Because seizures are one of the leading neurologic complications in brain tumor patients,
neurosurgeons prescribe antiepileptic drugs (AEDs) to help prevent them. Although the
American Academy of Neurology (AAN) guidelines recommend that AEDs be stopped after the first
post-operative week in patients without seizures, there is no standard length of treatment
and some patients may stay on AEDs indefinitely.
In an attempt to develop clinical guidelines for AED use in post-operative brain tumor
patients, we will try to determine if taking levetiracetam extended-release (Keppra XR) for 1
week results in less neurotoxicity than taking it for 6 weeks.