If you are willing to participate in this study you will be asked to undergo some screening
tests and procedures to confirm that you are eligible. Many of these tests and procedures are
likely to be part of regular cancer care and may be done even if it turns out that you do not
take part in the research study. If you have had some of these tests or procedures recently,
they may or may not have to be repeated. These tests and procedures include: a medical
history, physical examination, CT or MRI, blood tests, serum chromogranin A, urine tests,
24-hour urine collection, pregnancy test and an electrocardiogram. If these tests show that
you are eligible to participate in the research study, you will begin the study treatment. If
you do not meet the eligibility criteria, you will not be able to participate in this
If you meet the requirements for this study and you agree to continue your participation, you
will receive Ziv-aflibercept every two weeks. Each dose of Ziv-aflibercept consists of an
approximately 60 minutes infusion (through a needle into a vein). You will also receive an
injection of Octreotide LAR (long acting release) monthly as part of your treatment for
carcinoid tumor. This injection will be given to you by a nurse in your buttock. You may
already be on Octreotide LAR. In that case, you will continue taking it at the same dose and
You will need to come to the clinic every two weeks while participating in this study. Each
cycle is 28 days.
The following tests and procedures will be performed on Days 1 and 15 of each cycle:
questions about your health, physical exam (Day 1 of each cycle only), vital signs, blood
tests, pregnancy test (Day 1 of each cycle only).
Urine tests will be performed every other cycle.
The following tests and procedures will be done at the end of every third cycle: CT scan or
MRI, Serum Chromogranin A, 24-hour urine collection.
After the final dose of the study drug the following tests and procedures will be performed:
questions about your general health, physical exam, vital signs, blood tests, pregnancy test,
EKG, Serum Chromogranin A, 24-hour urine collection.