center- Scarborough Campus

Scarborough, Maine, 04074

Site Contact

Site Public Contact

[email protected]

207-396-8090

Maine Medical Partners Neurology, Scarborough, Maine

Status

Suspended

Address

Maine Medical Partners Neurology

Scarborough, Maine, 04074

Site Contact

904-953-7102

Maine Medical Partners - South Portland, South Portland, Maine

Status

Suspended

Address

Maine Medical Partners - South Portland

South Portland, Maine, 04106

Site Contact

904-953-7102

Baltimore, Maryland

Status

Recruiting

Address

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Site Contact

Site Public Contact

[email protected]

410-955-8804

Bethesda, Maryland

Status

Recruiting

Address

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600

Site Contact

Site Public Contact

301-319-2100

Cancer Trials Support Unit, Rockville, Maryland

Status

Recruiting

Address

Cancer Trials Support Unit

Rockville, Maryland, 20850-2062

Site Contact

Kurt A. Jaeckle

904-953-7102

Boston, Massachusetts

Status

Suspended

Address

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114

Site Contact

904-953-7102

Bixby Medical Center, Adrian, Michigan

Status

Active, not recruiting

Address

Bixby Medical Center

Adrian, Michigan, 49221

Site Contact

904-953-7102

Ann Arbor, Michigan

Status

Recruiting

Address

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109

Site Contact

Site Public Contact

800-865-1125

Henry Ford Hospital, Detroit, Michigan

Status

Active, not recruiting

Address

Henry Ford Hospital

Detroit, Michigan, 48202

Site Contact

904-953-7102

Grand Rapids, Michigan

Status

Recruiting

Address

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503

Site Contact

Site Public Contact

[email protected]

616-391-1230

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan

Status

Suspended

Address

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503

Site Contact

904-953-7102

West Michigan Cancer Center, Kalamazoo, Michigan

Status

Recruiting

Address

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

Site Contact

Site Public Contact

[email protected]

616-391-1230

William Beaumont Hospital-Royal Oak, Royal Oak, Michigan

Status

Active, not recruiting

Address

William Beaumont Hospital-Royal Oak

Royal Oak, Michigan, 48073

Site Contact

904-953-7102

Munson Medical Center, Traverse City, Michigan

Status

Recruiting

Address

Munson Medical Center

Traverse City, Michigan, 49684

Site Contact

Site Public Contact

[email protected]

616-391-1230

William Beaumont Hospital - Troy, Troy, Michigan

Status

Active, not recruiting

Address

William Beaumont Hospital - Troy

Troy, Michigan, 48085

Site Contact

904-953-7102

University of Michigan Health - West, Wyoming, Michigan

Status

Recruiting

Address

University of Michigan Health - West

Wyoming, Michigan, 49519

Site Contact

Site Public Contact

[email protected]

616-391-1230

Fairview Ridges Hospital, Burnsville, Minnesota

Status

Suspended

Address

Fairview Ridges Hospital

Burnsville, Minnesota, 55337

Site Contact

904-953-7102

Mercy Hospital, Coon Rapids, Minnesota

Status

Recruiting

Address

Mercy Hospital

Coon Rapids, Minnesota, 55433

Site Contact

Site Public Contact

[email protected]

952-993-1517

Essentia Health Cancer Center, Duluth, Minnesota

Status

Suspended

Address

Essentia Health Cancer Center

Duluth, Minnesota, 55805

Site Contact

904-953-7102

Miller-Dwan Hospital, Duluth, Minnesota

Status

Recruiting

Address

Miller-Dwan Hospital

Duluth, Minnesota, 55805

Site Contact

Site Public Contact

[email protected]

218-786-3308

Fairview Southdale Hospital, Edina, Minnesota

Status

Recruiting

Address

Fairview Southdale Hospital

Edina, Minnesota, 55435

Site Contact

Site Public Contact

[email protected]

952-993-1517

Unity Hospital, Fridley, Minnesota

Status

Active, not recruiting

Address

Unity Hospital

Fridley, Minnesota, 55432

Site Contact

904-953-7102

Maplewood, Minnesota

Status

Recruiting

Address

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109

Site Contact

Site Public Contact

[email protected]

952-993-1517

Saint John's Hospital - Healtheast, Maplewood, Minnesota

Status

Recruiting

Address

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109

Site Contact

Site Public Contact

[email protected]

952-993-1517

Abbott-Northwestern Hospital, Minneapolis, Minnesota

Status

Recruiting

Address

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407

Site Contact

Site Public Contact

[email protected]

952-993-1517

Hennepin County Medical Center, Minneapolis, Minnesota

Status

Recruiting

Address

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

Site Contact

Site Public Contact

[email protected]

952-993-1517

North Memorial Medical Health Center, Robbinsdale, Minnesota

Status

Recruiting

Address

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422

Site Contact

Site Public Contact

[email protected]

952-993-1517

Mayo Clinic in Rochester, Rochester, Minnesota

Status

Recruiting

Address

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

Site Contact

Site Public Contact

855-776-0015

Saint Cloud, Minnesota

Status

Recruiting

Address

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303

Site Contact

Site Public Contact

[email protected]

877-229-4907

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota

Status

Recruiting

Address

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

Site Contact

Site Public Contact

[email protected]

952-993-1517

Regions Hospital, Saint Paul, Minnesota

Status

Recruiting

Address

Regions Hospital

Saint Paul, Minnesota, 55101

Site Contact

Site Public Contact

[email protected]

952-993-1517

United Hospital, Saint Paul, Minnesota

Status

Recruiting

Address

United Hospital

Saint Paul, Minnesota, 55102

Site Contact

Site Public Contact

[email protected]

952-993-1517

Saint Francis Regional Medical Center, Shakopee, Minnesota

Status

Suspended

Address

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379

Site Contact

904-953-7102

Lakeview Hospital, Stillwater, Minnesota

Status

Suspended

Address

Lakeview Hospital

Stillwater, Minnesota, 55082

Site Contact

904-953-7102

Ridgeview Medical Center, Waconia, Minnesota

Status

Recruiting

Address

Ridgeview Medical Center

Waconia, Minnesota, 55387

Site Contact

Site Public Contact

[email protected]

952-993-1517

Rice Memorial Hospital, Willmar, Minnesota

Status

Suspended

Address

Rice Memorial Hospital

Willmar, Minnesota, 56201

Site Contact

904-953-7102

Woodbury, Minnesota

Status

Suspended

Address

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125

Site Contact

904-953-7102

Saint Francis Medical Center, Cape Girardeau, Missouri

Status

Recruiting

Address

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

Site Contact

Site Public Contact

[email protected]

573-334-2230

Columbia, Missouri

Status

Recruiting

Address

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212

Site Contact

Site Public Contact

573-882-7440

Kansas City, Missouri

Status

Recruiting

Address

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154

Site Contact

Site Public Contact

[email protected]

913-588-3671

Lee's Summit, Missouri

Status

Recruiting

Address

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064

Site Contact

Site Public Contact

[email protected]

913-588-3671

North Kansas City, Missouri

Status

Recruiting

Address

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116

Site Contact

Site Public Contact

[email protected]

913-588-3671

Washington University School of Medicine, Saint Louis, Missouri

Status

Recruiting

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Site Contact

Site Public Contact

[email protected]

800-600-3606

Mercy Hospital Saint Louis, Saint Louis, Missouri

Status

Recruiting

Address

Mercy Hospital Saint Louis

Saint Louis, Missouri, 63141

Site Contact

Site Public Contact

314-251-7066

Billings Clinic Cancer Center, Billings, Montana

Status

Recruiting

Address

Billings Clinic Cancer Center

Billings, Montana, 59101

Site Contact

Site Public Contact

[email protected]

800-996-2663

Saint Vincent Healthcare, Billings, Montana

Status

Suspended

Address

Saint Vincent Healthcare

Billings, Montana, 59101

Site Contact

904-953-7102

Benefis Sletten Cancer Institute, Great Falls, Montana

Status

Recruiting

Address

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405

Site Contact

Site Public Contact

[email protected]

406-969-6060

Great Falls Clinic, Great Falls, Montana

Status

Recruiting

Address

Great Falls Clinic

Great Falls, Montana, 59405

Site Contact

Site Public Contact

[email protected]

406-969-6060

Grand Island, Nebraska

Status

Suspended

Address

Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803

Site Contact

904-953-7102

CHI Health Good Samaritan, Kearney, Nebraska

Status

Suspended

Address

CHI Health Good Samaritan

Kearney, Nebraska, 68847

Site Contact

904-953-7102

Nebraska Hematology and Oncology, Lincoln, Nebraska

Status

Suspended

Address

Nebraska Hematology and Oncology

Lincoln, Nebraska, 68506

Site Contact

904-953-7102

Cancer Partners of Nebraska, Lincoln, Nebraska

Status

Suspended

Address

Cancer Partners of Nebraska

Lincoln, Nebraska, 68516

Site Contact

904-953-7102

Missouri Valley Cancer Consortium, Omaha, Nebraska

Status

Recruiting

Address

Missouri Valley Cancer Consortium

Omaha, Nebraska, 68106

Site Contact

Gamini S. Soori

[email protected]

402-991-8070 #202

Alegent Health Immanuel Medical Center, Omaha, Nebraska

Status

Suspended

Address

Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122

Site Contact

904-953-7102

Omaha, Nebraska

Status

Recruiting

Address

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124

Site Contact

Site Public Contact

[email protected]

720-874-1881

Nebraska Cancer Specialists - Omaha, Omaha, Nebraska

Status

Suspended

Address

Nebraska Cancer Specialists - Omaha

Omaha, Nebraska, 68124

Site Contact

904-953-7102

Alegent Health Lakeside Hospital, Omaha, Nebraska

Status

Suspended

Address

Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130

Site Contact

904-953-7102

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Site Contact

Site Public Contact

[email protected]

402-559-6941

Midlands Community Hospital, Papillion, Nebraska

Status

Suspended

Address

Midlands Community Hospital

Papillion, Nebraska, 68046

Site Contact

904-953-7102

Scottsbluff, Nebraska

Status

Suspended

Address

Regional West Medical Center Cancer Center

Scottsbluff, Nebraska, 69361

Site Contact

904-953-7102

Las Vegas, Nevada

Status

Recruiting

Address

Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106

Site Contact

Site Public Contact

[email protected]

702-384-0013

GenesisCare USA - Las Vegas, Las Vegas, Nevada

Status

Suspended

Address

GenesisCare USA - Las Vegas

Las Vegas, Nevada, 89109

Site Contact

904-953-7102

Las Vegas, Nevada

Status

Recruiting

Address

Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119

Site Contact

Site Public Contact

[email protected]

702-384-0013

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada

Status

Suspended

Address

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148

Site Contact

904-953-7102

Las Vegas, Nevada

Status

Recruiting

Address

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169

Site Contact

Site Public Contact

[email protected]

702-384-0013

Renown Regional Medical Center, Reno, Nevada

Status

Recruiting

Address

Renown Regional Medical Center

Reno, Nevada, 89502

Site Contact

Site Public Contact

[email protected]

702-384-0013

Saint Mary's Regional Medical Center, Reno, Nevada

Status

Recruiting

Address

Saint Mary's Regional Medical Center

Reno, Nevada, 89503

Site Contact

Site Public Contact

[email protected]

702-384-0013

Radiation Oncology Associates, Reno, Nevada

Status

Suspended

Address

Radiation Oncology Associates

Reno, Nevada, 89509

Site Contact

904-953-7102

Lebanon, New Hampshire

Status

Recruiting

Address

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756

Site Contact

Site Public Contact

[email protected]

800-639-6918

Jersey Shore Medical Center, Neptune, New Jersey

Status

Recruiting

Address

Jersey Shore Medical Center

Neptune, New Jersey, 07753

Site Contact

Site Public Contact

732-776-4240

New Brunswick, New Jersey

Status

Active, not recruiting

Address

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903

Site Contact

904-953-7102

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Status

Active, not recruiting

Address

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903

Site Contact

904-953-7102

Overlook Hospital, Summit, New Jersey

Status

Active, not recruiting

Address

Overlook Hospital

Summit, New Jersey, 07902

Site Contact

904-953-7102

University of New Mexico Cancer Center, Albuquerque, New Mexico

Status

Recruiting

Address

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106

Site Contact

Site Public Contact

[email protected]

505-925-0348

Brooklyn, New York

Status

Active, not recruiting

Address

New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215

Site Contact

904-953-7102

New York, New York

Status

Active, not recruiting

Address

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

Site Contact

904-953-7102

Highland Hospital, Rochester, New York

Status

Suspended

Address

Highland Hospital

Rochester, New York, 14620

Site Contact

904-953-7102

University of Rochester, Rochester, New York

Status

Recruiting

Address

University of Rochester

Rochester, New York, 14642

Site Contact

Site Public Contact

585-275-5830

Syracuse, New York

Status

Active, not recruiting

Address

State University of New York Upstate Medical University

Syracuse, New York, 13210

Site Contact

904-953-7102

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Status

Active, not recruiting

Address

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

Site Contact

904-953-7102

Altru Cancer Center, Grand Forks, North Dakota

Status

Recruiting

Address

Altru Cancer Center

Grand Forks, North Dakota, 58201

Site Contact

Site Public Contact

701-780-6520

Case Western Reserve University, Cleveland, Ohio

Status

Active, not recruiting

Address

Case Western Reserve University

Cleveland, Ohio, 44106

Site Contact

904-953-7102

MetroHealth Medical Center, Cleveland, Ohio

Status

Suspended

Address

MetroHealth Medical Center

Cleveland, Ohio, 44109

Site Contact

904-953-7102

Cleveland Clinic Foundation, Cleveland, Ohio

Status

Suspended

Address

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

Site Contact

904-953-7102

Columbus, Ohio

Status

Recruiting

Address

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Site Contact

Site Public Contact

[email protected]

800-293-5066

Riverside Methodist Hospital, Columbus, Ohio

Status

Recruiting

Address

Riverside Methodist Hospital

Columbus, Ohio, 43214

Site Contact

Site Public Contact

[email protected]

614-788-3860

The Mark H Zangmeister Center, Columbus, Ohio

Status

Recruiting

Address

The Mark H Zangmeister Center

Columbus, Ohio, 43219

Site Contact

Site Public Contact

[email protected]

614-488-2745

Mount Carmel Health Center West, Columbus, Ohio

Status

Suspended

Address

Mount Carmel Health Center West

Columbus, Ohio, 43222

Site Contact

904-953-7102

Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio

Status

Recruiting

Address

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124

Site Contact

Site Public Contact

[email protected]

866-223-8100

ProMedica Flower Hospital, Sylvania, Ohio

Status

Recruiting

Address

ProMedica Flower Hospital

Sylvania, Ohio, 43560

Site Contact

Site Public Contact

[email protected]

419-824-1842

Saint Ann's Hospital, Westerville, Ohio

Status

Suspended

Address

Saint Ann's Hospital

Westerville, Ohio, 43081

Site Contact

904-953-7102

Wooster, Ohio

Status

Active, not recruiting

Address

Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691

Site Contact

904-953-7102

Oklahoma City, Oklahoma

Status

Recruiting

Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Site Contact

Site Public Contact

[email protected]

405-271-8777

Tulsa, Oklahoma

Status

Recruiting

Address

Oklahoma Cancer Specialists and Research Institute-Tulsa

Tulsa, Oklahoma, 74146

Site Contact

Site Public Contact

918-505-3200

Clackamas Radiation Oncology Center, Clackamas, Oregon

Status

Suspended

Address

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015

Site Contact

904-953-7102

Legacy Mount Hood Medical Center, Gresham, Oregon

Status

Active, not recruiting

Address

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030

Site Contact

904-953-7102

Portland, Oregon

Status

Active, not recruiting

Address

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210

Site Contact

904-953-7102

Providence Portland Medical Center, Portland, Oregon

Status

Suspended

Address

Providence Portland Medical Center

Portland, Oregon, 97213

Site Contact

904-953-7102

Providence Saint Vincent Medical Center, Portland, Oregon

Status

Suspended

Address

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

Site Contact

904-953-7102

Jefferson Abington Hospital, Abington, Pennsylvania

Status

Active, not recruiting

Address

Jefferson Abington Hospital

Abington, Pennsylvania, 19001

Site Contact

904-953-7102

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania

Status

Suspended

Address

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103

Site Contact

904-953-7102

Bethlehem, Pennsylvania

Status

Recruiting

Address

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015

Site Contact

Site Public Contact

484-503-4151

Geisinger Medical Center, Danville, Pennsylvania

Status

Active, not recruiting

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822

Site Contact

904-953-7102

Saint Luke's Hospital-Anderson Campus, Easton, Pennsylvania

Status

Recruiting

Address

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045

Site Contact

Site Public Contact

[email protected]

888-823-5923

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Status

Recruiting

Address

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

Site Contact

Site Public Contact

[email protected]

215-600-9151

Temple University Hospital, Philadelphia, Pennsylvania

Status

Active, not recruiting

Address

Temple University Hospital

Philadelphia, Pennsylvania, 19140

Site Contact

904-953-7102

Allegheny General Hospital, Pittsburgh, Pennsylvania

Status

Active, not recruiting

Address

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212

Site Contact

904-953-7102

Pittsburgh, Pennsylvania

Status

Active, not recruiting

Address

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

Site Contact

904-953-7102

Reading Hospital, West Reading, Pennsylvania

Status

Recruiting

Address

Reading Hospital

West Reading, Pennsylvania, 19611

Site Contact

Site Public Contact

610-988-9323

Wilkes-Barre, Pennsylvania

Status

Active, not recruiting

Address

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

Site Contact

904-953-7102

Boiling Springs, South Carolina

Status

Active, not recruiting

Address

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316

Site Contact

904-953-7102

Medical University of South Carolina, Charleston, South Carolina

Status

Recruiting

Address

Medical University of South Carolina

Charleston, South Carolina, 29425

Site Contact

Site Public Contact

[email protected]

843-792-9321

Greenville, South Carolina

Status

Suspended

Address

Greenville Health System Cancer Institute-Andrews

Greenville, South Carolina, 29601

Site Contact

904-953-7102

Greenville, South Carolina

Status

Active, not recruiting

Address

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605

Site Contact

904-953-7102

Prisma Health Cancer Institute - Faris, Greenville, South Carolina

Status

Active, not recruiting

Address

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605

Site Contact

904-953-7102

Greenville, South Carolina

Status

Active, not recruiting

Address

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615

Site Contact

904-953-7102

Prisma Health Cancer Institute - Greer, Greer, South Carolina

Status

Active, not recruiting

Address

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650

Site Contact

904-953-7102

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina

Status

Active, not recruiting

Address

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672

Site Contact

904-953-7102

Spartanburg Medical Center, Spartanburg, South Carolina

Status

Suspended

Address

Spartanburg Medical Center

Spartanburg, South Carolina, 29303

Site Contact

904-953-7102

Rapid City Regional Hospital, Rapid City, South Dakota

Status

Recruiting

Address

Rapid City Regional Hospital

Rapid City, South Dakota, 57701

Site Contact

Site Public Contact

[email protected]

605-716-3982

Nashville, Tennessee

Status

Active, not recruiting

Address

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

Site Contact

904-953-7102

Parkland Memorial Hospital, Dallas, Texas

Status

Recruiting

Address

Parkland Memorial Hospital

Dallas, Texas, 75235

Site Contact

Site Public Contact

[email protected]

214-590-5582

Dallas, Texas

Status

Recruiting

Address

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

Site Contact

Site Public Contact

[email protected]

214-648-7097

University of Texas Medical Branch, Galveston, Texas

Status

Recruiting

Address

University of Texas Medical Branch

Galveston, Texas, 77555-0565

Site Contact

Site Public Contact

[email protected]

409-772-1950

UTMB Cancer Center at Victory Lakes, League City, Texas

Status

Suspended

Address

UTMB Cancer Center at Victory Lakes

League City, Texas, 77573

Site Contact

904-953-7102

Sandra L Maxwell Cancer Center, Cedar City, Utah

Status

Recruiting

Address

Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720

Site Contact

Site Public Contact

[email protected]

435-868-5680

Intermountain Medical Center, Murray, Utah

Status

Recruiting

Address

Intermountain Medical Center

Murray, Utah, 84107

Site Contact

Site Public Contact

[email protected]

801-507-3950

Utah Valley Regional Medical Center, Provo, Utah

Status

Recruiting

Address

Utah Valley Regional Medical Center

Provo, Utah, 84604

Site Contact

Site Public Contact

[email protected]

801-357-7965

Saint George Regional Medical Center, Saint George, Utah

Status

Recruiting

Address

Saint George Regional Medical Center

Saint George, Utah, 84770

Site Contact

Site Public Contact

[email protected]

833-321-3332

Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah

Status

Suspended

Address

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106

Site Contact

904-953-7102

Salt Lake City, Utah

Status

Active, not recruiting

Address

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

Site Contact

904-953-7102

LDS Hospital, Salt Lake City, Utah

Status

Suspended

Address

LDS Hospital

Salt Lake City, Utah, 84143

Site Contact

904-953-7102

Dartmouth Cancer Center - North, Saint Johnsbury, Vermont

Status

Recruiting

Address

Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819

Site Contact

Site Public Contact

[email protected]

800-639-6918

Richmond, Virginia

Status

Recruiting

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Site Contact

Site Public Contact

[email protected]

904-953-7102

VCU Community Memorial Health Center, South Hill, Virginia

Status

Recruiting

Address

VCU Community Memorial Health Center

South Hill, Virginia, 23970

Site Contact

Site Public Contact

[email protected]

904-953-7102

PeaceHealth Saint Joseph Medical Center, Bellingham, Washington

Status

Recruiting

Address

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225

Site Contact

Site Public Contact

360-788-8223

Kadlec Clinic Hematology and Oncology, Kennewick, Washington

Status

Suspended

Address

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336

Site Contact

904-953-7102

Tri-Cities Cancer Center, Kennewick, Washington

Status

Suspended

Address

Tri-Cities Cancer Center

Kennewick, Washington, 99336

Site Contact

904-953-7102

Mount Vernon, Washington

Status

Recruiting

Address

Skagit Regional Health Cancer Care Center

Mount Vernon, Washington, 98274

Site Contact

Site Public Contact

[email protected]

360-814-2182

Skagit Valley Hospital, Mount Vernon, Washington

Status

Active, not recruiting

Address

Skagit Valley Hospital

Mount Vernon, Washington, 98274

Site Contact

904-953-7102

Virginia Mason Medical Center, Seattle, Washington

Status

Active, not recruiting

Address

Virginia Mason Medical Center

Seattle, Washington, 98101

Site Contact

904-953-7102

FHCC South Lake Union, Seattle, Washington

Status

Active, not recruiting

Address

FHCC South Lake Union

Seattle, Washington, 98109

Site Contact

904-953-7102

Fred Hutchinson Cancer Center, Seattle, Washington

Status

Active, not recruiting

Address

Fred Hutchinson Cancer Center

Seattle, Washington, 98109

Site Contact

904-953-7102

Seattle, Washington

Status

Suspended

Address

University of Washington Medical Center - Montlake

Seattle, Washington, 98195

Site Contact

904-953-7102

PeaceHealth Southwest Medical Center, Vancouver, Washington

Status

Recruiting

Address

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664

Site Contact

Site Public Contact

[email protected]

360-514-3940

West Virginia University Healthcare, Morgantown, West Virginia

Status

Active, not recruiting

Address

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Site Contact

904-953-7102

Northwest Wisconsin Cancer Center, Ashland, Wisconsin

Status

Recruiting

Address

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806

Site Contact

Site Public Contact

[email protected]

218-786-3308

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

Status

Recruiting

Address

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Site Contact

Site Public Contact

[email protected]

608-775-2385

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin

Status

Active, not recruiting

Address

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215

Site Contact

904-953-7102

Medical College of Wisconsin, Milwaukee, Wisconsin

Status

Recruiting

Address

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Site Contact

Site Public Contact

414-805-3666

ProHealth D N Greenwald Center, Mukwonago, Wisconsin

Status

Recruiting

Address

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149

Site Contact

Site Public Contact

[email protected]

904-953-7102

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin

Status

Recruiting

Address

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066

Site Contact

Site Public Contact

262-928-7878

ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin

Status

Suspended

Address

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188

Site Contact

904-953-7102

UW Cancer Center at ProHealth Care, Waukesha, Wisconsin

Status

Recruiting

Address

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188

Site Contact

Site Public Contact

[email protected]

262-928-5539

International Sites

Medical University Vienna, Vienna, Austria

Status

Recruiting

Address

Medical University Vienna

Vienna, , A-1090

Site Contact

Kurt A. Jaeckle

904-953-7102

Alegemeen Ziekenhuis Middelheim, Antwerpen, Belgium

Status

Recruiting

Address

Alegemeen Ziekenhuis Middelheim

Antwerpen, , 2020

Site Contact

Kurt A. Jaeckle

[email protected]

904-953-7102

Tom Baker Cancer Centre, Calgary, Alberta, Canada

Status

Recruiting

Address

Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2

Site Contact

Site Public Contact

403-521-3433

Cross Cancer Institute, Edmonton, Alberta, Canada

Status

Active, not recruiting

Address

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2

Site Contact

904-953-7102

BCCA-Vancouver Cancer Centre, Vancouver, British Columbia, Canada

Status

Recruiting

Address

BCCA-Vancouver Cancer Centre

Vancouver, British Columbia, V5Z 4E6

Site Contact

Site Public Contact

888-939-3333

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Status

Recruiting

Address

CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9

Site Contact

Site Public Contact

[email protected]

866-561-1026

London Regional Cancer Program, London, Ontario, Canada

Status

Recruiting

Address

London Regional Cancer Program

London, Ontario, N6A 4L6

Site Contact

Site Public Contact

519-685-8600

Ottawa, Ontario, Canada

Status

Suspended

Address

Ottawa Hospital and Cancer Center-General Campus

Ottawa, Ontario, K1H 8L6

Site Contact

904-953-7102

Toronto, Ontario, Canada

Status

Suspended

Address

Odette Cancer Centre- Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5

Site Contact

904-953-7102

Toronto, Ontario, Canada

Status

Suspended

Address

University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9

Site Contact

904-953-7102

CHUM - Hopital Notre-Dame, Montreal, Quebec, Canada

Status

Suspended

Address

CHUM - Hopital Notre-Dame

Montreal, Quebec, H2L 4M1

Site Contact

904-953-7102

Montreal, Quebec, Canada

Status

Recruiting

Address

CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4

Site Contact

Site Public Contact

[email protected]

514-890-8000 #12725

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Status

Suspended

Address

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1

Site Contact

904-953-7102

Centre Leon Berard, Lyon, France

Status

Recruiting

Address

Centre Leon Berard

Lyon, , 69373

Site Contact

Kurt A. Jaeckle

904-953-7102

Centre Antoine Lacassagne, Nice, France

Status

Recruiting

Address

Centre Antoine Lacassagne

Nice, , 06189

Site Contact

Kurt A. Jaeckle

[email protected]

904-953-7102

Gustave Roussy, Villejuif, France

Status

Recruiting

Address

Gustave Roussy

Villejuif, , 94805

Site Contact

Kurt A. Jaeckle

904-953-7102

Academ Zienkenhuis Bij De University, Amsterdam, Netherlands

Status

Recruiting

Address

Academ Zienkenhuis Bij De University

Amsterdam, , 1007 MB

Site Contact

Kurt A. Jaeckle

904-953-7102

University Medical Center Groningen, Groningen, Netherlands

Status

Recruiting

Address

University Medical Center Groningen

Groningen, , 9700 GZ

Site Contact

Kurt A. Jaeckle

904-953-7102

Maastricht, Netherlands

Status

Recruiting

Address

Maastro Clinic-Maastricht Radiation Oncology

Maastricht, , 6229 NA

Site Contact

Kurt A. Jaeckle

[email protected]

904-953-7102

Erasmus University Medical Center, Rotterdam, Netherlands

Status

Recruiting

Address

Erasmus University Medical Center

Rotterdam, , 3015 CE

Site Contact

Kurt A. Jaeckle

904-953-7102

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