Clinical Trial Finder

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Study Purpose

This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

 No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

 Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Pathologically (histologically or cytologically) proven diagnosis of small cell lung cancer within 5 years of registration.
If the original histologic proof of malignancy is greater than 5 years, then pathological (i.e., more recent) confirmation is required (e.g., from a systemic or brain metastasis);
  • - Patients with de novo or recurrent small cell lung cancer are permitted.
  • - Ten or fewer brain metastases ≤ 3 cm in largest diameter and outside a 5-mm margin around either hippocampus must be visible on contrast-enhanced magnetic resonance imaging (MRI) performed ≤ 21 days prior to study entry.
  • - Brain metastases can be diagnosed synchronous to the initial diagnosis of small cell lung cancer or metachronous to the initial diagnosis and management of small cell lung cancer.
  • - The total tumor volume must be 30 cm^3 or less.
Lesion volume will be approximated by measuring the lesion's three perpendicular diameters on contrast enhanced, T1-weighted MRI and the product of those diameters will be divided by 2 to estimate the lesion volume (e.g. xyz/2). Alternatively, direct volumetric measurements via slice by slice contouring on a treatment planning software package can be used to calculate the total tumor volume.
  • - Brain metastases must be diagnosed on MRI, which will include the following elements: - REQUIRED MRI ELEMENTS.
  • - Post gadolinium contrast-enhanced T1-weighted three-dimensional (3D) spoiled gradient (SPGR).
Acceptable 3D SPGR sequences include magnetization prepared 3D gradient recalled echo (GRE) rapid gradient echo (MP-RAGE), turbo field echo (TFE) MRI, BRAVO (Brain Volume Imaging) or 3D Fast FE (field echo). The T1-weighted 3D scan should use the smallest possible axial slice thickness, not to exceed 1.5 mm.
  • - Pre-contrast T1 weighted imaging (3D imaging sequence strongly encouraged).
  • - A minimum of one axial T2 FLAIR (preferred) or T2 sequence is required.
This can be acquired as a two dimensional (2D) or 3D image. If 2D, the images should be obtained in the axial plane.
  • - ADDITIONAL RECOMMENDATIONS.
  • - Recommendation is that an axial T2 FLAIR (preferred) sequence be performed instead of a T2 sequence.
  • - Recommendation is that that pre-contrast 3D T1 be performed with the same parameters as the post-contrast 3D T1.
  • - Recommendation is that imaging be performed on a 3 Tesla (3T) MRI.
  • - Recommendation is that the study participants be scanned on the same MRI instrument at each time point.
  • - Recommendation is that if additional sequences are obtained, these should meet the criteria outlined in Kaufmann et al.
, 2020.
  • - If additional sequences are obtained, total imaging time should not exceed 60 minutes.
  • - History/physical examination.
  • - Age ≥ 18.
  • - Karnofsky performance status of ≥ 70.
  • - Creatinine clearance ≥ 30 ml/min.
  • - Following the diagnosis of brain metastases, patients can initiate and treat with systemic (chemotherapy and/or immunotherapy) before enrollment only if their brain metastases are asymptomatic and not located in eloquent locations (e.g., brainstem, pre-/post-central gyrus, visual cortex).
However, within 21 days prior to enrollment, brain MRI must be repeated to confirm eligibility.
  • - Patients with symptomatic brain metastases and/or brain metastases in eloquent locations (e.g., brainstem, pre-/post central gyrus, visual cortex) are eligible for enrollment on the trial; however, the specific treatment approach of starting with systemic therapy alone and delaying brain radiation is not recommended for these patients.
  • - Concurrent immunotherapy with brain radiation (SRS or HA-WBRT) is permitted.
  • - Negative urine or serum pregnancy test (in women of childbearing potential) within 14 days prior to registration.
Women of childbearing potential and men who are sexually active must use contraception while on study.
  • - Patients may have had prior intracranial surgical resection.
Patients must have completed prior intracranial surgical resection at least 14 days prior to registration.
  • - Because neurocognitive testing is the primary goal of this study, patients must be proficient in English or French Canadian.
  • - The patient must provide study-specific informed consent prior to study entry.
  • - Patients with impaired decision-making capacity are not permitted on study.
  • - ELIGIBILITY CRITERIA PRIOR TO STEP 2 REGISTRATION.
  • - The following baseline neurocognitive tests must be completed within 21 days prior to Step 2 registration: HVLT-R, TMT, and COWA.
The neurocognitive test will be uploaded into RAVE for evaluation by Dr. Wefel. Once the upload is complete, within 3 business days a notification will be sent via email to the RA to proceed to Step 2.
  • - NOTE: Completed baseline neurocognitive tests can be uploaded at the time of Step 1 registration.

Exclusion Criteria:

  • - Planned infusion of cytotoxic chemotherapy on the same day as SRS or HA-WBRT treatment.
Patients may have had prior chemotherapy. Concurrent immunotherapy is permitted.
  • - Prior allergic reaction to memantine.
  • - Intractable seizures while on adequate anticonvulsant therapy; more than 1 seizure per month for the past 2 months.
  • - Patients with definitive leptomeningeal metastases.
  • - Known history of demyelinating disease such as multiple sclerosis.
  • - Contraindication to MR imaging such as implanted metal devices that are MRI-incompatible, allergy to MRI contrast that cannot be adequately addressed with pre-contrast medications, or foreign bodies that preclude MRI imaging.
(Questions regarding MRI compatibility of implanted objects should be reviewed with the Radiology Department performing the MRI).
  • - Current use of (other N-methyl-D-aspartate [NMDA] antagonists) amantadine, ketamine, or dextromethorphan.
  • - Radiographic evidence of hydrocephalus or other architectural change of the ventricular system resulting in significant anatomic distortion of the hippocampus, including placement of external ventricular drain or ventriculoperitoneal shunt.
  • - Mild cases of hydrocephalus not resulting in significant anatomic distortion of the hippocampus are permitted.
  • - Prior radiotherapy to the brain, including SRS, WBRT, or prophylactic cranial irradiation (PCI).
  • - Severe, active co-morbidity defined as follows: - Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months.
  • - Transmural myocardial infarction within the last 6 months.
  • - Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration.
  • - Chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy at the time of registration.
- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

 NCT04804644
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

 Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

 NRG Oncology
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

 Vinai Gondi
Principal Investigator Affiliation NRG Oncology
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

 Other, NIH
Overall Status Recruiting
Countries Canada, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

 Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Recurrent Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
Additional Details

PRIMARY OBJECTIVE:

  • I. Determine whether stereotactic radiosurgery (SRS) relative to whole brain radiotherapy with hippocampal avoidance (HA-WBRT) plus memantine hydrochloride (memantine) for brain metastases from small cell lung cancer (SCLC) prevents cognitive function failure as measured by cognitive decline on a battery of tests: the Hopkins Verbal Learning Test - Revised (HVLT-R), Controlled Oral Word Association (COWA) test, and the Trail Making Test (TMT).
SECONDARY OBJECTIVES:
  • I. Determine whether SRS relative to HA-WBRT plus memantine for brain metastases from SCLC preserves cognitive function as separately measured by the HVLT-R, COWA, TMT Parts A and B, and Clinical Trial Battery Composite (CTB COMP).
  • II. Assess perceived difficulties in cognitive abilities using Patient Reported Outcomes Measurement Information System (PROMIS) after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • III. Assess symptom burden using the MD Anderson Symptom Inventory for brain tumor (MDASI-BT) after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • IV. Compare cumulative incidence of intracranial disease progression after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • V. Compare overall survival after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • VI. Compare cumulative incidence of neurologic death after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • VII. Compare the number of salvage procedures used to manage recurrent intracranial disease following SRS relative to HA-WBRT plus memantine for SCLC brain metastases.
  • VIII. Compare adverse events between the treatment arms according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0 criteria.
  • IX. Compare the risk of developing cerebral necrosis between SRS and HA-WBRT plus memantine in patients receiving concurrent immunotherapy.
EXPLORATORY OBJECTIVES:
  • I. Compare cumulative incidence of local brain recurrence, distant brain relapse, and leptomeningeal dissemination after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • II. Compare the cost of brain-related therapies and quality-adjusted life years in patients who receive SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • III. Evaluate the time delay to salvage WBRT or HA-WBRT in patients enrolled on the SRS arm.
  • IV. Evaluate whether a time delay for chemotherapy in patients receiving HA-WBRT plus memantine relative to SRS for brain metastases from SCLC has an effect on overall survival.
  • V. Evaluate baseline magnetic resonance (MR) imaging biomarkers of white matter injury and hippocampal volumetry as potential predictors of cognitive decline and differential benefit from SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
  • VI. Evaluate the correlation between neurocognitive functioning and patient-reported outcomes.
  • VII. Collect serum, plasma and imaging studies for future translational research analyses.
OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients undergo SRS over 1 day (in some cases several days). ARM II: Patients undergo HA-WBRT once daily (QD) for 2 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive memantine orally (PO) QD or twice daily (BID) for up to 24 weeks in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 2-3 months for 1 year, and then every 6 months thereafter.

Arms & Interventions

Arms

Experimental: Arm I (SRS)

Patients undergo SRS over 1 day (in some cases several days).

Active Comparator: Arm II (HA-WBRT, memantine)

Patients also undergo HA-WBRT QD for 2 weeks in the absence of disease progression or unacceptable toxicity. Patients will also receive memantine PO QD or BID for up to 24 weeks in the absence of disease progression or unacceptable toxicity.

Interventions

Drug: - Memantine Hydrochloride

Given PO

Other: - Neurocognitive Assessment

Ancillary studies

Radiation: - Stereotactic Radiosurgery

Undergo SRS

Radiation: - Whole-Brain Radiotherapy

Undergo HA-WBRT

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Mayo Clinic Hospital in Arizona, Phoenix, Arizona

Status

Recruiting

Address

Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054

Site Contact

Site Public Contact

855-776-0015

Los Angeles General Medical Center, Los Angeles, California

Status

Recruiting

Address

Los Angeles General Medical Center

Los Angeles, California, 90033

Site Contact

Site Public Contact

uscnorrisinfo@med.usc.edu

323-865-0451

USC / Norris Comprehensive Cancer Center, Los Angeles, California

Status

Recruiting

Address

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Site Contact

Site Public Contact

323-865-0451

UCHealth University of Colorado Hospital, Aurora, Colorado

Status

Recruiting

Address

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045

Site Contact

Site Public Contact

720-848-0650

UCHealth Memorial Hospital Central, Colorado Springs, Colorado

Status

Recruiting

Address

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909

Site Contact

Site Public Contact

719-365-2406

Memorial Hospital North, Colorado Springs, Colorado

Status

Recruiting

Address

Memorial Hospital North

Colorado Springs, Colorado, 80920

Site Contact

Site Public Contact

719-364-6700

Greenwich, Connecticut

Status

Recruiting

Address

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

Guilford, Connecticut

Status

Recruiting

Address

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

New Haven, Connecticut

Status

Recruiting

Address

Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

Yale University, New Haven, Connecticut

Status

Recruiting

Address

Yale University

New Haven, Connecticut, 06520

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

Trumbull, Connecticut

Status

Recruiting

Address

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

Waterford, Connecticut

Status

Recruiting

Address

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

Beebe Medical Center, Lewes, Delaware

Status

Recruiting

Address

Beebe Medical Center

Lewes, Delaware, 19958

Site Contact

Site Public Contact

research@beebehealthcare.org

302-291-6730

Newark, Delaware

Status

Suspended

Address

Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713

Helen F Graham Cancer Center, Newark, Delaware

Status

Recruiting

Address

Helen F Graham Cancer Center

Newark, Delaware, 19713

Site Contact

Site Public Contact

lbarone@christianacare.org

302-623-4450

Newark, Delaware

Status

Recruiting

Address

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713

Site Contact

Site Public Contact

lbarone@christianacare.org

302-623-4450

Newark, Delaware

Status

Recruiting

Address

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718

Site Contact

Site Public Contact

lbarone@christianacare.org

302-623-4450

Beebe Health Campus, Rehoboth Beach, Delaware

Status

Recruiting

Address

Beebe Health Campus

Rehoboth Beach, Delaware, 19971

Site Contact

Site Public Contact

research@beebehealthcare.org

302-291-6730

Coral Gables, Florida

Status

Recruiting

Address

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

Site Contact

Site Public Contact

305-243-2647

Deerfield Beach, Florida

Status

Recruiting

Address

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442

Site Contact

Site Public Contact

305-243-2647

Gainesville, Florida

Status

Active, not recruiting

Address

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Site Contact

Site Public Contact

305-243-2647

Emory University Hospital Midtown, Atlanta, Georgia

Status

Recruiting

Address

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Site Contact

Site Public Contact

888-946-7447

Atlanta, Georgia

Status

Recruiting

Address

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

Site Contact

Site Public Contact

404-778-1868

Emory Saint Joseph's Hospital, Atlanta, Georgia

Status

Recruiting

Address

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342

Site Contact

Site Public Contact

404-851-7115

Northside Hospital, Atlanta, Georgia

Status

Recruiting

Address

Northside Hospital

Atlanta, Georgia, 30342

Site Contact

Site Public Contact

ClinicalTrials@northside.com

404-303-3355

Northside Hospital-Cherokee, Canton, Georgia

Status

Recruiting

Address

Northside Hospital-Cherokee

Canton, Georgia, 30115

Site Contact

Site Public Contact

clinical.trials@northside.com

404-303-3355

Northside Hospital-Forsyth, Cumming, Georgia

Status

Recruiting

Address

Northside Hospital-Forsyth

Cumming, Georgia, 30041

Site Contact

Site Public Contact

clinicaltrials@northside.com

404-303-3355

Rush - Copley Medical Center, Aurora, Illinois

Status

Recruiting

Address

Rush - Copley Medical Center

Aurora, Illinois, 60504

Site Contact

Site Public Contact

Cancer.Research@rushcopley.com

630-978-6212

Centralia Oncology Clinic, Centralia, Illinois

Status

Recruiting

Address

Centralia Oncology Clinic

Centralia, Illinois, 62801

Site Contact

Site Public Contact

morganthaler.jodi@mhsil.com

217-876-4762

Rush University Medical Center, Chicago, Illinois

Status

Recruiting

Address

Rush University Medical Center

Chicago, Illinois, 60612

Site Contact

Site Public Contact

clinical_trials@rush.edu

312-942-5498

Chicago, Illinois

Status

Recruiting

Address

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

Site Contact

Site Public Contact

cancerclinicaltrials@bsd.uchicago.edu

773-702-8222

Carle at The Riverfront, Danville, Illinois

Status

Recruiting

Address

Carle at The Riverfront

Danville, Illinois, 61832

Site Contact

Site Public Contact

Research@Carle.com

800-446-5532

Decatur, Illinois

Status

Recruiting

Address

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526

Site Contact

Site Public Contact

morganthaler.jodi@mhsil.com

217-876-4762

Decatur Memorial Hospital, Decatur, Illinois

Status

Recruiting

Address

Decatur Memorial Hospital

Decatur, Illinois, 62526

Site Contact

Site Public Contact

morganthaler.jodi@mhsil.com

217-876-4762

DeKalb, Illinois

Status

Recruiting

Address

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115

Site Contact

Site Public Contact

Donald.Smith3@nm.org

630-352-5360

Carle Physician Group-Effingham, Effingham, Illinois

Status

Recruiting

Address

Carle Physician Group-Effingham

Effingham, Illinois, 62401

Site Contact

Site Public Contact

Research@carle.com

800-446-5532

Crossroads Cancer Center, Effingham, Illinois

Status

Recruiting

Address

Crossroads Cancer Center

Effingham, Illinois, 62401

Site Contact

Site Public Contact

morganthaler.jodi@mhsil.com

217-876-4762

Geneva, Illinois

Status

Recruiting

Address

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134

Site Contact

Site Public Contact

Donald.Smith3@nm.org

630-352-5360

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois

Status

Recruiting

Address

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938

Site Contact

Site Public Contact

Research@carle.com

800-446-5532

Cancer Care Center of O'Fallon, O'Fallon, Illinois

Status

Recruiting

Address

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269

Site Contact

Site Public Contact

morganthaler.jodi@mhsil.com

217-876-4762

OSF Saint Francis Medical Center, Peoria, Illinois

Status

Recruiting

Address

OSF Saint Francis Medical Center

Peoria, Illinois, 61637

Site Contact

Site Public Contact

andersonj@illinoiscancercare.com

309-243-3605

Carle Cancer Center, Urbana, Illinois

Status

Recruiting

Address

Carle Cancer Center

Urbana, Illinois, 61801

Site Contact

Site Public Contact

Research@carle.com

800-446-5532

The Carle Foundation Hospital, Urbana, Illinois

Status

Recruiting

Address

The Carle Foundation Hospital

Urbana, Illinois, 61801

Site Contact

Site Public Contact

Research@carle.com

800-446-5532

Warrenville, Illinois

Status

Recruiting

Address

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555

Site Contact

Site Public Contact

Donald.Smith3@nm.org

630-352-5360

Goshen Center for Cancer Care, Goshen, Indiana

Status

Recruiting

Address

Goshen Center for Cancer Care

Goshen, Indiana, 46526

Site Contact

Site Public Contact

cccois@goshenhealth.com

574-364-2973

Mary Greeley Medical Center, Ames, Iowa

Status

Recruiting

Address

Mary Greeley Medical Center

Ames, Iowa, 50010

Site Contact

Site Public Contact

515-956-4132

McFarland Clinic - Ames, Ames, Iowa

Status

Recruiting

Address

McFarland Clinic - Ames

Ames, Iowa, 50010

Site Contact

Site Public Contact

ksoder@mcfarlandclinic.com

515-239-4734

Baptist Health Lexington, Lexington, Kentucky

Status

Suspended

Address

Baptist Health Lexington

Lexington, Kentucky, 40503

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana

Status

Recruiting

Address

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809

Site Contact

Site Public Contact

clinicalresearch@marybird.com

225-215-1353

Anne Arundel Medical Center, Annapolis, Maryland

Status

Active, not recruiting

Address

Anne Arundel Medical Center

Annapolis, Maryland, 21401

Baltimore, Maryland

Status

Recruiting

Address

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

Site Contact

Site Public Contact

800-888-8823

Baltimore, Maryland

Status

Recruiting

Address

MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237

Site Contact

Site Public Contact

443-777-7364

UM Upper Chesapeake Medical Center, Bel Air, Maryland

Status

Recruiting

Address

UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014

Site Contact

Site Public Contact

443-643-3010

Columbia, Maryland

Status

Recruiting

Address

Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044

Site Contact

Site Public Contact

443-546-1300

Easton, Maryland

Status

Recruiting

Address

University of Maryland Shore Medical Center at Easton

Easton, Maryland, 21601

Site Contact

Site Public Contact

Christina.weisenborn@umm.edu

410-822-1000

Ocean Pines, Maryland

Status

Recruiting

Address

TidalHealth Richard A Henson Cancer Institute

Ocean Pines, Maryland, 21811

Site Contact

Site Public Contact

carol.messick@peninsula.org

410-543-7067

TidalHealth Peninsula Regional, Salisbury, Maryland

Status

Recruiting

Address

TidalHealth Peninsula Regional

Salisbury, Maryland, 21801

Site Contact

Site Public Contact

monika.naegeli@peninsula.org

410-543-7032

Boston Medical Center, Boston, Massachusetts

Status

Recruiting

Address

Boston Medical Center

Boston, Massachusetts, 02118

Site Contact

Site Public Contact

617-638-8265

Saint Joseph Mercy Hospital, Ann Arbor, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Saint Joseph Mercy Brighton, Brighton, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Brighton

Brighton, Michigan, 48114

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Brighton, Michigan

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Saint Joseph Mercy Canton, Canton, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Canton

Canton, Michigan, 48188

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Canton, Michigan

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Caro Cancer Center, Caro, Michigan

Status

Suspended

Address

Caro Cancer Center

Caro, Michigan, 48723

Saint Joseph Mercy Chelsea, Chelsea, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Chelsea

Chelsea, Michigan, 48118

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Chelsea, Michigan

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Livonia, Michigan

Status

Recruiting

Address

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Marlette, Michigan

Status

Suspended

Address

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453

Ascension Saint Mary's Hospital, Saginaw, Michigan

Status

Suspended

Address

Ascension Saint Mary's Hospital

Saginaw, Michigan, 48601

Saginaw, Michigan

Status

Suspended

Address

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604

Ascension Saint Joseph Hospital, Tawas City, Michigan

Status

Suspended

Address

Ascension Saint Joseph Hospital

Tawas City, Michigan, 48764

West Branch, Michigan

Status

Suspended

Address

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661

Ypsilanti, Michigan

Status

Recruiting

Address

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197

Site Contact

Site Public Contact

MCRCwebsitecontactform@stjoeshealth.org

734-712-7251

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota

Status

Recruiting

Address

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601

Mercy Hospital, Coon Rapids, Minnesota

Status

Recruiting

Address

Mercy Hospital

Coon Rapids, Minnesota, 55433

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Fairview Southdale Hospital, Edina, Minnesota

Status

Recruiting

Address

Fairview Southdale Hospital

Edina, Minnesota, 55435

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Unity Hospital, Fridley, Minnesota

Status

Active, not recruiting

Address

Unity Hospital

Fridley, Minnesota, 55432

Maple Grove, Minnesota

Status

Recruiting

Address

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Regions Hospital, Saint Paul, Minnesota

Status

Recruiting

Address

Regions Hospital

Saint Paul, Minnesota, 55101

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Lakeview Hospital, Stillwater, Minnesota

Status

Recruiting

Address

Lakeview Hospital

Stillwater, Minnesota, 55082

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Saint Francis Medical Center, Cape Girardeau, Missouri

Status

Recruiting

Address

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

Site Contact

Site Public Contact

sfmc@sfmc.net

573-334-2230

Parkland Health Center - Farmington, Farmington, Missouri

Status

Recruiting

Address

Parkland Health Center - Farmington

Farmington, Missouri, 63640

Site Contact

Site Public Contact

314-996-5569

Freeman Health System, Joplin, Missouri

Status

Recruiting

Address

Freeman Health System

Joplin, Missouri, 64804

Site Contact

Site Public Contact

LJCrockett@freemanhealth.com

417-347-4030

Missouri Baptist Medical Center, Saint Louis, Missouri

Status

Recruiting

Address

Missouri Baptist Medical Center

Saint Louis, Missouri, 63131

Site Contact

Site Public Contact

314-996-5569

Sainte Genevieve, Missouri

Status

Recruiting

Address

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

Site Contact

Site Public Contact

314-996-5569

Mercy Hospital Springfield, Springfield, Missouri

Status

Recruiting

Address

Mercy Hospital Springfield

Springfield, Missouri, 65804

Site Contact

Site Public Contact

417-269-4520

Missouri Baptist Sullivan Hospital, Sullivan, Missouri

Status

Recruiting

Address

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080

Site Contact

Site Public Contact

314-996-5569

BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri

Status

Recruiting

Address

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127

Site Contact

Site Public Contact

314-996-5569

Great Falls, Montana

Status

Suspended

Address

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405

Kalispell Regional Medical Center, Kalispell, Montana

Status

Recruiting

Address

Kalispell Regional Medical Center

Kalispell, Montana, 59901

Site Contact

Site Public Contact

mccinfo@mtcancer.org

406-969-6060

Bronx, New York

Status

Active, not recruiting

Address

Montefiore Medical Center-Einstein Campus

Bronx, New York, 10461

Bronx, New York

Status

Active, not recruiting

Address

Montefiore Medical Center-Weiler Hospital

Bronx, New York, 10461

Montefiore Medical Center - Moses Campus, Bronx, New York

Status

Active, not recruiting

Address

Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

Sands Cancer Center, Canandaigua, New York

Status

Recruiting

Address

Sands Cancer Center

Canandaigua, New York, 14424

Site Contact

Site Public Contact

585-396-6161

Lake Success, New York

Status

Recruiting

Address

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

Site Contact

Site Public Contact

516-734-8896

Northern Westchester Hospital, Mount Kisco, New York

Status

Recruiting

Address

Northern Westchester Hospital

Mount Kisco, New York, 10549

Site Contact

Site Public Contact

AMellor@northwell.edu

914-666-1366

Rochester, New York

Status

Recruiting

Address

Wilmot Cancer Institute Radiation Oncology at Greece

Rochester, New York, 14606

Site Contact

Site Public Contact

585-758-7877

University of Rochester, Rochester, New York

Status

Recruiting

Address

University of Rochester

Rochester, New York, 14642

Site Contact

Site Public Contact

585-275-5830

Syracuse, New York

Status

Recruiting

Address

State University of New York Upstate Medical University

Syracuse, New York, 13210

Site Contact

Site Public Contact

315-464-5476

Wilmot Cancer Institute at Webster, Webster, New York

Status

Recruiting

Address

Wilmot Cancer Institute at Webster

Webster, New York, 14580

Site Contact

Site Public Contact

WCICTOresearch@urmc.rochester.edu

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Status

Recruiting

Address

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

Site Contact

Site Public Contact

336-713-6771

Sanford Bismarck Medical Center, Bismarck, North Dakota

Status

Recruiting

Address

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501

Sanford Broadway Medical Center, Fargo, North Dakota

Status

Recruiting

Address

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

Sanford Roger Maris Cancer Center, Fargo, North Dakota

Status

Recruiting

Address

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122

Cincinnati, Ohio

Status

Recruiting

Address

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219

Site Contact

Site Public Contact

cancer@uchealth.com

513-584-7698

Case Western Reserve University, Cleveland, Ohio

Status

Recruiting

Address

Case Western Reserve University

Cleveland, Ohio, 44106

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Columbus, Ohio

Status

Recruiting

Address

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Site Contact

Site Public Contact

Jamesline@osumc.edu

800-293-5066

Riverside Methodist Hospital, Columbus, Ohio

Status

Recruiting

Address

Riverside Methodist Hospital

Columbus, Ohio, 43214

Site Contact

Site Public Contact

sheree@columbusccop.org

614-566-4475

Mentor, Ohio

Status

Recruiting

Address

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Mercy Health Perrysburg Cancer Center, Perrysburg, Ohio

Status

Recruiting

Address

Mercy Health Perrysburg Cancer Center

Perrysburg, Ohio, 43551

Site Contact

Site Public Contact

sheree@columbusccop.org

614-488-2118

Mercy Health - Saint Anne Hospital, Toledo, Ohio

Status

Suspended

Address

Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623

West Chester, Ohio

Status

Recruiting

Address

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069

Site Contact

Site Public Contact

cancer@uchealth.com

513-584-7698

Oklahoma City, Oklahoma

Status

Recruiting

Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Site Contact

Site Public Contact

ou-clinical-trials@ouhsc.edu

405-271-8777

Saint Luke's Cancer Center - Allentown, Allentown, Pennsylvania

Status

Recruiting

Address

Saint Luke's Cancer Center - Allentown

Allentown, Pennsylvania, 18104

Site Contact

Site Public Contact

610-776-4714

Bethlehem, Pennsylvania

Status

Recruiting

Address

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015

Site Contact

Site Public Contact

484-503-4151

Chadds Ford, Pennsylvania

Status

Recruiting

Address

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317

Site Contact

Site Public Contact

lbarone@christianacare.org

302-623-4450

Chambersburg Hospital, Chambersburg, Pennsylvania

Status

Recruiting

Address

Chambersburg Hospital

Chambersburg, Pennsylvania, 17201

Site Contact

Site Public Contact

Roster@nrgoncology.org

412-339-5294

Geisinger Medical Center, Danville, Pennsylvania

Status

Recruiting

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822

Site Contact

Site Public Contact

HemonCCTrials@geisinger.edu

570-271-5251

Saint Luke's Hospital-Anderson Campus, Easton, Pennsylvania

Status

Recruiting

Address

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045

Site Contact

Site Public Contact

Roster@nrgoncology.org

412-339-5294

Ephrata Cancer Center, Ephrata, Pennsylvania

Status

Recruiting

Address

Ephrata Cancer Center

Ephrata, Pennsylvania, 17522

Site Contact

Site Public Contact

717-721-4840

Saint Vincent Hospital, Erie, Pennsylvania

Status

Recruiting

Address

Saint Vincent Hospital

Erie, Pennsylvania, 16544

Site Contact

Site Public Contact

814-452-5000

Adams Cancer Center, Gettysburg, Pennsylvania

Status

Recruiting

Address

Adams Cancer Center

Gettysburg, Pennsylvania, 17325

Site Contact

Site Public Contact

877-441-7957

Sechler Family Cancer Center, Lebanon, Pennsylvania

Status

Recruiting

Address

Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042

Site Contact

Site Public Contact

doxenberg@wellspan.org

717-741-8303

Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania

Status

Recruiting

Address

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837

Site Contact

Site Public Contact

HemonCCTrials@geisinger.edu

570-374-8555

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Status

Recruiting

Address

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

Site Contact

Site Public Contact

ONCTrialNow@jefferson.edu

215-600-9151

Jefferson Torresdale Hospital, Philadelphia, Pennsylvania

Status

Recruiting

Address

Jefferson Torresdale Hospital

Philadelphia, Pennsylvania, 19114

Site Contact

Site Public Contact

ONCTrialNow@jefferson.edu

215-600-9151

Allegheny General Hospital, Pittsburgh, Pennsylvania

Status

Recruiting

Address

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212

Site Contact

Site Public Contact

877-284-2000

Quakertown, Pennsylvania

Status

Recruiting

Address

Saint Luke's Hospital - Upper Bucks Campus

Quakertown, Pennsylvania, 18951

Site Contact

Site Public Contact

610-776-4714

Saint Luke's Hospital-Quakertown Campus, Quakertown, Pennsylvania

Status

Recruiting

Address

Saint Luke's Hospital-Quakertown Campus

Quakertown, Pennsylvania, 18951

Site Contact

Site Public Contact

610-776-4714

Saint Luke's Hospital - Monroe Campus, Stroudsburg, Pennsylvania

Status

Recruiting

Address

Saint Luke's Hospital - Monroe Campus

Stroudsburg, Pennsylvania, 18360

Site Contact

Site Public Contact

ctsucontact@westat.com

888-823-5923

Wilkes-Barre, Pennsylvania

Status

Recruiting

Address

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

Site Contact

Site Public Contact

HemonCCTrials@geisinger.edu

570-271-5251

WellSpan Health-York Cancer Center, York, Pennsylvania

Status

Recruiting

Address

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403

Site Contact

Site Public Contact

877-441-7957

WellSpan Health-York Hospital, York, Pennsylvania

Status

Recruiting

Address

WellSpan Health-York Hospital

York, Pennsylvania, 17403

Site Contact

Site Public Contact

877-441-7957

McLeod Regional Medical Center, Florence, South Carolina

Status

Recruiting

Address

McLeod Regional Medical Center

Florence, South Carolina, 29506

Site Contact

Site Public Contact

dorie.sturgill@mcleodhealth.org

843-777-0770

Gibbs Cancer Center-Gaffney, Gaffney, South Carolina

Status

Active, not recruiting

Address

Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341

Self Regional Healthcare, Greenwood, South Carolina

Status

Recruiting

Address

Self Regional Healthcare

Greenwood, South Carolina, 29646

Site Contact

Site Public Contact

nmcgaha@selfregional.org

864-725-4771

Gibbs Cancer Center-Pelham, Greer, South Carolina

Status

Active, not recruiting

Address

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651

Spartanburg Medical Center, Spartanburg, South Carolina

Status

Active, not recruiting

Address

Spartanburg Medical Center

Spartanburg, South Carolina, 29303

MGC Hematology Oncology-Union, Union, South Carolina

Status

Active, not recruiting

Address

MGC Hematology Oncology-Union

Union, South Carolina, 29379

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104

Site Contact

Site Public Contact

OncologyClinicTrialsSF@sanfordhealth.org

605-312-3320

Avera Cancer Institute, Sioux Falls, South Dakota

Status

Active, not recruiting

Address

Avera Cancer Institute

Sioux Falls, South Dakota, 57105

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

Site Contact

Site Public Contact

OncologyClinicalTrialsSF@SanfordHealth.org

605-312-3320

Richmond, Virginia

Status

Active, not recruiting

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Langlade Hospital and Cancer Center, Antigo, Wisconsin

Status

Recruiting

Address

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

Site Contact

Site Public Contact

Juli.Alford@aspirus.org

715-623-9869

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

Status

Recruiting

Address

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Site Contact

Site Public Contact

cancerctr@gundersenhealth.org

608-775-2385

Madison, Wisconsin

Status

Recruiting

Address

University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792

Site Contact

Site Public Contact

800-622-8922

Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin

Status

Recruiting

Address

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051

Site Contact

Site Public Contact

262-257-5100

Medical College of Wisconsin, Milwaukee, Wisconsin

Status

Recruiting

Address

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Site Contact

Site Public Contact

414-805-3666

Cancer Center of Western Wisconsin, New Richmond, Wisconsin

Status

Recruiting

Address

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Drexel Town Square Health Center, Oak Creek, Wisconsin

Status

Recruiting

Address

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154

Site Contact

Site Public Contact

414-805-0505

Ascension Saint Mary's Hospital, Rhinelander, Wisconsin

Status

Recruiting

Address

Ascension Saint Mary's Hospital

Rhinelander, Wisconsin, 54501

Site Contact

Site Public Contact

Beth.Knetter@aspirus.org

715-847-2353

Ascension Saint Michael's Hospital, Stevens Point, Wisconsin

Status

Recruiting

Address

Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, 54481

Site Contact

Site Public Contact

Beth.Knetter@aspirus.org

715-847-2353

Aspirus Regional Cancer Center, Wausau, Wisconsin

Status

Recruiting

Address

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

Site Contact

Site Public Contact

877-405-6866

West Bend, Wisconsin

Status

Recruiting

Address

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095

Site Contact

Site Public Contact

414-805-0505

International Sites

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Status

Recruiting

Address

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1

Site Contact

Site Public Contact

306-766-2213

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Status

Recruiting

Address

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4

Site Contact

Site Public Contact

306-655-2914

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