Overall, cancer incidence has decreased and the rate of cancer deaths in both men and women
has also significantly declined among both men and women in all site.However, the prevalence
of chronic pain is 28.2%, ranging from 22.5% to 35.4%, depending on the location of the
primary tumor, and neuropathic characteristics were observed in 19.9% of patients with
chronic cancer pain.
Despite numerous studies on cancer pathogenesis and diagnosis, few reports have demonstrated
the brain mechanism underlying cancer pain. One study used resting functional magnetic
resonance imaging (fMRI) to identify the changes in the functional brain network of chronic
bone cancer pain mice under anesthesia. Cancer-induced bone pain (CIBP) might alter resting
state activity of the cingulate cortex, prefrontal cortex (PFC) and ventral striatum,
indicating a strong affective component of the CIBP mice.In imaging studies of human patients
with cancer, patients with chronic cancer pain exhibited activation in the PFC.
The 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)
images can provide quantitative results in clinical oncology.Owing to the higher glucose
metabolic rate in the brain, brain FDG-PET images are not routinely used in the clinical
setting. However, several studies have demonstrated functional brain changes in human pain
condition.In this study, we use FDG-PET to investigate changes concerning the glucose
metabolism in the brain with or without cancer pain.