Clinical Trial Finder

[11C]Acetate PET in Patients With Glioma

Study Purpose

At each point that the patient will have [11C]-Acetate PET study, this will be compared with standard clinical MR imaging. Abbreviations: XRT

  • - radiation therapy; TMZ - temozolomide (chemotherapy) Quantitative Image Data Analysis: The [11C]-Acetate uptake in tumor sites from images will be analyzed qualitatively by visual assessment, quantitatively using a standard uptake value (SUV) in the tumor relative to the contralateral normal brain, and the parameters obtained by compartmental modeling of dynamic data.

Recuitment Criteria

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Accepts Healthy Volunteers
No

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.

An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.

Study Type
Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Male or female, age 18 and older, of any ethnic group - Spanish-speaking patients will be eligible - Histological diagnosis of glioma or - Brain MR imaging suggestive of a glioma or 2HG > 2mM by MR spectroscopy in patients who have not had a surgical procedure to establish the diagnosis.
- Karnofsky Performance status > 70% - Negative serum pregnancy test or child bearing potential terminated by surgery, radiation, menopause or current use of two approved methods of birth control - Patient able and willing to provide informed consent

Exclusion Criteria:

- Patient or legal parent/guardian unable to provide informed consent - Psychiatric or addictive disorders that preclude obtaining informed consent - Karnofsky Performance status < 70% - NYHA class III and IV congestive heart failure - Unstable angina - Pregnant or lactating women - Women of childbearing potential who refuse a pregnancy test

Trial Details

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

Trial ID:
NCT02986815

Phase 0: Exploratory study involving very limited human exposure to the drug to determine whether a drug is modulating its target.

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase
N/A

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Lead Sponsor
University of Texas Southwestern Medical Center

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Agency Class
Other
Overall Status Recruiting
Countries United States

The disease, disorder, syndrome, illness, or injury that is being studied.

Conditions
Glioma
Additional Details

1. [11C]Acetate Administration [11C]Acetate will be administered in the Clinical PET Facility located on the 2nd floor of the Clements Imaging Building at UT Southwestern. Upon arrival, the patient will have an opportunity to have questions answered regarding the procedure. The patient will have one intravenous line placed prior to [11C]Acetate administration. The patient will receive the low-dose CT portion of a PET/CT scan, after which [11C]Acetate will be administered intravenously over approximately 1 min at a dose of 0.3 mCi/kg (maximum 30 mCi) and followed by a saline flush. The injection and imaging procedure will be terminated in any patient who exhibits anaphylaxis, significant dyspnea or chest pain. The administering physician will stay with the patient for at least 15 min after injection and will remain in the Clinical PET Facility through the duration of the imaging procedure. All adverse events occurring post [11C]Acetate infusion will be recorded within a 24-hour period. The adverse events to be specifically monitored during the infusion include localized discomfort at the IV injection site, pain, respiratory difficulties, flushing, dizziness, pruritus/rash, and any other symptoms that could be secondary to an anaphylactic reaction. The subject will be instructed to report any subjective symptoms or sensory changes noted. Patients will be imaged on a Siemens Biograph 64 slice PET CT scanner. After placing the patient on the scanner and securing the head in a head restraint, a low dose CT of the brain will be acquired. Images with 3 mm slice thickness and spaced at 1.5 mm intervals will be reconstructed in a 300 mm field of view. The purpose of the CT is for image localization and attenuation correction and it is not considered to be a diagnostic quality CT. Following the completion of the CT, the [11C]Acetate will be administered as described in Section VI.F.3.b. A dynamic PET image will be acquired in 3D list mode for a total of 30 minutes. From the list mode data a flow image series will be constructed as follows:

  • - 12 frames x 10 seconds each (out to 2 minutes post-injection) - then 6 frames x 30 seconds each - then 1 frame x 60 seconds each A second series will be -reconstructed to demonstrate dynamic brain regional metabolism as follows: - 12 frames x 10 seconds each (out to 2 minutes post-injection) - then 8 frames x 30 seconds each (from 2 to 6 minutes) - then 4 frames x 60 seconds each (from 6 to 10 minutes) - then 2 frames of 300 seconds each (from 10 to 20 minutes) - then 1 frame of 600 seconds (from 20 to 30 minutes) Reconstructions will be performed with a 128 x 128 image matrix using 3D OSEM (4 iterations, 21 subsets) and a 3 mm Gaussian filter.
3. Study Procedures and Schedule of Events: 1. Initial visits prior to [11C]Acetate PET/CT: Patients who are identified as potential candidates for the study will be approached to explain the study and to obtain their written informed consent to be enrolled in the protocol. The following additional patient data will be obtained: histologic diagnosis (if a surgical procedure has been carried out), IDH mutational status, age at radiologic diagnosis, weight, full medical and neurological history and physical exam. Correlative imaging will be performed using MR brain, with and without gadolinium, within 14 days prior to enrollment. In addition, when available, 2-hydroxyglutarate (2HG) MR spectroscopy will be available for review and determination of 2HG concentration. For patients referred from outside UTSW and Parkland hospital, patient records and imaging will be reviewed to determine eligibility for the study and to obtain baseline comparative imaging scans. 2. Day of baseline and follow up [11C]Acetate scans: [11C]Acetate PET/CT scan performed at baseline and at the time of clinical follow up; 3 months for grade 2 glioma patients on standard follow up, 2-3 months after treatment for patients being imaged pre- and post-treatment. The patient will be positioned supine in the PET/CT scanner for a dynamic scan over the brain. Patients will have two intravenous lines placed, one in each arm. [11C]Acetate PET/CT will be performed using the standard dose of 0.3 mCi/kg up to a maximum of 30mCi for [11C]Acetate. A single imaging field over the brain will be imaged dynamically for 30 min following the start of a 1-min intravenous infusion of [11C]Acetate, as described in Section VI.F.2. 4. General Concomitant Medication and Supportive Care Guidelines Any adverse effects, related or non-related to the injection of [11C]Acetate, will be treated as clinically indicated with no study-related restrictions. 5. Duration of Therapy and Follow-up: This is an observational study and patients will remain on study for the duration of their clinical follow up, as determined by their treating physician. [11C]Acetate PET scan timing will be determined based on their individual clinical course.

Contact a Trial Team

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Dallas, Texas

Status

Recruiting

Address

University of Texas Southwestern Medical Center

Dallas, Texas, 75063

Site Contact

Sarh McNeil, RN

sarah.mcneil@utsouthwestern.edu

214-645-8166

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