Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer

Study Purpose

This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only (limited stage) or has spread outside of the lung in which it began or to other parts of the body (extensive stage). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. The hippocampus is part of the brain that is important for memory. Avoiding the hippocampus during whole-brain radiation could decrease the chance of side effects on memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more effective with or without hippocampal avoidance in treating patients with small cell lung cancer.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - PRIOR TO STEP 1 REGISTRATION.
  • - Histologic proof or unequivocal cytologic proof (fine needle aspiration, biopsy or two positive sputa) of SCLC within 250 days prior to Step 1 registration.
  • - High-grade neuroendocrine carcinoma or combined SCLC and NSCLC is permitted.
  • - Patients must have received chemotherapy and be registered to Step 1 registration no earlier than 7 days and no later than 56 days after completing chemotherapy.
Note:
  • - Post-chemotherapy restaging imaging must be completed no more than 56 days prior to Step 1 registration.
  • - For patients with extensive-stage small cell lung cancer who are being considered for consolidative thoracic radiotherapy after chemotherapy, concomitant administration of consolidative thoracic radiotherapy and protocol-specified prophylactic cranial irradiation with or without hippocampal avoidance is permitted.
  • - Patients must have a gadolinium contrast-enhanced three-dimensional (3D), spoiled gradient (SPGR), magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo (TFE) MRI scan (see section 11.3 regarding axial T2/FLAIR sequence).
To yield acceptable image quality, the gadolinium contrast-enhanced three-dimensional SPGR, MP-RAGE or TFE axial MRI scan must use the smallest possible axial slice thickness not exceeding 1.5 mm. Sites may contact the Imaging Co-Chairs for further information or assistance if needed.
  • - This MRI must be obtained within 56 days prior to Step 1 registration.
Note: The MRI study is mandatory irrespective of randomization to the experimental or control arm of this study.
  • - Prior to chemotherapy +/- thoracic radiotherapy, patients must be defined as limited-stage or extensive-stage SCLC after clinical staging evaluation involving the following: 1.
History/physical examination; 2. CT of the chest and abdomen with contrast (does not have to be done if the patient has had a PET/CT scan prior to initiating chemotherapy or thoracic radiotherapy); 3. MRI of the brain with contrast or diagnostic head CT with contrast; 4. For patients without evidence of extensive-stage SCLC on chest and abdomen CT and brain MRI or head CT, a PET/CT or bone scan is required to confirm limited-stage SCLC.
  • - After chemotherapy, patients must be restaged prior to Step 1 registration using the same diagnostic work-up as required pre-chemotherapy.
Repeat PET/CT or bone scan is not required. Patients must have:
  • - History/physical examination within 30 days of Step 1 registration; - No CNS metastases (Repeat MRI required; see Section 3.2.
3 for details) within 56 days prior to Step 1 registration;
  • - No progression in any site; - Radiographic partial or complete response to chemotherapy in at least one disease site within 56 days prior to Step 1 registration.
1. If PET/CT was obtained prior to chemotherapy, either a repeat PET/CT or CT of the chest and abdomen with contrast can be obtained for response assessment. 2. Patients who underwent resection for limited-stage SCLC prior to chemotherapy and have no radiographically evident disease for response assessment remain eligible if post-chemotherapy imaging demonstrates no progression.
  • - Zubrod performance status 0-2.
  • - Women of childbearing potential and male participants must practice adequate contraception.
  • - Women of childbearing potential must have a negative qualitative serum pregnancy test =< 2 weeks prior to study entry.
  • - Patients who are primary English or French speakers are eligible.
  • - Patients must sign a study-specific informed consent prior to study entry.
  • - PRIOR TO STEP 2 REGISTRATION.
  • - The following baseline neurocognitive assessments must be completed and uploaded within 10 calendar days after or at the time of Step 1 registration: HVLT-R (recall, delayed recall, and recognition), TMT (Parts A and B), and COWA.
The neurocognitive assessments will be uploaded into the NRG Oncology RAVE System for evaluation by Dr. Wefel. Once the upload is complete, within 3 business days, a notification email will be sent to the site to proceed to Step 2 registration. At minimum, the HVLT-R delayed recall must be able to be scored (i.e. completed without error) in order to be eligible.
  • - Patients must have a baseline raw score greater than 2 on the HVLT-R delayed recall.

Exclusion Criteria:

  • - Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in overlap of radiation fields.
  • - Radiographic evidence of CNS metastases.
  • - Radiographic evidence of hydrocephalus or other architectural distortion of the ventricular system, including placement of external ventricular drain or ventriculoperitoneal shunt.
  • - Planned concurrent chemotherapy or anti-tumor agent during PCI.
  • - Concurrent atezolizumab permitted.
  • - Concomitant invasive malignancy or invasive malignancy within the past five years other than non-melanomatous skin cancer; history of in situ carcinoma (e.g. ductal carcinoma in situ of breast, in situ carcinoma of the cervix, vulva or larynx) is permitted.
  • - Contraindication to MR imaging, such as implanted metal devices or foreign bodies or severe claustrophobia.
  • - Severe, active comorbidity, defined as follows: - Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months.
  • - Transmural myocardial infarction within the last 6 months.
  • - Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration.
  • - Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects.
  • - Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration.
  • - Uncontrolled, clinically significant cardiac arrhythmias.
  • - HIV positive with CD4 count < 200 cells/microliter; 1.
Note: Patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count ≥ 200 cells/microliter within 30 days prior to Step 1 registration. 2. Note: HIV testing is not required for eligibility for this protocol. - Pregnant or lactating women or women of childbearing potential and male participants who are sexually active and not willing/able to use medically acceptable forms of contraception

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT02635009
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2/Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

NRG Oncology
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Vinai Gondi
Principal Investigator Affiliation NRG Oncology
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other, NIH
Overall Status Recruiting
Countries Canada, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Extensive Stage Small Cell Lung Carcinoma, Limited Stage Small Cell Lung Carcinoma
Additional Details

PRIMARY OBJECTIVES:

  • I. Determine whether the 12-month intracranial relapse rate following hippocampal avoidance (HA)-prophylactic cranial irradiation (PCI) is non-inferior compared to the rate following PCI for patients with small cell lung cancer (SCLC).
(Randomized Phase II Component [Non-Inferiority])
  • II. Determine whether HA-PCI reduces the likelihood of 6-month deterioration from baseline in Hopkins Verbal Learning Test (HVLT)-Revised (R) delayed recall compared to PCI for patients with SCLC.
(Phase III Component [Efficacy]) SECONDARY OBJECTIVES:
  • I. Compare time to cognitive failure, as measured by a battery of tests (HVLT-R, Controlled Oral Word Association [COWA] test, and Trail Making Test [TMT] parts A and B), after PCI versus HA-PCI in SCLC.
  • II. Compare time to cognitive failure as separately measured by each test (HVLT-R for Total Recall and Delayed Recognition, COWA test, and TMT parts A and B), after PCI versus HA-PCI for SCLC.
  • III. Compare patient-reported cognitive functioning and other quality of life domains (assessed by the European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire [QLQ]-Core [C]30 and BN20) between PCI versus HA-PCI for patients with SCLC.
  • IV. Compare overall survival after PCI versus HA-PCI for patients with SCLC.
  • V. Compare 12-month intracranial relapse rate (at completion of phase III) and time to intracranial relapse after PCI versus HA-PCI for patients with SCLC.
  • VI. Evaluate adverse events according to Common Terminology Criteria for Adverse Events (CTCAE) criteria.
  • VII. Correlate changes in health-related quality of life (HRQOL) domains with changes in cognitive testing outcomes following PCI versus HA-PCI for patients with SCLC.
  • VIII. Assess cost-effectiveness of HA-PCI (intensity modulated radiation therapy [IMRT]) and PCI (3-dimensional conformal radiation therapy [3DCRT]) using the EuroQual (EQ)-5-Dimensions (5D)-5L.
  • IX. Correlate miRNA signatures with cognitive failure in SCLC patients who received PCI and HA-PCI.
  • X. Evaluate APOE genotyping as potential predictor of neurocognitive decline, hippocampal atrophy after brain irradiation and/or differential benefit from hippocampal avoidance.
XI. Evaluate baseline MR imaging biomarkers of white matter injury and hippocampal volumetry as potential predictors of cognitive decline and differential benefit from HA-PCI as compared to PCI. TERTIARY OBJECTIVES:
  • I. Collect serum, whole blood, and urine for future translational research analyses.
  • II. Evaluate baseline magnetic resonance (MR) imaging biomarkers of white matter injury and hippocampal volumetry as potential predictors of cognitive decline and differential benefit from HAPCI as compared to PCI.
OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM I: Patients undergo PCI using 3DCRT daily for 2 weeks. ARM II: Patients undergo PCI with HA using IMRT daily for 2 weeks. After completion of study treatment, patients are followed every 3 months for 1 year, then every 6 months until 3 years and then annually until death.

Arms & Interventions

Arms

Active Comparator: Arm I (PCI using 3DCRT)

Patients undergo PCI using 3DCRT daily for 2 weeks.

Experimental: Arm II (PCI with HA using IMRT)

Patients undergo PCI with HA using IMRT daily for 2 weeks.

Interventions

Radiation: - 3-Dimensional Conformal Radiation Therapy

Undergo PCI using 3DCRT

Other: - Cognitive Assessment

Ancillary studies

Radiation: - Intensity-Modulated Radiation Therapy

Undergo PCI with HA using IMRT

Other: - Laboratory Biomarker Analysis

Correlative studies

Other: - Quality-of-Life Assessment

Ancillary studies

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Birmingham, Alabama

Status

Active, not recruiting

Address

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

Lewis and Faye Manderson Cancer Center, Tuscaloosa, Alabama

Status

Recruiting

Address

Lewis and Faye Manderson Cancer Center

Tuscaloosa, Alabama, 35401

Site Contact

Site Public Contact

800-338-2948

Tucson, Arizona

Status

Recruiting

Address

Banner University Medical Center - Tucson

Tucson, Arizona, 85719

Site Contact

Site Public Contact

aselegue@email.arizona.edu

Marin General Hospital, Greenbrae, California

Status

Suspended

Address

Marin General Hospital

Greenbrae, California, 94904

Los Angeles County-USC Medical Center, Los Angeles, California

Status

Recruiting

Address

Los Angeles County-USC Medical Center

Los Angeles, California, 90033

Site Contact

Site Public Contact

323-865-0451

USC / Norris Comprehensive Cancer Center, Los Angeles, California

Status

Recruiting

Address

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Site Contact

Site Public Contact

323-865-0451

Mercy UC Davis Cancer Center, Merced, California

Status

Active, not recruiting

Address

Mercy UC Davis Cancer Center

Merced, California, 95340

Kaiser Permanente Oakland-Broadway, Oakland, California

Status

Active, not recruiting

Address

Kaiser Permanente Oakland-Broadway

Oakland, California, 94611

Saint Joseph Hospital - Orange, Orange, California

Status

Recruiting

Address

Saint Joseph Hospital - Orange

Orange, California, 92868

Site Contact

Site Public Contact

714-734-6220

Rancho Cordova, California

Status

Active, not recruiting

Address

Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670

Roseville, California

Status

Recruiting

Address

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661

Site Contact

Site Public Contact

bernicl@sutterhealth.org

415-209-2686

Roseville, California

Status

Active, not recruiting

Address

The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678

Sutter Medical Center Sacramento, Sacramento, California

Status

Recruiting

Address

Sutter Medical Center Sacramento

Sacramento, California, 95816

Site Contact

Site Public Contact

bernicl@sutterhealth.org

415-209-2686

Sacramento, California

Status

Active, not recruiting

Address

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

San Francisco, California

Status

Recruiting

Address

California Pacific Medical Center-Pacific Campus

San Francisco, California, 94115

Site Contact

Site Public Contact

bernicl@sutterhealth.org

415-209-2686

Santa Clara, California

Status

Active, not recruiting

Address

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051

Truckee, California

Status

Active, not recruiting

Address

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161

Vallejo, California

Status

Suspended

Address

Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589

Swedish Medical Center, Englewood, Colorado

Status

Suspended

Address

Swedish Medical Center

Englewood, Colorado, 80113

Poudre Valley Hospital, Fort Collins, Colorado

Status

Active, not recruiting

Address

Poudre Valley Hospital

Fort Collins, Colorado, 80524

Bridgeport, Connecticut

Status

Suspended

Address

Hartford HealthCare - Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606

Yale University, New Haven, Connecticut

Status

Recruiting

Address

Yale University

New Haven, Connecticut, 06520

Site Contact

Site Public Contact

canceranswers@yale.edu

203-785-5702

Helen F Graham Cancer Center, Newark, Delaware

Status

Recruiting

Address

Helen F Graham Cancer Center

Newark, Delaware, 19713

Site Contact

Site Public Contact

mhayden@christianacare.org

302-623-4450

Newark, Delaware

Status

Recruiting

Address

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718

Site Contact

Site Public Contact

mhayden@christianacare.org

302-623-4450

Boca Raton Regional Hospital, Boca Raton, Florida

Status

Recruiting

Address

Boca Raton Regional Hospital

Boca Raton, Florida, 33486

Site Contact

Site Public Contact

561-955-4800

Coral Gables, Florida

Status

Recruiting

Address

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

Site Contact

Site Public Contact

305-243-2647

Broward Health Medical Center, Fort Lauderdale, Florida

Status

Recruiting

Address

Broward Health Medical Center

Fort Lauderdale, Florida, 33316

Site Contact

Site Public Contact

954-355-5346

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Site Contact

Site Public Contact

305-243-2647

Miami Cancer Institute, Miami, Florida

Status

Recruiting

Address

Miami Cancer Institute

Miami, Florida, 33176

Site Contact

Site Public Contact

786-596-2000

Orlando Health Cancer Institute, Orlando, Florida

Status

Recruiting

Address

Orlando Health Cancer Institute

Orlando, Florida, 32806

Site Contact

Site Public Contact

CancerClinicalTrials@orlandohealth.com

321-841-7246

Moffitt Cancer Center, Tampa, Florida

Status

Suspended

Address

Moffitt Cancer Center

Tampa, Florida, 33612

Grady Health System, Atlanta, Georgia

Status

Recruiting

Address

Grady Health System

Atlanta, Georgia, 30303

Site Contact

Site Public Contact

404-489-9164

Emory University Hospital Midtown, Atlanta, Georgia

Status

Recruiting

Address

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Site Contact

Site Public Contact

888-946-7447

Atlanta, Georgia

Status

Recruiting

Address

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

Site Contact

Site Public Contact

404-778-1868

Northside Hospital, Atlanta, Georgia

Status

Recruiting

Address

Northside Hospital

Atlanta, Georgia, 30342

Site Contact

Site Public Contact

ClinicalTrials@northside.com

404-303-3355

Northside Hospital-Forsyth, Cumming, Georgia

Status

Recruiting

Address

Northside Hospital-Forsyth

Cumming, Georgia, 30041

Site Contact

Site Public Contact

clinicaltrials@northside.com

404-303-3355

Savannah, Georgia

Status

Recruiting

Address

Memorial Health University Medical Center

Savannah, Georgia, 31404

Site Contact

Site Public Contact

Lorraine.OHara@hcahealthcare.com

912-350-7887

Savannah, Georgia

Status

Recruiting

Address

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405

Site Contact

Site Public Contact

underberga@sjchs.org

912-819-5704

The Cancer Center of Hawaii-Pali Momi, 'Aiea, Hawaii

Status

Recruiting

Address

The Cancer Center of Hawaii-Pali Momi

'Aiea, Hawaii, 96701

Site Contact

Site Public Contact

808-678-9000

Queen's Medical Center, Honolulu, Hawaii

Status

Recruiting

Address

Queen's Medical Center

Honolulu, Hawaii, 96813

Site Contact

Site Public Contact

808-545-8548

The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii

Status

Recruiting

Address

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817

Site Contact

Site Public Contact

808-547-6881

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho

Status

Recruiting

Address

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Status

Recruiting

Address

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712

Site Contact

Site Public Contact

eslinget@slhs.org

208-381-2774

Caldwell, Idaho

Status

Recruiting

Address

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho

Status

Recruiting

Address

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642

Site Contact

Site Public Contact

eslinget@slhs.org

208-381-2774

Saint Alphonsus Medical Center-Nampa, Nampa, Idaho

Status

Recruiting

Address

Saint Alphonsus Medical Center-Nampa

Nampa, Idaho, 83686

Site Contact

Site Public Contact

mccinfo@mtcancer.org

406-969-6060

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho

Status

Recruiting

Address

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686

Site Contact

Site Public Contact

eslinget@slhs.org

208-381-2774

Twin Falls, Idaho

Status

Recruiting

Address

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301

Site Contact

Site Public Contact

eslinget@slhs.org

208-381-2774

Northwestern University, Chicago, Illinois

Status

Active, not recruiting

Address

Northwestern University

Chicago, Illinois, 60611

Chicago, Illinois

Status

Suspended

Address

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612

Rush University Medical Center, Chicago, Illinois

Status

Recruiting

Address

Rush University Medical Center

Chicago, Illinois, 60612

Site Contact

Site Public Contact

clinical_trials@rush.edu

312-942-5498

Decatur Memorial Hospital, Decatur, Illinois

Status

Recruiting

Address

Decatur Memorial Hospital

Decatur, Illinois, 62526

Site Contact

Site Public Contact

rhamrick@dmhhs.org

217-876-4740

Crossroads Cancer Center, Effingham, Illinois

Status

Recruiting

Address

Crossroads Cancer Center

Effingham, Illinois, 62401

Site Contact

Site Public Contact

rhamrick@dmhhs.org

217-876-4740

Geneva, Illinois

Status

Recruiting

Address

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134

Site Contact

Site Public Contact

Donald.Smith3@nm.org

630-352-5360

Edward Hines Jr VA Hospital, Hines, Illinois

Status

Recruiting

Address

Edward Hines Jr VA Hospital

Hines, Illinois, 60141

Site Contact

Site Public Contact

708-202-8387

Condell Memorial Hospital, Libertyville, Illinois

Status

Suspended

Address

Condell Memorial Hospital

Libertyville, Illinois, 60048

Loyola University Medical Center, Maywood, Illinois

Status

Recruiting

Address

Loyola University Medical Center

Maywood, Illinois, 60153

Site Contact

Site Public Contact

708-226-4357

Illinois CancerCare-Peoria, Peoria, Illinois

Status

Suspended

Address

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

Methodist Medical Center of Illinois, Peoria, Illinois

Status

Recruiting

Address

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

Site Contact

Site Public Contact

andersonj@illinoiscancercare.com

309-243-3605

OSF Saint Francis Medical Center, Peoria, Illinois

Status

Recruiting

Address

OSF Saint Francis Medical Center

Peoria, Illinois, 61637

Site Contact

Site Public Contact

andersonj@illinoiscancercare.com

309-243-3605

Memorial Medical Center, Springfield, Illinois

Status

Recruiting

Address

Memorial Medical Center

Springfield, Illinois, 62781

Site Contact

Site Public Contact

217-788-3528

Carle Cancer Center, Urbana, Illinois

Status

Recruiting

Address

Carle Cancer Center

Urbana, Illinois, 61801

Site Contact

Site Public Contact

Research@carle.com

800-446-5532

Warrenville, Illinois

Status

Recruiting

Address

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555

Site Contact

Site Public Contact

Donald.Smith3@nm.org

630-352-5360

Anderson, Indiana

Status

Active, not recruiting

Address

Saint Vincent Anderson Regional Hospital/Cancer Center

Anderson, Indiana, 46016

Parkview Hospital Randallia, Fort Wayne, Indiana

Status

Active, not recruiting

Address

Parkview Hospital Randallia

Fort Wayne, Indiana, 46805

Parkview Regional Medical Center, Fort Wayne, Indiana

Status

Recruiting

Address

Parkview Regional Medical Center

Fort Wayne, Indiana, 46845

Site Contact

Site Public Contact

877-784-4673

Goshen Center for Cancer Care, Goshen, Indiana

Status

Active, not recruiting

Address

Goshen Center for Cancer Care

Goshen, Indiana, 46526

IU Health Ball Memorial Hospital, Muncie, Indiana

Status

Active, not recruiting

Address

IU Health Ball Memorial Hospital

Muncie, Indiana, 47303

Saint Luke's Hospital, Cedar Rapids, Iowa

Status

Recruiting

Address

Saint Luke's Hospital

Cedar Rapids, Iowa, 52402

Site Contact

Site Public Contact

Rachel.varner@unitypoint.org

319-368-5514

Mercy Hospital, Cedar Rapids, Iowa

Status

Active, not recruiting

Address

Mercy Hospital

Cedar Rapids, Iowa, 52403

Iowa Methodist Medical Center, Des Moines, Iowa

Status

Recruiting

Address

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

Site Contact

Site Public Contact

515-241-6727

University of Kansas Cancer Center, Kansas City, Kansas

Status

Recruiting

Address

University of Kansas Cancer Center

Kansas City, Kansas, 66160

Site Contact

Site Public Contact

KUCC_Navigation@kumc.edu

913-588-3671

Lawrence Memorial Hospital, Lawrence, Kansas

Status

Suspended

Address

Lawrence Memorial Hospital

Lawrence, Kansas, 66044

Overland Park, Kansas

Status

Recruiting

Address

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210

Site Contact

Site Public Contact

KUCC_Navigation@kumc.edu

913-588-3671

Ascension Via Christi Hospitals Wichita, Wichita, Kansas

Status

Recruiting

Address

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214

Site Contact

Site Public Contact

Keisha.humphries@ascension.org

800-362-0070

Wesley Medical Center, Wichita, Kansas

Status

Recruiting

Address

Wesley Medical Center

Wichita, Kansas, 67214

Site Contact

Site Public Contact

Keisha.humphries@ascension.org

316-268-5374

Lexington, Kentucky

Status

Recruiting

Address

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Site Contact

Site Public Contact

859-257-3379

Tulane University Health Sciences Center, New Orleans, Louisiana

Status

Active, not recruiting

Address

Tulane University Health Sciences Center

New Orleans, Louisiana, 70112

Anne Arundel Medical Center, Annapolis, Maryland

Status

Active, not recruiting

Address

Anne Arundel Medical Center

Annapolis, Maryland, 21401

University of Maryland Medical Center, Baltimore, Maryland

Status

Not yet recruiting

Address

University of Maryland Medical Center

Baltimore, Maryland, 21201

Site Contact

Minesh P. Mehta

mmehta@umm.edu

410-328-6921

Baltimore, Maryland

Status

Recruiting

Address

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

Site Contact

Site Public Contact

800-888-8823

Baltimore, Maryland

Status

Recruiting

Address

MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237

Site Contact

Site Public Contact

443-777-7364

MedStar Good Samaritan Hospital, Baltimore, Maryland

Status

Recruiting

Address

MedStar Good Samaritan Hospital

Baltimore, Maryland, 21239

Site Contact

Site Public Contact

Barbara.rector@medstar.net

410-261-8151

Baltimore, Maryland

Status

Recruiting

Address

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Site Contact

Site Public Contact

jhcccro@jhmi.edu

410-955-8804

UM Upper Chesapeake Medical Center, Bel Air, Maryland

Status

Recruiting

Address

UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014

Site Contact

Site Public Contact

443-643-3010

Columbia, Maryland

Status

Recruiting

Address

Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044

Site Contact

Site Public Contact

443-546-1300

Glen Burnie, Maryland

Status

Recruiting

Address

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061

Site Contact

Site Public Contact

410-553-8100

Ocean Pines, Maryland

Status

Recruiting

Address

TidalHealth Richard A Henson Cancer Institute

Ocean Pines, Maryland, 21811

Site Contact

Site Public Contact

carol.messick@peninsula.org

410-543-7067

TidalHealth Peninsula Regional, Salisbury, Maryland

Status

Recruiting

Address

TidalHealth Peninsula Regional

Salisbury, Maryland, 21801

Site Contact

Site Public Contact

monika.naegeli@peninsula.org

410-543-7032

UM Saint Joseph Medical Center, Towson, Maryland

Status

Active, not recruiting

Address

UM Saint Joseph Medical Center

Towson, Maryland, 21204

Lahey Hospital and Medical Center, Burlington, Massachusetts

Status

Recruiting

Address

Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805

Site Contact

Site Public Contact

cancerclinicaltrials@lahey.org

781-744-3421

Lowell General Hospital, Lowell, Massachusetts

Status

Active, not recruiting

Address

Lowell General Hospital

Lowell, Massachusetts, 01854

Worcester, Massachusetts

Status

Recruiting

Address

UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655

Site Contact

Site Public Contact

cancer.research@umassmed.edu

508-856-3216

Saint Joseph Mercy Hospital, Ann Arbor, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

McLaren Cancer Institute-Bay City, Bay City, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706

Saint Joseph Mercy Brighton, Brighton, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Brighton

Brighton, Michigan, 48114

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

Henry Ford Cancer Institute-Downriver, Brownstown, Michigan

Status

Recruiting

Address

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183

Site Contact

Site Public Contact

CTOResearch@hfhs.org

313-916-3721

Saint Joseph Mercy Chelsea, Chelsea, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Chelsea

Chelsea, Michigan, 48118

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

GenesisCare USA - Clarkston, Clarkston, Michigan

Status

Recruiting

Address

GenesisCare USA - Clarkston

Clarkston, Michigan, 48346

Site Contact

Site Public Contact

Rudi.Ross@usa.genesiscare.com

941-833-5700

McLaren Cancer Institute-Clarkston, Clarkston, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346

Clinton Township, Michigan

Status

Recruiting

Address

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038

Site Contact

Site Public Contact

CTOResearch@hfhs.org

313-916-3721

Beaumont Hospital - Dearborn, Dearborn, Michigan

Status

Recruiting

Address

Beaumont Hospital - Dearborn

Dearborn, Michigan, 48124

Site Contact

Site Public Contact

248-551-7695

Detroit, Michigan

Status

Recruiting

Address

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

Site Contact

Site Public Contact

ctoadmin@karmanos.org

313-576-9790

Henry Ford Hospital, Detroit, Michigan

Status

Recruiting

Address

Henry Ford Hospital

Detroit, Michigan, 48202

Site Contact

Site Public Contact

CTOResearch@hfhs.org

313-916-3721

GenesisCare USA - Farmington Hills, Farmington Hills, Michigan

Status

Recruiting

Address

GenesisCare USA - Farmington Hills

Farmington Hills, Michigan, 48334

Site Contact

Site Public Contact

Rudi.Ross@usa.genesiscare.com

941-833-5700

Genesys Hurley Cancer Institute, Flint, Michigan

Status

Recruiting

Address

Genesys Hurley Cancer Institute

Flint, Michigan, 48503

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

McLaren Cancer Institute-Flint, Flint, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Flint

Flint, Michigan, 48532

Mercy Health Saint Mary's, Grand Rapids, Michigan

Status

Suspended

Address

Mercy Health Saint Mary's

Grand Rapids, Michigan, 49503

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan

Status

Suspended

Address

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503

West Michigan Cancer Center, Kalamazoo, Michigan

Status

Recruiting

Address

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

Site Contact

Site Public Contact

crcwm-regulatory@crcwm.org

616-391-1230

McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446

Saint Mary Mercy Hospital, Livonia, Michigan

Status

Recruiting

Address

Saint Mary Mercy Hospital

Livonia, Michigan, 48154

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

GenesisCare USA - Macomb, Macomb, Michigan

Status

Recruiting

Address

GenesisCare USA - Macomb

Macomb, Michigan, 48044

Site Contact

Site Public Contact

Rudi.Ross@usa.genesiscare.com

941-833-5700

McLaren Cancer Institute-Macomb, Mount Clemens, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043

Mount Pleasant, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858

Mercy Health Mercy Campus, Muskegon, Michigan

Status

Suspended

Address

Mercy Health Mercy Campus

Muskegon, Michigan, 49444

McLaren Cancer Institute-Owosso, Owosso, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Owosso

Owosso, Michigan, 48867

Petoskey, Michigan

Status

Suspended

Address

McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770

Saint Joseph Mercy Oakland, Pontiac, Michigan

Status

Recruiting

Address

Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341

Site Contact

Site Public Contact

stephanie.couch@stjoeshealth.org

734-712-3671

McLaren-Port Huron, Port Huron, Michigan

Status

Suspended

Address

McLaren-Port Huron

Port Huron, Michigan, 48060

William Beaumont Hospital-Royal Oak, Royal Oak, Michigan

Status

Recruiting

Address

William Beaumont Hospital-Royal Oak

Royal Oak, Michigan, 48073

Site Contact

Site Public Contact

248-551-7695

Lakeland Medical Center Saint Joseph, Saint Joseph, Michigan

Status

Recruiting

Address

Lakeland Medical Center Saint Joseph

Saint Joseph, Michigan, 49085

Site Contact

Site Public Contact

crcwm-regulatory@crcwm.org

616-391-1230

William Beaumont Hospital - Troy, Troy, Michigan

Status

Recruiting

Address

William Beaumont Hospital - Troy

Troy, Michigan, 48085

Site Contact

Site Public Contact

248-551-7695

21st Century Oncology MHP - Troy, Troy, Michigan

Status

Recruiting

Address

21st Century Oncology MHP - Troy

Troy, Michigan, 48098

Site Contact

Site Public Contact

Rudi.Ross@usa.genesiscare.com

941-833-5700

Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan

Status

Recruiting

Address

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322

Site Contact

Site Public Contact

CTOResearch@hfhs.org

313-916-3721

Mayo Clinic Health System in Albert Lea, Albert Lea, Minnesota

Status

Active, not recruiting

Address

Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, 56007

Saint Luke's Hospital of Duluth, Duluth, Minnesota

Status

Recruiting

Address

Saint Luke's Hospital of Duluth

Duluth, Minnesota, 55805

Site Contact

Site Public Contact

kdean@slhduluth.com

218-249-7825

Mayo Clinic Health Systems-Mankato, Mankato, Minnesota

Status

Active, not recruiting

Address

Mayo Clinic Health Systems-Mankato

Mankato, Minnesota, 56001

Abbott-Northwestern Hospital, Minneapolis, Minnesota

Status

Recruiting

Address

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Mayo Clinic Radiation Therapy-Northfield, Northfield, Minnesota

Status

Active, not recruiting

Address

Mayo Clinic Radiation Therapy-Northfield

Northfield, Minnesota, 55057

Mayo Clinic in Rochester, Rochester, Minnesota

Status

Active, not recruiting

Address

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota

Status

Recruiting

Address

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

Site Contact

Site Public Contact

mmcorc@healthpartners.com

952-993-1517

Saint Francis Medical Center, Cape Girardeau, Missouri

Status

Recruiting

Address

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

Site Contact

Site Public Contact

sfmc@sfmc.net

573-334-2230

Creve Coeur, Missouri

Status

Recruiting

Address

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141

Site Contact

Site Public Contact

info@siteman.wustl.edu

800-600-3606

Freeman Health System, Joplin, Missouri

Status

Recruiting

Address

Freeman Health System

Joplin, Missouri, 64804

Site Contact

Site Public Contact

LJCrockett@freemanhealth.com

417-347-4030

Saint Luke's Hospital of Kansas City, Kansas City, Missouri

Status

Active, not recruiting

Address

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111

North Kansas City Hospital, Kansas City, Missouri

Status

Suspended

Address

North Kansas City Hospital

Kansas City, Missouri, 64116

North Kansas City, Missouri

Status

Recruiting

Address

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116

Site Contact

Site Public Contact

KUCC_Navigation@kumc.edu

913-588-3671

Washington University School of Medicine, Saint Louis, Missouri

Status

Recruiting

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Site Contact

Site Public Contact

info@siteman.wustl.edu

800-600-3606

Siteman Cancer Center-South County, Saint Louis, Missouri

Status

Recruiting

Address

Siteman Cancer Center-South County

Saint Louis, Missouri, 63129

Site Contact

Site Public Contact

info@siteman.wustl.edu

800-600-3606

Missouri Baptist Medical Center, Saint Louis, Missouri

Status

Recruiting

Address

Missouri Baptist Medical Center

Saint Louis, Missouri, 63131

Site Contact

Site Public Contact

314-996-5569

Mercy Hospital Saint Louis, Saint Louis, Missouri

Status

Recruiting

Address

Mercy Hospital Saint Louis

Saint Louis, Missouri, 63141

Site Contact

Site Public Contact

314-251-7066

Billings Clinic Cancer Center, Billings, Montana

Status

Recruiting

Address

Billings Clinic Cancer Center

Billings, Montana, 59101

Site Contact

Site Public Contact

research@billingsclinic.org

800-996-2663

Great Falls, Montana

Status

Recruiting

Address

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405

Site Contact

Site Public Contact

mccinfo@mtcancer.org

406-969-6060

Community Medical Hospital, Missoula, Montana

Status

Recruiting

Address

Community Medical Hospital

Missoula, Montana, 59804

Site Contact

Site Public Contact

mccinfo@mtcancer.org

406-969-6060

University of Nebraska Medical Center, Omaha, Nebraska

Status

Recruiting

Address

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Site Contact

Site Public Contact

unmcrsa@unmc.edu

402-559-6941

Renown Regional Medical Center, Reno, Nevada

Status

Recruiting

Address

Renown Regional Medical Center

Reno, Nevada, 89502

Site Contact

Site Public Contact

research@sncrf.org

702-384-0013

Wentworth-Douglass Hospital, Dover, New Hampshire

Status

Active, not recruiting

Address

Wentworth-Douglass Hospital

Dover, New Hampshire, 03820

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Status

Recruiting

Address

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756

Site Contact

Site Public Contact

cancer.research.nurse@dartmouth.edu

800-639-6918

Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey

Status

Recruiting

Address

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920

Site Contact

Site Public Contact

212-639-7592

Englewood Hospital and Medical Center, Englewood, New Jersey

Status

Recruiting

Address

Englewood Hospital and Medical Center

Englewood, New Jersey, 07631

Site Contact

Site Public Contact

201-894-3456

Memorial Sloan Kettering Monmouth, Middletown, New Jersey

Status

Recruiting

Address

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748

Site Contact

Site Public Contact

212-639-7592

Virtua Memorial, Mount Holly, New Jersey

Status

Active, not recruiting

Address

Virtua Memorial

Mount Holly, New Jersey, 08060

Virtua Voorhees, Voorhees, New Jersey

Status

Active, not recruiting

Address

Virtua Voorhees

Voorhees, New Jersey, 08043

University of New Mexico Cancer Center, Albuquerque, New Mexico

Status

Recruiting

Address

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102

Site Contact

Site Public Contact

LByatt@nmcca.org

505-925-0366

Northwell Health Imbert Cancer Center, Bay Shore, New York

Status

Recruiting

Address

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706

Site Contact

Site Public Contact

516-734-8896

Bronx, New York

Status

Recruiting

Address

Montefiore Medical Center-Einstein Campus

Bronx, New York, 10461

Site Contact

Site Public Contact

eskwak@montefiore.org

718-379-6866

Montefiore Medical Center - Moses Campus, Bronx, New York

Status

Recruiting

Address

Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

Site Contact

Site Public Contact

eskwak@montefiore.org

718-379-6866

Brooklyn, New York

Status

Suspended

Address

New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215

Roswell Park Cancer Institute, Buffalo, New York

Status

Active, not recruiting

Address

Roswell Park Cancer Institute

Buffalo, New York, 14263

Memorial Sloan Kettering Commack, Commack, New York

Status

Recruiting

Address

Memorial Sloan Kettering Commack

Commack, New York, 11725

Site Contact

Site Public Contact

212-639-7592

Elmira, New York

Status

Recruiting

Address

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905

Site Contact

Site Public Contact

607-271-7000

Memorial Sloan Kettering Westchester, Harrison, New York

Status

Recruiting

Address

Memorial Sloan Kettering Westchester

Harrison, New York, 10604

Site Contact

Site Public Contact

212-639-7592

Lake Success, New York

Status

Recruiting

Address

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

Site Contact

Site Public Contact

516-734-8896

Lenox Hill Hospital, New York, New York

Status

Recruiting

Address

Lenox Hill Hospital

New York, New York, 10021

Site Contact

Site Public Contact

516-734-8896

New York, New York

Status

Active, not recruiting

Address

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

Memorial Sloan Kettering Cancer Center, New York, New York

Status

Recruiting

Address

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Site Contact

Site Public Contact

212-639-7592

University of Rochester, Rochester, New York

Status

Recruiting

Address

University of Rochester

Rochester, New York, 14642

Site Contact

Site Public Contact

585-275-5830

Staten Island University Hospital, Staten Island, New York

Status

Active, not recruiting

Address

Staten Island University Hospital

Staten Island, New York, 10305

Syracuse, New York

Status

Recruiting

Address

State University of New York Upstate Medical University

Syracuse, New York, 13210

Site Contact

Site Public Contact

315-464-5476

Memorial Sloan Kettering Nassau, Uniondale, New York

Status

Recruiting

Address

Memorial Sloan Kettering Nassau

Uniondale, New York, 11553

Site Contact

Site Public Contact

212-639-7592

Charlotte, North Carolina

Status

Recruiting

Address

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

Site Contact

Site Public Contact

800-804-9376

Atrium Health Pineville/LCI-Pineville, Charlotte, North Carolina

Status

Recruiting

Address

Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, 28210

Site Contact

Site Public Contact

980-442-2000

Charlotte, North Carolina

Status

Recruiting

Address

Atrium Health University City/LCI-University

Charlotte, North Carolina, 28262

Site Contact

Site Public Contact

800-804-9376

Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina

Status

Recruiting

Address

Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025

Site Contact

Site Public Contact

800-804-9376

Atrium Health Union/LCI-Union, Monroe, North Carolina

Status

Recruiting

Address

Atrium Health Union/LCI-Union

Monroe, North Carolina, 28112

Site Contact

Site Public Contact

980-442-2000

Atrium Health Cleveland/LCI-Cleveland, Shelby, North Carolina

Status

Recruiting

Address

Atrium Health Cleveland/LCI-Cleveland

Shelby, North Carolina, 28150

Site Contact

Site Public Contact

800-804-9376

Sanford Bismarck Medical Center, Bismarck, North Dakota

Status

Recruiting

Address

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501

Sanford Roger Maris Cancer Center, Fargo, North Dakota

Status

Recruiting

Address

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122

Summa Health System - Akron Campus, Akron, Ohio

Status

Recruiting

Address

Summa Health System - Akron Campus

Akron, Ohio, 44304

Site Contact

Site Public Contact

cancerresearch@summahealth.org

330-375-4221

Cleveland Clinic Akron General, Akron, Ohio

Status

Recruiting

Address

Cleveland Clinic Akron General

Akron, Ohio, 44307

Site Contact

Site Public Contact

CancerAnswer@ccf.org

866-223-8100

Geauga Hospital, Chardon, Ohio

Status

Recruiting

Address

Geauga Hospital

Chardon, Ohio, 44024

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Adena Regional Medical Center, Chillicothe, Ohio

Status

Recruiting

Address

Adena Regional Medical Center

Chillicothe, Ohio, 45601

Site Contact

Site Public Contact

sheree@columbusccop.org

877-779-7585

Case Western Reserve University, Cleveland, Ohio

Status

Recruiting

Address

Case Western Reserve University

Cleveland, Ohio, 44106

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Cleveland, Ohio

Status

Recruiting

Address

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111

Site Contact

Site Public Contact

TaussigResearch@ccf.org

866-223-8100

Cleveland Clinic Foundation, Cleveland, Ohio

Status

Recruiting

Address

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

Site Contact

Site Public Contact

TaussigResearch@ccf.org

866-223-8100

Columbus, Ohio

Status

Recruiting

Address

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Site Contact

Site Public Contact

Jamesline@osumc.edu

800-293-5066

Mount Carmel Health Center West, Columbus, Ohio

Status

Suspended

Address

Mount Carmel Health Center West

Columbus, Ohio, 43222

Dayton, Ohio

Status

Suspended

Address

Dayton Physician LLC-Miami Valley Hospital North

Dayton, Ohio, 45415

Mercy Cancer Center-Elyria, Elyria, Ohio

Status

Recruiting

Address

Mercy Cancer Center-Elyria

Elyria, Ohio, 44035

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Independence, Ohio

Status

Recruiting

Address

Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131

Site Contact

Site Public Contact

TaussigResearch@ccf.org

866-223-8100

Mentor, Ohio

Status

Recruiting

Address

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Middleburg Heights, Ohio

Status

Recruiting

Address

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Parma, Ohio

Status

Recruiting

Address

University Hospitals Parma Medical Center

Parma, Ohio, 44129

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Strongsville, Ohio

Status

Recruiting

Address

Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136

Site Contact

Site Public Contact

TaussigResearch@ccf.org

866-223-8100

UHHS-Westlake Medical Center, Westlake, Ohio

Status

Recruiting

Address

UHHS-Westlake Medical Center

Westlake, Ohio, 44145

Site Contact

Site Public Contact

CTUReferral@UHhospitals.org

800-641-2422

Wooster, Ohio

Status

Recruiting

Address

Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691

Site Contact

Site Public Contact

TaussigResearch@ccf.org

866-223-8100

Oklahoma City, Oklahoma

Status

Completed

Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Legacy Mount Hood Medical Center, Gresham, Oregon

Status

Suspended

Address

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030

Portland, Oregon

Status

Suspended

Address

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210

Abington Memorial Hospital, Abington, Pennsylvania

Status

Active, not recruiting

Address

Abington Memorial Hospital

Abington, Pennsylvania, 19001

Broomall, Pennsylvania

Status

Recruiting

Address

Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008

Site Contact

Site Public Contact

Jolene.garney@crozer.org

610-284-8237

Bryn Mawr Hospital, Bryn Mawr, Pennsylvania

Status

Recruiting

Address

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010

Site Contact

Site Public Contact

turzoe@mlhs.org

484-476-2649

Chadds Ford, Pennsylvania

Status

Recruiting

Address

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317

Site Contact

Site Public Contact

mhayden@christianacare.org

302-623-4450

Geisinger Medical Center, Danville, Pennsylvania

Status

Recruiting

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822

Site Contact

Site Public Contact

HemonCCTrials@geisinger.edu

570-271-5251

Northeast Radiation Oncology Center, Dunmore, Pennsylvania

Status

Recruiting

Address

Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512

Site Contact

Site Public Contact

888-808-6762

Adams Cancer Center, Gettysburg, Pennsylvania

Status

Recruiting

Address

Adams Cancer Center

Gettysburg, Pennsylvania, 17325

Site Contact

Site Public Contact

877-441-7957

Glen Mills, Pennsylvania

Status

Recruiting

Address

Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, 19342

Site Contact

Site Public Contact

610-284-8237

Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania

Status

Recruiting

Address

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837

Site Contact

Site Public Contact

HemonCCTrials@geisinger.edu

570-374-8555

Riddle Memorial Hospital, Media, Pennsylvania

Status

Recruiting

Address

Riddle Memorial Hospital

Media, Pennsylvania, 19063

Site Contact

Site Public Contact

turzoe@mlhs.org

484-476-2649

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Status

Recruiting

Address

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

Site Contact

Site Public Contact

215-955-6084

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Status

Recruiting

Address

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Site Contact

Site Public Contact

215-728-4790

Aria Health-Torresdale Campus, Philadelphia, Pennsylvania

Status

Recruiting

Address

Aria Health-Torresdale Campus

Philadelphia, Pennsylvania, 19114

Site Contact

Site Public Contact

215-612-5296

Temple University Hospital, Philadelphia, Pennsylvania

Status

Recruiting

Address

Temple University Hospital

Philadelphia, Pennsylvania, 19140

Site Contact

Site Public Contact

215-728-2983

Reading, Pennsylvania

Status

Suspended

Address

Penn State Health Saint Joseph Medical Center

Reading, Pennsylvania, 19605

Reading Hospital, West Reading, Pennsylvania

Status

Recruiting

Address

Reading Hospital

West Reading, Pennsylvania, 19611

Site Contact

Site Public Contact

610-988-9323

Wilkes-Barre, Pennsylvania

Status

Recruiting

Address

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

Site Contact

Site Public Contact

HemonCCTrials@geisinger.edu

570-271-5251

Lankenau Medical Center, Wynnewood, Pennsylvania

Status

Recruiting

Address

Lankenau Medical Center

Wynnewood, Pennsylvania, 19096

Site Contact

Site Public Contact

turzoe@mlhs.org

484-476-2649

WellSpan Health-York Cancer Center, York, Pennsylvania

Status

Recruiting

Address

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403

Site Contact

Site Public Contact

877-441-7957

AnMed Health Cancer Center, Anderson, South Carolina

Status

Recruiting

Address

AnMed Health Cancer Center

Anderson, South Carolina, 29621

Site Contact

Site Public Contact

rhonda.ballew@anmedhealth.org

864-512-4651

Boiling Springs, South Carolina

Status

Suspended

Address

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316

Prisma Health Cancer Institute - Faris, Greenville, South Carolina

Status

Recruiting

Address

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605

Site Contact

Site Public Contact

kim.williams3@prismahealth.org

864-522-2066

Greenville, South Carolina

Status

Recruiting

Address

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615

Site Contact

Site Public Contact

kim.williams3@prismahealth.org

864-522-2066

Self Regional Healthcare, Greenwood, South Carolina

Status

Recruiting

Address

Self Regional Healthcare

Greenwood, South Carolina, 29646

Site Contact

Site Public Contact

nmcgaha@selfregional.org

864-725-4771

Hilton Head Island, South Carolina

Status

Recruiting

Address

The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, 29926

Site Contact

Site Public Contact

underberga@sjchs.org

912-819-5704

Lancaster Radiation Therapy Center, Lancaster, South Carolina

Status

Suspended

Address

Lancaster Radiation Therapy Center

Lancaster, South Carolina, 29720

Rock Hill Radiation Therapy Center, Rock Hill, South Carolina

Status

Suspended

Address

Rock Hill Radiation Therapy Center

Rock Hill, South Carolina, 29730

Rapid City Regional Hospital, Rapid City, South Dakota

Status

Active, not recruiting

Address

Rapid City Regional Hospital

Rapid City, South Dakota, 57701

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

Site Contact

Site Public Contact

OncologyClinicalTrialsSF@SanfordHealth.org

605-312-3320

Thompson Cancer Survival Center, Knoxville, Tennessee

Status

Recruiting

Address

Thompson Cancer Survival Center

Knoxville, Tennessee, 37916

Site Contact

Site Public Contact

865-331-1812

Blount Memorial Hospital, Maryville, Tennessee

Status

Recruiting

Address

Blount Memorial Hospital

Maryville, Tennessee, 37804

Site Contact

Site Public Contact

865-331-1812

Nashville, Tennessee

Status

Active, not recruiting

Address

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

University of Texas Medical Branch, Galveston, Texas

Status

Recruiting

Address

University of Texas Medical Branch

Galveston, Texas, 77555-0565

Site Contact

Site Public Contact

clinical.research@utmb.edu

409-772-1950

M D Anderson Cancer Center, Houston, Texas

Status

Active, not recruiting

Address

M D Anderson Cancer Center

Houston, Texas, 77030

UTMB Cancer Center at Victory Lakes, League City, Texas

Status

Recruiting

Address

UTMB Cancer Center at Victory Lakes

League City, Texas, 77573

Site Contact

Site Public Contact

800-917-8906

Ogden Regional Medical Center, Ogden, Utah

Status

Active, not recruiting

Address

Ogden Regional Medical Center

Ogden, Utah, 84405

Salt Lake City, Utah

Status

Recruiting

Address

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

Site Contact

Site Public Contact

cancerinfo@hci.utah.edu

888-424-2100

Berlin, Vermont

Status

Recruiting

Address

Central Vermont Medical Center/National Life Cancer Treatment

Berlin, Vermont, 05602

Site Contact

Site Public Contact

802-225-5400

University of Vermont Medical Center, Burlington, Vermont

Status

Recruiting

Address

University of Vermont Medical Center

Burlington, Vermont, 05401

Site Contact

Site Public Contact

rpo@uvm.edu

802-656-4101

Norris Cotton Cancer Center-North, Saint Johnsbury, Vermont

Status

Recruiting

Address

Norris Cotton Cancer Center-North

Saint Johnsbury, Vermont, 05819

Site Contact

Site Public Contact

802-473-4100

Richmond, Virginia

Status

Active, not recruiting

Address

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

West Virginia University Healthcare, Morgantown, West Virginia

Status

Suspended

Address

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Wheeling, West Virginia

Status

Suspended

Address

Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003

Langlade Hospital and Cancer Center, Antigo, Wisconsin

Status

Recruiting

Address

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

Site Contact

Site Public Contact

Juli.Alford@aspirus.org

715-623-9869

Brookfield, Wisconsin

Status

Recruiting

Address

Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045

Site Contact

Site Public Contact

AWRI.Inquiry@Ascension.org

414-635-6420

Eau Claire, Wisconsin

Status

Active, not recruiting

Address

Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, 54701

Eau Claire, Wisconsin

Status

Active, not recruiting

Address

Mayo Clinic Health System Eau Claire Hospital-Luther Campus

Eau Claire, Wisconsin, 54703

Franklin, Wisconsin

Status

Recruiting

Address

Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132

Site Contact

Site Public Contact

AWRI.Inquiry@Ascension.org

414-635-6420

Aurora Cancer Care-Grafton, Grafton, Wisconsin

Status

Active, not recruiting

Address

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024

Aurora BayCare Medical Center, Green Bay, Wisconsin

Status

Active, not recruiting

Address

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311

UW Cancer Center Johnson Creek, Johnson Creek, Wisconsin

Status

Recruiting

Address

UW Cancer Center Johnson Creek

Johnson Creek, Wisconsin, 53038

Site Contact

Site Public Contact

lynda.persico@uwmf.wisc.edu

920-699-3500

Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin

Status

Active, not recruiting

Address

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

Status

Recruiting

Address

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Site Contact

Site Public Contact

cancerctr@gundersenhealth.org

608-775-2385

La Crosse, Wisconsin

Status

Active, not recruiting

Address

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601

Madison, Wisconsin

Status

Recruiting

Address

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792

Site Contact

Site Public Contact

800-622-8922

Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin

Status

Suspended

Address

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin

Status

Active, not recruiting

Address

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215

Medical College of Wisconsin, Milwaukee, Wisconsin

Status

Suspended

Address

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Aurora Sinai Medical Center, Milwaukee, Wisconsin

Status

Active, not recruiting

Address

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin

Status

Active, not recruiting

Address

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904

Ascension All Saints Hospital, Racine, Wisconsin

Status

Recruiting

Address

Ascension All Saints Hospital

Racine, Wisconsin, 53405

Site Contact

Site Public Contact

AWRI.Inquiry@Ascension.org

414-635-6420

Marshfield Clinic Stevens Point Center, Stevens Point, Wisconsin

Status

Recruiting

Address

Marshfield Clinic Stevens Point Center

Stevens Point, Wisconsin, 54482

Aurora Medical Center in Summit, Summit, Wisconsin

Status

Active, not recruiting

Address

Aurora Medical Center in Summit

Summit, Wisconsin, 53066

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin

Status

Active, not recruiting

Address

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241

Aspirus Regional Cancer Center, Wausau, Wisconsin

Status

Recruiting

Address

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

Site Contact

Site Public Contact

877-405-6866

Aurora West Allis Medical Center, West Allis, Wisconsin

Status

Active, not recruiting

Address

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227

Diagnostic and Treatment Center, Weston, Wisconsin

Status

Recruiting

Address

Diagnostic and Treatment Center

Weston, Wisconsin, 54476

Marshfield Medical Center - Weston, Weston, Wisconsin

Status

Recruiting

Address

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin

Status

Recruiting

Address

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494

Site Contact

Site Public Contact

715-422-7718

International Sites

Kingston Health Sciences Centre, Kingston, Ontario, Canada

Status

Active, not recruiting

Address

Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7

London Regional Cancer Program, London, Ontario, Canada

Status

Suspended

Address

London Regional Cancer Program

London, Ontario, N6A 4L6

Newmarket, Ontario, Canada

Status

Recruiting

Address

Stronach Regional Health Centre at Southlake

Newmarket, Ontario, L3Y 2P9

Site Contact

Site Public Contact

905-895-4521 #6820

Ottawa, Ontario, Canada

Status

Active, not recruiting

Address

Ottawa Hospital and Cancer Center-General Campus

Ottawa, Ontario, K1H 8L6

Toronto, Ontario, Canada

Status

Recruiting

Address

University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9

Site Contact

Site Public Contact

clinical.trials@uhn.on.ca

416-946-4501

CHUM - Hopital Notre-Dame, Montreal, Quebec, Canada

Status

Suspended

Address

CHUM - Hopital Notre-Dame

Montreal, Quebec, H2L 4M1

McGill University Department of Oncology, Montreal, Quebec, Canada

Status

Recruiting

Address

McGill University Department of Oncology

Montreal, Quebec, H2W 1S6

Site Contact

Anne Dagnault

rechclinique@crchuq.ulaval.ca

Montreal, Quebec, Canada

Status

Suspended

Address

CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4

Montreal, Quebec, Canada

Status

Recruiting

Address

The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9

Site Contact

Site Public Contact

evelyn.ortega@muhc.mcgill.ca

514-934-1934 #48354

Quebec City, Quebec, Canada

Status

Recruiting

Address

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Quebec City, Quebec, G1R 2J6

Site Contact

Site Public Contact

rechclinique@crchuq.ulaval.ca

Sherbrooke, Quebec, Canada

Status

Suspended

Address

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, J1H 5N4

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Status

Recruiting

Address

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1

Site Contact

Site Public Contact

306-766-2213

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Status

Recruiting

Address

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4

Site Contact

Site Public Contact

306-655-2914

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